AR035688A1 - Sistema terapeutico transdermal, con un contenido de nicotina - Google Patents

Sistema terapeutico transdermal, con un contenido de nicotina

Info

Publication number
AR035688A1
AR035688A1 ARP020100725A ARP020100725A AR035688A1 AR 035688 A1 AR035688 A1 AR 035688A1 AR P020100725 A ARP020100725 A AR P020100725A AR P020100725 A ARP020100725 A AR P020100725A AR 035688 A1 AR035688 A1 AR 035688A1
Authority
AR
Argentina
Prior art keywords
nicotine
layer
matrix
skin
nicotine content
Prior art date
Application number
ARP020100725A
Other languages
English (en)
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of AR035688A1 publication Critical patent/AR035688A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Sistema terapéutico transdermal con un contenido de nicotina, consistente en una capa de respaldo que no es permeable a la nicotina, una capa intermedia matriz situada inmediatamente adyacente a la capa de respaldo y que contiene nicotina, otra capa matriz que contiene nicotina, y una capa de protección redesprendible, estando las capas matriz estructuradas con copolímeros de (met)-acrilato, caracterizado porque el espesor conjunto de estas capas no sobrepasa 205 micrones y el contenido de nicotina es de por lo menos 1,5 miligramos por cm cuadrado de área de aplicación, que se destacan por una flexibilidad especialmente elevada. Dicha flexibilidad mejora de manera decisiva la comodidad del usuario que los lleva sobre la piel, ya que el sistema puede adaptarse fácilmente a la superficie de la piel y al constante movimiento de la misma. El TTS de nicotina es manifiestamente más flexible que los productos de TTS con nicotina actualmente usuales y predominantes en el mercado, a pesar de que por lo menos algunos de estos sistemas son comparativamente más delgados. Dicho sistema transdermal contiene una o más sustancias activas y/o adyuvantes que tiene un efecto sobre el sistema nervioso central.
ARP020100725A 2001-03-03 2002-02-28 Sistema terapeutico transdermal, con un contenido de nicotina AR035688A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10110391A DE10110391A1 (de) 2001-03-03 2001-03-03 Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff

Publications (1)

Publication Number Publication Date
AR035688A1 true AR035688A1 (es) 2004-06-23

Family

ID=7676278

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100725A AR035688A1 (es) 2001-03-03 2002-02-28 Sistema terapeutico transdermal, con un contenido de nicotina

Country Status (21)

Country Link
US (1) US8226974B2 (es)
EP (1) EP1372619B1 (es)
JP (1) JP2004529890A (es)
KR (1) KR100873257B1 (es)
CN (1) CN1330305C (es)
AR (1) AR035688A1 (es)
AU (1) AU2002308289B2 (es)
BR (1) BR0207738A (es)
CA (1) CA2440012C (es)
CZ (1) CZ20032379A3 (es)
DE (1) DE10110391A1 (es)
ES (1) ES2386886T3 (es)
HU (1) HUP0303311A3 (es)
IL (2) IL157692A0 (es)
MX (1) MXPA03007903A (es)
NZ (1) NZ527824A (es)
PL (1) PL205582B1 (es)
RU (1) RU2302856C2 (es)
TW (1) TWI264312B (es)
WO (1) WO2002069940A2 (es)
ZA (1) ZA200306194B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1894563B2 (de) * 2002-05-28 2022-04-27 ratiopharm GmbH Pflaster, enthaltend Fentanylum
PL1648421T3 (pl) * 2003-07-24 2018-03-30 Glaxosmithkline Llc Folie rozpuszczające się w jamie ustnej
ITMI20041628A1 (it) 2004-08-06 2004-11-06 Bouty S P A Sistema terapeutico a rilascio controllato per uso topico transdermico
DE102005010255A1 (de) 2005-03-07 2006-09-14 Lts Lohmann Therapie-Systeme Ag Faserfreies transdermales therapeutisches System und Verfahren zu seiner Herstellung
JP5000932B2 (ja) * 2005-06-21 2012-08-15 日東電工株式会社 ニコチン含有経皮吸収製剤
IL177071A0 (en) * 2005-08-01 2006-12-10 Nitto Denko Corp Method of preparing a nicotine transdermal preparation
ES2499067T3 (es) 2005-10-13 2014-09-26 Nitto Denko Corporation Preparación transdérmica de nicotina y método de producción de la misma
US20090246264A1 (en) * 2005-12-08 2009-10-01 Fertin Pharma Transdermal Tobacco Alkaloid Patch
US20090169606A1 (en) * 2005-12-08 2009-07-02 Fertin Pharma Low Flexural Strength Transdermal Tobacco Alkaloid Patch
DE102006026060B4 (de) * 2006-01-12 2013-01-31 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme
DE102006054733A1 (de) 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
CN101790373A (zh) * 2007-05-31 2010-07-28 费廷药业股份有限公司 烟草生物碱储库型经皮贴剂
KR101883410B1 (ko) * 2011-04-22 2018-07-30 아이큐어 주식회사 경피 흡수 제제 및 그 제조방법
FR2987561B1 (fr) * 2012-03-02 2014-04-11 Pf Medicament Dispositif transdermique comprenant des micro-particules poreuses
CA2981397C (en) * 2015-04-08 2023-04-04 Lts Lohmann Therapie-Systeme Ag Electrically heatable plaster
WO2017030555A1 (en) * 2015-08-17 2017-02-23 Bhalani Vinayak T Topical film delivery system
DE102018220589A1 (de) * 2018-11-29 2020-06-04 Lts Lohmann Therapie-Systeme Ag Transdermales System mit Überpflaster und Ringsystem
DE102020112143B4 (de) 2020-05-05 2022-03-17 Lts Lohmann Therapie-Systeme Ag Nicotin - Corona

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278018A (en) * 1979-11-16 1981-07-14 Ncr Canada Ltd. - Ncr Canada Ltee Printing means
JPS61251619A (ja) * 1985-04-30 1986-11-08 Nitto Electric Ind Co Ltd ニコチン含有テ−プ製剤
DE3629304A1 (de) 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
DE3727232A1 (de) * 1987-08-14 1989-02-23 Lohmann Therapie Syst Lts Verfahren zur herstellung einer darreichungs- und/oder dosierungsform fuer arzneimittelwirkstoffe
US4943435A (en) * 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US5364630A (en) * 1988-06-14 1994-11-15 Alza Corporation Subsaturated nicotine transdermal therapeutic system
DE3827561C1 (es) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE3908432A1 (de) * 1989-03-14 1990-09-27 Lohmann Therapie Syst Lts Pflaster als therapeutisches system zur verabreichung von wirkstoffen an die haut mit einer abgestuften wirkstoffabgabe, verfahren zu seiner herstellung sowie verwendung
KR950005865B1 (ko) 1990-04-23 1995-06-02 데이진 가부시끼가이샤 첩부제
CA2075517C (en) 1992-04-01 1997-03-11 John Wick Transdermal patch incorporating a polymer film incorporated with an active agent
EP0656771A4 (en) 1992-08-25 1996-07-31 Cygnus Therapeutic Systems DEVICE FOR TRANSDERMAL DRUG DELIVERY.
AU7323794A (en) 1993-07-09 1995-02-06 Cygnus Therapeutic Systems Method and device for providing nicotine replacement therapy transdermally/transbuccally
DE4332094C2 (de) 1993-09-22 1995-09-07 Lohmann Therapie Syst Lts Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung
AU676430B2 (en) * 1994-03-07 1997-03-06 Theratech, Inc. Drug-containing adhesive composite transdermal delivery device
DE4416927C1 (de) * 1994-05-13 1995-08-31 Lohmann Therapie Syst Lts Vorrichtung zur Abgabe von Wirkstoffen aus Haftschmelzklebern, Verfahren zu ihrer Herstellung und ihre Verwendung
KR0155193B1 (ko) * 1994-10-04 1998-10-15 신재인 중하중 취급 및 미끄럼 방지용 전방향 바퀴
DE19653605C2 (de) * 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
DE19653606A1 (de) * 1996-12-20 1998-06-25 Roehm Gmbh Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher
DE19826592A1 (de) * 1998-06-15 1999-12-16 Lohmann Therapie Syst Lts Verfahren zur Herstellung eines aus einzelnen Schichten bestehenden Laminats
ATE264098T1 (de) 1998-12-07 2004-04-15 Elan Pharma Int Ltd Pflaster zur transdermalen applikation von flüchtigen, flüssigen wirkstoffen
DE19918106A1 (de) * 1999-04-22 2000-10-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern

Also Published As

Publication number Publication date
WO2002069940A2 (de) 2002-09-12
CN1494421A (zh) 2004-05-05
ES2386886T3 (es) 2012-09-04
EP1372619A2 (de) 2004-01-02
IL157692A (en) 2012-06-28
DE10110391A1 (de) 2002-09-26
CA2440012C (en) 2011-05-31
PL205582B1 (pl) 2010-05-31
KR100873257B1 (ko) 2008-12-11
RU2302856C2 (ru) 2007-07-20
WO2002069940A3 (de) 2003-01-09
CZ20032379A3 (cs) 2004-02-18
JP2004529890A (ja) 2004-09-30
CA2440012A1 (en) 2002-09-12
AU2002308289B2 (en) 2006-07-20
PL363697A1 (en) 2004-11-29
RU2003129636A (ru) 2005-01-27
EP1372619B1 (de) 2012-05-30
CN1330305C (zh) 2007-08-08
US8226974B2 (en) 2012-07-24
US20040096490A1 (en) 2004-05-20
KR20030082952A (ko) 2003-10-23
BR0207738A (pt) 2004-03-09
HUP0303311A3 (en) 2010-04-28
NZ527824A (en) 2005-05-27
MXPA03007903A (es) 2003-12-04
IL157692A0 (en) 2004-03-28
HUP0303311A2 (hu) 2004-01-28
TWI264312B (en) 2006-10-21
ZA200306194B (en) 2004-02-17

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