CN1177806C - 可延长血液潴留的诊断成像用造影剂 - Google Patents

可延长血液潴留的诊断成像用造影剂 Download PDF

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Publication number
CN1177806C
CN1177806C CNB961917474A CN96191747A CN1177806C CN 1177806 C CN1177806 C CN 1177806C CN B961917474 A CNB961917474 A CN B961917474A CN 96191747 A CN96191747 A CN 96191747A CN 1177806 C CN1177806 C CN 1177806C
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China
Prior art keywords
blood
agents
binding
imaging
bhem
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Expired - Lifetime
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CNB961917474A
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Chinese (zh)
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CN1172436A (zh
Inventor
T��J.����������
T·J.·迈克穆里
H·萨吉金
D·M·思考特
R·B·拉芙尔
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Epix Pharmaceuticals Inc
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Epix Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CNB961917474A 1995-02-01 1996-01-16 可延长血液潴留的诊断成像用造影剂 Expired - Lifetime CN1177806C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38231795A 1995-02-01 1995-02-01
US08/382,317 1995-02-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB200410083591XA Division CN100361711C (zh) 1995-02-01 1996-01-16 可延长血液潴留的诊断成像用造影剂

Publications (2)

Publication Number Publication Date
CN1172436A CN1172436A (zh) 1998-02-04
CN1177806C true CN1177806C (zh) 2004-12-01

Family

ID=23508434

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB200410083591XA Expired - Lifetime CN100361711C (zh) 1995-02-01 1996-01-16 可延长血液潴留的诊断成像用造影剂
CNA2006100957916A Pending CN101011586A (zh) 1995-02-01 1996-01-16 可延长血液潴留的诊断成像用造影剂
CNB961917474A Expired - Lifetime CN1177806C (zh) 1995-02-01 1996-01-16 可延长血液潴留的诊断成像用造影剂

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CNB200410083591XA Expired - Lifetime CN100361711C (zh) 1995-02-01 1996-01-16 可延长血液潴留的诊断成像用造影剂
CNA2006100957916A Pending CN101011586A (zh) 1995-02-01 1996-01-16 可延长血液潴留的诊断成像用造影剂

Country Status (24)

Country Link
US (8) US6676929B2 (OSRAM)
EP (2) EP0806968B1 (OSRAM)
JP (4) JP4064458B2 (OSRAM)
KR (1) KR100403755B1 (OSRAM)
CN (3) CN100361711C (OSRAM)
AR (1) AR006510A1 (OSRAM)
AT (1) ATE342738T1 (OSRAM)
AU (1) AU689700B2 (OSRAM)
BR (1) BR9607136A (OSRAM)
CA (1) CA2211100C (OSRAM)
DE (3) DE122006000061I1 (OSRAM)
DK (1) DK0806968T3 (OSRAM)
ES (1) ES2274523T3 (OSRAM)
FI (1) FI973183A0 (OSRAM)
IL (1) IL116847A (OSRAM)
IS (1) IS2505B (OSRAM)
MY (1) MY128089A (OSRAM)
NL (1) NL300253I2 (OSRAM)
NO (2) NO326114B1 (OSRAM)
NZ (1) NZ301181A (OSRAM)
PT (1) PT806968E (OSRAM)
TW (1) TW319763B (OSRAM)
WO (1) WO1996023526A2 (OSRAM)
ZA (1) ZA96417B (OSRAM)

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