CN1266059A - 通过在聚合树脂柱上的工业制备低压色谱分离和纯化紫杉醇和其它相关的紫杉烷类化合物 - Google Patents

通过在聚合树脂柱上的工业制备低压色谱分离和纯化紫杉醇和其它相关的紫杉烷类化合物 Download PDF

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Publication number
CN1266059A
CN1266059A CN00102118A CN00102118A CN1266059A CN 1266059 A CN1266059 A CN 1266059A CN 00102118 A CN00102118 A CN 00102118A CN 00102118 A CN00102118 A CN 00102118A CN 1266059 A CN1266059 A CN 1266059A
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Prior art keywords
deacetyltaxol
bearing taxanes
wash
raw material
purifying
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CN00102118A
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Chinese (zh)
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刘健
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    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B7/00—Special arrangements or measures in connection with doors or windows
    • E06B7/16—Sealing arrangements on wings or parts co-operating with the wings
    • E06B7/22—Sealing arrangements on wings or parts co-operating with the wings by means of elastic edgings, e.g. elastic rubber tubes; by means of resilient edgings, e.g. felt or plush strips, resilient metal strips
    • E06B7/23—Plastic, sponge rubber, or like strips or tubes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B3/00—Window sashes, door leaves, or like elements for closing wall or like openings; Layout of fixed or moving closures, e.g. windows in wall or like openings; Features of rigidly-mounted outer frames relating to the mounting of wing frames
    • E06B3/66—Units comprising two or more parallel glass or like panes permanently secured together
    • E06B3/67—Units comprising two or more parallel glass or like panes permanently secured together characterised by additional arrangements or devices for heat or sound insulation or for controlled passage of light

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Structural Engineering (AREA)
  • Civil Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN00102118A 1999-01-07 2000-01-07 通过在聚合树脂柱上的工业制备低压色谱分离和纯化紫杉醇和其它相关的紫杉烷类化合物 Pending CN1266059A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/226,192 1999-01-07
US09/226,192 US5969165A (en) 1999-01-07 1999-01-07 Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column

Publications (1)

Publication Number Publication Date
CN1266059A true CN1266059A (zh) 2000-09-13

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Family Applications (1)

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CN00102118A Pending CN1266059A (zh) 1999-01-07 2000-01-07 通过在聚合树脂柱上的工业制备低压色谱分离和纯化紫杉醇和其它相关的紫杉烷类化合物

Country Status (22)

Country Link
US (1) US5969165A (enExample)
EP (1) EP1018510B1 (enExample)
JP (1) JP2000204090A (enExample)
KR (1) KR20000062437A (enExample)
CN (1) CN1266059A (enExample)
AR (1) AR022218A1 (enExample)
AT (1) ATE260908T1 (enExample)
AU (1) AU768026B2 (enExample)
BR (1) BR0000884A (enExample)
DE (1) DE69915241T2 (enExample)
DK (1) DK1018510T3 (enExample)
ES (1) ES2216431T3 (enExample)
IL (1) IL133956A (enExample)
IN (1) IN186600B (enExample)
NO (1) NO321779B1 (enExample)
NZ (1) NZ502204A (enExample)
PL (1) PL337764A1 (enExample)
PT (1) PT1018510E (enExample)
RU (1) RU2201788C2 (enExample)
SG (1) SG87072A1 (enExample)
SK (1) SK292000A3 (enExample)
ZA (1) ZA200000036B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1331859C (zh) * 2005-01-04 2007-08-15 四川华申科技开发有限公司 分离紫杉醇和三尖杉磷碱的方法
CN100448859C (zh) * 2003-03-17 2009-01-07 天然医药品公司 使用键合有聚乙烯亚胺的树脂提纯紫杉醇和紫杉醇混合物的方法
CN103588736A (zh) * 2013-12-03 2014-02-19 云南汉德生物技术有限公司 13-乙酰基-9-羟基巴卡亭iii的提取分离方法

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AU784323B2 (en) * 2000-01-13 2006-03-09 Purdue Research Foundation Production of taxol and taxanes
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US6229027B1 (en) * 2000-03-10 2001-05-08 Jian Liu Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin IV
AU2006201733B2 (en) * 2000-03-10 2007-05-24 Ivax Research, Inc. Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin III
AU2002223319A1 (en) * 2000-11-08 2002-05-21 Actipharm Inc. Process for mass production of gmp paclitaxel and related taxanes
CN1247558C (zh) * 2000-11-13 2006-03-29 拉胡·塞吉 紫杉烷类化合物的分离
US6333419B1 (en) * 2000-11-28 2001-12-25 Indena Spa Chromatographic separation method of paclitaxel and cephalomannin
JP2006503102A (ja) * 2002-10-17 2006-01-26 ジンギュ リァン 糖尿病の予防および治療のための天然化合物、その調製方法、およびその薬物的使用。
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US6956123B2 (en) 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
EP1550659B1 (en) * 2003-12-31 2008-08-13 Samyang Genex Corporation Method for purification of paclitaxel from paclitaxel-containing materials
ES2293129T3 (es) * 2004-07-13 2008-03-16 Indena Spa Procedimiento para obtener paclitaxel de plantas de taxus.
US7169307B2 (en) * 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
US20060074254A1 (en) * 2004-09-30 2006-04-06 Zisheng Zhang Process for extracting taxanes
EP1818328A1 (en) * 2006-02-10 2007-08-15 6570763 Canada Inc. Chromatographic method for the isolation and purification of taxane derivatives
DE602006018532D1 (de) * 2006-03-24 2011-01-05 Postech Acad Ind Found Stationäre phase und säule unter verwendung von cucurbiturilgebundenem kieselgel, und verfahren zur abtrennung von taxol unter verwendung der säule
EP2007744B1 (en) * 2006-04-03 2017-05-17 Pharmatherm Chemicals Inc. Thermal extraction method for producing a taxane extract
US7905990B2 (en) 2007-11-20 2011-03-15 Ensyn Renewables, Inc. Rapid thermal conversion of biomass
KR101149600B1 (ko) * 2009-12-31 2012-05-29 주식회사 삼양제넥스바이오 고순도 무수결정형 도세탁셀 제조방법
US20110284359A1 (en) 2010-05-20 2011-11-24 Uop Llc Processes for controlling afterburn in a reheater and for controlling loss of entrained solid particles in combustion product flue gas
US8499702B2 (en) 2010-07-15 2013-08-06 Ensyn Renewables, Inc. Char-handling processes in a pyrolysis system
US9441887B2 (en) 2011-02-22 2016-09-13 Ensyn Renewables, Inc. Heat removal and recovery in biomass pyrolysis
US9347005B2 (en) 2011-09-13 2016-05-24 Ensyn Renewables, Inc. Methods and apparatuses for rapid thermal processing of carbonaceous material
US10400175B2 (en) 2011-09-22 2019-09-03 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US10041667B2 (en) 2011-09-22 2018-08-07 Ensyn Renewables, Inc. Apparatuses for controlling heat for rapid thermal processing of carbonaceous material and methods for the same
US9044727B2 (en) 2011-09-22 2015-06-02 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US9109177B2 (en) 2011-12-12 2015-08-18 Ensyn Renewables, Inc. Systems and methods for renewable fuel
US9670413B2 (en) 2012-06-28 2017-06-06 Ensyn Renewables, Inc. Methods and apparatuses for thermally converting biomass
EP3013922A4 (en) 2013-06-26 2017-02-08 Ensyn Renewables, Inc. Systems and methods for renewable fuel
CN104422749A (zh) * 2013-09-04 2015-03-18 南京工业大学 一种分离、纯化紫杉醇与三尖杉宁碱的制备方法
US10337726B2 (en) 2015-08-21 2019-07-02 Ensyn Renewables, Inc. Liquid biomass heating system
HUP1500603A2 (en) 2015-12-11 2017-06-28 Rotachrom Tech Kft Process for the separation of 10-deacetyl baccatin iii
CA3048681A1 (en) 2016-12-29 2018-07-05 Ensyn Renewables, Inc. Demetallization of liquid biomass

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
AU1888792A (en) * 1991-04-19 1992-11-17 University Of Mississippi, The Methods and compositions for isolating taxanes
FR2696462B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
US5281727A (en) * 1992-11-27 1994-01-25 Napro Biotherapeutics, Inc. Method of using ion exchange media to increase taxane yields
DE69333905T2 (de) * 1992-12-23 2006-08-03 Bristol-Myers Squibb Co. Seitenkette tragende Taxane und deren Zwischenprodukte
US5620875A (en) * 1995-02-17 1997-04-15 University Of Portland Transfer of taxol from yew tree cuttings into a culture medium over time
JPH08277280A (ja) * 1995-04-06 1996-10-22 Nippon Steel Corp イチイ細胞からのタキサン化合物の抽出方法
EP0774010B1 (en) * 1995-04-29 2001-09-26 Samyang Genex Co., Ltd. A method for mass production of taxol from taxus genus plant
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
JPH1052296A (ja) * 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉｉ）

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100448859C (zh) * 2003-03-17 2009-01-07 天然医药品公司 使用键合有聚乙烯亚胺的树脂提纯紫杉醇和紫杉醇混合物的方法
CN1331859C (zh) * 2005-01-04 2007-08-15 四川华申科技开发有限公司 分离紫杉醇和三尖杉磷碱的方法
CN103588736A (zh) * 2013-12-03 2014-02-19 云南汉德生物技术有限公司 13-乙酰基-9-羟基巴卡亭iii的提取分离方法
CN103588736B (zh) * 2013-12-03 2015-06-03 云南汉德生物技术有限公司 13-乙酰基-9-羟基巴卡亭iii的提取分离方法

Also Published As

Publication number Publication date
DE69915241D1 (de) 2004-04-08
IL133956A (en) 2003-10-31
NO20000070D0 (no) 2000-01-06
IL133956A0 (en) 2001-04-30
ZA200000036B (en) 2000-07-12
KR20000062437A (ko) 2000-10-25
DK1018510T3 (da) 2004-07-05
EP1018510B1 (en) 2004-03-03
ES2216431T3 (es) 2004-10-16
AR022218A1 (es) 2002-09-04
DE69915241T2 (de) 2004-12-30
NO20000070L (no) 2000-07-10
SK292000A3 (en) 2000-10-09
AU768026B2 (en) 2003-11-27
AU1014500A (en) 2000-07-13
IN186600B (enExample) 2001-10-06
NO321779B1 (no) 2006-07-03
US5969165A (en) 1999-10-19
PL337764A1 (en) 2000-07-17
EP1018510A1 (en) 2000-07-12
NZ502204A (en) 2001-06-29
RU2201788C2 (ru) 2003-04-10
ATE260908T1 (de) 2004-03-15
PT1018510E (pt) 2004-06-30
BR0000884A (pt) 2001-08-21
SG87072A1 (en) 2002-03-19
JP2000204090A (ja) 2000-07-25

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