CN1307300C - 造血干细胞和治疗新生血管性眼部疾病的方法 - Google Patents

造血干细胞和治疗新生血管性眼部疾病的方法 Download PDF

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CN1307300C
CN1307300C CNB038177358A CN03817735A CN1307300C CN 1307300 C CN1307300 C CN 1307300C CN B038177358 A CNB038177358 A CN B038177358A CN 03817735 A CN03817735 A CN 03817735A CN 1307300 C CN1307300 C CN 1307300C
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CN1688196A (zh
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M·弗里兰德
A·奥塔尼
K·达西尔瓦
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Scripps Research Institute
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0692—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Urology & Nephrology (AREA)
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CNB038177358A 2002-07-25 2003-07-25 造血干细胞和治疗新生血管性眼部疾病的方法 Expired - Fee Related CN1307300C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39852202P 2002-07-25 2002-07-25
US60/398,522 2002-07-25
US46705103P 2003-05-02 2003-05-02
US60/467,051 2003-05-02
PCT/US2003/024839 WO2004010959A2 (en) 2002-07-25 2003-07-25 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

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CN1688196A CN1688196A (zh) 2005-10-26
CN1307300C true CN1307300C (zh) 2007-03-28

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US (2) US7153501B2 (enExample)
EP (1) EP1542536B1 (enExample)
JP (2) JP2005538742A (enExample)
KR (2) KR101095287B1 (enExample)
CN (1) CN1307300C (enExample)
AT (1) ATE536405T1 (enExample)
AU (1) AU2003259687B2 (enExample)
BR (1) BR0312920A (enExample)
CA (1) CA2493122C (enExample)
DK (1) DK1542536T3 (enExample)
ES (1) ES2376866T3 (enExample)
MX (1) MXPA05000972A (enExample)
PL (1) PL216193B1 (enExample)
PT (1) PT1542536E (enExample)
RU (1) RU2331669C2 (enExample)
WO (2) WO2004010959A2 (enExample)
ZA (1) ZA200500682B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060104962A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
WO2006031467A2 (en) * 2002-07-25 2006-03-23 The Scripps Research Institute Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
US20060104963A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells
EP1624758A4 (en) * 2003-05-02 2007-03-07 Scripps Research Inst HEMOPOETIC STEM CELLS AND METHOD FOR THE TREATMENT OF EYE-RELATED VASCULAR DISEASES USING THESE STEM CELLS
US8088585B2 (en) * 2003-10-31 2012-01-03 Children's Medical Center Corporation Methods for purifying hematopoietic stem cells
RU2279886C2 (ru) * 2004-06-10 2006-07-20 Московский научно-исследовательский институт глазных болезней им. Гельмгольца Минздрава РФ Способ улучшения функциональной активности сетчатки при ее патологии различного генеза
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
CA2574186A1 (en) * 2004-08-13 2006-02-23 Medtronic, Inc. Isolation of endothelial progenitor cell subsets and methods for their use
JP2008512376A (ja) * 2004-09-03 2008-04-24 ザ・スクリプス・リサーチ・インステイチユート 単離された系統陰性造血幹細胞及びこれを用いた治療方法
DE102004055615A1 (de) * 2004-11-16 2006-05-18 Universitätsklinikum Hamburg-Eppendorf In vitro aus Knochenmarkstammzellen differenzierte Retina-spezifische Zellen, ihre Herstellung und Verwendung
US20070231306A1 (en) * 2005-02-24 2007-10-04 The Scripps Research Institute Isolated myeloid-like cell populations and methods of treatment therewith
CA2599139A1 (en) * 2005-02-24 2006-08-31 The Scripps Research Institute Revascularization of ischemic retinal tissue and screening method therefor
JP2008537478A (ja) * 2005-02-24 2008-09-18 ザ・スクリプス・リサーチ・インステイチユート 単離骨髄球様骨髄細胞集団及びそれを用いた治療方法
JP5173442B2 (ja) * 2005-02-24 2013-04-03 ザ スクリプス リサーチ インスティチュート 未熟児網膜症及び関連網膜症疾患の治療のための方法
JP4734636B2 (ja) * 2005-11-02 2011-07-27 国立大学法人 鹿児島大学 免疫染色法、及び当該免疫染色法を利用した細胞の評価方法
DK2441461T3 (da) 2005-11-07 2014-07-28 Amorcyte Inc Sammensætninger og fremgangsmåder til reparation af vaskulær skade
US20110076255A1 (en) 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
US8637005B2 (en) 2005-11-07 2014-01-28 Amorcyte, Inc. Compositions and methods of vascular injury repair
AP2949A (en) 2006-03-07 2014-07-31 Shroff Geeta Compositions comprising human embryonic stem cellsand their derivatives, methods of use, and method s of preparation
KR100757265B1 (ko) * 2006-04-27 2007-09-10 (주) 차바이오텍 제대혈 유래 줄기 세포를 포함하는 요실금 치료용 조성물
US20100111910A1 (en) * 2006-07-12 2010-05-06 Angioblast Systems, Inc. Treatment of excessive neovascularization
SG176460A1 (en) * 2006-11-07 2011-12-29 Pervasis Therapeutics Inc Materials and methods for treating and managing angiogenesis-mediated diseases
US20100098675A1 (en) * 2008-05-30 2010-04-22 Nikolai Tankovich Methods for reducing the side effects of ophthalmic laser surgery
RU2535966C2 (ru) * 2008-09-12 2014-12-20 Криопрашис Криобиоложия Лтда. Клеточная терапия ишемической ткани
WO2010065601A1 (en) 2008-12-03 2010-06-10 Amorcyte, Inc. Infarct area perfusion-improving compositions and methods of vascular injury repair
RU2428956C2 (ru) * 2009-07-13 2011-09-20 Александр Дмитриевич Ромащенко Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток
WO2012005763A1 (en) 2010-07-06 2012-01-12 The Scripps Research Institute Use of myeloid-like progenitor cell populations to treat tumors
WO2013063383A2 (en) 2011-10-27 2013-05-02 Wellstat Ophthalmics Corporation Vectors encoding rod-derived cone viability factor
WO2013158258A1 (en) * 2012-04-16 2013-10-24 The Regents Of The University Of California Ocular therapeutics using embryonic system cell microvesicles
US11033586B2 (en) * 2012-08-24 2021-06-15 Riken Method for producing retinal pigment epithelial cell sheet
WO2020172854A1 (en) * 2019-02-28 2020-09-03 Shenzhen University Use of endothelial progenitor cells (epcs) in rejuvenating microvasculature, preventing aging and treating age-related diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017564A1 (en) * 2001-02-23 2003-01-23 Paul Schimmel Tryptophanyl-tRNA synthetase derived polypeptides useful for the regulation of angiogenesis
US6767737B1 (en) * 1998-08-31 2004-07-27 New York University Stem cells bearing an FGF receptor on the cell surface

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA27055C2 (uk) * 1993-12-14 2000-02-28 Центр Ембріональних Тканин "Емселл" Лікарський препарат імуhозаміhhої дії hа осhові клітиhhої суспеhзії та спосіб лікуваhhя сиhдрому hабутого імуhодефіциту (віл-іhфекції) з використаhhям цього препарату
US6908763B1 (en) * 1997-08-22 2005-06-21 The Board Of Trustees Of The Leland Stanford Junior University Mammalian common lymphoid progenitor cell
ATE265525T1 (de) * 1998-04-28 2004-05-15 Amersham Health As Verbesserung von trennungsverfahren
US6780627B1 (en) * 2000-01-31 2004-08-24 Millennium Pharmaceuticals, Inc. 22438, 23553, 25278, and 26212 novel human sulfatases
US20020061587A1 (en) * 2000-07-31 2002-05-23 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
US7491389B2 (en) * 2002-03-21 2009-02-17 University Of Florida Reasearch Foundation, Inc. Modulating angiogenesis
WO2004005531A2 (en) * 2002-07-05 2004-01-15 Roger Williams Medical Center Targeting and tracking of cells to specific organs and tissues in vivo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767737B1 (en) * 1998-08-31 2004-07-27 New York University Stem cells bearing an FGF receptor on the cell surface
US20030017564A1 (en) * 2001-02-23 2003-01-23 Paul Schimmel Tryptophanyl-tRNA synthetase derived polypeptides useful for the regulation of angiogenesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Isolation of putative progenitor endothelial cells forangiogenesis. ASAHARA T等,SCIENCE,Vol.20 No.2A 2000 *
Neovascularization of ischemic myocardium by humanbone-marrow-derived angioblasts prevents cardiomyocyteapoptosis,reduces remodeling and improves cardiacfunction. KOCHER A.A.等,NATURE MEDICINE,Vol.20 No.2A 2000 *

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Publication number Publication date
EP1542536B1 (en) 2011-12-07
US7153501B2 (en) 2006-12-26
RU2005105065A (ru) 2005-09-10
ATE536405T1 (de) 2011-12-15
CA2493122A1 (en) 2004-02-05
CN1688196A (zh) 2005-10-26
WO2004010959A2 (en) 2004-02-05
KR20110102961A (ko) 2011-09-19
WO2004010959A3 (en) 2005-04-07
EP1542536A4 (en) 2007-05-16
PL216193B1 (pl) 2014-03-31
JP2010285434A (ja) 2010-12-24
US20040197902A1 (en) 2004-10-07
BR0312920A (pt) 2007-07-10
JP2005538742A (ja) 2005-12-22
KR101095287B1 (ko) 2011-12-16
US20070116685A1 (en) 2007-05-24
AU2003259687B2 (en) 2009-10-29
ES2376866T3 (es) 2012-03-20
AU2003259687A1 (en) 2004-02-16
MXPA05000972A (es) 2005-09-12
PL374868A1 (en) 2005-11-14
CA2493122C (en) 2012-11-27
KR20050027132A (ko) 2005-03-17
WO2004098499A3 (en) 2005-10-06
ZA200500682B (en) 2006-07-26
WO2004098499A2 (en) 2004-11-18
DK1542536T3 (da) 2012-01-23
EP1542536A2 (en) 2005-06-22
RU2331669C2 (ru) 2008-08-20
JP5385219B2 (ja) 2014-01-08
PT1542536E (pt) 2012-02-14

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