CN1338947B - 粘膜递送系统 - Google Patents

粘膜递送系统 Download PDF

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Publication number
CN1338947B
CN1338947B CN008034524A CN00803452A CN1338947B CN 1338947 B CN1338947 B CN 1338947B CN 008034524 A CN008034524 A CN 008034524A CN 00803452 A CN00803452 A CN 00803452A CN 1338947 B CN1338947 B CN 1338947B
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CN
China
Prior art keywords
aluminum
mucosa
vaccine
delivery system
hydroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN008034524A
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English (en)
Chinese (zh)
Other versions
CN1338947A (zh
Inventor
H·H·伊普森
J·尤耳达尔拉贝克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALK Abello AS
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ALK Abello AS
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Publication of CN1338947A publication Critical patent/CN1338947A/zh
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Publication of CN1338947B publication Critical patent/CN1338947B/zh
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Vending Machines For Individual Products (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN008034524A 1999-02-05 2000-02-04 粘膜递送系统 Expired - Fee Related CN1338947B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11889699P 1999-02-05 1999-02-05
US60/118,896 1999-02-05
DKPA199900155 1999-02-05
DKPA199900115 1999-02-05

Publications (2)

Publication Number Publication Date
CN1338947A CN1338947A (zh) 2002-03-06
CN1338947B true CN1338947B (zh) 2012-11-14

Family

ID=26063341

Family Applications (1)

Application Number Title Priority Date Filing Date
CN008034524A Expired - Fee Related CN1338947B (zh) 1999-02-05 2000-02-04 粘膜递送系统

Country Status (10)

Country Link
EP (1) EP1146906B1 (enExample)
JP (1) JP2003517452A (enExample)
CN (1) CN1338947B (enExample)
AT (1) ATE515258T1 (enExample)
AU (1) AU771552B2 (enExample)
CA (1) CA2361377C (enExample)
DK (1) DK1146906T3 (enExample)
ES (1) ES2368987T3 (enExample)
HK (1) HK1041219B (enExample)
WO (1) WO2000045847A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2330507T3 (es) * 2000-08-09 2009-12-11 Alk-Abello A/S Formulaciones parenterales de vacuna y usos de la mismas.
DK2116257T3 (da) 2000-08-09 2013-02-04 Alk Abello As Parenterale vaccineformuleringer og anvendelser deraf
AU2004203772B2 (en) * 2003-01-07 2009-07-16 Yeda Research And Development Co. Ltd. Eye-drop vaccine containing copolymer 1 for therapeutic immunization
US20060115499A1 (en) * 2004-09-27 2006-06-01 Alk-Abello A/S Liquid allergy vaccine formulation for oromucosal administration
DE602005021388D1 (de) * 2004-11-10 2010-07-01 Alk Abello As Verfahren für die präventive behandlung von allergien durch verabreichung einer allergie-vakzine auf die schleimhäute
US20090155351A1 (en) * 2005-10-04 2009-06-18 Alk-Abello A/S Solid Vaccine Formulation
DK1814516T3 (da) * 2005-11-04 2013-03-25 Alk Abello As Anvendelse af en flydende allergivaccineformulering til oromucosal indgivelse
US20090297564A1 (en) * 2005-11-04 2009-12-03 Domingo Barber Hernandez Use of a Liquid Allergy Vaccine Formulation for Oromucosal Administration
WO2009142772A2 (en) * 2008-05-23 2009-11-26 Mastcell Pharmaceuticals, Inc. Methods and treatment for allergies and inflammation associated with gastrointestinal diseases
CN102441162B (zh) * 2010-10-04 2018-07-24 免疫产品美国股份有限公司 结核病的治疗和预防
EP3556398A1 (en) * 2018-04-16 2019-10-23 Croda Denmark A/S Phytates for use as a biomolecules delivery or adsorption system
BR112021025025A2 (pt) * 2019-06-11 2022-02-22 Glaxosmithkline Biologicals Sa Formulações de vacinas de mucosa
CN111658611B (zh) * 2020-04-13 2021-06-01 四川大学 一种基于微乳的疫苗递送系统及其制备方法和应用

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US3329564A (en) 1965-06-28 1967-07-04 Parke Davis & Co Antacid preparations and means of producing the same
DE2126957B2 (de) 1971-05-29 1977-07-07 Schettler, Hermann, Dr, East Lan sing, Mich (VStA) Verfahren zur herstellung von impfstoffen gegen gaensehepatitis
US4233288A (en) * 1979-03-12 1980-11-11 Cornell John A Gum emulsified liquid package for delivering and preserving liquid content in the mouth
JPS61238728A (ja) 1985-04-16 1986-10-24 Mitsui Norin Kk 茶葉抽出物と活性水酸化アルミニウムとの抗潰瘍性複合体
IL84167A (en) 1986-10-24 1991-04-15 Southern Res Inst Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation
JPH02124832A (ja) * 1988-07-08 1990-05-14 Toray Ind Inc インターヘェロンβ組成物
US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
JP3132863B2 (ja) * 1991-10-24 2001-02-05 富山化学工業株式会社 徐放性口腔用軟膏
US5360792A (en) 1991-12-20 1994-11-01 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
JP3880063B2 (ja) 1993-03-18 2007-02-14 シティミューン サイエンシーズ，インコーポレイテッド 生物学的に活性な因子の毒性を低減させる組成物および方法
GB9316745D0 (en) 1993-08-12 1993-09-29 Medeva Holdings Bv Vaccine compositions
JP3414539B2 (ja) * 1994-05-11 2003-06-09 有限会社ドット 経鼻吸収用組成物
JP2001515457A (ja) * 1995-06-07 2001-09-18 アルカームズ コントロールド セラピューティックス，インコーポレイテッド 凝集安定化生理活性物質放出用装置
US6221365B1 (en) * 1996-07-26 2001-04-24 American Cyanamid Company NucA protein of Haemophilus influenzae
EP2172216A3 (en) * 1997-03-10 2010-11-24 Ottawa Hospital Research Institute Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
DE69822542T2 (de) * 1997-04-23 2004-08-05 Pfizer Inc. Verkapslung einer Untereinheit des Bovinen Herpes Virus Typ-1 in wässrigen Lösungsmitteln als Impfstoff.
JPH11216357A (ja) * 1998-02-03 1999-08-10 Tsutsumi Techno Planning Kk 生理活性物質用の吸着担体
JPH11286438A (ja) * 1998-03-31 1999-10-19 Shiseido Co Ltd 徐放性製剤
JPH11302184A (ja) * 1998-04-21 1999-11-02 Taisho Pharmaceut Co Ltd 点鼻用組成物
JPH11322582A (ja) * 1998-05-06 1999-11-24 Dot:Kk 経鼻吸収用鼻粘膜付着・滞留型キャリヤ

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Gilligan CA et al..口服疫苗：设计和传送.国外医学药物分册19 3.1992,19(3),160-163.
Gilligan CA et al..口服疫苗:设计和传送.国外医学药物分册19 3.1992,19(3),160-163. *
Hossein Mirchamsy et al..Stimulating role of toxoids-laden liposomes in oral immunizationagainst diphtheria and tetanus infection.Biologlicals24.1996,24343-350. *

Also Published As

Publication number Publication date
CA2361377A1 (en) 2000-08-10
ES2368987T3 (es) 2011-11-24
WO2000045847A8 (en) 2010-12-02
WO2000045847A1 (en) 2000-08-10
AU771552B2 (en) 2004-03-25
CA2361377C (en) 2009-02-03
EP1146906B1 (en) 2011-07-06
EP1146906A1 (en) 2001-10-24
HK1041219A1 (en) 2002-07-05
CN1338947A (zh) 2002-03-06
ATE515258T1 (de) 2011-07-15
AU2279700A (en) 2000-08-25
HK1041219B (en) 2011-10-21
JP2003517452A (ja) 2003-05-27
DK1146906T3 (da) 2011-10-24

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: Holm Hess, Denmark

Applicant after: Alk Abello AS

Address before: Holm Hess, Denmark

Applicant before: Alk Abello AS

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: ALK-ABELLO A/S TO: ALK-ABELLO A/S

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121114

Termination date: 20140204