RU2331669C2 - Популяция стволовых кроветворных клеток и ее применение - Google Patents

Популяция стволовых кроветворных клеток и ее применение Download PDF

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RU2331669C2
RU2331669C2 RU2005105065/13A RU2005105065A RU2331669C2 RU 2331669 C2 RU2331669 C2 RU 2331669C2 RU 2005105065/13 A RU2005105065/13 A RU 2005105065/13A RU 2005105065 A RU2005105065 A RU 2005105065A RU 2331669 C2 RU2331669 C2 RU 2331669C2
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lin
cells
ccm
retina
retinal
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RU2005105065/13A
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RU2005105065A (ru
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Мартин ФРИДЛЭНДЕР (US)
Мартин Фридлэндер
Ацуси ОТАНИ (US)
Ацуси ОТАНИ
Карен ДАСИЛВА (US)
Карен ДАСИЛВА
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Дзе Скриппс Рисерч Инститьют
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0692—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2005105065/13A 2002-07-25 2003-07-25 Популяция стволовых кроветворных клеток и ее применение RU2331669C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39852202P 2002-07-25 2002-07-25
US60/398,522 2002-07-25
US46705103P 2003-05-02 2003-05-02
US60/467,051 2003-05-02

Publications (2)

Publication Number Publication Date
RU2005105065A RU2005105065A (ru) 2005-09-10
RU2331669C2 true RU2331669C2 (ru) 2008-08-20

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Country Link
US (2) US7153501B2 (enExample)
EP (1) EP1542536B1 (enExample)
JP (2) JP2005538742A (enExample)
KR (2) KR101095287B1 (enExample)
CN (1) CN1307300C (enExample)
AT (1) ATE536405T1 (enExample)
AU (1) AU2003259687B2 (enExample)
BR (1) BR0312920A (enExample)
CA (1) CA2493122C (enExample)
DK (1) DK1542536T3 (enExample)
ES (1) ES2376866T3 (enExample)
MX (1) MXPA05000972A (enExample)
PL (1) PL216193B1 (enExample)
PT (1) PT1542536E (enExample)
RU (1) RU2331669C2 (enExample)
WO (2) WO2004010959A2 (enExample)
ZA (1) ZA200500682B (enExample)

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WO2006031467A2 (en) * 2002-07-25 2006-03-23 The Scripps Research Institute Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
US20060104963A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells
US20060104962A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
CA2524063C (en) * 2003-05-02 2015-02-17 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
US8088585B2 (en) * 2003-10-31 2012-01-03 Children's Medical Center Corporation Methods for purifying hematopoietic stem cells
RU2279886C2 (ru) * 2004-06-10 2006-07-20 Московский научно-исследовательский институт глазных болезней им. Гельмгольца Минздрава РФ Способ улучшения функциональной активности сетчатки при ее патологии различного генеза
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
JP2008509678A (ja) * 2004-08-13 2008-04-03 メドトロニック・インコーポレーテッド 内皮前駆細胞サブセットの単離とそれらの使用方法
EP1802199A4 (en) * 2004-09-03 2008-08-27 Scripps Research Inst HEMATOPOIETIC STEM CELLS OF ISOLATED NEGATIVE LINES AND METHODS OF TREATMENT THEREOF
DE102004055615A1 (de) * 2004-11-16 2006-05-18 Universitätsklinikum Hamburg-Eppendorf In vitro aus Knochenmarkstammzellen differenzierte Retina-spezifische Zellen, ihre Herstellung und Verwendung
US20080193435A1 (en) * 2005-02-24 2008-08-14 Martin Friedlander Revascularization of Ischemic Retinal Tissue and Screening Method Therefor
RU2403906C2 (ru) * 2005-02-24 2010-11-20 Дзе Скриппс Рисерч Инститьют Способ лечения ретинопатии при недоношенности и родственных ретинопатических заболеваний
RU2418856C2 (ru) * 2005-02-24 2011-05-20 Дзе Скриппс Рисерч Инститьют Изолированные популяции миелоидоподобных клеток костного мозга и способы лечения с ними
US20070231306A1 (en) * 2005-02-24 2007-10-04 The Scripps Research Institute Isolated myeloid-like cell populations and methods of treatment therewith
JP4734636B2 (ja) * 2005-11-02 2011-07-27 国立大学法人 鹿児島大学 免疫染色法、及び当該免疫染色法を利用した細胞の評価方法
US8637005B2 (en) 2005-11-07 2014-01-28 Amorcyte, Inc. Compositions and methods of vascular injury repair
WO2007055905A2 (en) 2005-11-07 2007-05-18 Amorcyte, Inc. Compositions and methods of vascular injury repair
US20110076255A1 (en) 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
GEP20135796B (en) 2006-03-07 2013-04-10 Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
KR100757265B1 (ko) * 2006-04-27 2007-09-10 (주) 차바이오텍 제대혈 유래 줄기 세포를 포함하는 요실금 치료용 조성물
AU2007272313B2 (en) * 2006-07-12 2013-11-21 Mesoblast, Inc. Treatment of excessive neovascularization
CN101583367B (zh) * 2006-11-07 2013-05-01 夏尔再生医学公司 用于治疗和控制血管生成介导的疾病的材料和方法
US20100098675A1 (en) * 2008-05-30 2010-04-22 Nikolai Tankovich Methods for reducing the side effects of ophthalmic laser surgery
CA2737193A1 (en) * 2008-09-12 2010-03-18 Universidade Federal De Sao Paulo - Unifesp Ischemic tissue cell therapy
BRPI0920976A2 (pt) 2008-12-03 2015-08-18 Amorcyte Inc Composições que melhoram a perfusão da area de infarto e metodos de restauração da lesão vascular.
RU2428956C2 (ru) * 2009-07-13 2011-09-20 Александр Дмитриевич Ромащенко Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток
WO2012005763A1 (en) 2010-07-06 2012-01-12 The Scripps Research Institute Use of myeloid-like progenitor cell populations to treat tumors
CN110777124A (zh) 2011-10-27 2020-02-11 威尔斯达眼科制剂公司 编码视杆细胞来源的视锥细胞活力因子的载体
WO2013158258A1 (en) * 2012-04-16 2013-10-24 The Regents Of The University Of California Ocular therapeutics using embryonic system cell microvesicles
US11033586B2 (en) 2012-08-24 2021-06-15 Riken Method for producing retinal pigment epithelial cell sheet
CN113498347B (zh) * 2019-02-28 2024-02-02 深圳大学 内皮祖细胞(epc)在治疗早衰综合症疾病的用途
CN121550400B (zh) * 2026-01-26 2026-05-19 天津医科大学眼科医院 Crybb2重组蛋白在治疗和/或预防糖尿病性视网膜病变中的应用

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Publication number Publication date
EP1542536A2 (en) 2005-06-22
MXPA05000972A (es) 2005-09-12
AU2003259687A1 (en) 2004-02-16
JP2010285434A (ja) 2010-12-24
PL374868A1 (en) 2005-11-14
KR101095287B1 (ko) 2011-12-16
DK1542536T3 (da) 2012-01-23
PT1542536E (pt) 2012-02-14
CA2493122A1 (en) 2004-02-05
BR0312920A (pt) 2007-07-10
JP5385219B2 (ja) 2014-01-08
RU2005105065A (ru) 2005-09-10
WO2004010959A3 (en) 2005-04-07
CN1688196A (zh) 2005-10-26
US7153501B2 (en) 2006-12-26
WO2004098499A2 (en) 2004-11-18
US20040197902A1 (en) 2004-10-07
WO2004098499A3 (en) 2005-10-06
CA2493122C (en) 2012-11-27
JP2005538742A (ja) 2005-12-22
ATE536405T1 (de) 2011-12-15
KR20050027132A (ko) 2005-03-17
ES2376866T3 (es) 2012-03-20
CN1307300C (zh) 2007-03-28
EP1542536A4 (en) 2007-05-16
WO2004010959A2 (en) 2004-02-05
KR20110102961A (ko) 2011-09-19
AU2003259687B2 (en) 2009-10-29
ZA200500682B (en) 2006-07-26
EP1542536B1 (en) 2011-12-07
US20070116685A1 (en) 2007-05-24
PL216193B1 (pl) 2014-03-31

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