JP2003517452A - 新規粘膜デリバリーシステム - Google Patents
新規粘膜デリバリーシステムInfo
- Publication number
- JP2003517452A JP2003517452A JP2000596966A JP2000596966A JP2003517452A JP 2003517452 A JP2003517452 A JP 2003517452A JP 2000596966 A JP2000596966 A JP 2000596966A JP 2000596966 A JP2000596966 A JP 2000596966A JP 2003517452 A JP2003517452 A JP 2003517452A
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- mucosa
- oxygen
- containing metal
- hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000002184 metal Substances 0.000 claims abstract description 100
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- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 88
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- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 8
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- WPJWIROQQFWMMK-UHFFFAOYSA-L beryllium dihydroxide Chemical compound [Be+2].[OH-].[OH-] WPJWIROQQFWMMK-UHFFFAOYSA-L 0.000 claims description 8
- 229910001865 beryllium hydroxide Inorganic materials 0.000 claims description 8
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- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 claims description 8
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 claims description 8
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- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 8
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 claims description 8
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Vending Machines For Individual Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US11889699P | 1999-02-05 | 1999-02-05 | |
| DK199900155 | 1999-02-05 | ||
| US60/118,896 | 1999-02-05 | ||
| DKPA199900155 | 1999-02-05 | ||
| PCT/DK2000/000049 WO2000045847A1 (en) | 1999-02-05 | 2000-02-04 | Novel mucosal delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003517452A true JP2003517452A (ja) | 2003-05-27 |
| JP2003517452A5 JP2003517452A5 (enExample) | 2011-09-15 |
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| EP (1) | EP1146906B1 (enExample) |
| JP (1) | JP2003517452A (enExample) |
| CN (1) | CN1338947B (enExample) |
| AT (1) | ATE515258T1 (enExample) |
| AU (1) | AU771552B2 (enExample) |
| CA (1) | CA2361377C (enExample) |
| DK (1) | DK1146906T3 (enExample) |
| ES (1) | ES2368987T3 (enExample) |
| HK (1) | HK1041219B (enExample) |
| WO (1) | WO2000045847A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2116257T3 (da) | 2000-08-09 | 2013-02-04 | Alk Abello As | Parenterale vaccineformuleringer og anvendelser deraf |
| ATE437651T1 (de) * | 2000-08-09 | 2009-08-15 | Alk Abello As | Parenterale impfstoff-formulierungen und deren verwendung |
| CA2512735C (en) * | 2003-01-07 | 2016-03-08 | Yeda Research And Development Co. Ltd. | Eye-drop vaccine containing copolymer 1 for therapeutic immunization |
| US20060115499A1 (en) * | 2004-09-27 | 2006-06-01 | Alk-Abello A/S | Liquid allergy vaccine formulation for oromucosal administration |
| CA2586283A1 (en) * | 2004-11-10 | 2006-05-18 | Jens Brimnes | Method of preventive treatment of allergy by mucosal administration of an allergy vaccine |
| RU2008117396A (ru) * | 2005-10-04 | 2009-11-10 | Альк-Абелло А/С (Dk) | Твердая вакцинная композиция |
| EP1814516B1 (en) * | 2005-11-04 | 2012-12-26 | Alk-Abelló A/S | Use of a liquid allergy vaccine formulation for oromucosal administration |
| DK1814516T3 (da) * | 2005-11-04 | 2013-03-25 | Alk Abello As | Anvendelse af en flydende allergivaccineformulering til oromucosal indgivelse |
| WO2009142772A2 (en) * | 2008-05-23 | 2009-11-26 | Mastcell Pharmaceuticals, Inc. | Methods and treatment for allergies and inflammation associated with gastrointestinal diseases |
| CN102441162B (zh) * | 2010-10-04 | 2018-07-24 | 免疫产品美国股份有限公司 | 结核病的治疗和预防 |
| EP3556398A1 (en) * | 2018-04-16 | 2019-10-23 | Croda Denmark A/S | Phytates for use as a biomolecules delivery or adsorption system |
| WO2020250130A1 (en) * | 2019-06-11 | 2020-12-17 | Glaxosmithkline Biologicals Sa | Mucosal vaccine formulations |
| CN111658611B (zh) * | 2020-04-13 | 2021-06-01 | 四川大学 | 一种基于微乳的疫苗递送系统及其制备方法和应用 |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02124832A (ja) * | 1988-07-08 | 1990-05-14 | Toray Ind Inc | インターヘェロンβ組成物 |
| JPH0789847A (ja) * | 1991-10-24 | 1995-04-04 | Toyama Chem Co Ltd | 徐放性口腔用軟膏 |
| JPH0827031A (ja) * | 1994-05-11 | 1996-01-30 | Dot:Kk | 経鼻吸収用組成物 |
| WO1996040074A2 (en) * | 1995-06-07 | 1996-12-19 | Alkermes Controlled Therapeutics, Inc. | Device for releasing aggregation-stabilized, biologically active agent |
| WO1998004703A1 (en) * | 1996-07-26 | 1998-02-05 | American Cyanamid Company | THE NucA PROTEIN OF HAEMOPHILUS INFLUENZAE AND THE GENE ENCODING THAT PROTEIN |
| JPH10316586A (ja) * | 1997-04-23 | 1998-12-02 | Pfizer Inc | 水性溶剤に基づいたウシヘルペスウイルスタイプ−１サブユニットワクチンのカプセル化 |
| JPH11216357A (ja) * | 1998-02-03 | 1999-08-10 | Tsutsumi Techno Planning Kk | 生理活性物質用の吸着担体 |
| JPH11286438A (ja) * | 1998-03-31 | 1999-10-19 | Shiseido Co Ltd | 徐放性製剤 |
| JPH11302184A (ja) * | 1998-04-21 | 1999-11-02 | Taisho Pharmaceut Co Ltd | 点鼻用組成物 |
| JPH11322582A (ja) * | 1998-05-06 | 1999-11-24 | Dot:Kk | 経鼻吸収用鼻粘膜付着・滞留型キャリヤ |
| JP2002511841A (ja) * | 1997-03-10 | 2002-04-16 | オタワ シビック ローブ リサーチ インスティチュート | アジュバントとして非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3329564A (en) | 1965-06-28 | 1967-07-04 | Parke Davis & Co | Antacid preparations and means of producing the same |
| DE2126957B2 (de) | 1971-05-29 | 1977-07-07 | Schettler, Hermann, Dr, East Lan sing, Mich (VStA) | Verfahren zur herstellung von impfstoffen gegen gaensehepatitis |
| US4233288A (en) * | 1979-03-12 | 1980-11-11 | Cornell John A | Gum emulsified liquid package for delivering and preserving liquid content in the mouth |
| JPS61238728A (ja) | 1985-04-16 | 1986-10-24 | Mitsui Norin Kk | 茶葉抽出物と活性水酸化アルミニウムとの抗潰瘍性複合体 |
| IL84167A (en) | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
| US5443832A (en) * | 1990-04-16 | 1995-08-22 | Institut Swisse De Recherches Experimentales Sur Le Cancer | Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response |
| US5360792A (en) | 1991-12-20 | 1994-11-01 | Greenwich Pharmaceuticals Incorporated | Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom |
| US5972336A (en) * | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
| ATE270111T1 (de) | 1993-03-18 | 2004-07-15 | Cytimmune Sciences Inc | Zusammensetzung und methode zur reduktion der toxizität von biologisch-aktiven faktoren |
| GB9316745D0 (en) | 1993-08-12 | 1993-09-29 | Medeva Holdings Bv | Vaccine compositions |
-
2000
- 2000-02-04 JP JP2000596966A patent/JP2003517452A/ja not_active Withdrawn
- 2000-02-04 DK DK00901497.8T patent/DK1146906T3/da active
- 2000-02-04 HK HK02102996.8A patent/HK1041219B/en not_active IP Right Cessation
- 2000-02-04 CA CA002361377A patent/CA2361377C/en not_active Expired - Fee Related
- 2000-02-04 AU AU22797/00A patent/AU771552B2/en not_active Ceased
- 2000-02-04 EP EP00901497A patent/EP1146906B1/en not_active Expired - Lifetime
- 2000-02-04 CN CN008034524A patent/CN1338947B/zh not_active Expired - Fee Related
- 2000-02-04 WO PCT/DK2000/000049 patent/WO2000045847A1/en not_active Ceased
- 2000-02-04 AT AT00901497T patent/ATE515258T1/de not_active IP Right Cessation
- 2000-02-04 ES ES00901497T patent/ES2368987T3/es not_active Expired - Lifetime
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02124832A (ja) * | 1988-07-08 | 1990-05-14 | Toray Ind Inc | インターヘェロンβ組成物 |
| JPH0789847A (ja) * | 1991-10-24 | 1995-04-04 | Toyama Chem Co Ltd | 徐放性口腔用軟膏 |
| JPH0827031A (ja) * | 1994-05-11 | 1996-01-30 | Dot:Kk | 経鼻吸収用組成物 |
| WO1996040074A2 (en) * | 1995-06-07 | 1996-12-19 | Alkermes Controlled Therapeutics, Inc. | Device for releasing aggregation-stabilized, biologically active agent |
| WO1998004703A1 (en) * | 1996-07-26 | 1998-02-05 | American Cyanamid Company | THE NucA PROTEIN OF HAEMOPHILUS INFLUENZAE AND THE GENE ENCODING THAT PROTEIN |
| JP2002511841A (ja) * | 1997-03-10 | 2002-04-16 | オタワ シビック ローブ リサーチ インスティチュート | アジュバントとして非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
| JPH10316586A (ja) * | 1997-04-23 | 1998-12-02 | Pfizer Inc | 水性溶剤に基づいたウシヘルペスウイルスタイプ−１サブユニットワクチンのカプセル化 |
| JPH11216357A (ja) * | 1998-02-03 | 1999-08-10 | Tsutsumi Techno Planning Kk | 生理活性物質用の吸着担体 |
| JPH11286438A (ja) * | 1998-03-31 | 1999-10-19 | Shiseido Co Ltd | 徐放性製剤 |
| JPH11302184A (ja) * | 1998-04-21 | 1999-11-02 | Taisho Pharmaceut Co Ltd | 点鼻用組成物 |
| JPH11322582A (ja) * | 1998-05-06 | 1999-11-24 | Dot:Kk | 経鼻吸収用鼻粘膜付着・滞留型キャリヤ |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000045847A1 (en) | 2000-08-10 |
| EP1146906A1 (en) | 2001-10-24 |
| WO2000045847A8 (en) | 2010-12-02 |
| CA2361377A1 (en) | 2000-08-10 |
| ATE515258T1 (de) | 2011-07-15 |
| AU2279700A (en) | 2000-08-25 |
| DK1146906T3 (da) | 2011-10-24 |
| ES2368987T3 (es) | 2011-11-24 |
| HK1041219B (en) | 2011-10-21 |
| HK1041219A1 (en) | 2002-07-05 |
| CN1338947A (zh) | 2002-03-06 |
| CN1338947B (zh) | 2012-11-14 |
| AU771552B2 (en) | 2004-03-25 |
| CA2361377C (en) | 2009-02-03 |
| EP1146906B1 (en) | 2011-07-06 |
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