HUP9902817A2 - Endothelin receptor antagonisták - Google Patents
Endothelin receptor antagonistákInfo
- Publication number
- HUP9902817A2 HUP9902817A2 HU9902817A HUP9902817A HUP9902817A2 HU P9902817 A2 HUP9902817 A2 HU P9902817A2 HU 9902817 A HU9902817 A HU 9902817A HU P9902817 A HUP9902817 A HU P9902817A HU P9902817 A2 HUP9902817 A2 HU P9902817A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- atom
- powder
- optionally substituted
- hydrogen atom
- Prior art date
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
- -1 5-tetrazolyl Chemical group 0.000 abstract 14
- 239000000843 powder Substances 0.000 abstract 13
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- PHWXUGHIIBDVKD-UHFFFAOYSA-N sitaxentan Chemical compound CC1=NOC(NS(=O)(=O)C2=C(SC=C2)C(=O)CC=2C(=CC=3OCOC=3C=2)C)=C1Cl PHWXUGHIIBDVKD-UHFFFAOYSA-N 0.000 abstract 1
- 229960002578 sitaxentan Drugs 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
- 125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
A találmány új (I) általánős képletű vegyületekre, (I) - amelynekképletében (Z) P 5-tetrazőlilcsőpőrt, -CO2R6 vagy -C(O)N(R6)S(OP)qR10, Ra hidrőgénatőm vagy alkilcsőpőrt, R1 hidrőgénatőm, Ar, alkil- vagy alkőxicsőpőrt, R2 R3 és R5 -R13OH, alkőxi-, -S(O)qR11, -N(R6)2, nitrőcsőpőrt, bróm-,flűőr-, jód-, klóratőm, triflűőr-metil-, -NHCOR6, -R13COR6, -R13CO2R7,-X-R9-Y, -X[C(R6)2]OR6, -(CH2)mX'R8 vagy -X(CH2)nR8 csőpőrt, ahől a -X(CH2)nR8 csőpőrtban lévő metiléncsőpőrtők adőtt esetbenszűbsztitűáltak, R4 R11, hidrőxil, adőtt esetben szűbsztitűált alkőxi-,-S(O)qR11, -N(R6)2 csőpőrt, bróm, flűőr, jód-, klóratőm vagy -NHCOR6 csőpőrt, R6 hidrőgénatőm vagy alkilcsőpőrt, R7 hidrőgénatőm, adőtt esetben szűbsztitűált alkil-, alkenil- vagyalkinilcsőpőrt vagy -(CH2)nAr csőpőrt, R8 R11, -CO2R7, -CO2C(R11)2O(CO)XR7, -PO3(R7)2, -SO2NR7R11, -NR7SO2R11, -CONR7SO2R11, -SO3R7, -SO2R7, -P(O) (OR7)R7, cianő-, -CO2(CH2)mC(O)N(R6)2, -C(R11)2N(R7)2, -C(O)N(R6)2, -NR7C(O)NR7SO2R11, -OR6 vagy adőtt esetben szűbsztitűált tetrazőlilcsőpőrt, R9 kötés, adőtt esetben szűbsztitűált alkilén-, alkenilén-, alkilidén-vagy feniléncsőpőrt, R10 alkil-, -N(R6)2 vagy Ar csőpőrt, R11 hidrőgénatőm, Ar, adőtt esetben szűbsztitűált alkil-, alkenil-,alkinilcsőpőrt, R12 hidrőgénatőm, alkil-, alkenil- vagy alkinilcsőpőrt, R13 két vegyértékű Ar, adőtt esetben szűbsztitűált alkilén-,alkilidén-, alkeniléncsőpőrt, R14 hidrőgénatőm, alkil-, alkil-X-, Ar vagy -X-Ar csőpőrt, R15 hidrőgénatőm, alkil-, Ar vagy -X-Ar csőpőrt R16 alkil-, vagy szűbsztitűált fenilcsőpőrt, X őxigénatőm, -(CH2)n-, -N(R6)- vagy -S(O)q-csőpőrt, X' őxigénatőm, -N(R6)- vagy -S(O)q- csőpőrt, Y metil- vagy -X(CH2)nAr csőpőrt Ar adőtt esetben szűbsztitűált (a) (b) naftil-, indőlil-, piridil-, tienil-, őxazőlidinil-, tiazőlil-,izőtiazőlil-, pirazőlil-, triazőlil-, tetrazőlil-, imidazőlil-,imidazőlidinil-, tiazőlidinil-, izőxazőlil-, őxadiazőlil-,tiadiazőlil-, mőrfőlinil-, piperidil-, piperazinil-, pirrőlil- vagypirimidinilcsőpőrt, A karbőnil- vagy -[C(R6)2]m- csőpőrt, B metiléncsőpőrt vagy őxigénatőm, Z1 és Z2 hidrőgénatőm, -XR6, alkil-, -(CH2)qCO2R6, -C(O)N(R6)2,cianő-, -(CH2)nOH, nitrőcsőpőrt, flűőr-, klór-, bróm-, jódatőm, -N(R6)2, -NHC(O)R6, -O(CH2)mC(O)NRaSO2R16, -(CH2)mC(O)NRaSO2R16, -O(CH2)mNRaC(O)NRaSO2R16 csőpőrt vagy adőtt esetben szűbsztitűálttetrazőlilcsőpőrt, m 1, 2 vagy 3, n 0, 1, 2, 3, 4, 5 vagy 6, q 0, 1 vagy 2, azzal a megkötéssel, hőgy R3, R4 és R5 jelentése -O-(CH2)nAr vagy -O-OR6 általánős képletű csőpőrttól eltérő - avegyületeket tartalmazó gyógyszerkészítményekre, valamint a vegyületekendőthelin receptőr antagőnistákként történő felhasználásáravőnatkőzik. ŕ
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US179295P | 1995-08-02 | 1995-08-02 | |
| US1098296P | 1996-02-01 | 1996-02-01 | |
| PCT/US1996/012581 WO1997004772A1 (en) | 1995-08-02 | 1996-08-02 | Endothelin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9902817A2 true HUP9902817A2 (hu) | 1999-12-28 |
| HUP9902817A3 HUP9902817A3 (en) | 2001-03-28 |
| HU220776B1 HU220776B1 (hu) | 2002-05-28 |
Family
ID=26669471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902817A HU220776B1 (hu) | 1995-08-02 | 1996-08-02 | Endothelin receptor antagonisták |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US5969151A (hu) |
| EP (2) | EP0843551B1 (hu) |
| JP (2) | JPH11511133A (hu) |
| KR (1) | KR19990036032A (hu) |
| CN (1) | CN1196680A (hu) |
| AP (1) | AP9801182A0 (hu) |
| AT (1) | ATE341324T1 (hu) |
| AU (2) | AU717172B2 (hu) |
| BG (1) | BG102229A (hu) |
| BR (1) | BR9609914A (hu) |
| CA (2) | CA2228296A1 (hu) |
| CZ (1) | CZ30498A3 (hu) |
| DE (2) | DE69636597T2 (hu) |
| EA (1) | EA000952B1 (hu) |
| ES (2) | ES2273350T3 (hu) |
| HU (1) | HU220776B1 (hu) |
| MX (1) | MX9800975A (hu) |
| NO (1) | NO980422L (hu) |
| NZ (1) | NZ315846A (hu) |
| OA (1) | OA10755A (hu) |
| PL (1) | PL184272B1 (hu) |
| RO (1) | RO115802B1 (hu) |
| SK (1) | SK282584B6 (hu) |
| TR (1) | TR199800152T1 (hu) |
| WO (2) | WO1997004772A1 (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5021171A1 (es) * | 1997-12-08 | 2001-03-27 | Smithkline Beechman Corp | Sal de monoargininilo del acido(e)-3-(1-n-butil-5-(2-(2- carboxifenil)metoxi-4-clorofenil)-1h-pirazol-4-il)-2- ((5-metoxi-2,3-dihidrobenzofuran-5-il)metil)-prop-2-enoico |
| DE10155076A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen |
| US7087630B2 (en) * | 2002-06-27 | 2006-08-08 | Nitromed, Inc. | Cyclooxygenase 2 selective inhibitors, compositions and methods of use |
| WO2006075955A1 (en) * | 2005-01-13 | 2006-07-20 | Astrazeneca Ab | Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease |
| US7521435B2 (en) * | 2005-02-18 | 2009-04-21 | Pharma Diagnostics, N.V. | Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same |
| US8012038B1 (en) | 2008-12-11 | 2011-09-06 | Taylor Made Golf Company, Inc. | Golf club head |
| US10086240B1 (en) | 2015-08-14 | 2018-10-02 | Taylor Made Golf Company, Inc. | Golf club head |
| US10626096B2 (en) | 2015-11-24 | 2020-04-21 | Sanford Burnham Prebys Medical Discovery Institute | Azole derivatives as apelin receptor agonist |
| US10773135B1 (en) | 2019-08-28 | 2020-09-15 | Taylor Made Golf Company, Inc. | Golf club head |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1937241A1 (de) * | 1968-08-02 | 1970-02-19 | Sumitomo Chemical Co | 3,5-Dioxopyrazolidinderivate und Verfahren zu ihrer Herstellung |
| JPH01211582A (ja) * | 1988-02-16 | 1989-08-24 | Tanabe Seiyaku Co Ltd | ベンゾジオキソール誘導体 |
| EP0403158A3 (en) * | 1989-06-14 | 1991-12-18 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
| EP0563238B1 (en) * | 1990-12-14 | 2002-05-22 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
| FR2682379B1 (fr) * | 1991-10-09 | 1994-02-11 | Rhone Poulenc Agrochimie | Nouveaux phenylpyrazoles fongicides. |
| WO1994022830A1 (en) * | 1993-03-31 | 1994-10-13 | Smithkline Beecham Corporation | Chemical compounds |
| CN1049219C (zh) * | 1993-08-18 | 2000-02-09 | 万有制药株式会社 | 具有内皮素拮抗活性的芳香杂环并环戊烯衍生物 |
| IL111613A0 (en) * | 1993-11-12 | 1995-01-24 | Rhone Poulenc Rorer Ltd | Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them |
| WO1996007653A1 (en) * | 1994-09-02 | 1996-03-14 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
-
1996
- 1996-08-02 EP EP96926243A patent/EP0843551B1/en not_active Expired - Lifetime
- 1996-08-02 ES ES96928036T patent/ES2273350T3/es not_active Expired - Lifetime
- 1996-08-02 SK SK113-98A patent/SK282584B6/sk unknown
- 1996-08-02 ES ES96926243T patent/ES2171697T3/es not_active Expired - Lifetime
- 1996-08-02 CA CA002228296A patent/CA2228296A1/en not_active Abandoned
- 1996-08-02 AU AU67645/96A patent/AU717172B2/en not_active Ceased
- 1996-08-02 TR TR1998/00152T patent/TR199800152T1/xx unknown
- 1996-08-02 EP EP96928036A patent/EP0841925B1/en not_active Expired - Lifetime
- 1996-08-02 PL PL96324745A patent/PL184272B1/pl not_active IP Right Cessation
- 1996-08-02 CN CN96197111A patent/CN1196680A/zh active Pending
- 1996-08-02 EA EA199800185A patent/EA000952B1/ru not_active IP Right Cessation
- 1996-08-02 MX MX9800975A patent/MX9800975A/es not_active IP Right Cessation
- 1996-08-02 DE DE69636597T patent/DE69636597T2/de not_active Expired - Fee Related
- 1996-08-02 NZ NZ315846A patent/NZ315846A/xx unknown
- 1996-08-02 RO RO98-00135A patent/RO115802B1/ro unknown
- 1996-08-02 WO PCT/US1996/012581 patent/WO1997004772A1/en active IP Right Grant
- 1996-08-02 JP JP9507907A patent/JPH11511133A/ja not_active Ceased
- 1996-08-02 BR BR9609914A patent/BR9609914A/pt not_active Application Discontinuation
- 1996-08-02 JP JP50788797A patent/JP2001517195A/ja not_active Ceased
- 1996-08-02 HU HU9902817A patent/HU220776B1/hu not_active IP Right Cessation
- 1996-08-02 CA CA002228293A patent/CA2228293A1/en not_active Abandoned
- 1996-08-02 CZ CZ98304A patent/CZ30498A3/cs unknown
- 1996-08-02 AP APAP/P/1998/001182A patent/AP9801182A0/en unknown
- 1996-08-02 DE DE69619116T patent/DE69619116T2/de not_active Expired - Fee Related
- 1996-08-02 WO PCT/US1996/012661 patent/WO1997004773A1/en active IP Right Grant
- 1996-08-02 AU AU66463/96A patent/AU6646396A/en not_active Abandoned
- 1996-08-02 KR KR1019980700697A patent/KR19990036032A/ko not_active Application Discontinuation
- 1996-08-02 AT AT96928036T patent/ATE341324T1/de not_active IP Right Cessation
-
1998
- 1998-01-28 OA OA9800014A patent/OA10755A/en unknown
- 1998-01-30 NO NO980422A patent/NO980422L/no not_active Application Discontinuation
- 1998-02-02 BG BG102229A patent/BG102229A/xx unknown
- 1998-07-23 US US09/121,545 patent/US5969151A/en not_active Expired - Fee Related
-
1999
- 1999-01-08 US US09/227,361 patent/US5958968A/en not_active Expired - Fee Related
- 1999-06-29 US US09/342,989 patent/US6096897A/en not_active Expired - Fee Related
- 1999-12-14 US US09/460,487 patent/US6353116B1/en not_active Expired - Fee Related
-
2001
- 2001-11-30 US US10/021,461 patent/US6482956B2/en not_active Expired - Fee Related
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