CN1330305C - 以尼古丁作为有效成份的高柔韧性的经皮治疗体系 - Google Patents

以尼古丁作为有效成份的高柔韧性的经皮治疗体系 Download PDF

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Publication number
CN1330305C
CN1330305C CNB028059018A CN02805901A CN1330305C CN 1330305 C CN1330305 C CN 1330305C CN B028059018 A CNB028059018 A CN B028059018A CN 02805901 A CN02805901 A CN 02805901A CN 1330305 C CN1330305 C CN 1330305C
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CN
China
Prior art keywords
nicotine
tts
layer
skin
transdermal therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028059018A
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English (en)
Chinese (zh)
Other versions
CN1494421A (zh
Inventor
S·布拉特
S·沃纳斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
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LTS Lohmann Therapie Systeme AG
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Publication date
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Publication of CN1494421A publication Critical patent/CN1494421A/zh
Application granted granted Critical
Publication of CN1330305C publication Critical patent/CN1330305C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028059018A 2001-03-03 2002-02-19 以尼古丁作为有效成份的高柔韧性的经皮治疗体系 Expired - Fee Related CN1330305C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10110391.3 2001-03-03
DE10110391A DE10110391A1 (de) 2001-03-03 2001-03-03 Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff

Publications (2)

Publication Number Publication Date
CN1494421A CN1494421A (zh) 2004-05-05
CN1330305C true CN1330305C (zh) 2007-08-08

Family

ID=7676278

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028059018A Expired - Fee Related CN1330305C (zh) 2001-03-03 2002-02-19 以尼古丁作为有效成份的高柔韧性的经皮治疗体系

Country Status (21)

Country Link
US (1) US8226974B2 (enExample)
EP (1) EP1372619B1 (enExample)
JP (1) JP2004529890A (enExample)
KR (1) KR100873257B1 (enExample)
CN (1) CN1330305C (enExample)
AR (1) AR035688A1 (enExample)
AU (1) AU2002308289B2 (enExample)
BR (1) BR0207738A (enExample)
CA (1) CA2440012C (enExample)
CZ (1) CZ20032379A3 (enExample)
DE (1) DE10110391A1 (enExample)
ES (1) ES2386886T3 (enExample)
HU (1) HUP0303311A3 (enExample)
IL (2) IL157692A0 (enExample)
MX (1) MXPA03007903A (enExample)
NZ (1) NZ527824A (enExample)
PL (1) PL205582B1 (enExample)
RU (1) RU2302856C2 (enExample)
TW (1) TWI264312B (enExample)
WO (1) WO2002069940A2 (enExample)
ZA (1) ZA200306194B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1655772B (zh) * 2002-05-28 2010-05-26 拉伯泰克技术研发有限公司 含有芬太尼的贴剂
RU2351315C2 (ru) * 2003-07-24 2009-04-10 Смитклайн Бичам Корпорейшн Пленки, растворяющиеся в полости рта
RU2263503C1 (ru) * 2004-04-23 2005-11-10 Каш Тенгиз Способ получения препарата и препарат для трансдермального введения никотина
ITMI20041628A1 (it) 2004-08-06 2004-11-06 Bouty S P A Sistema terapeutico a rilascio controllato per uso topico transdermico
DE102005010255A1 (de) * 2005-03-07 2006-09-14 Lts Lohmann Therapie-Systeme Ag Faserfreies transdermales therapeutisches System und Verfahren zu seiner Herstellung
JP5000932B2 (ja) * 2005-06-21 2012-08-15 日東電工株式会社 ニコチン含有経皮吸収製剤
IL177071A0 (en) * 2005-08-01 2006-12-10 Nitto Denko Corp Method of preparing a nicotine transdermal preparation
EP1774964B1 (en) 2005-10-13 2014-08-06 Nitto Denko Corporation Nicotine transdermal preparation and production method thereof
US20090246264A1 (en) * 2005-12-08 2009-10-01 Fertin Pharma Transdermal Tobacco Alkaloid Patch
US20090169606A1 (en) * 2005-12-08 2009-07-02 Fertin Pharma Low Flexural Strength Transdermal Tobacco Alkaloid Patch
DE102006026060B4 (de) * 2006-01-12 2013-01-31 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme
DE102006054733A1 (de) * 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
WO2008145119A1 (en) * 2007-05-31 2008-12-04 Fertin Pharma A/S Transdermal tobacco alkaloid reservoir patch
KR101883410B1 (ko) * 2011-04-22 2018-07-30 아이큐어 주식회사 경피 흡수 제제 및 그 제조방법
FR2987561B1 (fr) * 2012-03-02 2014-04-11 Pf Medicament Dispositif transdermique comprenant des micro-particules poreuses
EP3280371B1 (de) * 2015-04-08 2019-06-05 LTS Lohmann Therapie-Systeme AG Elektrisch erwärmbares pflaster
CA3033570C (en) * 2015-08-17 2022-12-06 Sidmak Laboratories (India) Pvt. Ltd. Topical film delivery system
DE102018220589A1 (de) * 2018-11-29 2020-06-04 Lts Lohmann Therapie-Systeme Ag Transdermales System mit Überpflaster und Ringsystem
DE102020112143B4 (de) 2020-05-05 2022-03-17 Lts Lohmann Therapie-Systeme Ag Nicotin - Corona
US20220175812A1 (en) 2020-12-03 2022-06-09 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
JP2024516108A (ja) 2021-04-07 2024-04-12 バテル・メモリアル・インスティテュート 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603947A (en) * 1993-07-09 1997-02-18 Cygnus Terapeutic Systems Method and device for providing nicotine replacement therapy transdermally/transbuccally
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
WO2000064418A2 (de) * 1999-04-22 2000-11-02 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches system mit neutralisierten acrylhaftklebern

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278018A (en) * 1979-11-16 1981-07-14 Ncr Canada Ltd. - Ncr Canada Ltee Printing means
JPS61251619A (ja) 1985-04-30 1986-11-08 Nitto Electric Ind Co Ltd ニコチン含有テ−プ製剤
DE3629304A1 (de) 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
DE3727232A1 (de) 1987-08-14 1989-02-23 Lohmann Therapie Syst Lts Verfahren zur herstellung einer darreichungs- und/oder dosierungsform fuer arzneimittelwirkstoffe
US4943435A (en) 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US5364630A (en) * 1988-06-14 1994-11-15 Alza Corporation Subsaturated nicotine transdermal therapeutic system
DE3827561C1 (enExample) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE3843238C1 (enExample) * 1988-12-22 1990-02-22 Lohmann Therapie Syst Lts
DE3908432A1 (de) * 1989-03-14 1990-09-27 Lohmann Therapie Syst Lts Pflaster als therapeutisches system zur verabreichung von wirkstoffen an die haut mit einer abgestuften wirkstoffabgabe, verfahren zu seiner herstellung sowie verwendung
DK0484543T3 (da) * 1990-04-24 1996-01-22 Teijin Ltd Plaster
CA2075517C (en) * 1992-04-01 1997-03-11 John Wick Transdermal patch incorporating a polymer film incorporated with an active agent
JPH08502727A (ja) 1992-08-25 1996-03-26 シグナス セラピューティック システムズ プリントされた経皮薬剤送達デバイス
DE4332094C2 (de) * 1993-09-22 1995-09-07 Lohmann Therapie Syst Lts Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung
WO1995024172A1 (en) * 1994-03-07 1995-09-14 Theratech, Inc. Drug-containing adhesive composite transdermal delivery device
DE4416927C1 (de) * 1994-05-13 1995-08-31 Lohmann Therapie Syst Lts Vorrichtung zur Abgabe von Wirkstoffen aus Haftschmelzklebern, Verfahren zu ihrer Herstellung und ihre Verwendung
KR0155193B1 (ko) * 1994-10-04 1998-10-15 신재인 중하중 취급 및 미끄럼 방지용 전방향 바퀴
FR2732223B1 (fr) * 1995-03-30 1997-06-13 Sanofi Sa Composition pharmaceutique pour administration transdermique
DE19653606A1 (de) * 1996-12-20 1998-06-25 Roehm Gmbh Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher
DE19653605C2 (de) * 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
DE19826592A1 (de) * 1998-06-15 1999-12-16 Lohmann Therapie Syst Lts Verfahren zur Herstellung eines aus einzelnen Schichten bestehenden Laminats
EP1137406B2 (en) 1998-12-07 2008-01-23 J. Dev Limited Transdermal patch for delivering volatile liquid drugs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US5603947A (en) * 1993-07-09 1997-02-18 Cygnus Terapeutic Systems Method and device for providing nicotine replacement therapy transdermally/transbuccally
WO2000064418A2 (de) * 1999-04-22 2000-11-02 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches system mit neutralisierten acrylhaftklebern

Also Published As

Publication number Publication date
MXPA03007903A (es) 2003-12-04
KR20030082952A (ko) 2003-10-23
DE10110391A1 (de) 2002-09-26
IL157692A0 (en) 2004-03-28
PL363697A1 (en) 2004-11-29
CA2440012C (en) 2011-05-31
CZ20032379A3 (cs) 2004-02-18
EP1372619B1 (de) 2012-05-30
WO2002069940A2 (de) 2002-09-12
RU2003129636A (ru) 2005-01-27
ZA200306194B (en) 2004-02-17
US8226974B2 (en) 2012-07-24
ES2386886T3 (es) 2012-09-04
PL205582B1 (pl) 2010-05-31
KR100873257B1 (ko) 2008-12-11
RU2302856C2 (ru) 2007-07-20
JP2004529890A (ja) 2004-09-30
CN1494421A (zh) 2004-05-05
HUP0303311A2 (hu) 2004-01-28
TWI264312B (en) 2006-10-21
AU2002308289B2 (en) 2006-07-20
AR035688A1 (es) 2004-06-23
NZ527824A (en) 2005-05-27
HUP0303311A3 (en) 2010-04-28
US20040096490A1 (en) 2004-05-20
CA2440012A1 (en) 2002-09-12
IL157692A (en) 2012-06-28
EP1372619A2 (de) 2004-01-02
WO2002069940A3 (de) 2003-01-09
BR0207738A (pt) 2004-03-09

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070808

Termination date: 20210219