CN1173037C - 单链双功能的糖蛋白激素 - Google Patents

单链双功能的糖蛋白激素 Download PDF

Info

Publication number
CN1173037C
CN1173037C CNB988112353A CN98811235A CN1173037C CN 1173037 C CN1173037 C CN 1173037C CN B988112353 A CNB988112353 A CN B988112353A CN 98811235 A CN98811235 A CN 98811235A CN 1173037 C CN1173037 C CN 1173037C
Authority
CN
China
Prior art keywords
protein
joint
subunit
varient
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988112353A
Other languages
English (en)
Chinese (zh)
Other versions
CN1290301A (zh
Inventor
I
I·布伊米
÷�ɺ�
D·本－梅纳汉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Publication of CN1290301A publication Critical patent/CN1290301A/zh
Application granted granted Critical
Publication of CN1173037C publication Critical patent/CN1173037C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB988112353A 1997-11-17 1998-11-09 单链双功能的糖蛋白激素 Expired - Fee Related CN1173037C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/971,439 1997-11-17
US08/971,439 US6103501A (en) 1997-11-17 1997-11-17 Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof

Publications (2)

Publication Number Publication Date
CN1290301A CN1290301A (zh) 2001-04-04
CN1173037C true CN1173037C (zh) 2004-10-27

Family

ID=25518394

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988112353A Expired - Fee Related CN1173037C (zh) 1997-11-17 1998-11-09 单链双功能的糖蛋白激素

Country Status (16)

Country Link
US (1) US6103501A (enExample)
EP (1) EP1032688B1 (enExample)
JP (1) JP4255618B2 (enExample)
KR (1) KR20010032147A (enExample)
CN (1) CN1173037C (enExample)
AU (1) AU754296B2 (enExample)
BR (1) BR9814880A (enExample)
CA (1) CA2308571C (enExample)
CZ (1) CZ299742B6 (enExample)
DE (1) DE69839779D1 (enExample)
HU (1) HUP0004394A3 (enExample)
IL (2) IL135995A0 (enExample)
NO (1) NO20002527L (enExample)
PL (1) PL342853A1 (enExample)
TR (1) TR200001406T2 (enExample)
WO (1) WO1999025849A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
US6583109B1 (en) 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
US6635256B1 (en) * 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US7994278B1 (en) 1999-08-06 2011-08-09 Nobel Biosciences Llc Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
AU7546600A (en) * 1999-10-08 2001-04-23 Biofocus Discovery Limited Methods and compositions for targeting a cell
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
AU2001255624A1 (en) * 2000-04-25 2001-11-07 Washington University Single-chain fertility hormones with variable lh activity
JP2001333772A (ja) * 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
US6987172B2 (en) * 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
US10105417B2 (en) 2003-03-04 2018-10-23 Aspenbio Pharma, Inc. Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
US20080039372A1 (en) * 2005-07-21 2008-02-14 The Trustees Of Columbia University In The City Of New York Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
ES2534465T3 (es) * 2005-11-15 2015-04-23 Glycofi, Inc. Producción de glucoproteínas con O-glucosilación reducida
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US7553941B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2009143041A1 (en) 2008-05-20 2009-11-26 Merck & Co., Inc. Efficient production of heterologous proteins using mannosyl transferase inhibitors
JP2011530311A (ja) 2008-08-12 2011-12-22 グライコフィ， インコーポレイテッド タンパク質製造のための改良されたベクターおよび酵母株：Ｃａ２＋ＡＴＰアーゼ過剰発現
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
BR112014001274A2 (pt) 2011-07-18 2017-04-18 Arts Biologics As composto de hormônio luteinizante, e, composição farmacêutica
SG11201406671RA (en) 2012-04-19 2014-11-27 Opko Biolog Ltd Long-acting oxyntomodulin variants and methods of producing same
CN112661863A (zh) 2012-11-20 2021-04-16 奥普科生物制品有限公司 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
TWI746427B (zh) 2014-12-10 2021-11-21 以色列商歐科生物製品有限公司 製造長效ｃｔｐ修飾的多肽之方法
EP3310347B1 (en) 2015-06-19 2021-08-04 OPKO Biologics Ltd. Long-acting coagulation factors and methods of producing same
ES2963725T3 (es) 2016-07-11 2024-04-01 Opko Biologics Ltd Factor VII de coagulación de acción prolongada y métodos para producir el mismo
CN106279437B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
US11123438B2 (en) 2016-08-19 2021-09-21 Ampsource Biopharma Shanghai Inc. Linker peptide for constructing fusion protein
CN107759697B (zh) * 2016-08-19 2023-03-24 安源医药科技（上海）有限公司 制备融合蛋白的方法
CN106256835A (zh) * 2016-08-19 2016-12-28 安源医药科技（上海）有限公司 高糖基化人生长激素融合蛋白及其制备方法与用途
CN106279436B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 活化的人凝血因子vii融合蛋白及其制备方法与用途
CN107827987B (zh) * 2017-01-04 2021-04-27 华侨大学 一种促黄体激素类似物及其制备方法
CN113105562B (zh) * 2018-09-26 2023-12-01 安源医药科技（上海）有限公司 突变型单链人凝血因子viii在制备融合蛋白中的应用
BR102019004147A2 (pt) 2019-02-28 2020-10-06 Ouro Fino Saude Animal Participacoes S.A. Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso
EP3969026A1 (en) 2019-05-16 2022-03-23 Ceva Santé Animale Compositions and methods for increasing reproduction performance in non human mammals using recombinant luteinizing hormone
KR20220053003A (ko) * 2019-08-30 2022-04-28 신텍스 에세.아. 재조합 융모막 고나도트로핀, 그의 제조방법, 의약 조성물 및 용도
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3486469T2 (de) * 1983-11-02 1999-04-15 Applied Research Systems Ars Holding N.V., Curacao Herstellung heterodimirer menschlicher Fruchtbarkeitshormone
CA1213537A (en) * 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
DE69029799T2 (de) * 1989-02-21 1997-05-28 Washington University, St. Louis, Mo. Modifizierte formen von fortpflanzungshormonen
CA2082424C (en) * 1990-05-08 2003-09-23 Robert K. Campbell Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity
FI932477L (fi) * 1990-12-13 1993-06-11 Immunex Corp Receptorer foer leukemi-inhiberande faktor
ZA942206B (en) * 1993-04-01 1994-10-31 Amgen Inc Biologically active polypeptide fusion dimers
EP1849802A2 (en) * 1994-02-18 2007-10-31 Laboratoires Serono SA Methods for altering fertility
PT725795E (pt) * 1994-08-12 2004-05-31 Univ Washington Formas de cadeia simples do quarteto de hormonas glicoproteicas

Also Published As

Publication number Publication date
BR9814880A (pt) 2000-10-03
NO20002527D0 (no) 2000-05-16
HUP0004394A3 (en) 2003-04-28
KR20010032147A (ko) 2001-04-16
EP1032688B1 (en) 2008-07-23
JP4255618B2 (ja) 2009-04-15
HUP0004394A2 (hu) 2001-09-28
AU754296B2 (en) 2002-11-14
DE69839779D1 (de) 2008-09-04
CZ20001774A3 (cs) 2000-10-11
CA2308571C (en) 2013-04-23
CZ299742B6 (cs) 2008-11-05
TR200001406T2 (tr) 2000-12-21
US6103501A (en) 2000-08-15
PL342853A1 (en) 2001-07-16
NO20002527L (no) 2000-07-10
AU1313199A (en) 1999-06-07
JP2001523465A (ja) 2001-11-27
CN1290301A (zh) 2001-04-04
EP1032688A1 (en) 2000-09-06
IL135995A0 (en) 2001-05-20
IL135995A (en) 2007-03-08
CA2308571A1 (en) 1999-05-27
WO1999025849A1 (en) 1999-05-27

Similar Documents

Publication Publication Date Title
CN1173037C (zh) 单链双功能的糖蛋白激素
US5705478A (en) Covalently linked β subunits of the glycoprotein hormones as antagonists
JP4156024B2 (ja) 修飾されたタンパク質及びペプチド医薬品
US5958737A (en) Single-chain β subunit dimers of the glycoprotein hormones and recombinant materials related thereto
JPH07508178A (ja) レセプター活性化
FI120150B (fi) Glykoproteiinihormonikvartetin yksiketjumuotoja
CN107074928A (zh) 新型猫促红细胞生成素受体激动剂
CN1330665A (zh) 多结构域糖蛋白激素及其使用方法
US5883073A (en) Single-chain double-alpha peptide
JP2009050278A (ja) 糖タンパク質ホルモンカルテットの一本鎖形態
JP2001333772A (ja) 可変性の活性を有する単鎖稔性ホルモン
MXPA00004761A (en) Single-chain bifunctional glycoprotein hormones
MXPA01003947A (en) Multiple domain glycoprotein hormones and methods of using

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041027

Termination date: 20161109

CF01 Termination of patent right due to non-payment of annual fee