CN1247574C - 异吲哚啉－1－酮葡糖激酶激活剂 - Google Patents

异吲哚啉－1－酮葡糖激酶激活剂 Download PDF

Info

Publication number
CN1247574C
CN1247574C CNB018206107A CN01820610A CN1247574C CN 1247574 C CN1247574 C CN 1247574C CN B018206107 A CNB018206107 A CN B018206107A CN 01820610 A CN01820610 A CN 01820610A CN 1247574 C CN1247574 C CN 1247574C
Authority
CN
China
Prior art keywords
oxo
dihydro
cyclohexyl
isozainden
propionamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018206107A
Other languages
English (en)
Chinese (zh)
Other versions
CN1481382A (zh
Inventor
凯文·理查德·格廷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1481382A publication Critical patent/CN1481382A/zh
Application granted granted Critical
Publication of CN1247574C publication Critical patent/CN1247574C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
CNB018206107A 2000-12-13 2001-12-07 异吲哚啉－1－酮葡糖激酶激活剂 Expired - Fee Related CN1247574C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25527300P 2000-12-13 2000-12-13
US60/255,273 2000-12-13
US31871501P 2001-09-13 2001-09-13
US60/318,715 2001-09-13

Publications (2)

Publication Number Publication Date
CN1481382A CN1481382A (zh) 2004-03-10
CN1247574C true CN1247574C (zh) 2006-03-29

Family

ID=26944583

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018206107A Expired - Fee Related CN1247574C (zh) 2000-12-13 2001-12-07 异吲哚啉－1－酮葡糖激酶激活剂

Country Status (35)

Country Link
US (1) US6482951B2 (https=)
EP (1) EP1349856B1 (https=)
JP (1) JP4021766B2 (https=)
KR (1) KR100520651B1 (https=)
CN (1) CN1247574C (https=)
AT (1) ATE297922T1 (https=)
AU (2) AU2002238415B2 (https=)
BG (1) BG107903A (https=)
BR (1) BR0116169A (https=)
CA (1) CA2430579C (https=)
CY (1) CY1105587T1 (https=)
CZ (1) CZ20031882A3 (https=)
DE (1) DE60111570T2 (https=)
DK (1) DK1349856T3 (https=)
EG (1) EG24358A (https=)
ES (1) ES2243578T3 (https=)
HR (1) HRP20030450B1 (https=)
HU (1) HUP0400587A3 (https=)
IL (2) IL156264A0 (https=)
MA (1) MA26973A1 (https=)
MX (1) MXPA03005170A (https=)
MY (1) MY136741A (https=)
NO (1) NO325810B1 (https=)
NZ (1) NZ526236A (https=)
PA (1) PA8534601A1 (https=)
PE (1) PE20020593A1 (https=)
PL (1) PL366006A1 (https=)
PT (1) PT1349856E (https=)
RS (1) RS50933B (https=)
RU (1) RU2249590C2 (https=)
SI (1) SI1349856T1 (https=)
SK (1) SK8732003A3 (https=)
TW (1) TWI294876B (https=)
UY (1) UY27069A1 (https=)
WO (1) WO2002048106A2 (https=)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
BR0314864A (pt) 2002-10-03 2005-08-02 Novartis Ag Compostos orgânicos
PL375149A1 (en) 2002-10-03 2005-11-28 F.Hoffmann-La Roche Ag Indole-3-carboxamides as glucokinase (gk) activators
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
AU2003294376A1 (en) * 2003-01-06 2004-08-10 Eli Lilly And Company Heteroaryl compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
US7262196B2 (en) * 2003-02-11 2007-08-28 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US7781451B2 (en) * 2004-04-02 2010-08-24 Novartis Ag Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
BRPI0509573A (pt) 2004-04-02 2007-09-25 Novartis Ag derivados de sulfonamida-tiazolpiridina como ativadores de glicocinase úteis para o tratamento de diabetes do tipo 2
KR101346902B1 (ko) 2005-07-09 2014-01-02 아스트라제네카 아베 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
WO2007026761A1 (ja) * 2005-08-31 2007-03-08 Astellas Pharma Inc. チアゾール誘導体
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CA2624102A1 (en) 2005-09-29 2007-04-12 Sanofi-Aventis Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
CN101316836A (zh) 2005-11-01 2008-12-03 詹森药业有限公司 作为葡萄糖激酶变构调节剂的取代的二氢异吲哚酮类
EP1951706A1 (en) 2005-11-01 2008-08-06 Janssen Pharmaceutica N.V. Dihydroisoindolones as allosteric modulators of glucokinase
EP1960386A2 (en) * 2005-11-01 2008-08-27 Janssen Pharmaceutica N.V. Substituted cycloalkylpyrrolones as allosteric modulators of glucokinase
CA2627813A1 (en) * 2005-11-01 2007-05-10 Janssen Pharmaceutica N.V. Substituted pyrrolones as allosteric modulators of glucokinase
WO2007051845A1 (en) * 2005-11-03 2007-05-10 Prosidion Ltd Tricyclo substituted amides
EP1948614A2 (en) * 2005-11-18 2008-07-30 Takeda San Diego, Inc. Glucokinase activators
EP2001875A2 (en) * 2006-03-08 2008-12-17 Takeda San Diego, Inc. Glucokinase activators
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2049518B1 (en) * 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
WO2008074694A1 (en) * 2006-12-20 2008-06-26 F. Hoffmann-La Roche Ag Crystallization of glucokinase activators
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) * 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
JP5248477B2 (ja) * 2007-03-07 2013-07-31 杏林製薬株式会社 グルコキナーゼ活性化物質
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
TW200934772A (en) * 2008-01-15 2009-08-16 Lilly Co Eli Crystalline(R)-2-(4-cyclopropanesulphonyl-phenyl)-N-pyrazin-2-yl-3-(tetrahydropyran-4-yl)-propionamide
WO2009092432A1 (en) * 2008-01-24 2009-07-30 Merck Patent Gmbh Beta-amino acid derivatives for treatment of diabetes
KR101608259B1 (ko) * 2008-04-28 2016-04-01 교린 세이야꾸 가부시키 가이샤 시클로펜틸아크릴산아미드 유도체
KR20110018366A (ko) * 2008-05-16 2011-02-23 다케다 샌디에고, 인코포레이티드 글루코키나아제 활성제
AU2009290474A1 (en) * 2008-09-11 2010-03-18 Pfizer Inc. Heteroaryls amide derivatives and their use as glucokinase activators
CN102959076B (zh) 2010-03-31 2015-09-16 斯克里普斯研究所 重编程细胞
US8178689B2 (en) * 2010-06-17 2012-05-15 Hoffman-La Roche Inc. Tricyclic compounds
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en) 2011-03-01 2018-04-16 Synergy Pharmaceuticals Inc PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
US8470866B2 (en) * 2011-05-03 2013-06-25 Hoffmann-La Roche Inc. Isoindolinone derivatives
SI3004076T1 (sl) * 2013-05-27 2020-02-28 F. Hoffmann-La Roche Ag Novi spojini 3,4-dihidro-2H-izokinolin-1-on in 2,3-dihidro-izoindol-1-on
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
WO2018069532A1 (en) 2016-10-14 2018-04-19 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
CN116283717B (zh) * 2023-01-06 2025-04-08 暨南大学 一种藁本内酯衍生物及其制备方法和应用
WO2024229228A2 (en) * 2023-05-02 2024-11-07 The Rockefeller University 1-oxoisoindolin-2-yl amide activators of vcp and derivatives thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687147A1 (fr) * 1992-02-11 1993-08-13 Union Pharma Scient Appl Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE69523182T2 (de) * 1995-06-06 2002-02-07 Pfizer Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren
PL350669A1 (en) 1999-03-29 2003-01-27 Hoffmann La Roche Glucokinase activators
AU5227001A (en) 2000-05-03 2001-11-12 Hoffmann La Roche Hydantoin-containing glucokinase activators
DK1282611T3 (da) 2000-05-08 2005-02-14 Hoffmann La Roche Substituerede phenylacetatamider og anvendelse deraf som glucokinaseaktivatorer

Also Published As

Publication number Publication date
KR20030064817A (ko) 2003-08-02
EG24358A (en) 2009-03-04
CA2430579C (en) 2010-01-26
IL156264A (en) 2010-11-30
US20020082260A1 (en) 2002-06-27
UY27069A1 (es) 2002-07-31
EP1349856B1 (en) 2005-06-15
CA2430579A1 (en) 2002-06-20
NZ526236A (en) 2004-12-24
MXPA03005170A (es) 2003-09-22
NO20032674D0 (no) 2003-06-12
PE20020593A1 (es) 2002-07-06
HUP0400587A3 (en) 2011-03-28
DE60111570T2 (de) 2006-05-11
PT1349856E (pt) 2005-09-30
HUP0400587A2 (hu) 2004-06-28
PA8534601A1 (es) 2002-08-26
KR100520651B1 (ko) 2005-10-11
WO2002048106A2 (en) 2002-06-20
BG107903A (bg) 2004-02-27
CN1481382A (zh) 2004-03-10
BR0116169A (pt) 2003-12-23
CY1105587T1 (el) 2010-07-28
WO2002048106A3 (en) 2002-11-28
HK1063314A1 (en) 2004-12-24
NO20032674L (no) 2003-06-12
RS50933B (sr) 2010-08-31
IL156264A0 (en) 2004-01-04
SI1349856T1 (en) 2005-10-31
MA26973A1 (fr) 2004-12-20
MY136741A (en) 2008-11-28
US6482951B2 (en) 2002-11-19
ATE297922T1 (de) 2005-07-15
NO325810B1 (no) 2008-07-21
AU2002238415B2 (en) 2007-01-04
DK1349856T3 (da) 2005-10-17
JP4021766B2 (ja) 2007-12-12
CZ20031882A3 (cs) 2003-12-17
PL366006A1 (en) 2005-01-24
RU2249590C2 (ru) 2005-04-10
JP2004521095A (ja) 2004-07-15
HRP20030450A2 (en) 2005-04-30
ES2243578T3 (es) 2005-12-01
YU47703A (sh) 2006-05-25
SK8732003A3 (en) 2004-04-06
HRP20030450B1 (en) 2006-02-28
DE60111570D1 (de) 2005-07-21
AU3841502A (en) 2002-06-24
TWI294876B (en) 2008-03-21
EP1349856A2 (en) 2003-10-08

Similar Documents

Publication Publication Date Title
CN1247574C (zh) 异吲哚啉－1－酮葡糖激酶激活剂
CN1209362C (zh) 四唑基－苯基乙酰胺的葡糖激酶激活剂
CN1226294C (zh) 稠合的杂芳族葡萄糖激酶活化剂
CN1245394C (zh) 作为葡糖激酶激活剂的取代的苯乙酰胺及其用途
CN1688574A (zh) 作为葡糖激酶(gk)激活剂的吲哚－3－甲酰胺
CN1184214C (zh) α－酰基和α－杂原子取代的苯乙酰胺葡糖激酶活化剂
CN1185219C (zh) 反式烯属葡糖激酶活化剂
CN1185220C (zh) 对－胺基取代的苯基酰胺葡糖激酶激活剂
CN1209361C (zh) 含乙内酰脲的葡糖激酶激活剂
CN1176915C (zh) 炔基苯基芳香杂环的菊糖激酶激活剂
AU2002238415A1 (en) Isoindolin-1-one glucokinase activators
CN1374082A (zh) 糖原磺酸化酶抑制剂的用途
CN1642938A (zh) 新化合物
CN1845900A (zh) 作为嗜中性白细胞弹性蛋白酶抑制剂的喹啉衍生物及它们的用途
CN101056875A (zh) 被取代的苯基氨基噻唑类化合物以及其应用
CN1802368A (zh) 作为谷氨酸受体拮抗剂的杂芳基取代的咪唑衍生物
HK1063314B (en) Isoindolin-1-one glucokinase activators
CN1134699A (zh) 琥珀酰胺酸化合物、其制备方法及其用途
CN1993336A (zh) 取代的n－酰基－2－氨基噻唑
HK1074623A (en) Amide derivatives as glycogen synthase kinase 3-beta inhibitors
CN101039901A (zh) 制备苯氧基苯甲酰胺化合物的方法
HK1079427B (en) Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
HK1079427A1 (en) Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1063314

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060329

Termination date: 20111207