EA199800185A1 - Антагонисты рецепторов эндотелина - Google Patents

Антагонисты рецепторов эндотелина

Info

Publication number
EA199800185A1
EA199800185A1 EA199800185A EA199800185A EA199800185A1 EA 199800185 A1 EA199800185 A1 EA 199800185A1 EA 199800185 A EA199800185 A EA 199800185A EA 199800185 A EA199800185 A EA 199800185A EA 199800185 A1 EA199800185 A1 EA 199800185A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor antagonists
endothelin receptor
antagonists
triazoles
pyrazoles
Prior art date
Application number
EA199800185A
Other languages
English (en)
Other versions
EA000952B1 (ru
Inventor
Хуан Игнасио Луэнго
Джон Дункан Эллиотт
Original Assignee
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of EA199800185A1 publication Critical patent/EA199800185A1/ru
Publication of EA000952B1 publication Critical patent/EA000952B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Описываются новые пирролы, пиразолы и триазолы, фармацевтические композиции, содержащие эти соединения, и их использование в качестве антагонистов рецепторов эндотелина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800185A 1995-08-02 1996-08-02 Антагонисты рецепторов эндотелина EA000952B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US179295P 1995-08-02 1995-08-02
US1098296P 1996-02-01 1996-02-01
PCT/US1996/012581 WO1997004772A1 (en) 1995-08-02 1996-08-02 Endothelin receptor antagonists

Publications (2)

Publication Number Publication Date
EA199800185A1 true EA199800185A1 (ru) 1998-10-29
EA000952B1 EA000952B1 (ru) 2000-08-28

Family

ID=26669471

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800185A EA000952B1 (ru) 1995-08-02 1996-08-02 Антагонисты рецепторов эндотелина

Country Status (25)

Country Link
US (5) US5969151A (ru)
EP (2) EP0841925B1 (ru)
JP (2) JP2001517195A (ru)
KR (1) KR19990036032A (ru)
CN (1) CN1196680A (ru)
AP (1) AP9801182A0 (ru)
AT (1) ATE341324T1 (ru)
AU (2) AU6646396A (ru)
BG (1) BG102229A (ru)
BR (1) BR9609914A (ru)
CA (2) CA2228296A1 (ru)
CZ (1) CZ30498A3 (ru)
DE (2) DE69619116T2 (ru)
EA (1) EA000952B1 (ru)
ES (2) ES2273350T3 (ru)
HU (1) HU220776B1 (ru)
MX (1) MX9800975A (ru)
NO (1) NO980422L (ru)
NZ (1) NZ315846A (ru)
OA (1) OA10755A (ru)
PL (1) PL184272B1 (ru)
RO (1) RO115802B1 (ru)
SK (1) SK282584B6 (ru)
TR (1) TR199800152T1 (ru)
WO (2) WO1997004773A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017426A1 (es) * 1997-12-08 2001-09-05 Smithkline Beecham Corp Sal de monoargininilo del acido (e)-3-[1-n-butil-5-[2-(2-carboxifenil)metoxi-4-clorofenil]-1h-pirazol-4-il]-2-[(5-metoxi-2,3-dihidrobenzofuran-6-il)metil]-prop-2-enoico, composicion farmaceutica que la contiene, su uso para la manufactura de un medicamento y procedimiento para su preparacion
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
WO2004002409A2 (en) * 2002-06-27 2004-01-08 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2006075955A1 (en) * 2005-01-13 2006-07-20 Astrazeneca Ab Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease
US7521435B2 (en) * 2005-02-18 2009-04-21 Pharma Diagnostics, N.V. Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
US8012038B1 (en) 2008-12-11 2011-09-06 Taylor Made Golf Company, Inc. Golf club head
US10086240B1 (en) 2015-08-14 2018-10-02 Taylor Made Golf Company, Inc. Golf club head
WO2017091513A1 (en) * 2015-11-24 2017-06-01 Daiichi Sankyo Company, Limited Novel azole derivatives as apelin receptor agonist
US10773135B1 (en) 2019-08-28 2020-09-15 Taylor Made Golf Company, Inc. Golf club head

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937241A1 (de) * 1968-08-02 1970-02-19 Sumitomo Chemical Co 3,5-Dioxopyrazolidinderivate und Verfahren zu ihrer Herstellung
JPH01211582A (ja) * 1988-02-16 1989-08-24 Tanabe Seiyaku Co Ltd ベンゾジオキソール誘導体
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
JP3214856B2 (ja) * 1990-12-14 2001-10-02 スミスクライン・ビーチャム・コーポレイション イミダゾリル−アルケン酸
FR2682379B1 (fr) * 1991-10-09 1994-02-11 Rhone Poulenc Agrochimie Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) * 1993-03-31 1994-10-13 Smithkline Beecham Corporation Chemical compounds
EP0714897B1 (en) * 1993-08-18 2001-02-14 Banyu Pharmaceutical Co., Ltd. Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity
IL111613A0 (en) * 1993-11-12 1995-01-24 Rhone Poulenc Rorer Ltd Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
AU3416995A (en) * 1994-09-02 1996-03-27 Smithkline Beecham Corporation Endothelin receptor antagonists

Also Published As

Publication number Publication date
BR9609914A (pt) 1999-07-06
DE69636597D1 (de) 2006-11-16
JPH11511133A (ja) 1999-09-28
EP0843551B1 (en) 2002-02-06
PL324745A1 (en) 1998-06-08
SK11398A3 (en) 1998-07-08
NO980422D0 (no) 1998-01-30
PL184272B1 (pl) 2002-09-30
AU6764596A (en) 1997-02-26
US6353116B1 (en) 2002-03-05
EP0843551A1 (en) 1998-05-27
HUP9902817A3 (en) 2001-03-28
US20020072614A1 (en) 2002-06-13
CZ30498A3 (cs) 1998-07-15
US5969151A (en) 1999-10-19
HU220776B1 (hu) 2002-05-28
ATE341324T1 (de) 2006-10-15
AU6646396A (en) 1997-02-26
JP2001517195A (ja) 2001-10-02
WO1997004772A1 (en) 1997-02-13
CA2228296A1 (en) 1997-02-13
US5958968A (en) 1999-09-28
KR19990036032A (ko) 1999-05-25
AU717172B2 (en) 2000-03-16
AP9801182A0 (en) 1998-01-31
EP0841925A1 (en) 1998-05-20
OA10755A (en) 2002-12-13
ES2273350T3 (es) 2007-05-01
NO980422L (no) 1998-03-24
RO115802B1 (ro) 2000-06-30
HUP9902817A2 (hu) 1999-12-28
EA000952B1 (ru) 2000-08-28
TR199800152T1 (xx) 1998-05-21
CA2228293A1 (en) 1997-02-13
MX9800975A (es) 1998-04-30
EP0841925A4 (en) 2001-10-17
US6096897A (en) 2000-08-01
DE69619116T2 (de) 2002-09-19
SK282584B6 (sk) 2002-10-08
DE69636597T2 (de) 2007-08-16
ES2171697T3 (es) 2002-09-16
WO1997004773A1 (en) 1997-02-13
EP0843551A4 (en) 1998-08-12
EP0841925B1 (en) 2006-10-04
BG102229A (en) 1998-09-30
NZ315846A (en) 1999-01-28
CN1196680A (zh) 1998-10-21
US6482956B2 (en) 2002-11-19
DE69619116D1 (de) 2002-03-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU