CN1280492A - 作为药物载体的多孔羟基磷灰石颗粒 - Google Patents

作为药物载体的多孔羟基磷灰石颗粒 Download PDF

Info

Publication number
CN1280492A
CN1280492A CN98811634A CN98811634A CN1280492A CN 1280492 A CN1280492 A CN 1280492A CN 98811634 A CN98811634 A CN 98811634A CN 98811634 A CN98811634 A CN 98811634A CN 1280492 A CN1280492 A CN 1280492A
Authority
CN
China
Prior art keywords
oily
pharmaceutically active
viscous
greasy
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98811634A
Other languages
English (en)
Chinese (zh)
Inventor
C·卡尔松
P·J·伦德贝里
A·罗辛斯基
M·瑟德波姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1280492A publication Critical patent/CN1280492A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN98811634A 1997-11-28 1998-11-19 作为药物载体的多孔羟基磷灰石颗粒 Pending CN1280492A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704400A SE9704400D0 (sv) 1997-11-28 1997-11-28 Porous inorganic particles as carriers for drug substances
SE97044002 1997-11-28

Publications (1)

Publication Number Publication Date
CN1280492A true CN1280492A (zh) 2001-01-17

Family

ID=20409177

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98811634A Pending CN1280492A (zh) 1997-11-28 1998-11-19 作为药物载体的多孔羟基磷灰石颗粒

Country Status (26)

Country Link
US (1) US6558703B1 (cg-RX-API-DMAC7.html)
EP (1) EP1032370B1 (cg-RX-API-DMAC7.html)
JP (1) JP2001524513A (cg-RX-API-DMAC7.html)
KR (1) KR20010032557A (cg-RX-API-DMAC7.html)
CN (1) CN1280492A (cg-RX-API-DMAC7.html)
AR (1) AR016683A1 (cg-RX-API-DMAC7.html)
AT (1) ATE256453T1 (cg-RX-API-DMAC7.html)
AU (1) AU752044B2 (cg-RX-API-DMAC7.html)
BR (1) BR9814751A (cg-RX-API-DMAC7.html)
CA (1) CA2311780A1 (cg-RX-API-DMAC7.html)
DE (1) DE69820674T2 (cg-RX-API-DMAC7.html)
DK (1) DK1032370T3 (cg-RX-API-DMAC7.html)
ES (1) ES2210840T3 (cg-RX-API-DMAC7.html)
HU (1) HUP0100303A3 (cg-RX-API-DMAC7.html)
ID (1) ID24700A (cg-RX-API-DMAC7.html)
IL (1) IL136146A0 (cg-RX-API-DMAC7.html)
NO (1) NO20002719L (cg-RX-API-DMAC7.html)
NZ (1) NZ504353A (cg-RX-API-DMAC7.html)
PL (1) PL340927A1 (cg-RX-API-DMAC7.html)
PT (1) PT1032370E (cg-RX-API-DMAC7.html)
RU (1) RU2219907C2 (cg-RX-API-DMAC7.html)
SE (1) SE9704400D0 (cg-RX-API-DMAC7.html)
SK (1) SK6602000A3 (cg-RX-API-DMAC7.html)
TW (1) TW524694B (cg-RX-API-DMAC7.html)
WO (1) WO1999027912A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA9810463B (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924334D0 (en) * 1999-10-15 1999-12-15 Secr Defence Pharmaceutical products and methods of fabrication therefor
BR0109991A (pt) * 2000-04-11 2003-05-27 Sankyo Co Composição farmacêutica
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
CN100513398C (zh) 2002-12-03 2009-07-15 Axys药物公司 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
KR101207553B1 (ko) 2005-06-02 2012-12-03 (주)씨앤팜 금속 이중층 수산화물을 포함하는 생체 주사제용 약물 담체
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
JP5027410B2 (ja) * 2005-12-13 2012-09-19 株式会社サンギ ユビキノン含有組成物
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
AU2007224651B8 (en) * 2006-03-14 2011-10-27 Lidds Ab Bioresorbable controlled-release composition
GB0909460D0 (en) 2009-06-02 2009-07-15 Intrinsiq Materials Global Ltd Mesoporus material
WO2014120922A1 (en) 2013-02-01 2014-08-07 W. R. Grace & Co.-Conn. Porous silica gel as a carrier for liquid technologies
WO2015040212A1 (en) * 2013-09-20 2015-03-26 Tillotts Pharma Ag Delayed release pharmaceutical formulation
CN104133014B (zh) * 2014-07-16 2015-09-16 广州法尔麦兰药物技术有限公司 一种考察布洛伪麻缓释制剂释放度的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413191D0 (en) 1984-05-23 1984-06-27 Beecham Group Plc Pharmaceutical composition
GB8713263D0 (en) 1987-06-05 1987-07-08 Unilever Plc Spheroidal silica
EP0376331A3 (en) 1988-12-29 1991-03-13 Asahi Kogaku Kogyo Kabushiki Kaisha Slow release drug delivery granules and process for production thereof
US5149523A (en) * 1989-06-20 1992-09-22 Aktiebolaget Hassle Polystyrenesulfonate-drug complex and solid dosage forms thereof
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US6096324A (en) * 1995-06-13 2000-08-01 Laboratory Skin Care Methods of delivering materials into the skin, and compositions used therein
JP3562878B2 (ja) * 1995-07-07 2004-09-08 丸尾カルシウム株式会社 花弁状多孔質ヒドロキシアパタイト微粒子及びその製造方法

Also Published As

Publication number Publication date
AU1356399A (en) 1999-06-16
ES2210840T3 (es) 2004-07-01
JP2001524513A (ja) 2001-12-04
EP1032370B1 (en) 2003-12-17
DE69820674D1 (de) 2004-01-29
DE69820674T2 (de) 2004-09-30
CA2311780A1 (en) 1999-06-10
US6558703B1 (en) 2003-05-06
ATE256453T1 (de) 2004-01-15
EP1032370A1 (en) 2000-09-06
DK1032370T3 (da) 2004-03-15
BR9814751A (pt) 2000-10-03
RU2219907C2 (ru) 2003-12-27
WO1999027912A1 (en) 1999-06-10
ID24700A (id) 2000-08-03
AR016683A1 (es) 2001-07-25
SE9704400D0 (sv) 1997-11-28
KR20010032557A (ko) 2001-04-25
AU752044B2 (en) 2002-09-05
NO20002719D0 (no) 2000-05-26
HUP0100303A3 (en) 2004-03-29
IL136146A0 (en) 2001-05-20
NO20002719L (no) 2000-07-28
NZ504353A (en) 2001-10-26
PT1032370E (pt) 2004-05-31
TW524694B (en) 2003-03-21
HUP0100303A2 (hu) 2001-08-28
ZA9810463B (en) 1999-05-21
PL340927A1 (en) 2001-03-12
SK6602000A3 (en) 2001-01-18

Similar Documents

Publication Publication Date Title
RU2174832C2 (ru) Лекарственная композиция для релизконтроля
US6558703B1 (en) Porous hydroxyapatite particles as carriers for drug substances
CN1298317C (zh) 坦洛新片剂
RU2216316C2 (ru) Гранулы с полиэтиленгликолевой матрицей для жирных, маслянистых или клейких лекарственных веществ
JPH07215843A (ja) 生物学的付着性を有する徐放性薬理組成物
TWI285116B (en) Drug delivery system for enhanced bioavailability of hydrophobic active ingredients
KR20000005554A (ko) 방출 지속성 다분산 하이드로겔 시스템 - 비정질 약물
KR20040079967A (ko) 고체 약물 분산액을 함유하는 속방형 제형
KR20100052453A (ko) 타달라필 함유 약제의 제조방법
JP2006213713A (ja) コレステリルエステル輸送タンパク質阻害剤およびＨＭＧ−ＣｏＡレダクターゼ阻害剤の剤形
Sun et al. A microcrystalline cellulose based drug-composite formulation strategy for developing low dose drug tablets
US20240325610A1 (en) Drug coating, drug-coated balloon and preparation method thereof
Sangnim et al. Development and evaluation of taste-masked paracetamol chewable tablets using a polymer and/or wax dispersion technique
JP5684440B2 (ja) 組成物および固形製剤
MXPA00005116A (en) Porous hydroxyapatite particles as carriers for drug substances
CN113786393A (zh) 一种利伐沙班微球及其制备方法与应用
JP2005508369A (ja) マイクロカプセルマトリックス微小球、吸収を促進する薬剤組成物および方法
CZ20001946A3 (cs) Porézní částice hydroxyapatitu jako nosiče léčivých substancí
JP2727009B2 (ja) 持続性製剤
EP1666024A1 (en) Preparation for rectal administration
MXPA00005112A (en) Polyethylene glycol matrix pellets for greasy, oily or sticky drug substances
CZ20001945A3 (cs) Pelety z polyethylenglykolové matrice pro mastné, olejové nebo lepivé léčivé substance

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication