CN1178917C - 作为nk1受体拮抗剂前药的4-苯基-吡啶衍生物的n-氧化物 - Google Patents

作为nk1受体拮抗剂前药的4-苯基-吡啶衍生物的n-氧化物 Download PDF

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CN1178917C
CN1178917C CNB018128246A CN01812824A CN1178917C CN 1178917 C CN1178917 C CN 1178917C CN B018128246 A CNB018128246 A CN B018128246A CN 01812824 A CN01812824 A CN 01812824A CN 1178917 C CN1178917 C CN 1178917C
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methyl
tolyl
trifluoromethyl
morpholin
bis
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Expired - Lifetime
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Chinese (zh)
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CN1441782A (zh
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T
T·霍夫曼
S·M·波利
P·施尼德
A·斯莱特
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CNB018128246A 2000-07-14 2001-07-09 作为nk1受体拮抗剂前药的4-苯基-吡啶衍生物的n-氧化物 Expired - Lifetime CN1178917C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00115287.5 2000-07-14
EP00115287 2000-07-14

Publications (2)

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CN1441782A CN1441782A (zh) 2003-09-10
CN1178917C true CN1178917C (zh) 2004-12-08

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US (4) US6593472B2 (https=)
EP (1) EP1303490B1 (https=)
JP (1) JP3950044B2 (https=)
KR (1) KR100501608B1 (https=)
CN (1) CN1178917C (https=)
AR (1) AR029717A1 (https=)
AT (1) ATE400556T1 (https=)
AU (1) AU7061901A (https=)
BR (1) BRPI0112475B8 (https=)
CA (1) CA2415890C (https=)
CY (1) CY1108557T1 (https=)
CZ (1) CZ303639B6 (https=)
DE (1) DE60134749D1 (https=)
DK (1) DK1303490T3 (https=)
EC (1) ECSP034431A (https=)
EG (1) EG24968A (https=)
ES (1) ES2309075T3 (https=)
GT (1) GT200100137A (https=)
HR (1) HRP20030003B1 (https=)
HU (1) HU230316B1 (https=)
IL (2) IL153834A0 (https=)
JO (1) JO2372B1 (https=)
MA (1) MA26929A1 (https=)
ME (1) ME01311B (https=)
MX (1) MXPA03000366A (https=)
MY (1) MY154976A (https=)
NO (1) NO324700B1 (https=)
NZ (1) NZ523273A (https=)
PA (1) PA8522001A1 (https=)
PE (1) PE20020272A1 (https=)
PL (1) PL205207B1 (https=)
PT (1) PT1303490E (https=)
RS (1) RS50932B (https=)
RU (1) RU2266284C2 (https=)
SI (1) SI1303490T1 (https=)
UY (1) UY26839A1 (https=)
WO (1) WO2002006236A1 (https=)
ZA (1) ZA200210207B (https=)

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