HUP0004394A2 - Egyláncú bifunkcionális glikoprotein hormonok - Google Patents

Egyláncú bifunkcionális glikoprotein hormonok

Info

Publication number
HUP0004394A2
HUP0004394A2 HU0004394A HUP0004394A HUP0004394A2 HU P0004394 A2 HUP0004394 A2 HU P0004394A2 HU 0004394 A HU0004394 A HU 0004394A HU P0004394 A HUP0004394 A HU P0004394A HU P0004394 A2 HUP0004394 A2 HU P0004394A2
Authority
HU
Hungary
Prior art keywords
subunit
formula
glycoprotein hormones
binding2
binding1
Prior art date
Application number
HU0004394A
Other languages
English (en)
Inventor
Irving Boime
Original Assignee
Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Washington University filed Critical Washington University
Publication of HUP0004394A2 publication Critical patent/HUP0004394A2/hu
Publication of HUP0004394A3 publication Critical patent/HUP0004394A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

A glikoprotein hormonok egyláncú agonistái és/vagy antagonistáikerültek leírásra. Ezek a proteinek az (I) képlettel rendelkeznek: <1-(kötő1)m-a-(kötő2)n-<2 vagy a (II) képlettel rendelkeznek: <1-(kötő1)m-<2-(kötő2)n-a, vagy (III) képlettel rendelkeznek: a-(kötő1)m-<1-(kötő2)n-<2, ahol <1 és <2 a gerinces glikoprotein hormon vagyennek egy variánsa < alegységének aminosav szekvenciájávalrendelkezik; <a< a gerinces glikoprotein hormon vagy ennek egyvariánsa a alegységét jelöli; a <kötő< kovalensen kapcsolódó egységetjelöl úgy, hogy az a alegységtől és egymástól távol levő <1 és <2alegység helyek hatékonyak az említett aktivitás megtartásához és m ésn jelentése egymástól függetlenül 0 vagy 1. Ó
HU0004394A 1997-11-17 1998-11-09 Single-chain bifunctional glycoprotein hormones HUP0004394A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/971,439 US6103501A (en) 1997-11-17 1997-11-17 Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
PCT/US1998/023744 WO1999025849A1 (en) 1997-11-17 1998-11-09 Single-chain bifunctional glycoprotein hormones

Publications (2)

Publication Number Publication Date
HUP0004394A2 true HUP0004394A2 (hu) 2001-09-28
HUP0004394A3 HUP0004394A3 (en) 2003-04-28

Family

ID=25518394

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004394A HUP0004394A3 (en) 1997-11-17 1998-11-09 Single-chain bifunctional glycoprotein hormones

Country Status (16)

Country Link
US (1) US6103501A (hu)
EP (1) EP1032688B1 (hu)
JP (1) JP4255618B2 (hu)
KR (1) KR20010032147A (hu)
CN (1) CN1173037C (hu)
AU (1) AU754296B2 (hu)
BR (1) BR9814880A (hu)
CA (1) CA2308571C (hu)
CZ (1) CZ299742B6 (hu)
DE (1) DE69839779D1 (hu)
HU (1) HUP0004394A3 (hu)
IL (2) IL135995A0 (hu)
NO (1) NO20002527L (hu)
PL (1) PL342853A1 (hu)
TR (1) TR200001406T2 (hu)
WO (1) WO1999025849A1 (hu)

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AU7546600A (en) * 1999-10-08 2001-04-23 Biofocus Discovery Limited Methods and compositions for targeting a cell
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JP2001333772A (ja) * 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
WO2001081406A2 (en) * 2000-04-25 2001-11-01 Washington University Single-chain fertility hormones with variable lh activity
US6987172B2 (en) * 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
DE602004030546D1 (de) 2003-03-04 2011-01-27 Aspenbio Pharma Inc LH zur Verwendung der Erhaltung einer oder mehreren Schwangerschaften durch Induktion der Bildung des sekundären Gelbkörpers.
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
US20080039372A1 (en) * 2005-07-21 2008-02-14 The Trustees Of Columbia University In The City Of New York Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
AU2006316838B2 (en) 2005-11-15 2012-04-12 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US7553940B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting EPO polypeptides and derivatives thereof and methods thereof
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
MX2010012626A (es) 2008-05-20 2011-02-22 Merck Sharp & Dohme Produccion eficiente de proteinas heterologas utilizando inhibidores de manosil transferasa.
EP2324121B1 (en) 2008-08-12 2012-11-07 GlycoFi, Inc. Improved vectors and yeast strains for protein production: ca2+ atpase overexpression
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
AU2012286048A1 (en) 2011-07-18 2014-02-20 Arts Biologics A/S Long acting luteinizing hormone (LH) compound
AU2013250711A1 (en) 2012-04-19 2014-11-27 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same
CN112661863A (zh) 2012-11-20 2021-04-16 奥普科生物制品有限公司 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
WO2016203482A2 (en) 2015-06-19 2016-12-22 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
ES2963725T3 (es) 2016-07-11 2024-04-01 Opko Biologics Ltd Factor VII de coagulación de acción prolongada y métodos para producir el mismo
US11123438B2 (en) 2016-08-19 2021-09-21 Ampsource Biopharma Shanghai Inc. Linker peptide for constructing fusion protein
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
CN106279436B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 活化的人凝血因子vii融合蛋白及其制备方法与用途
CN107759697B (zh) 2016-08-19 2023-03-24 安源医药科技（上海）有限公司 制备融合蛋白的方法
CN106256835A (zh) * 2016-08-19 2016-12-28 安源医药科技（上海）有限公司 高糖基化人生长激素融合蛋白及其制备方法与用途
CN107827987B (zh) * 2017-01-04 2021-04-27 华侨大学 一种促黄体激素类似物及其制备方法
CN113105562B (zh) * 2018-09-26 2023-12-01 安源医药科技（上海）有限公司 突变型单链人凝血因子viii在制备融合蛋白中的应用
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ZA942206B (en) * 1993-04-01 1994-10-31 Amgen Inc Biologically active polypeptide fusion dimers
WO1995022340A1 (en) * 1994-02-18 1995-08-24 Sensi-Test Methods for altering fertility
DE69532436T2 (de) * 1994-08-12 2004-11-25 Washington University Einzelkettenformen des clycoprotein-hormon-quartetts

Also Published As

Publication number Publication date
AU754296B2 (en) 2002-11-14
KR20010032147A (ko) 2001-04-16
TR200001406T2 (tr) 2000-12-21
CZ20001774A3 (cs) 2000-10-11
NO20002527D0 (no) 2000-05-16
DE69839779D1 (de) 2008-09-04
CN1173037C (zh) 2004-10-27
IL135995A0 (en) 2001-05-20
CN1290301A (zh) 2001-04-04
CA2308571C (en) 2013-04-23
AU1313199A (en) 1999-06-07
NO20002527L (no) 2000-07-10
IL135995A (en) 2007-03-08
HUP0004394A3 (en) 2003-04-28
EP1032688A1 (en) 2000-09-06
WO1999025849A1 (en) 1999-05-27
CZ299742B6 (cs) 2008-11-05
JP4255618B2 (ja) 2009-04-15
CA2308571A1 (en) 1999-05-27
EP1032688B1 (en) 2008-07-23
US6103501A (en) 2000-08-15
PL342853A1 (en) 2001-07-16
JP2001523465A (ja) 2001-11-27
BR9814880A (pt) 2000-10-03

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees