NO20002527L - Enkeltkjede bifunksjonelle glykoproteinhormoner - Google Patents

Enkeltkjede bifunksjonelle glykoproteinhormoner

Info

Publication number
NO20002527L
NO20002527L NO20002527A NO20002527A NO20002527L NO 20002527 L NO20002527 L NO 20002527L NO 20002527 A NO20002527 A NO 20002527A NO 20002527 A NO20002527 A NO 20002527A NO 20002527 L NO20002527 L NO 20002527L
Authority
NO
Norway
Prior art keywords
glycoprotein hormones
chain bifunctional
bifunctional glycoprotein
chain
hormones
Prior art date
Application number
NO20002527A
Other languages
English (en)
Other versions
NO20002527D0 (no
Inventor
Irving Boime
David Ben-Menahem
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of NO20002527D0 publication Critical patent/NO20002527D0/no
Publication of NO20002527L publication Critical patent/NO20002527L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20002527A 1997-11-17 2000-05-16 Enkeltkjede bifunksjonelle glykoproteinhormoner NO20002527L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/971,439 US6103501A (en) 1997-11-17 1997-11-17 Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
PCT/US1998/023744 WO1999025849A1 (en) 1997-11-17 1998-11-09 Single-chain bifunctional glycoprotein hormones

Publications (2)

Publication Number Publication Date
NO20002527D0 NO20002527D0 (no) 2000-05-16
NO20002527L true NO20002527L (no) 2000-07-10

Family

ID=25518394

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002527A NO20002527L (no) 1997-11-17 2000-05-16 Enkeltkjede bifunksjonelle glykoproteinhormoner

Country Status (16)

Country Link
US (1) US6103501A (no)
EP (1) EP1032688B1 (no)
JP (1) JP4255618B2 (no)
KR (1) KR20010032147A (no)
CN (1) CN1173037C (no)
AU (1) AU754296B2 (no)
BR (1) BR9814880A (no)
CA (1) CA2308571C (no)
CZ (1) CZ299742B6 (no)
DE (1) DE69839779D1 (no)
HU (1) HUP0004394A3 (no)
IL (2) IL135995A0 (no)
NO (1) NO20002527L (no)
PL (1) PL342853A1 (no)
TR (1) TR200001406T2 (no)
WO (1) WO1999025849A1 (no)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
US6583109B1 (en) 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
US6635256B1 (en) * 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US7994278B1 (en) 1999-08-06 2011-08-09 Nobel Biosciences Llc Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
AU7546600A (en) * 1999-10-08 2001-04-23 Biofocus Discovery Limited Methods and compositions for targeting a cell
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
JP2001333772A (ja) * 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
AU2001255624A1 (en) * 2000-04-25 2001-11-07 Washington University Single-chain fertility hormones with variable lh activity
US6987172B2 (en) * 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
BRPI0409571B1 (pt) 2003-03-04 2016-05-31 Aspenbio Pharma Inc método para manter uma ou mais gravidezes em um ou mais mamíferos
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
US20080039372A1 (en) * 2005-07-21 2008-02-14 The Trustees Of Columbia University In The City Of New York Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
EP1954815B1 (en) 2005-11-15 2015-02-25 GlycoFi, Inc. Production of glycoproteins with reduced o-glycosylation
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US7553940B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting EPO polypeptides and derivatives thereof and methods thereof
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
CA2721459A1 (en) 2008-05-20 2009-11-26 Merck Sharp & Dohme Corp. Efficient production of heterologous proteins using mannosyl transferase inhibitors
CA2733567A1 (en) 2008-08-12 2010-02-18 Glycofi, Inc. Improved vectors and yeast strains for protein production: ca2+ atpase overexpression
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
RU2014103185A (ru) 2011-07-18 2015-08-27 Артс Байолоджикс А/С Биологически активное соединение на основе лютеинизирующего гормона (lh) с пролонгированным действием
WO2013157002A1 (en) 2012-04-19 2013-10-24 Prolor Biotech Inc. Long-acting oxyntomodulin variants and methods of producing same
EP3848386A1 (en) 2012-11-20 2021-07-14 OPKO Biologics Ltd. Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
US10960058B2 (en) 2015-06-19 2021-03-30 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
HUE064463T2 (hu) 2016-07-11 2024-03-28 Opko Biologics Ltd Hosszantartó hatású VII. koagulációs faktor és az elõállítására vonatkozó eljárások
EP3502143A4 (en) 2016-08-19 2020-07-15 Ampsource Biopharma Shanghai Inc. BINDING PEPTIDE FOR THE CONSTRUCTION OF A FUSION PROTEIN
CN106279436B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 活化的人凝血因子vii融合蛋白及其制备方法与用途
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
CN106256835A (zh) * 2016-08-19 2016-12-28 安源医药科技（上海）有限公司 高糖基化人生长激素融合蛋白及其制备方法与用途
CN106317226B (zh) * 2016-08-19 2017-09-05 安源医药科技（上海）有限公司 用于构建融合蛋白的连接肽
CN107827987B (zh) * 2017-01-04 2021-04-27 华侨大学 一种促黄体激素类似物及其制备方法
CN110950964B (zh) * 2018-09-26 2021-06-18 安源医药科技（上海）有限公司 突变型单链人凝血因子viii融合蛋白及其制备方法与用途
BR102019004147A2 (pt) 2019-02-28 2020-10-06 Ouro Fino Saude Animal Participacoes S.A. Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso
WO2020229699A1 (en) 2019-05-16 2020-11-19 Ceva Sante Animale Compositions and methods for increasing reproduction performance in non human mammals using recombinant luteinizing hormone
US20220289810A1 (en) * 2019-08-30 2022-09-15 Alejandro Dario ABENTIN Recombinant Chorionic Gonadotropin, Procedure for Preparation, Pharmaceutical Compositions and Uses of the Same
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9203334A (es) * 1983-11-02 1992-09-01 Applied Research Ars Holding N Proteinas heteropolimericas.
CA1213537A (en) * 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
DE69029799T2 (de) * 1989-02-21 1997-05-28 Washington University, St. Louis, Mo. Modifizierte formen von fortpflanzungshormonen
CA2082424C (en) * 1990-05-08 2003-09-23 Robert K. Campbell Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity
AU647566B2 (en) * 1990-12-13 1994-03-24 Immunex Corporation Leukemia inhibitory factor receptors
ZA942206B (en) * 1993-04-01 1994-10-31 Amgen Inc Biologically active polypeptide fusion dimers
WO1995022340A1 (en) * 1994-02-18 1995-08-24 Sensi-Test Methods for altering fertility
DE69532436T2 (de) * 1994-08-12 2004-11-25 Washington University Einzelkettenformen des clycoprotein-hormon-quartetts

Also Published As

Publication number Publication date
CN1290301A (zh) 2001-04-04
CZ20001774A3 (cs) 2000-10-11
HUP0004394A2 (hu) 2001-09-28
WO1999025849A1 (en) 1999-05-27
IL135995A (en) 2007-03-08
EP1032688B1 (en) 2008-07-23
CA2308571C (en) 2013-04-23
NO20002527D0 (no) 2000-05-16
HUP0004394A3 (en) 2003-04-28
JP4255618B2 (ja) 2009-04-15
TR200001406T2 (tr) 2000-12-21
CA2308571A1 (en) 1999-05-27
US6103501A (en) 2000-08-15
BR9814880A (pt) 2000-10-03
CZ299742B6 (cs) 2008-11-05
AU1313199A (en) 1999-06-07
IL135995A0 (en) 2001-05-20
EP1032688A1 (en) 2000-09-06
PL342853A1 (en) 2001-07-16
DE69839779D1 (de) 2008-09-04
JP2001523465A (ja) 2001-11-27
AU754296B2 (en) 2002-11-14
KR20010032147A (ko) 2001-04-16
CN1173037C (zh) 2004-10-27

Similar Documents

Publication Publication Date Title
NO20002527D0 (no) Enkeltkjede bifunksjonelle glykoproteinhormoner
DE69837355D1 (de) Kugelkette
DK0869075T3 (da) Udleveringstætning
ATE241787T1 (de) Behälter
DE69831486D1 (de) Antiproliferative zubereitungen
ID21303A (id) Wadah
NO984679D0 (no) Container
ES1037514Y (es) Recipiente
ID20818A (id) Wadah penyalur
NL1009421A1 (nl) Applicator.
IT236209Y1 (it) Bottiglia ad afferramento facilitato
DE69811630D1 (de) Gummiervorrichtung
DE69834530D1 (de) Kinderwagen
ID19844A (id) Komponen tumbukan
DE59702565D1 (de) Flachlegbarer Behälterverbund
ATA120997A (de) Standseilbahn
ID21647A (id) Wadah
NO981914D0 (no) Container
BR7702258U (pt) Menu promocional
NO20000525D0 (no) Kombinert transportoer
SE9702991D0 (sv) Package
SE9702782D0 (sv) Package
IT236155Y1 (it) Bustina porta-cd
FI970695A0 (fi) Datalink
SE9704714D0 (sv) Bonding agent

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application