DE69820674D1 - Poröse hydroxyapatit-partikel als träger für medikamente - Google Patents

Poröse hydroxyapatit-partikel als träger für medikamente

Info

Publication number
DE69820674D1
DE69820674D1 DE69820674T DE69820674T DE69820674D1 DE 69820674 D1 DE69820674 D1 DE 69820674D1 DE 69820674 T DE69820674 T DE 69820674T DE 69820674 T DE69820674 T DE 69820674T DE 69820674 D1 DE69820674 D1 DE 69820674D1
Authority
DE
Germany
Prior art keywords
medications
support
hydroxyapatite particles
porous hydroxyapatite
porous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820674T
Other languages
English (en)
Other versions
DE69820674T2 (de
Inventor
Christer Karlsson
Johan Lundberg
Adam Rosinski
Malin Soederbom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69820674D1 publication Critical patent/DE69820674D1/de
Publication of DE69820674T2 publication Critical patent/DE69820674T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69820674T 1997-11-28 1998-11-19 Poröse hydroxyapatit-partikel als träger für medikamente Expired - Lifetime DE69820674T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9704400A SE9704400D0 (sv) 1997-11-28 1997-11-28 Porous inorganic particles as carriers for drug substances
SE9704400 1997-11-28
PCT/SE1998/002089 WO1999027912A1 (en) 1997-11-28 1998-11-19 Porous hydroxyapatite particles as carriers for drug substances

Publications (2)

Publication Number Publication Date
DE69820674D1 true DE69820674D1 (de) 2004-01-29
DE69820674T2 DE69820674T2 (de) 2004-09-30

Family

ID=20409177

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820674T Expired - Lifetime DE69820674T2 (de) 1997-11-28 1998-11-19 Poröse hydroxyapatit-partikel als träger für medikamente

Country Status (26)

Country Link
US (1) US6558703B1 (de)
EP (1) EP1032370B1 (de)
JP (1) JP2001524513A (de)
KR (1) KR20010032557A (de)
CN (1) CN1280492A (de)
AR (1) AR016683A1 (de)
AT (1) ATE256453T1 (de)
AU (1) AU752044B2 (de)
BR (1) BR9814751A (de)
CA (1) CA2311780A1 (de)
DE (1) DE69820674T2 (de)
DK (1) DK1032370T3 (de)
ES (1) ES2210840T3 (de)
HU (1) HUP0100303A3 (de)
ID (1) ID24700A (de)
IL (1) IL136146A0 (de)
NO (1) NO20002719L (de)
NZ (1) NZ504353A (de)
PL (1) PL340927A1 (de)
PT (1) PT1032370E (de)
RU (1) RU2219907C2 (de)
SE (1) SE9704400D0 (de)
SK (1) SK6602000A3 (de)
TW (1) TW524694B (de)
WO (1) WO1999027912A1 (de)
ZA (1) ZA9810463B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924334D0 (en) * 1999-10-15 1999-12-15 Secr Defence Pharmaceutical products and methods of fabrication therefor
CN100450483C (zh) * 2000-04-11 2009-01-14 三共株式会社 含有钙阻滞剂的稳定药物组合物
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
KR101207553B1 (ko) 2005-06-02 2012-12-03 (주)씨앤팜 금속 이중층 수산화물을 포함하는 생체 주사제용 약물 담체
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
JP5027410B2 (ja) * 2005-12-13 2012-09-19 株式会社サンギ ユビキノン含有組成物
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
GB0909460D0 (en) 2009-06-02 2009-07-15 Intrinsiq Materials Global Ltd Mesoporus material
ES2908958T3 (es) 2013-02-01 2022-05-04 Grace W R & Co Gel de sílice porosa como portador para tecnologías líquidas
AU2014322985B2 (en) * 2013-09-20 2019-05-16 Tillotts Pharma Ag Delayed release pharmaceutical formulation
CN104133014B (zh) * 2014-07-16 2015-09-16 广州法尔麦兰药物技术有限公司 一种考察布洛伪麻缓释制剂释放度的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413191D0 (en) 1984-05-23 1984-06-27 Beecham Group Plc Pharmaceutical composition
GB8713263D0 (en) 1987-06-05 1987-07-08 Unilever Plc Spheroidal silica
EP0376331A3 (de) 1988-12-29 1991-03-13 Asahi Kogaku Kogyo Kabushiki Kaisha Granula zur langsamen Wirkstoffabgabe sowie Verfahren zu deren Herstellung
US5149523A (en) * 1989-06-20 1992-09-22 Aktiebolaget Hassle Polystyrenesulfonate-drug complex and solid dosage forms thereof
NL9100105A (nl) * 1991-01-23 1992-08-17 Kuil R A Holding Voedingssupplement.
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US6096324A (en) * 1995-06-13 2000-08-01 Laboratory Skin Care Methods of delivering materials into the skin, and compositions used therein

Also Published As

Publication number Publication date
ID24700A (id) 2000-08-03
AU752044B2 (en) 2002-09-05
EP1032370B1 (de) 2003-12-17
WO1999027912A1 (en) 1999-06-10
ES2210840T3 (es) 2004-07-01
US6558703B1 (en) 2003-05-06
AU1356399A (en) 1999-06-16
IL136146A0 (en) 2001-05-20
CN1280492A (zh) 2001-01-17
NZ504353A (en) 2001-10-26
SK6602000A3 (en) 2001-01-18
DK1032370T3 (da) 2004-03-15
DE69820674T2 (de) 2004-09-30
JP2001524513A (ja) 2001-12-04
EP1032370A1 (de) 2000-09-06
BR9814751A (pt) 2000-10-03
HUP0100303A2 (hu) 2001-08-28
SE9704400D0 (sv) 1997-11-28
PT1032370E (pt) 2004-05-31
NO20002719L (no) 2000-07-28
TW524694B (en) 2003-03-21
NO20002719D0 (no) 2000-05-26
RU2219907C2 (ru) 2003-12-27
KR20010032557A (ko) 2001-04-25
HUP0100303A3 (en) 2004-03-29
CA2311780A1 (en) 1999-06-10
PL340927A1 (en) 2001-03-12
AR016683A1 (es) 2001-07-25
ZA9810463B (en) 1999-05-21
ATE256453T1 (de) 2004-01-15

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