DE69915241D1 - Isolierung und Reinigung von Paclitaxel und anderen verwandten Taxanen durch gewerbliche preparative Tiefdruckchromatographie auf einer polymerischen resinhaltigen Säule - Google Patents

Isolierung und Reinigung von Paclitaxel und anderen verwandten Taxanen durch gewerbliche preparative Tiefdruckchromatographie auf einer polymerischen resinhaltigen Säule

Info

Publication number
DE69915241D1
DE69915241D1 DE69915241T DE69915241T DE69915241D1 DE 69915241 D1 DE69915241 D1 DE 69915241D1 DE 69915241 T DE69915241 T DE 69915241T DE 69915241 T DE69915241 T DE 69915241T DE 69915241 D1 DE69915241 D1 DE 69915241D1
Authority
DE
Germany
Prior art keywords
paclitaxel
isolation
purification
low pressure
pressure chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69915241T
Other languages
English (en)
Other versions
DE69915241T2 (de
Inventor
Research Inc Ivax
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax Research Holdings Inc
Original Assignee
Ivax Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Research Inc filed Critical Ivax Research Inc
Application granted granted Critical
Publication of DE69915241D1 publication Critical patent/DE69915241D1/de
Publication of DE69915241T2 publication Critical patent/DE69915241T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B7/00—Special arrangements or measures in connection with doors or windows
    • E06B7/16—Sealing arrangements on wings or parts co-operating with the wings
    • E06B7/22—Sealing arrangements on wings or parts co-operating with the wings by means of elastic edgings, e.g. elastic rubber tubes; by means of resilient edgings, e.g. felt or plush strips, resilient metal strips
    • E06B7/23—Plastic, sponge rubber, or like strips or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • E—FIXED CONSTRUCTIONS
    • E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
    • E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
    • E06B3/00—Window sashes, door leaves, or like elements for closing wall or like openings; Layout of fixed or moving closures, e.g. windows in wall or like openings; Features of rigidly-mounted outer frames relating to the mounting of wing frames
    • E06B3/66—Units comprising two or more parallel glass or like panes permanently secured together
    • E06B3/67—Units comprising two or more parallel glass or like panes permanently secured together characterised by additional arrangements or devices for heat or sound insulation or for controlled passage of light

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Civil Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Structural Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69915241T 1999-01-07 1999-12-27 Isolierung und Reinigung von Paclitaxel und anderen verwandten Taxanen durch gewerbliche preparative Tiefdruckchromatographie auf einer polymerischen resinhaltigen Säule Expired - Fee Related DE69915241T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/226,192 US5969165A (en) 1999-01-07 1999-01-07 Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
US226192 1999-01-07

Publications (2)

Publication Number Publication Date
DE69915241D1 true DE69915241D1 (de) 2004-04-08
DE69915241T2 DE69915241T2 (de) 2004-12-30

Family

ID=22847945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69915241T Expired - Fee Related DE69915241T2 (de) 1999-01-07 1999-12-27 Isolierung und Reinigung von Paclitaxel und anderen verwandten Taxanen durch gewerbliche preparative Tiefdruckchromatographie auf einer polymerischen resinhaltigen Säule

Country Status (22)

Country Link
US (1) US5969165A (de)
EP (1) EP1018510B1 (de)
JP (1) JP2000204090A (de)
KR (1) KR20000062437A (de)
CN (1) CN1266059A (de)
AR (1) AR022218A1 (de)
AT (1) ATE260908T1 (de)
AU (1) AU768026B2 (de)
BR (1) BR0000884A (de)
DE (1) DE69915241T2 (de)
DK (1) DK1018510T3 (de)
ES (1) ES2216431T3 (de)
IL (1) IL133956A (de)
IN (1) IN186600B (de)
NO (1) NO321779B1 (de)
NZ (1) NZ502204A (de)
PL (1) PL337764A1 (de)
PT (1) PT1018510E (de)
RU (1) RU2201788C2 (de)
SG (1) SG87072A1 (de)
SK (1) SK292000A3 (de)
ZA (1) ZA200000036B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001051476A2 (en) * 2000-01-13 2001-07-19 Purdue Research Foundation Production of taxol and taxanes
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
AU2006201733B2 (en) * 2000-03-10 2007-05-24 Ivax Research, Inc. Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin III
US6229027B1 (en) * 2000-03-10 2001-05-08 Jian Liu Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin IV
US6469186B1 (en) 2000-11-08 2002-10-22 Actipharm, Inc. Process for mass production of GMP paclitaxel and related taxanes
AU2002214883A1 (en) * 2000-11-13 2002-05-21 Lahu Saiji Isolation of taxanes
US6333419B1 (en) * 2000-11-28 2001-12-25 Indena Spa Chromatographic separation method of paclitaxel and cephalomannin
AU2002344514A1 (en) * 2002-10-17 2004-05-25 Jingyu Liang A natural compound useful for treating diabetes, its preparation and use
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
CN100448859C (zh) * 2003-03-17 2009-01-07 天然医药品公司 使用键合有聚乙烯亚胺的树脂提纯紫杉醇和紫杉醇混合物的方法
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
US7259268B2 (en) * 2003-12-31 2007-08-21 Samyang Genex Corporation Method for purification of paclitaxel from paclitaxel-containing materials
SI1616868T1 (sl) * 2004-07-13 2008-02-29 Indena Spa Postopki pridobivanja paklitaksela iz rastlin tise
US7169307B2 (en) * 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
CA2521829A1 (en) * 2004-09-30 2006-03-30 University Of Ottawa Process for extracting taxanes
CN1331859C (zh) * 2005-01-04 2007-08-15 四川华申科技开发有限公司 分离紫杉醇和三尖杉磷碱的方法
EP1818328A1 (de) * 2006-02-10 2007-08-15 6570763 Canada Inc. Chromatographisches Verfahren zur Isolierung und Reinigung von Taxanderivaten
ATE489375T1 (de) * 2006-03-24 2010-12-15 Postech Foundation Stationäre phase und säule unter verwendung von cucurbiturilgebundenem kieselgel, und verfahren zur abtrennung von taxol unter verwendung der säule
CN101460473A (zh) 2006-04-03 2009-06-17 药物热化学品公司 热提取方法和产物
US7905990B2 (en) 2007-11-20 2011-03-15 Ensyn Renewables, Inc. Rapid thermal conversion of biomass
KR101149600B1 (ko) * 2009-12-31 2012-05-29 주식회사 삼양제넥스바이오 고순도 무수결정형 도세탁셀 제조방법
US20110284359A1 (en) 2010-05-20 2011-11-24 Uop Llc Processes for controlling afterburn in a reheater and for controlling loss of entrained solid particles in combustion product flue gas
US8499702B2 (en) 2010-07-15 2013-08-06 Ensyn Renewables, Inc. Char-handling processes in a pyrolysis system
US9441887B2 (en) 2011-02-22 2016-09-13 Ensyn Renewables, Inc. Heat removal and recovery in biomass pyrolysis
US9347005B2 (en) 2011-09-13 2016-05-24 Ensyn Renewables, Inc. Methods and apparatuses for rapid thermal processing of carbonaceous material
US9044727B2 (en) 2011-09-22 2015-06-02 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US10400175B2 (en) 2011-09-22 2019-09-03 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US10041667B2 (en) 2011-09-22 2018-08-07 Ensyn Renewables, Inc. Apparatuses for controlling heat for rapid thermal processing of carbonaceous material and methods for the same
US9109177B2 (en) 2011-12-12 2015-08-18 Ensyn Renewables, Inc. Systems and methods for renewable fuel
US9670413B2 (en) 2012-06-28 2017-06-06 Ensyn Renewables, Inc. Methods and apparatuses for thermally converting biomass
EP3013922A4 (de) 2013-06-26 2017-02-08 Ensyn Renewables, Inc. Systeme und verfahren für erneuerbaren kraftstoff
CN104422749A (zh) * 2013-09-04 2015-03-18 南京工业大学 一种分离、纯化紫杉醇与三尖杉宁碱的制备方法
CN103588736B (zh) * 2013-12-03 2015-06-03 云南汉德生物技术有限公司 13-乙酰基-9-羟基巴卡亭iii的提取分离方法
DK3337966T3 (da) 2015-08-21 2022-02-28 Ensyn Renewables Inc Opvarmningssystem med flydende biomasse
HUP1500603A2 (en) 2015-12-11 2017-06-28 Rotachrom Tech Kft Process for the separation of 10-deacetyl baccatin iii
EP3565664A4 (de) 2016-12-29 2020-08-05 Ensyn Renewables, Inc. Entmetallisierung von flüssiger biomasse

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
ATE180477T1 (de) * 1991-04-19 1999-06-15 Univ Mississippi Verfahren und zubereitungen zur isolierung von taxanen
FR2696462B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
US5281727A (en) * 1992-11-27 1994-01-25 Napro Biotherapeutics, Inc. Method of using ion exchange media to increase taxane yields
US5620875A (en) * 1995-02-17 1997-04-15 University Of Portland Transfer of taxol from yew tree cuttings into a culture medium over time
JPH08277280A (ja) * 1995-04-06 1996-10-22 Nippon Steel Corp イチイ細胞からのタキサン化合物の抽出方法
DE69615499T2 (de) * 1995-04-29 2002-06-06 Samyang Genex Co Massenherstellungsverfahren von taxol aus pflanzen der gattung taxus
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
JPH1052296A (ja) * 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉｉ）

Also Published As

Publication number Publication date
KR20000062437A (ko) 2000-10-25
BR0000884A (pt) 2001-08-21
IL133956A0 (en) 2001-04-30
AU768026B2 (en) 2003-11-27
RU2201788C2 (ru) 2003-04-10
NZ502204A (en) 2001-06-29
PT1018510E (pt) 2004-06-30
JP2000204090A (ja) 2000-07-25
EP1018510B1 (de) 2004-03-03
PL337764A1 (en) 2000-07-17
DE69915241T2 (de) 2004-12-30
ATE260908T1 (de) 2004-03-15
CN1266059A (zh) 2000-09-13
NO20000070D0 (no) 2000-01-06
IL133956A (en) 2003-10-31
DK1018510T3 (da) 2004-07-05
US5969165A (en) 1999-10-19
SG87072A1 (en) 2002-03-19
EP1018510A1 (de) 2000-07-12
NO20000070L (no) 2000-07-10
ES2216431T3 (es) 2004-10-16
SK292000A3 (en) 2000-10-09
NO321779B1 (no) 2006-07-03
IN186600B (de) 2001-10-06
AU1014500A (en) 2000-07-13
AR022218A1 (es) 2002-09-04
ZA200000036B (en) 2000-07-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee