ES2499067T3 - Preparación transdérmica de nicotina y método de producción de la misma - Google Patents
Preparación transdérmica de nicotina y método de producción de la misma Download PDFInfo
- Publication number
- ES2499067T3 ES2499067T3 ES06255234.4T ES06255234T ES2499067T3 ES 2499067 T3 ES2499067 T3 ES 2499067T3 ES 06255234 T ES06255234 T ES 06255234T ES 2499067 T3 ES2499067 T3 ES 2499067T3
- Authority
- ES
- Spain
- Prior art keywords
- adhesive layer
- nicotine
- monomer
- monomers containing
- main component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Abstract
Una preparación transdérmica de nicotina que comprende un soporte y una capa adhesiva formada sobre él, cuya capa adhesiva comprende nicotina y un ingrediente líquido compatible con el adhesivo, en donde un ángulo de contacto de nicotina con la capa adhesiva antes de que contenga la nicotina es 20-60°, la capa adhesiva es una capa adhesiva de tipo acrílico que comprende un componente principal que es éster alquílico del ácido (met)acrílico y que comprende un monómero secundario y un monómero terciario ambos copolimerizados con dicho componente principal, siendo dicho monómero secundario un monómero capaz de estar involucrado en una reacción de reticulación, comprendiendo dicho monómero terciario uno o más tipos de componentes monómeros seleccionados del grupo constituido por ésteres vinílicos, éteres vinílicos, amidas vinílicas, monómeros que contienen grupos hidroxi, monómeros que contienen grupos amido, monómeros que contienen grupos alcoxi, y monómeros vinílicos, y siendo dicho ingrediente líquido palmitato de isopropilo contenido en una proporción de 30-60 % en peso respecto al peso total de la capa adhesiva antes de que contenga nicotina, en donde la capa adhesiva tiene un espesor de 80- 120 μm.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005299203 | 2005-10-13 | ||
JP2005299203 | 2005-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2499067T3 true ES2499067T3 (es) | 2014-09-26 |
Family
ID=37708220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06255234.4T Active ES2499067T3 (es) | 2005-10-13 | 2006-10-11 | Preparación transdérmica de nicotina y método de producción de la misma |
Country Status (9)
Country | Link |
---|---|
US (1) | US8506991B2 (es) |
EP (1) | EP1774964B1 (es) |
KR (1) | KR101317053B1 (es) |
CN (1) | CN1951375B (es) |
CA (1) | CA2563496C (es) |
ES (1) | ES2499067T3 (es) |
IL (1) | IL178537A0 (es) |
RU (1) | RU2407516C2 (es) |
TW (1) | TWI383794B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL177071A0 (en) * | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
JP4327841B2 (ja) | 2006-12-20 | 2009-09-09 | 日東電工株式会社 | 経皮吸収製剤の製造装置および製造方法 |
JP5725940B2 (ja) * | 2011-04-01 | 2015-05-27 | 日東電工株式会社 | ニコチン含有貼付製剤 |
KR101883410B1 (ko) * | 2011-04-22 | 2018-07-30 | 아이큐어 주식회사 | 경피 흡수 제제 및 그 제조방법 |
RU2572720C1 (ru) * | 2014-07-29 | 2016-01-20 | Дмитрий Евгеньевич Денисов | Комплексное антиникотиновое средство |
CN112618617A (zh) * | 2021-01-05 | 2021-04-09 | 鹤壁市星银凯丰科技有限公司 | 一种含咖啡粉贴剂及其制备方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4687481A (en) | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
DE3629304A1 (de) | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
US6139868A (en) | 1986-08-28 | 2000-10-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Transdermal therapeutic system, its use and production process |
IL86170A (en) | 1987-05-01 | 1992-12-01 | Elan Transdermal Ltd | Preparations and compositions comprising nicotine for percutaneous administration |
US4915950A (en) | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
US5474783A (en) | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5508038A (en) | 1990-04-16 | 1996-04-16 | Alza Corporation | Polyisobutylene adhesives for transdermal devices |
US5202125A (en) * | 1990-12-10 | 1993-04-13 | Theratech, Inc. | Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes |
TW221970B (es) * | 1991-06-26 | 1994-04-01 | Tbs Lab Inc | |
WO1994004109A1 (en) | 1992-08-25 | 1994-03-03 | Cygnus Therapeutic Systems | Printed transdermal drug delivery device |
CA2183083C (en) | 1994-03-07 | 2006-01-03 | Charles D. Ebert | Drug-containing adhesive composite transdermal delivery device |
PT781122E (pt) | 1994-09-14 | 2000-11-30 | Minnesota Mining & Mfg | Matriz para a distribuicao transdermica de farmacos |
KR0159145B1 (ko) | 1995-02-24 | 1998-12-01 | 강박광 | 피부 약물 전달 체계용 에멀젼 네트웍의 제조방법 |
US5688523A (en) * | 1995-03-31 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Method of making a pressure sensitive skin adhesive sheet material |
US7150881B2 (en) * | 1997-06-26 | 2006-12-19 | Mylan Technologies, Inc. | Adhesive mixture for transdermal delivery of highly plasticizing drugs |
WO2000033812A2 (en) | 1998-12-07 | 2000-06-15 | Elan Corporation, Plc | Transdermal patch for delivering volatile liquid drugs |
ES2336054T3 (es) | 1998-12-18 | 2010-04-07 | Alza Corporation | Dispositivo transparente para la administracion transdermica de nicotina. |
AU2121600A (en) | 1999-01-29 | 2000-08-18 | Strakan Limited | Adhesives |
DE19913732A1 (de) | 1999-03-26 | 2000-09-28 | Lohmann Therapie Syst Lts | Nikotin-TTS mit einem Zusatz von Monoterpenketonen |
DE10110391A1 (de) | 2001-03-03 | 2002-09-26 | Lohmann Therapie Syst Lts | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
DE10121471A1 (de) * | 2001-05-02 | 2002-11-07 | Beiersdorf Ag | Oberflächendotierte wirkstoffhaltige Pflaster |
JP4777542B2 (ja) * | 2001-06-19 | 2011-09-21 | 日東電工株式会社 | 貼付剤および貼付製剤、ならびにそれらの製造方法 |
UA88464C2 (ru) * | 2004-04-29 | 2009-10-26 | Колдуэлл Гейлер, Инк. | Способ дермального введения метадоновой композиции с обеспечением системного действия |
JP5000932B2 (ja) | 2005-06-21 | 2012-08-15 | 日東電工株式会社 | ニコチン含有経皮吸収製剤 |
IL177071A0 (en) | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
-
2006
- 2006-10-11 ES ES06255234.4T patent/ES2499067T3/es active Active
- 2006-10-11 EP EP06255234.4A patent/EP1774964B1/en not_active Not-in-force
- 2006-10-12 TW TW095137482A patent/TWI383794B/zh not_active IP Right Cessation
- 2006-10-12 US US11/546,302 patent/US8506991B2/en not_active Expired - Fee Related
- 2006-10-12 RU RU2006136140/15A patent/RU2407516C2/ru not_active IP Right Cessation
- 2006-10-12 CA CA2563496A patent/CA2563496C/en not_active Expired - Fee Related
- 2006-10-13 CN CN2006101646435A patent/CN1951375B/zh not_active Expired - Fee Related
- 2006-10-13 KR KR1020060099816A patent/KR101317053B1/ko not_active IP Right Cessation
- 2006-10-15 IL IL178537A patent/IL178537A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2006136140A (ru) | 2008-04-20 |
KR20070041390A (ko) | 2007-04-18 |
IL178537A0 (en) | 2007-02-11 |
CA2563496C (en) | 2013-12-31 |
TWI383794B (zh) | 2013-02-01 |
CN1951375A (zh) | 2007-04-25 |
CN1951375B (zh) | 2010-11-03 |
CA2563496A1 (en) | 2007-04-13 |
US20070087043A1 (en) | 2007-04-19 |
EP1774964B1 (en) | 2014-08-06 |
KR101317053B1 (ko) | 2013-10-11 |
US8506991B2 (en) | 2013-08-13 |
TW200800190A (en) | 2008-01-01 |
EP1774964A1 (en) | 2007-04-18 |
RU2407516C2 (ru) | 2010-12-27 |
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