DE69619116D1 - Endothelinrezeptorantagonisten - Google Patents

Endothelinrezeptorantagonisten

Info

Publication number
DE69619116D1
DE69619116D1 DE69619116T DE69619116T DE69619116D1 DE 69619116 D1 DE69619116 D1 DE 69619116D1 DE 69619116 T DE69619116 T DE 69619116T DE 69619116 T DE69619116 T DE 69619116T DE 69619116 D1 DE69619116 D1 DE 69619116D1
Authority
DE
Germany
Prior art keywords
endothelin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69619116T
Other languages
English (en)
Other versions
DE69619116T2 (de
Inventor
Juan Ignacio Luengo
Duncan Elliott
Jia-Ning Xiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE69619116D1 publication Critical patent/DE69619116D1/de
Publication of DE69619116T2 publication Critical patent/DE69619116T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE69619116T 1995-08-02 1996-08-02 Endothelinrezeptorantagonisten Expired - Fee Related DE69619116T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US179295P 1995-08-02 1995-08-02
US1098296P 1996-02-01 1996-02-01
PCT/US1996/012661 WO1997004773A1 (en) 1995-08-02 1996-08-02 Endothelin receptor antagonists

Publications (2)

Publication Number Publication Date
DE69619116D1 true DE69619116D1 (de) 2002-03-21
DE69619116T2 DE69619116T2 (de) 2002-09-19

Family

ID=26669471

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69619116T Expired - Fee Related DE69619116T2 (de) 1995-08-02 1996-08-02 Endothelinrezeptorantagonisten
DE69636597T Expired - Fee Related DE69636597T2 (de) 1995-08-02 1996-08-02 Endothelin rezeptor antagonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69636597T Expired - Fee Related DE69636597T2 (de) 1995-08-02 1996-08-02 Endothelin rezeptor antagonisten

Country Status (25)

Country Link
US (5) US5969151A (de)
EP (2) EP0841925B1 (de)
JP (2) JP2001517195A (de)
KR (1) KR19990036032A (de)
CN (1) CN1196680A (de)
AP (1) AP9801182A0 (de)
AT (1) ATE341324T1 (de)
AU (2) AU6646396A (de)
BG (1) BG102229A (de)
BR (1) BR9609914A (de)
CA (2) CA2228296A1 (de)
CZ (1) CZ30498A3 (de)
DE (2) DE69619116T2 (de)
EA (1) EA000952B1 (de)
ES (2) ES2273350T3 (de)
HU (1) HU220776B1 (de)
MX (1) MX9800975A (de)
NO (1) NO980422L (de)
NZ (1) NZ315846A (de)
OA (1) OA10755A (de)
PL (1) PL184272B1 (de)
RO (1) RO115802B1 (de)
SK (1) SK282584B6 (de)
TR (1) TR199800152T1 (de)
WO (2) WO1997004773A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017426A1 (es) * 1997-12-08 2001-09-05 Smithkline Beecham Corp Sal de monoargininilo del acido (e)-3-[1-n-butil-5-[2-(2-carboxifenil)metoxi-4-clorofenil]-1h-pirazol-4-il]-2-[(5-metoxi-2,3-dihidrobenzofuran-6-il)metil]-prop-2-enoico, composicion farmaceutica que la contiene, su uso para la manufactura de un medicamento y procedimiento para su preparacion
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
WO2004002409A2 (en) * 2002-06-27 2004-01-08 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2006075955A1 (en) * 2005-01-13 2006-07-20 Astrazeneca Ab Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease
US7521435B2 (en) * 2005-02-18 2009-04-21 Pharma Diagnostics, N.V. Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
US8012038B1 (en) 2008-12-11 2011-09-06 Taylor Made Golf Company, Inc. Golf club head
US10086240B1 (en) 2015-08-14 2018-10-02 Taylor Made Golf Company, Inc. Golf club head
WO2017091513A1 (en) * 2015-11-24 2017-06-01 Daiichi Sankyo Company, Limited Novel azole derivatives as apelin receptor agonist
US10773135B1 (en) 2019-08-28 2020-09-15 Taylor Made Golf Company, Inc. Golf club head

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937241A1 (de) * 1968-08-02 1970-02-19 Sumitomo Chemical Co 3,5-Dioxopyrazolidinderivate und Verfahren zu ihrer Herstellung
JPH01211582A (ja) * 1988-02-16 1989-08-24 Tanabe Seiyaku Co Ltd ベンゾジオキソール誘導体
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
JP3214856B2 (ja) * 1990-12-14 2001-10-02 スミスクライン・ビーチャム・コーポレイション イミダゾリル−アルケン酸
FR2682379B1 (fr) * 1991-10-09 1994-02-11 Rhone Poulenc Agrochimie Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) * 1993-03-31 1994-10-13 Smithkline Beecham Corporation Chemical compounds
EP0714897B1 (de) * 1993-08-18 2001-02-14 Banyu Pharmaceutical Co., Ltd. Kondensierte heteroaromatische cyclopentenderivate mit endothelin-antagonistischer aktivität
IL111613A0 (en) * 1993-11-12 1995-01-24 Rhone Poulenc Rorer Ltd Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
AU3416995A (en) * 1994-09-02 1996-03-27 Smithkline Beecham Corporation Endothelin receptor antagonists

Also Published As

Publication number Publication date
BR9609914A (pt) 1999-07-06
DE69636597D1 (de) 2006-11-16
JPH11511133A (ja) 1999-09-28
EP0843551B1 (de) 2002-02-06
PL324745A1 (en) 1998-06-08
SK11398A3 (en) 1998-07-08
NO980422D0 (no) 1998-01-30
PL184272B1 (pl) 2002-09-30
AU6764596A (en) 1997-02-26
US6353116B1 (en) 2002-03-05
EP0843551A1 (de) 1998-05-27
HUP9902817A3 (en) 2001-03-28
US20020072614A1 (en) 2002-06-13
CZ30498A3 (cs) 1998-07-15
US5969151A (en) 1999-10-19
HU220776B1 (hu) 2002-05-28
ATE341324T1 (de) 2006-10-15
AU6646396A (en) 1997-02-26
JP2001517195A (ja) 2001-10-02
WO1997004772A1 (en) 1997-02-13
CA2228296A1 (en) 1997-02-13
US5958968A (en) 1999-09-28
KR19990036032A (ko) 1999-05-25
AU717172B2 (en) 2000-03-16
AP9801182A0 (en) 1998-01-31
EP0841925A1 (de) 1998-05-20
OA10755A (en) 2002-12-13
ES2273350T3 (es) 2007-05-01
EA199800185A1 (ru) 1998-10-29
NO980422L (no) 1998-03-24
RO115802B1 (ro) 2000-06-30
HUP9902817A2 (hu) 1999-12-28
EA000952B1 (ru) 2000-08-28
TR199800152T1 (xx) 1998-05-21
CA2228293A1 (en) 1997-02-13
MX9800975A (es) 1998-04-30
EP0841925A4 (de) 2001-10-17
US6096897A (en) 2000-08-01
DE69619116T2 (de) 2002-09-19
SK282584B6 (sk) 2002-10-08
DE69636597T2 (de) 2007-08-16
ES2171697T3 (es) 2002-09-16
WO1997004773A1 (en) 1997-02-13
EP0843551A4 (de) 1998-08-12
EP0841925B1 (de) 2006-10-04
BG102229A (en) 1998-09-30
NZ315846A (en) 1999-01-28
CN1196680A (zh) 1998-10-21
US6482956B2 (en) 2002-11-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee