CA2361377C - Novel mucosal delivery system - Google Patents
Novel mucosal delivery system Download PDFInfo
- Publication number
- CA2361377C CA2361377C CA002361377A CA2361377A CA2361377C CA 2361377 C CA2361377 C CA 2361377C CA 002361377 A CA002361377 A CA 002361377A CA 2361377 A CA2361377 A CA 2361377A CA 2361377 C CA2361377 C CA 2361377C
- Authority
- CA
- Canada
- Prior art keywords
- aluminium
- mucosal
- delivery system
- sulphate
- hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000001556 precipitation Methods 0.000 description 1
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- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960003127 rabies vaccine Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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- 238000003118 sandwich ELISA Methods 0.000 description 1
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- 206010041232 sneezing Diseases 0.000 description 1
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- 229960005202 streptokinase Drugs 0.000 description 1
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- 229940092665 tea leaf extract Drugs 0.000 description 1
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- 229960002766 tetanus vaccines Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
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- 239000011710 vitamin D Substances 0.000 description 1
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- 235000005282 vitamin D3 Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Vending Machines For Individual Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11889699P | 1999-02-05 | 1999-02-05 | |
| US60/118,896 | 1999-02-05 | ||
| DKPA199900155 | 1999-02-05 | ||
| DKPA199900115 | 1999-02-05 | ||
| PCT/DK2000/000049 WO2000045847A1 (en) | 1999-02-05 | 2000-02-04 | Novel mucosal delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2361377A1 CA2361377A1 (en) | 2000-08-10 |
| CA2361377C true CA2361377C (en) | 2009-02-03 |
Family
ID=26063341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002361377A Expired - Fee Related CA2361377C (en) | 1999-02-05 | 2000-02-04 | Novel mucosal delivery system |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1146906B1 (enExample) |
| JP (1) | JP2003517452A (enExample) |
| CN (1) | CN1338947B (enExample) |
| AT (1) | ATE515258T1 (enExample) |
| AU (1) | AU771552B2 (enExample) |
| CA (1) | CA2361377C (enExample) |
| DK (1) | DK1146906T3 (enExample) |
| ES (1) | ES2368987T3 (enExample) |
| HK (1) | HK1041219B (enExample) |
| WO (1) | WO2000045847A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2330507T3 (es) * | 2000-08-09 | 2009-12-11 | Alk-Abello A/S | Formulaciones parenterales de vacuna y usos de la mismas. |
| DK2116257T3 (da) | 2000-08-09 | 2013-02-04 | Alk Abello As | Parenterale vaccineformuleringer og anvendelser deraf |
| AU2004203772B2 (en) * | 2003-01-07 | 2009-07-16 | Yeda Research And Development Co. Ltd. | Eye-drop vaccine containing copolymer 1 for therapeutic immunization |
| US20060115499A1 (en) * | 2004-09-27 | 2006-06-01 | Alk-Abello A/S | Liquid allergy vaccine formulation for oromucosal administration |
| DE602005021388D1 (de) * | 2004-11-10 | 2010-07-01 | Alk Abello As | Verfahren für die präventive behandlung von allergien durch verabreichung einer allergie-vakzine auf die schleimhäute |
| US20090155351A1 (en) * | 2005-10-04 | 2009-06-18 | Alk-Abello A/S | Solid Vaccine Formulation |
| DK1814516T3 (da) * | 2005-11-04 | 2013-03-25 | Alk Abello As | Anvendelse af en flydende allergivaccineformulering til oromucosal indgivelse |
| US20090297564A1 (en) * | 2005-11-04 | 2009-12-03 | Domingo Barber Hernandez | Use of a Liquid Allergy Vaccine Formulation for Oromucosal Administration |
| WO2009142772A2 (en) * | 2008-05-23 | 2009-11-26 | Mastcell Pharmaceuticals, Inc. | Methods and treatment for allergies and inflammation associated with gastrointestinal diseases |
| CN102441162B (zh) * | 2010-10-04 | 2018-07-24 | 免疫产品美国股份有限公司 | 结核病的治疗和预防 |
| EP3556398A1 (en) * | 2018-04-16 | 2019-10-23 | Croda Denmark A/S | Phytates for use as a biomolecules delivery or adsorption system |
| BR112021025025A2 (pt) * | 2019-06-11 | 2022-02-22 | Glaxosmithkline Biologicals Sa | Formulações de vacinas de mucosa |
| CN111658611B (zh) * | 2020-04-13 | 2021-06-01 | 四川大学 | 一种基于微乳的疫苗递送系统及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3329564A (en) | 1965-06-28 | 1967-07-04 | Parke Davis & Co | Antacid preparations and means of producing the same |
| DE2126957B2 (de) | 1971-05-29 | 1977-07-07 | Schettler, Hermann, Dr, East Lan sing, Mich (VStA) | Verfahren zur herstellung von impfstoffen gegen gaensehepatitis |
| US4233288A (en) * | 1979-03-12 | 1980-11-11 | Cornell John A | Gum emulsified liquid package for delivering and preserving liquid content in the mouth |
| JPS61238728A (ja) | 1985-04-16 | 1986-10-24 | Mitsui Norin Kk | 茶葉抽出物と活性水酸化アルミニウムとの抗潰瘍性複合体 |
| IL84167A (en) | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
| JPH02124832A (ja) * | 1988-07-08 | 1990-05-14 | Toray Ind Inc | インターヘェロンβ組成物 |
| US5443832A (en) * | 1990-04-16 | 1995-08-22 | Institut Swisse De Recherches Experimentales Sur Le Cancer | Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response |
| JP3132863B2 (ja) * | 1991-10-24 | 2001-02-05 | 富山化学工業株式会社 | 徐放性口腔用軟膏 |
| US5360792A (en) | 1991-12-20 | 1994-11-01 | Greenwich Pharmaceuticals Incorporated | Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom |
| US5972336A (en) * | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
| JP3880063B2 (ja) | 1993-03-18 | 2007-02-14 | シティミューン サイエンシーズ，インコーポレイテッド | 生物学的に活性な因子の毒性を低減させる組成物および方法 |
| GB9316745D0 (en) | 1993-08-12 | 1993-09-29 | Medeva Holdings Bv | Vaccine compositions |
| JP3414539B2 (ja) * | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
| JP2001515457A (ja) * | 1995-06-07 | 2001-09-18 | アルカームズ コントロールド セラピューティックス，インコーポレイテッド | 凝集安定化生理活性物質放出用装置 |
| US6221365B1 (en) * | 1996-07-26 | 2001-04-24 | American Cyanamid Company | NucA protein of Haemophilus influenzae |
| EP2172216A3 (en) * | 1997-03-10 | 2010-11-24 | Ottawa Hospital Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| DE69822542T2 (de) * | 1997-04-23 | 2004-08-05 | Pfizer Inc. | Verkapslung einer Untereinheit des Bovinen Herpes Virus Typ-1 in wässrigen Lösungsmitteln als Impfstoff. |
| JPH11216357A (ja) * | 1998-02-03 | 1999-08-10 | Tsutsumi Techno Planning Kk | 生理活性物質用の吸着担体 |
| JPH11286438A (ja) * | 1998-03-31 | 1999-10-19 | Shiseido Co Ltd | 徐放性製剤 |
| JPH11302184A (ja) * | 1998-04-21 | 1999-11-02 | Taisho Pharmaceut Co Ltd | 点鼻用組成物 |
| JPH11322582A (ja) * | 1998-05-06 | 1999-11-24 | Dot:Kk | 経鼻吸収用鼻粘膜付着・滞留型キャリヤ |
-
2000
- 2000-02-04 AU AU22797/00A patent/AU771552B2/en not_active Ceased
- 2000-02-04 EP EP00901497A patent/EP1146906B1/en not_active Expired - Lifetime
- 2000-02-04 CA CA002361377A patent/CA2361377C/en not_active Expired - Fee Related
- 2000-02-04 DK DK00901497.8T patent/DK1146906T3/da active
- 2000-02-04 HK HK02102996.8A patent/HK1041219B/en not_active IP Right Cessation
- 2000-02-04 AT AT00901497T patent/ATE515258T1/de not_active IP Right Cessation
- 2000-02-04 ES ES00901497T patent/ES2368987T3/es not_active Expired - Lifetime
- 2000-02-04 JP JP2000596966A patent/JP2003517452A/ja not_active Withdrawn
- 2000-02-04 CN CN008034524A patent/CN1338947B/zh not_active Expired - Fee Related
- 2000-02-04 WO PCT/DK2000/000049 patent/WO2000045847A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2361377A1 (en) | 2000-08-10 |
| ES2368987T3 (es) | 2011-11-24 |
| WO2000045847A8 (en) | 2010-12-02 |
| WO2000045847A1 (en) | 2000-08-10 |
| AU771552B2 (en) | 2004-03-25 |
| EP1146906B1 (en) | 2011-07-06 |
| EP1146906A1 (en) | 2001-10-24 |
| HK1041219A1 (en) | 2002-07-05 |
| CN1338947A (zh) | 2002-03-06 |
| ATE515258T1 (de) | 2011-07-15 |
| AU2279700A (en) | 2000-08-25 |
| HK1041219B (en) | 2011-10-21 |
| CN1338947B (zh) | 2012-11-14 |
| JP2003517452A (ja) | 2003-05-27 |
| DK1146906T3 (da) | 2011-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150204 |