HUP0100303A2 - Porózus hidroxiapatit részecskék mint gyógyszerhatóanyag hordozók - Google Patents
Porózus hidroxiapatit részecskék mint gyógyszerhatóanyag hordozókInfo
- Publication number
- HUP0100303A2 HUP0100303A2 HU0100303A HUP0100303A HUP0100303A2 HU P0100303 A2 HUP0100303 A2 HU P0100303A2 HU 0100303 A HU0100303 A HU 0100303A HU P0100303 A HUP0100303 A HU P0100303A HU P0100303 A2 HUP0100303 A2 HU P0100303A2
- Authority
- HU
- Hungary
- Prior art keywords
- composition
- carriers
- drug substances
- hydroxyapatite particles
- porous hydroxyapatite
- Prior art date
Links
- 229940088679 drug related substance Drugs 0.000 title abstract 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 title abstract 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title abstract 2
- 239000000969 carrier Substances 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 239000000919 ceramic Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000010954 inorganic particle Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgyát olyan száraz, szilárd gyógyszeradagoló kompozícióképezi, amely tartalmaz i) legalább egy zsíros, olajos vagy ragacsosanyagot és legalább egy gyógyszerhatóanyagot; vagy ii) legalább egyzsíros, olajos vagy ragacsos gyógyszerhatóanyagot, amely kompozíció 5és 150 mm közötti átmérőjű kerámiai hidroxiapatitból álló porózusszervetlen részecskék többségének formájában van; a hatóanyag gyorsfelszabadítási tulajdonságaival rendelkezik, és az i) vagy ii)komponenst 15 és 40 tömeg% közötti mennyiségben tartalmazza. Atalálmány tárgyát képezi még a fenti kompozíció előállítására szolgálóeljárás és annak alkalmazása a hatóanyag gyors felszabadításitulajdonságaival rendelkező kompozíció előállítására. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704400A SE9704400D0 (sv) | 1997-11-28 | 1997-11-28 | Porous inorganic particles as carriers for drug substances |
PCT/SE1998/002089 WO1999027912A1 (en) | 1997-11-28 | 1998-11-19 | Porous hydroxyapatite particles as carriers for drug substances |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0100303A2 true HUP0100303A2 (hu) | 2001-08-28 |
HUP0100303A3 HUP0100303A3 (en) | 2004-03-29 |
Family
ID=20409177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0100303A HUP0100303A3 (en) | 1997-11-28 | 1998-11-19 | Porous hydroxyapatite particles as carriers for drug substances |
Country Status (26)
Country | Link |
---|---|
US (1) | US6558703B1 (hu) |
EP (1) | EP1032370B1 (hu) |
JP (1) | JP2001524513A (hu) |
KR (1) | KR20010032557A (hu) |
CN (1) | CN1280492A (hu) |
AR (1) | AR016683A1 (hu) |
AT (1) | ATE256453T1 (hu) |
AU (1) | AU752044B2 (hu) |
BR (1) | BR9814751A (hu) |
CA (1) | CA2311780A1 (hu) |
DE (1) | DE69820674T2 (hu) |
DK (1) | DK1032370T3 (hu) |
ES (1) | ES2210840T3 (hu) |
HU (1) | HUP0100303A3 (hu) |
ID (1) | ID24700A (hu) |
IL (1) | IL136146A0 (hu) |
NO (1) | NO20002719L (hu) |
NZ (1) | NZ504353A (hu) |
PL (1) | PL340927A1 (hu) |
PT (1) | PT1032370E (hu) |
RU (1) | RU2219907C2 (hu) |
SE (1) | SE9704400D0 (hu) |
SK (1) | SK6602000A3 (hu) |
TW (1) | TW524694B (hu) |
WO (1) | WO1999027912A1 (hu) |
ZA (1) | ZA9810463B (hu) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9924334D0 (en) * | 1999-10-15 | 1999-12-15 | Secr Defence | Pharmaceutical products and methods of fabrication therefor |
AU2001246883B2 (en) | 2000-04-11 | 2004-08-12 | Sankyo Company, Limited | Stabilized pharmaceutical compositions containing calcium channel blockers |
IT1319202B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
US6462021B1 (en) | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
KR101207553B1 (ko) | 2005-06-02 | 2012-12-03 | (주)씨앤팜 | 금속 이중층 수산화물을 포함하는 생체 주사제용 약물 담체 |
TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
JP5027410B2 (ja) * | 2005-12-13 | 2012-09-19 | 株式会社サンギ | ユビキノン含有組成物 |
US20100040668A1 (en) * | 2006-01-12 | 2010-02-18 | Rutgers, The State University Of New Jersey | Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof |
US8287914B2 (en) * | 2006-01-12 | 2012-10-16 | Rutgers, The State University Of New Jersey | Biomimetic hydroxyapatite synthesis |
GB0909460D0 (en) | 2009-06-02 | 2009-07-15 | Intrinsiq Materials Global Ltd | Mesoporus material |
EP2950923B1 (en) | 2013-02-01 | 2022-03-09 | W.R. Grace & CO. - CONN. | Porous silica gel as a carrier for liquid technologies |
JP6441940B2 (ja) | 2013-09-20 | 2018-12-19 | ティロッツ・ファルマ・アクチエンゲゼルシャフトTillotts Pharma Ag | 遅延放出製剤処方物 |
CN104133014B (zh) * | 2014-07-16 | 2015-09-16 | 广州法尔麦兰药物技术有限公司 | 一种考察布洛伪麻缓释制剂释放度的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8413191D0 (en) | 1984-05-23 | 1984-06-27 | Beecham Group Plc | Pharmaceutical composition |
GB8713263D0 (en) | 1987-06-05 | 1987-07-08 | Unilever Plc | Spheroidal silica |
US5055307A (en) | 1988-12-29 | 1991-10-08 | Asahi Kagaku Kogyo Kabushiki Kaisha | Slow release drug delivery granules and process for production thereof |
US5149523A (en) * | 1989-06-20 | 1992-09-22 | Aktiebolaget Hassle | Polystyrenesulfonate-drug complex and solid dosage forms thereof |
US5443459A (en) * | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
US5834496A (en) * | 1991-12-02 | 1998-11-10 | Sepracor, Inc. | Methods for treating hypertension using optically pure S(-) felodipine |
US5947893A (en) * | 1994-04-27 | 1999-09-07 | Board Of Regents, The University Of Texas System | Method of making a porous prothesis with biodegradable coatings |
US6096324A (en) * | 1995-06-13 | 2000-08-01 | Laboratory Skin Care | Methods of delivering materials into the skin, and compositions used therein |
-
1997
- 1997-11-28 SE SE9704400A patent/SE9704400D0/xx unknown
-
1998
- 1998-10-27 TW TW087117781A patent/TW524694B/zh not_active IP Right Cessation
- 1998-11-16 AR ARP980105798A patent/AR016683A1/es not_active Application Discontinuation
- 1998-11-16 ZA ZA9810463A patent/ZA9810463B/xx unknown
- 1998-11-18 US US09/214,318 patent/US6558703B1/en not_active Expired - Fee Related
- 1998-11-19 AU AU13563/99A patent/AU752044B2/en not_active Ceased
- 1998-11-19 AT AT98957268T patent/ATE256453T1/de not_active IP Right Cessation
- 1998-11-19 KR KR1020007005802A patent/KR20010032557A/ko not_active Application Discontinuation
- 1998-11-19 PT PT98957268T patent/PT1032370E/pt unknown
- 1998-11-19 ES ES98957268T patent/ES2210840T3/es not_active Expired - Lifetime
- 1998-11-19 NZ NZ504353A patent/NZ504353A/en unknown
- 1998-11-19 CA CA002311780A patent/CA2311780A1/en not_active Abandoned
- 1998-11-19 WO PCT/SE1998/002089 patent/WO1999027912A1/en not_active Application Discontinuation
- 1998-11-19 JP JP2000522898A patent/JP2001524513A/ja active Pending
- 1998-11-19 PL PL98340927A patent/PL340927A1/xx unknown
- 1998-11-19 DE DE69820674T patent/DE69820674T2/de not_active Expired - Lifetime
- 1998-11-19 RU RU2000113731/15A patent/RU2219907C2/ru not_active IP Right Cessation
- 1998-11-19 BR BR9814751-0A patent/BR9814751A/pt not_active IP Right Cessation
- 1998-11-19 SK SK660-2000A patent/SK6602000A3/sk unknown
- 1998-11-19 EP EP98957268A patent/EP1032370B1/en not_active Expired - Lifetime
- 1998-11-19 ID IDW20000937A patent/ID24700A/id unknown
- 1998-11-19 HU HU0100303A patent/HUP0100303A3/hu unknown
- 1998-11-19 CN CN98811634A patent/CN1280492A/zh active Pending
- 1998-11-19 DK DK98957268T patent/DK1032370T3/da active
- 1998-11-19 IL IL13614698A patent/IL136146A0/xx unknown
-
2000
- 2000-05-26 NO NO20002719A patent/NO20002719L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JP2001524513A (ja) | 2001-12-04 |
ES2210840T3 (es) | 2004-07-01 |
SE9704400D0 (sv) | 1997-11-28 |
ZA9810463B (en) | 1999-05-21 |
NO20002719L (no) | 2000-07-28 |
AU752044B2 (en) | 2002-09-05 |
US6558703B1 (en) | 2003-05-06 |
RU2219907C2 (ru) | 2003-12-27 |
EP1032370B1 (en) | 2003-12-17 |
DK1032370T3 (da) | 2004-03-15 |
ATE256453T1 (de) | 2004-01-15 |
EP1032370A1 (en) | 2000-09-06 |
AR016683A1 (es) | 2001-07-25 |
HUP0100303A3 (en) | 2004-03-29 |
PT1032370E (pt) | 2004-05-31 |
CA2311780A1 (en) | 1999-06-10 |
AU1356399A (en) | 1999-06-16 |
WO1999027912A1 (en) | 1999-06-10 |
DE69820674T2 (de) | 2004-09-30 |
BR9814751A (pt) | 2000-10-03 |
PL340927A1 (en) | 2001-03-12 |
CN1280492A (zh) | 2001-01-17 |
IL136146A0 (en) | 2001-05-20 |
DE69820674D1 (de) | 2004-01-29 |
SK6602000A3 (en) | 2001-01-18 |
NZ504353A (en) | 2001-10-26 |
ID24700A (id) | 2000-08-03 |
TW524694B (en) | 2003-03-21 |
NO20002719D0 (no) | 2000-05-26 |
KR20010032557A (ko) | 2001-04-25 |
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