DE10110391A1 - Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff - Google Patents
Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als WirkstoffInfo
- Publication number
- DE10110391A1 DE10110391A1 DE10110391A DE10110391A DE10110391A1 DE 10110391 A1 DE10110391 A1 DE 10110391A1 DE 10110391 A DE10110391 A DE 10110391A DE 10110391 A DE10110391 A DE 10110391A DE 10110391 A1 DE10110391 A1 DE 10110391A1
- Authority
- DE
- Germany
- Prior art keywords
- nicotine
- tts
- layer
- transdermal system
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 73
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 229960002715 nicotine Drugs 0.000 title claims abstract description 70
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 6
- 239000004480 active ingredient Substances 0.000 title abstract description 11
- 239000010410 layer Substances 0.000 claims description 55
- 229920000642 polymer Polymers 0.000 claims description 24
- 229920001577 copolymer Polymers 0.000 claims description 22
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 18
- 239000011159 matrix material Substances 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 14
- -1 titanium ions Chemical class 0.000 claims description 11
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 239000012790 adhesive layer Substances 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 5
- SOGAXMICEFXMKE-UHFFFAOYSA-N alpha-Methyl-n-butyl acrylate Natural products CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 3
- 210000003169 central nervous system Anatomy 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 239000011241 protective layer Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000010936 titanium Substances 0.000 claims description 2
- 229910052719 titanium Inorganic materials 0.000 claims description 2
- 229940100640 transdermal system Drugs 0.000 claims 7
- 230000000996 additive effect Effects 0.000 claims 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 description 16
- 238000012360 testing method Methods 0.000 description 11
- 238000000576 coating method Methods 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 239000011248 coating agent Substances 0.000 description 8
- 229920000139 polyethylene terephthalate Polymers 0.000 description 8
- 239000005020 polyethylene terephthalate Substances 0.000 description 8
- 230000008569 process Effects 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 239000004014 plasticizer Substances 0.000 description 6
- 230000001681 protective effect Effects 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 4
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 4
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 4
- 238000005452 bending Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002985 plastic film Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 229920003134 Eudragit® polymer Polymers 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 229930182833 estradiol Natural products 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000009477 glass transition Effects 0.000 description 2
- 229940087730 nicorette Drugs 0.000 description 2
- 229920000307 polymer substrate Polymers 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- BTXXTMOWISPQSJ-UHFFFAOYSA-N 4,4,4-trifluorobutan-2-one Chemical class CC(=O)CC(F)(F)F BTXXTMOWISPQSJ-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 229920001824 Barex® Polymers 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 241001602730 Monza Species 0.000 description 1
- 229920000459 Nitrile rubber Polymers 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 238000003854 Surface Print Methods 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- NTXGQCSETZTARF-UHFFFAOYSA-N buta-1,3-diene;prop-2-enenitrile Chemical compound C=CC=C.C=CC#N NTXGQCSETZTARF-UHFFFAOYSA-N 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
- 238000010559 graft polymerization reaction Methods 0.000 description 1
- 229940087496 habitrol Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229940099632 nicotrol Drugs 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001748 polybutylene Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000009516 primary packaging Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10110391A DE10110391A1 (de) | 2001-03-03 | 2001-03-03 | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
| US10/469,163 US8226974B2 (en) | 2001-03-03 | 2002-02-19 | Highly flexible transdermal therapeutic system having nicotine as active substance |
| JP2002569118A JP2004529890A (ja) | 2001-03-03 | 2002-02-19 | 活性成分としてのニコチンを有する可撓性の著しい皮膚透過性治療系 |
| PCT/EP2002/001728 WO2002069940A2 (de) | 2001-03-03 | 2002-02-19 | Hochflexibles transdermales therapeutisches system mit nikotin als wirkstoff |
| CZ20032379A CZ20032379A3 (cs) | 2001-03-03 | 2002-02-19 | Vysoce flexibilní transdermální terapeutický systém s nikotinem jako účinnou látkou |
| PL363697A PL205582B1 (pl) | 2001-03-03 | 2002-02-19 | Sposób wytwarzania transdermalnego systemu terapeutycznego z zawartością nikotyny |
| AU2002308289A AU2002308289B2 (en) | 2001-03-03 | 2002-02-19 | Highly flexible transdermal therapeutic system having nicotine as active substance |
| BR0207738-8A BR0207738A (pt) | 2001-03-03 | 2002-02-19 | Sistema terapêutico transdermal altamente flexvel com nicotina como subst ncia ativa |
| ES02748317T ES2386886T3 (es) | 2001-03-03 | 2002-02-19 | Procedimiento para la producción de un sistema terapéutico transdermal altamente flexible con nicotina en calidad de principio activo |
| IL15769202A IL157692A0 (en) | 2001-03-03 | 2002-02-19 | Highly flexible transdermal therapeutic system having nicotine as active substance |
| CA2440012A CA2440012C (en) | 2001-03-03 | 2002-02-19 | Highly flexible transdermal therapeutic system having nicotine as active substance |
| CNB028059018A CN1330305C (zh) | 2001-03-03 | 2002-02-19 | 以尼古丁作为有效成份的高柔韧性的经皮治疗体系 |
| HU0303311A HUP0303311A3 (en) | 2001-03-03 | 2002-02-19 | Highly flexible transdermal therapeutic system having nicotine as active substance |
| KR1020037011540A KR100873257B1 (ko) | 2001-03-03 | 2002-02-19 | 활성 물질로서 니코틴을 갖는 고가요성 경피 치료 시스템 |
| MXPA03007903A MXPA03007903A (es) | 2001-03-03 | 2002-02-19 | Sistema terapeutico transdermico altamente flexible con nicotina como ingrediente activo. |
| NZ527824A NZ527824A (en) | 2001-03-03 | 2002-02-19 | Thin and highly flexible transdermal therapeutic system (TTS) comprising nicotine and. where appropriate, other active ingredients which act on the nervous system |
| EP02748317A EP1372619B1 (de) | 2001-03-03 | 2002-02-19 | Verfahren zur herstellung eines hochflexiblen transdermalen therapeutischen systems mit nikotin als wirkstoff |
| RU2003129636/15A RU2302856C2 (ru) | 2001-03-03 | 2002-02-19 | Обладающая высокой гибкостью трансдермальная терапевтическая система с никотином в качестве активного вещества |
| ARP020100725A AR035688A1 (es) | 2001-03-03 | 2002-02-28 | Sistema terapeutico transdermal, con un contenido de nicotina |
| TW091103842A TWI264312B (en) | 2001-03-03 | 2002-03-01 | Highly flexible transdermal therapeutic system with nicotine as active ingredient |
| ZA200306194A ZA200306194B (en) | 2001-03-03 | 2003-08-11 | Highly flexible transdermal therapeutic system having nicotine as active substance. |
| IL157692A IL157692A (en) | 2001-03-03 | 2003-09-01 | Method for the manufacture of transdermal therapeutic system with nicotine content |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10110391A DE10110391A1 (de) | 2001-03-03 | 2001-03-03 | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10110391A1 true DE10110391A1 (de) | 2002-09-26 |
Family
ID=7676278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10110391A Ceased DE10110391A1 (de) | 2001-03-03 | 2001-03-03 | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8226974B2 (enExample) |
| EP (1) | EP1372619B1 (enExample) |
| JP (1) | JP2004529890A (enExample) |
| KR (1) | KR100873257B1 (enExample) |
| CN (1) | CN1330305C (enExample) |
| AR (1) | AR035688A1 (enExample) |
| AU (1) | AU2002308289B2 (enExample) |
| BR (1) | BR0207738A (enExample) |
| CA (1) | CA2440012C (enExample) |
| CZ (1) | CZ20032379A3 (enExample) |
| DE (1) | DE10110391A1 (enExample) |
| ES (1) | ES2386886T3 (enExample) |
| HU (1) | HUP0303311A3 (enExample) |
| IL (2) | IL157692A0 (enExample) |
| MX (1) | MXPA03007903A (enExample) |
| NZ (1) | NZ527824A (enExample) |
| PL (1) | PL205582B1 (enExample) |
| RU (1) | RU2302856C2 (enExample) |
| TW (1) | TWI264312B (enExample) |
| WO (1) | WO2002069940A2 (enExample) |
| ZA (1) | ZA200306194B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005010255A1 (de) * | 2005-03-07 | 2006-09-14 | Lts Lohmann Therapie-Systeme Ag | Faserfreies transdermales therapeutisches System und Verfahren zu seiner Herstellung |
| DE102006054733A1 (de) * | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit |
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| ITMI20041628A1 (it) | 2004-08-06 | 2004-11-06 | Bouty S P A | Sistema terapeutico a rilascio controllato per uso topico transdermico |
| JP5000932B2 (ja) * | 2005-06-21 | 2012-08-15 | 日東電工株式会社 | ニコチン含有経皮吸収製剤 |
| IL177071A0 (en) * | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
| EP1774964B1 (en) | 2005-10-13 | 2014-08-06 | Nitto Denko Corporation | Nicotine transdermal preparation and production method thereof |
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| US20090169606A1 (en) * | 2005-12-08 | 2009-07-02 | Fertin Pharma | Low Flexural Strength Transdermal Tobacco Alkaloid Patch |
| WO2008145119A1 (en) * | 2007-05-31 | 2008-12-04 | Fertin Pharma A/S | Transdermal tobacco alkaloid reservoir patch |
| KR101883410B1 (ko) * | 2011-04-22 | 2018-07-30 | 아이큐어 주식회사 | 경피 흡수 제제 및 그 제조방법 |
| FR2987561B1 (fr) * | 2012-03-02 | 2014-04-11 | Pf Medicament | Dispositif transdermique comprenant des micro-particules poreuses |
| EP3280371B1 (de) * | 2015-04-08 | 2019-06-05 | LTS Lohmann Therapie-Systeme AG | Elektrisch erwärmbares pflaster |
| CA3033570C (en) * | 2015-08-17 | 2022-12-06 | Sidmak Laboratories (India) Pvt. Ltd. | Topical film delivery system |
| DE102018220589A1 (de) * | 2018-11-29 | 2020-06-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales System mit Überpflaster und Ringsystem |
| US20220175812A1 (en) | 2020-12-03 | 2022-06-09 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| JP2024516108A (ja) | 2021-04-07 | 2024-04-12 | バテル・メモリアル・インスティテュート | 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005010255A1 (de) * | 2005-03-07 | 2006-09-14 | Lts Lohmann Therapie-Systeme Ag | Faserfreies transdermales therapeutisches System und Verfahren zu seiner Herstellung |
| EP1855660B2 (de) † | 2005-03-07 | 2019-10-16 | LTS LOHMANN Therapie-Systeme AG | Faserfreies transdermales therapeutisches system und verfahren zu seiner herstellung |
| US11311495B2 (en) | 2005-03-07 | 2022-04-26 | Lts Lohmann Therapie-Systeme Ag | Fibre-free transdermal therapeutic system and method for its production |
| US11478434B2 (en) | 2005-03-07 | 2022-10-25 | Lts Lohmann Therapie-Systeme Ag | Fibre-free transdermal therapeutic system and method for its production |
| DE102006026060B4 (de) * | 2006-01-12 | 2013-01-31 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme |
| DE102006054733A1 (de) * | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit |
| US9056026B2 (en) | 2006-11-21 | 2015-06-16 | Lts Lohmann Therapie Systeme Ag | Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy |
| US9421174B2 (en) | 2006-11-21 | 2016-08-23 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy |
| US9717698B2 (en) | 2006-11-21 | 2017-08-01 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy |
| DE102020112143A1 (de) | 2020-05-05 | 2021-11-11 | Lts Lohmann Therapie-Systeme Ag | Nicotin - Corona |
| WO2021224334A1 (de) | 2020-05-05 | 2021-11-11 | Lts Lohmann Therapie-Systeme Ag | Kombination enthaltend zwei nikotinhaltige arzneimittel zur behandlung von covid-19 |
| DE102020112143B4 (de) | 2020-05-05 | 2022-03-17 | Lts Lohmann Therapie-Systeme Ag | Nicotin - Corona |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03007903A (es) | 2003-12-04 |
| KR20030082952A (ko) | 2003-10-23 |
| IL157692A0 (en) | 2004-03-28 |
| PL363697A1 (en) | 2004-11-29 |
| CA2440012C (en) | 2011-05-31 |
| CN1330305C (zh) | 2007-08-08 |
| CZ20032379A3 (cs) | 2004-02-18 |
| EP1372619B1 (de) | 2012-05-30 |
| WO2002069940A2 (de) | 2002-09-12 |
| RU2003129636A (ru) | 2005-01-27 |
| ZA200306194B (en) | 2004-02-17 |
| US8226974B2 (en) | 2012-07-24 |
| ES2386886T3 (es) | 2012-09-04 |
| PL205582B1 (pl) | 2010-05-31 |
| KR100873257B1 (ko) | 2008-12-11 |
| RU2302856C2 (ru) | 2007-07-20 |
| JP2004529890A (ja) | 2004-09-30 |
| CN1494421A (zh) | 2004-05-05 |
| HUP0303311A2 (hu) | 2004-01-28 |
| TWI264312B (en) | 2006-10-21 |
| AU2002308289B2 (en) | 2006-07-20 |
| AR035688A1 (es) | 2004-06-23 |
| NZ527824A (en) | 2005-05-27 |
| HUP0303311A3 (en) | 2010-04-28 |
| US20040096490A1 (en) | 2004-05-20 |
| CA2440012A1 (en) | 2002-09-12 |
| IL157692A (en) | 2012-06-28 |
| EP1372619A2 (de) | 2004-01-02 |
| WO2002069940A3 (de) | 2003-01-09 |
| BR0207738A (pt) | 2004-03-09 |
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