AU2003259687B2 - Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith - Google Patents

Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith Download PDF

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Publication number
AU2003259687B2
AU2003259687B2 AU2003259687A AU2003259687A AU2003259687B2 AU 2003259687 B2 AU2003259687 B2 AU 2003259687B2 AU 2003259687 A AU2003259687 A AU 2003259687A AU 2003259687 A AU2003259687 A AU 2003259687A AU 2003259687 B2 AU2003259687 B2 AU 2003259687B2
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Australia
Prior art keywords
cells
lin
stem cell
hematopoietic stem
hsc
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Ceased
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AU2003259687A
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AU2003259687A1 (en
Inventor
Karen Dasilva
Martin Friedlander
Atsushi Otani
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Scripps Research Institute
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Scripps Research Institute
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Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/069Vascular Endothelial cells
    • C12N5/0692Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0696Artificially induced pluripotent stem cells, e.g. iPS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003259687A 2002-07-25 2003-07-25 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith Ceased AU2003259687B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39852202P 2002-07-25 2002-07-25
US60/398,522 2002-07-25
US46705103P 2003-05-02 2003-05-02
US60/467,051 2003-05-02
PCT/US2003/024839 WO2004010959A2 (en) 2002-07-25 2003-07-25 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Publications (2)

Publication Number Publication Date
AU2003259687A1 AU2003259687A1 (en) 2004-02-16
AU2003259687B2 true AU2003259687B2 (en) 2009-10-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003259687A Ceased AU2003259687B2 (en) 2002-07-25 2003-07-25 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Country Status (17)

Country Link
US (2) US7153501B2 (enExample)
EP (1) EP1542536B1 (enExample)
JP (2) JP2005538742A (enExample)
KR (2) KR101095287B1 (enExample)
CN (1) CN1307300C (enExample)
AT (1) ATE536405T1 (enExample)
AU (1) AU2003259687B2 (enExample)
BR (1) BR0312920A (enExample)
CA (1) CA2493122C (enExample)
DK (1) DK1542536T3 (enExample)
ES (1) ES2376866T3 (enExample)
MX (1) MXPA05000972A (enExample)
PL (1) PL216193B1 (enExample)
PT (1) PT1542536E (enExample)
RU (1) RU2331669C2 (enExample)
WO (2) WO2004010959A2 (enExample)
ZA (1) ZA200500682B (enExample)

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US20060104962A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
WO2006031467A2 (en) * 2002-07-25 2006-03-23 The Scripps Research Institute Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
US20060104963A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells
EP1624758A4 (en) * 2003-05-02 2007-03-07 Scripps Research Inst HEMOPOETIC STEM CELLS AND METHOD FOR THE TREATMENT OF EYE-RELATED VASCULAR DISEASES USING THESE STEM CELLS
US8088585B2 (en) * 2003-10-31 2012-01-03 Children's Medical Center Corporation Methods for purifying hematopoietic stem cells
RU2279886C2 (ru) * 2004-06-10 2006-07-20 Московский научно-исследовательский институт глазных болезней им. Гельмгольца Минздрава РФ Способ улучшения функциональной активности сетчатки при ее патологии различного генеза
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
CA2574186A1 (en) * 2004-08-13 2006-02-23 Medtronic, Inc. Isolation of endothelial progenitor cell subsets and methods for their use
JP2008512376A (ja) * 2004-09-03 2008-04-24 ザ・スクリプス・リサーチ・インステイチユート 単離された系統陰性造血幹細胞及びこれを用いた治療方法
DE102004055615A1 (de) * 2004-11-16 2006-05-18 Universitätsklinikum Hamburg-Eppendorf In vitro aus Knochenmarkstammzellen differenzierte Retina-spezifische Zellen, ihre Herstellung und Verwendung
US20070231306A1 (en) * 2005-02-24 2007-10-04 The Scripps Research Institute Isolated myeloid-like cell populations and methods of treatment therewith
CA2599139A1 (en) * 2005-02-24 2006-08-31 The Scripps Research Institute Revascularization of ischemic retinal tissue and screening method therefor
JP2008537478A (ja) * 2005-02-24 2008-09-18 ザ・スクリプス・リサーチ・インステイチユート 単離骨髄球様骨髄細胞集団及びそれを用いた治療方法
JP5173442B2 (ja) * 2005-02-24 2013-04-03 ザ スクリプス リサーチ インスティチュート 未熟児網膜症及び関連網膜症疾患の治療のための方法
JP4734636B2 (ja) * 2005-11-02 2011-07-27 国立大学法人 鹿児島大学 免疫染色法、及び当該免疫染色法を利用した細胞の評価方法
DK2441461T3 (da) 2005-11-07 2014-07-28 Amorcyte Inc Sammensætninger og fremgangsmåder til reparation af vaskulær skade
US20110076255A1 (en) 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
US8637005B2 (en) 2005-11-07 2014-01-28 Amorcyte, Inc. Compositions and methods of vascular injury repair
AP2949A (en) 2006-03-07 2014-07-31 Shroff Geeta Compositions comprising human embryonic stem cellsand their derivatives, methods of use, and method s of preparation
KR100757265B1 (ko) * 2006-04-27 2007-09-10 (주) 차바이오텍 제대혈 유래 줄기 세포를 포함하는 요실금 치료용 조성물
US20100111910A1 (en) * 2006-07-12 2010-05-06 Angioblast Systems, Inc. Treatment of excessive neovascularization
SG176460A1 (en) * 2006-11-07 2011-12-29 Pervasis Therapeutics Inc Materials and methods for treating and managing angiogenesis-mediated diseases
US20100098675A1 (en) * 2008-05-30 2010-04-22 Nikolai Tankovich Methods for reducing the side effects of ophthalmic laser surgery
RU2535966C2 (ru) * 2008-09-12 2014-12-20 Криопрашис Криобиоложия Лтда. Клеточная терапия ишемической ткани
WO2010065601A1 (en) 2008-12-03 2010-06-10 Amorcyte, Inc. Infarct area perfusion-improving compositions and methods of vascular injury repair
RU2428956C2 (ru) * 2009-07-13 2011-09-20 Александр Дмитриевич Ромащенко Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток
WO2012005763A1 (en) 2010-07-06 2012-01-12 The Scripps Research Institute Use of myeloid-like progenitor cell populations to treat tumors
WO2013063383A2 (en) 2011-10-27 2013-05-02 Wellstat Ophthalmics Corporation Vectors encoding rod-derived cone viability factor
WO2013158258A1 (en) * 2012-04-16 2013-10-24 The Regents Of The University Of California Ocular therapeutics using embryonic system cell microvesicles
US11033586B2 (en) * 2012-08-24 2021-06-15 Riken Method for producing retinal pigment epithelial cell sheet
WO2020172854A1 (en) * 2019-02-28 2020-09-03 Shenzhen University Use of endothelial progenitor cells (epcs) in rejuvenating microvasculature, preventing aging and treating age-related diseases

Citations (1)

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WO1999010478A1 (en) * 1997-08-22 1999-03-04 The Board Of Trustees Of The Leland Stanford Junior University Mammalian common lymphoid progenitor cell

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Also Published As

Publication number Publication date
EP1542536B1 (en) 2011-12-07
US7153501B2 (en) 2006-12-26
RU2005105065A (ru) 2005-09-10
ATE536405T1 (de) 2011-12-15
CA2493122A1 (en) 2004-02-05
CN1688196A (zh) 2005-10-26
WO2004010959A2 (en) 2004-02-05
KR20110102961A (ko) 2011-09-19
WO2004010959A3 (en) 2005-04-07
EP1542536A4 (en) 2007-05-16
PL216193B1 (pl) 2014-03-31
JP2010285434A (ja) 2010-12-24
US20040197902A1 (en) 2004-10-07
BR0312920A (pt) 2007-07-10
JP2005538742A (ja) 2005-12-22
KR101095287B1 (ko) 2011-12-16
US20070116685A1 (en) 2007-05-24
CN1307300C (zh) 2007-03-28
ES2376866T3 (es) 2012-03-20
AU2003259687A1 (en) 2004-02-16
MXPA05000972A (es) 2005-09-12
PL374868A1 (en) 2005-11-14
CA2493122C (en) 2012-11-27
KR20050027132A (ko) 2005-03-17
WO2004098499A3 (en) 2005-10-06
ZA200500682B (en) 2006-07-26
WO2004098499A2 (en) 2004-11-18
DK1542536T3 (da) 2012-01-23
EP1542536A2 (en) 2005-06-22
RU2331669C2 (ru) 2008-08-20
JP5385219B2 (ja) 2014-01-08
PT1542536E (pt) 2012-02-14

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired