AR037371A1 - Compuesto macrolida, proceso para su preparacion, composicion farmaceutica que lo comprende y su uso para la preparacion de un medicamento - Google Patents
Compuesto macrolida, proceso para su preparacion, composicion farmaceutica que lo comprende y su uso para la preparacion de un medicamentoInfo
- Publication number
- AR037371A1 AR037371A1 ARP020104364A ARP020104364A AR037371A1 AR 037371 A1 AR037371 A1 AR 037371A1 AR P020104364 A ARP020104364 A AR P020104364A AR P020104364 A ARP020104364 A AR P020104364A AR 037371 A1 AR037371 A1 AR 037371A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- optionally substituted
- alkyl
- bicyclic heteroaryl
- hydroxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229940126601 medicinal product Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 22
- 239000001257 hydrogen Substances 0.000 abstract 22
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 22
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 4
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000004122 cyclic group Chemical group 0.000 abstract 4
- 229910052731 fluorine Chemical group 0.000 abstract 4
- 239000011737 fluorine Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000012453 solvate Substances 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 2
- 101100240518 Caenorhabditis elegans nhr-12 gene Proteins 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 230000009885 systemic effect Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 125000004001 thioalkyl group Chemical group 0.000 abstract 2
- 230000000699 topical effect Effects 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0127349.9A GB0127349D0 (en) | 2001-11-14 | 2001-11-14 | Macrolides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037371A1 true AR037371A1 (es) | 2004-11-03 |
Family
ID=9925777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104364A AR037371A1 (es) | 2001-11-14 | 2002-11-13 | Compuesto macrolida, proceso para su preparacion, composicion farmaceutica que lo comprende y su uso para la preparacion de un medicamento |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7202221B2 (https=) |
| EP (1) | EP1453846B1 (https=) |
| JP (1) | JP2005515978A (https=) |
| CN (1) | CN1307194C (https=) |
| AR (1) | AR037371A1 (https=) |
| AT (1) | ATE362479T1 (https=) |
| BR (1) | BR0214132A (https=) |
| CA (1) | CA2466975A1 (https=) |
| DE (1) | DE60220180T2 (https=) |
| EA (1) | EA007433B1 (https=) |
| ES (1) | ES2287332T3 (https=) |
| GB (1) | GB0127349D0 (https=) |
| HR (1) | HRP20040433A2 (https=) |
| HU (1) | HUP0402225A3 (https=) |
| IL (1) | IL161710A0 (https=) |
| PL (1) | PL371472A1 (https=) |
| RS (1) | RS41904A (https=) |
| UA (1) | UA77210C2 (https=) |
| WO (1) | WO2003042228A1 (https=) |
| ZA (1) | ZA200403684B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6995143B2 (en) * | 2002-02-28 | 2006-02-07 | Basilea Pharmaceutica Ag | Macrolides with antibacterial activity |
| WO2005070918A1 (en) | 2002-05-13 | 2005-08-04 | Enanta Pharmaceuticals, Inc. | Process for the preparation of t-11 bicyclic erythromycin derivatives |
| US7910558B2 (en) | 2002-05-13 | 2011-03-22 | Enanta Pharmaceuticals, Inc. | Bridged macrocyclic compounds and processes for the preparation thereof |
| US6764998B1 (en) | 2003-06-18 | 2004-07-20 | Enanta Pharmaceuticals, Inc. | 6,11-4C-bicyclic 9a-azalide derivatives |
| US7135573B2 (en) | 2002-05-13 | 2006-11-14 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine |
| DK1503759T3 (da) * | 2002-05-14 | 2009-04-14 | Univ California | Substituerede quinoloncarboxylsyrer, deres derivater, virkningssted og anvendelser heraf |
| TW200420573A (en) | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
| GB0225384D0 (en) * | 2002-10-31 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| US6645941B1 (en) | 2003-03-26 | 2003-11-11 | Enanta Pharmaceuticals, Inc. | 6,11-3C-bicyclic 9a-azalide derivatives |
| GB0310980D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| GB0310979D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| ES2278319T3 (es) * | 2003-05-13 | 2007-08-01 | Glaxo Group Limited | Nuevos compuestos con 14 y 15 miembros en el anillo. |
| GB0310986D0 (en) | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| GB0310984D0 (en) * | 2003-05-13 | 2003-06-18 | Glaxo Group Ltd | Novel compounds |
| WO2005030227A1 (en) | 2003-09-23 | 2005-04-07 | Enanta Pharmaceuticals, Inc. | 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES |
| WO2005070113A2 (en) | 2004-01-09 | 2005-08-04 | Enanta Pharmaceuticals, Inc. | 9n-substituted 6-11 bicyclic erythromycin derivatives |
| EP1723159B1 (en) | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
| WO2005108412A1 (en) * | 2004-05-06 | 2005-11-17 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Ester linked macrolides useful for the treatment of microbial infections |
| JP2007536372A (ja) * | 2004-05-06 | 2007-12-13 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 微生物感染症の治療に有用なカルバミン酸エステル結合マクロライド |
| WO2006047167A2 (en) * | 2004-10-21 | 2006-05-04 | Janssen Pharmaceutica, N.V. | 9 alkyl and 9 alkylidenyl 6-0 alkyl-11, 12 carbamate ketolide antimicrobials |
| GB0424961D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| GB0424959D0 (en) | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| GB0424951D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| GB0424958D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| BRPI0716408A2 (pt) | 2006-08-09 | 2013-09-24 | Basilea Pharmaceutica Ag | macrolÍdeos éteis doenÇa inflamatària e alÉrgica |
| CA2661538A1 (en) | 2006-08-24 | 2008-02-28 | Wockhardt Research Centre | Novel macrolides and ketolides having antimicrobial activity |
| WO2009106419A1 (en) | 2008-02-08 | 2009-09-03 | Basilea Pharmaceutica Ag | New macrolides and their use |
| ES2561332T3 (es) | 2009-05-27 | 2016-02-25 | Wockhardt Limited | Compuestos cetólidos que tienen actividad antimicrobiana |
| PT2673285T (pt) | 2010-12-09 | 2017-10-19 | Wockhardt Ltd | Resumo |
| BR112013019283A2 (pt) * | 2011-01-31 | 2016-09-13 | Meiji Seika Pharma Co Ltd | composto, fármaco, composição farmacêutica e uso |
| JP5718488B2 (ja) | 2011-03-01 | 2015-05-13 | ウォックハート リミテッド | ケトライド中間体の調製方法 |
| CN119060110A (zh) * | 2023-05-30 | 2024-12-03 | 北京理工大学 | 一种红霉素衍生物及其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0126344A2 (en) | 1983-05-20 | 1984-11-28 | Abbott Laboratories | Tripeptide esters of therapeutic agents |
| US4742049A (en) * | 1986-06-04 | 1988-05-03 | Abbott Laboratories | Semisynthetic erythromycin antibiotics |
| WO1990011288A1 (en) | 1989-03-28 | 1990-10-04 | Abbott Laboratories | Erythromycin derivatives |
| CA2064634C (en) * | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
| DE69734678T2 (de) | 1996-05-07 | 2006-08-17 | Abbott Laboratories, Abbott Park | 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung |
| EP0895999A1 (en) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
| US6262030B1 (en) | 1998-11-03 | 2001-07-17 | Pfizer Inc. | Erythromycin derivatives |
| HUP0201516A3 (en) | 1999-05-24 | 2003-03-28 | Pfizer Prod Inc | 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them |
| DK1206476T3 (da) | 1999-08-24 | 2006-05-15 | Abbott Lab | 9a-azalider med antibakteriel virkning |
| ATE312839T1 (de) | 2000-02-24 | 2005-12-15 | Abbott Lab | Anti-infektionsmittel, die gegen gegenüber mehreren arzneimitteln resistente bakterienstämme nützlich sind |
| US6946446B2 (en) | 2000-02-24 | 2005-09-20 | Abbott Laboratories | Anti-infective agents useful against multidrug-resistant strains of bacteria |
| JP2002173498A (ja) | 2000-09-27 | 2002-06-21 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
| GB0025688D0 (en) * | 2000-10-19 | 2000-12-06 | Glaxo Group Ltd | Macrolides |
-
2001
- 2001-11-14 GB GBGB0127349.9A patent/GB0127349D0/en not_active Ceased
-
2002
- 2002-11-13 BR BR0214132-9A patent/BR0214132A/pt not_active IP Right Cessation
- 2002-11-13 US US10/495,413 patent/US7202221B2/en not_active Expired - Fee Related
- 2002-11-13 DE DE60220180T patent/DE60220180T2/de not_active Expired - Fee Related
- 2002-11-13 IL IL16171002A patent/IL161710A0/xx unknown
- 2002-11-13 AR ARP020104364A patent/AR037371A1/es unknown
- 2002-11-13 JP JP2003544063A patent/JP2005515978A/ja active Pending
- 2002-11-13 CN CNB028270452A patent/CN1307194C/zh not_active Expired - Fee Related
- 2002-11-13 HU HU0402225A patent/HUP0402225A3/hu unknown
- 2002-11-13 UA UA20040503313A patent/UA77210C2/uk unknown
- 2002-11-13 PL PL02371472A patent/PL371472A1/xx not_active Application Discontinuation
- 2002-11-13 CA CA002466975A patent/CA2466975A1/en not_active Abandoned
- 2002-11-13 EA EA200400536A patent/EA007433B1/ru not_active IP Right Cessation
- 2002-11-13 WO PCT/GB2002/005101 patent/WO2003042228A1/en not_active Ceased
- 2002-11-13 HR HR20040433A patent/HRP20040433A2/hr not_active Application Discontinuation
- 2002-11-13 RS YU41904A patent/RS41904A/sr unknown
- 2002-11-13 EP EP02779670A patent/EP1453846B1/en not_active Expired - Lifetime
- 2002-11-13 AT AT02779670T patent/ATE362479T1/de not_active IP Right Cessation
- 2002-11-13 ES ES02779670T patent/ES2287332T3/es not_active Expired - Lifetime
-
2004
- 2004-05-13 ZA ZA200403684A patent/ZA200403684B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1612888A (zh) | 2005-05-04 |
| RS41904A (sr) | 2006-10-27 |
| WO2003042228A1 (en) | 2003-05-22 |
| PL371472A1 (en) | 2005-06-13 |
| DE60220180T2 (de) | 2008-01-17 |
| UA77210C2 (en) | 2006-11-15 |
| HUP0402225A2 (hu) | 2005-02-28 |
| HRP20040433A2 (en) | 2005-04-30 |
| ES2287332T3 (es) | 2007-12-16 |
| ZA200403684B (en) | 2005-09-13 |
| EP1453846A1 (en) | 2004-09-08 |
| BR0214132A (pt) | 2004-09-14 |
| CA2466975A1 (en) | 2003-05-22 |
| GB0127349D0 (en) | 2002-01-02 |
| EA007433B1 (ru) | 2006-10-27 |
| CN1307194C (zh) | 2007-03-28 |
| ATE362479T1 (de) | 2007-06-15 |
| HUP0402225A3 (en) | 2006-01-30 |
| JP2005515978A (ja) | 2005-06-02 |
| US7202221B2 (en) | 2007-04-10 |
| EA200400536A1 (ru) | 2004-12-30 |
| EP1453846B1 (en) | 2007-05-16 |
| US20050080025A1 (en) | 2005-04-14 |
| DE60220180D1 (de) | 2007-06-28 |
| IL161710A0 (en) | 2004-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |