CN1307194C - 大环内酯类化合物 - Google Patents

大环内酯类化合物 Download PDF

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Publication number
CN1307194C
CN1307194C CNB028270452A CN02827045A CN1307194C CN 1307194 C CN1307194 C CN 1307194C CN B028270452 A CNB028270452 A CN B028270452A CN 02827045 A CN02827045 A CN 02827045A CN 1307194 C CN1307194 C CN 1307194C
Authority
CN
China
Prior art keywords
amino
dihydro
oxo
ethyl
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028270452A
Other languages
English (en)
Chinese (zh)
Other versions
CN1612888A (zh
Inventor
S·阿利霍德兹克
D·安德雷奥蒂
A·贝尔迪克
I·比恩蒂内斯
S·比安迪
M·茨拉科
F·达米亚尼
M·德耶雷克
M·杜米克
V·埃拉科维克
A·胡蒂内克
G·拉扎雷夫斯基
S·罗丘罗
N·马西克
Z·马鲁西克－伊斯图克
S·穆塔克
A·派奥
D·帕夫罗维克
A·夸格利亚
W·舍恩费尔德
V·斯蒂马克
J·蒂巴斯各
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Pliva Farmaceutika dd
Original Assignee
Glaxo Group Ltd
Pliva Farmaceutika dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Pliva Farmaceutika dd filed Critical Glaxo Group Ltd
Publication of CN1612888A publication Critical patent/CN1612888A/zh
Application granted granted Critical
Publication of CN1307194C publication Critical patent/CN1307194C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
CNB028270452A 2001-11-14 2002-11-13 大环内酯类化合物 Expired - Fee Related CN1307194C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0127349.9A GB0127349D0 (en) 2001-11-14 2001-11-14 Macrolides
GB0127349.9 2001-11-14

Publications (2)

Publication Number Publication Date
CN1612888A CN1612888A (zh) 2005-05-04
CN1307194C true CN1307194C (zh) 2007-03-28

Family

ID=9925777

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028270452A Expired - Fee Related CN1307194C (zh) 2001-11-14 2002-11-13 大环内酯类化合物

Country Status (20)

Country Link
US (1) US7202221B2 (https=)
EP (1) EP1453846B1 (https=)
JP (1) JP2005515978A (https=)
CN (1) CN1307194C (https=)
AR (1) AR037371A1 (https=)
AT (1) ATE362479T1 (https=)
BR (1) BR0214132A (https=)
CA (1) CA2466975A1 (https=)
DE (1) DE60220180T2 (https=)
EA (1) EA007433B1 (https=)
ES (1) ES2287332T3 (https=)
GB (1) GB0127349D0 (https=)
HR (1) HRP20040433A2 (https=)
HU (1) HUP0402225A3 (https=)
IL (1) IL161710A0 (https=)
PL (1) PL371472A1 (https=)
RS (1) RS41904A (https=)
UA (1) UA77210C2 (https=)
WO (1) WO2003042228A1 (https=)
ZA (1) ZA200403684B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7022679B2 (en) 2002-05-13 2006-04-04 Enanta Pharmaceuticals, Inc. Processes for the preparation of 6-11 bicyclic erythromycin derivatives
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US7910558B2 (en) 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7135573B2 (en) 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
NZ536061A (en) * 2002-05-14 2008-09-26 Univ California Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
GB0225384D0 (en) * 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
SI1628989T1 (sl) * 2003-05-13 2007-06-30 Glaxo Group Ltd Nove cikliäśne spojine s 14 in 15 obroäśnimi äśleni
GB0310986D0 (en) 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310980D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310979D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
GB0310984D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
WO2005070113A2 (en) 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
BRPI0510328A (pt) * 2004-05-06 2007-10-23 Glaxosmithkline Zagreb macrolìdeos ligados a éster úteis para o tratamento de infecções microbianas
WO2005108413A1 (en) * 2004-05-06 2005-11-17 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O Carbamate linked macrolides useful for the treatment of microbial infections
WO2006047167A2 (en) * 2004-10-21 2006-05-04 Janssen Pharmaceutica, N.V. 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials
GB0424961D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424951D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424958D0 (en) * 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424959D0 (en) 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
DK2049556T3 (da) * 2006-08-09 2013-08-12 Basilea Pharmaceutica Ag Nye makrolider anvendelige mod inflammatoriske og allergiske sygdomme
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
WO2009106419A1 (en) 2008-02-08 2009-09-03 Basilea Pharmaceutica Ag New macrolides and their use
BRPI1011959A2 (pt) 2009-05-27 2016-04-26 Wockhardt Research Center compostos de cetolídeo tendo atividade antimicrobiana.
WO2012076989A1 (en) 2010-12-09 2012-06-14 Wockhardt Limited Ketolide compounds
KR20140004187A (ko) * 2011-01-31 2014-01-10 메이지 세이카 파루마 가부시키가이샤 신규 마크로라이드 유도체
KR101567658B1 (ko) 2011-03-01 2015-11-09 욱크하르트 리미티드 케톨리드 중간체의 제조 방법
CN119060110A (zh) * 2023-05-30 2024-12-03 北京理工大学 一种红霉素衍生物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248279A2 (en) * 1986-06-04 1987-12-09 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126344A2 (en) 1983-05-20 1984-11-28 Abbott Laboratories Tripeptide esters of therapeutic agents
WO1990011288A1 (en) 1989-03-28 1990-10-04 Abbott Laboratories Erythromycin derivatives
EP1007530B1 (en) 1996-05-07 2005-11-16 Abbott Laboratories 6-o-substituted erythromycin compounds and method for making same
US6262030B1 (en) * 1998-11-03 2001-07-17 Pfizer Inc. Erythromycin derivatives
EA200100983A1 (ru) 1999-05-24 2002-10-31 Пфайзер Продактс Инк. Производные 13-метилэритромицина
PT1206476E (pt) 1999-08-24 2006-05-31 Abbott Lab 9a-azalidos com actividade antibacteriana
US6946446B2 (en) * 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
ES2254389T3 (es) 2000-02-24 2006-06-16 Abbott Laboratories Agentes anti-infecciosos utiles contra cepas bacterianas resistntes a multiples farmacos.
JP2002173498A (ja) 2000-09-27 2002-06-21 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
GB0025688D0 (en) * 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248279A2 (en) * 1986-06-04 1987-12-09 Abbott Laboratories Semisynthetic erythromycin antibiotics
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
US6025350A (en) * 1997-08-06 2000-02-15 Pfizer Inc. C-4" substituted macrolide antibiotics

Also Published As

Publication number Publication date
EA007433B1 (ru) 2006-10-27
ZA200403684B (en) 2005-09-13
GB0127349D0 (en) 2002-01-02
EP1453846B1 (en) 2007-05-16
DE60220180T2 (de) 2008-01-17
JP2005515978A (ja) 2005-06-02
DE60220180D1 (de) 2007-06-28
AR037371A1 (es) 2004-11-03
PL371472A1 (en) 2005-06-13
CA2466975A1 (en) 2003-05-22
EA200400536A1 (ru) 2004-12-30
ATE362479T1 (de) 2007-06-15
BR0214132A (pt) 2004-09-14
CN1612888A (zh) 2005-05-04
IL161710A0 (en) 2004-09-27
EP1453846A1 (en) 2004-09-08
RS41904A (sr) 2006-10-27
US20050080025A1 (en) 2005-04-14
US7202221B2 (en) 2007-04-10
UA77210C2 (en) 2006-11-15
HUP0402225A2 (hu) 2005-02-28
HUP0402225A3 (en) 2006-01-30
ES2287332T3 (es) 2007-12-16
WO2003042228A1 (en) 2003-05-22
HRP20040433A2 (en) 2005-04-30

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070328

Termination date: 20091214