HUP0203681A2 - Perifériális kannabinoid receptor specifikus agonistákat tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Perifériális kannabinoid receptor specifikus agonistákat tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0203681A2
HUP0203681A2 HU0203681A HUP0203681A HUP0203681A2 HU P0203681 A2 HUP0203681 A2 HU P0203681A2 HU 0203681 A HU0203681 A HU 0203681A HU P0203681 A HUP0203681 A HU P0203681A HU P0203681 A2 HUP0203681 A2 HU P0203681A2
Authority
HU
Hungary
Prior art keywords
alkyl group
hydrogen atom
receptors
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0203681A
Other languages
English (en)
Inventor
Aviva Breuer
Ester Fride
Aaron Garzon
Lumir Hanus
Michael Horowitz
Raphael Mechoulam
Susanna Tchilibon
Original Assignee
Yissum Research Development Company Of The Hebrew University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Company Of The Hebrew University filed Critical Yissum Research Development Company Of The Hebrew University
Publication of HUP0203681A2 publication Critical patent/HUP0203681A2/hu
Publication of HUP0203681A3 publication Critical patent/HUP0203681A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

A találmány tárgya új gyógyszerkészítmény, amely hatóanyagként (I)általános képletű 4-fenil-pinén-származékokat tartalmaz, amelyek aperifériális kannabinoid receptorokra specifikusak. Közelebbről atalálmány szerinti vegyületek hatékonyan kötődnek a CB2-receptorokhoz,de nem kötődnek a CB1-receptorokhoz. A vegyületek csökkentik avérnyomást, blokkolják a bélmozgást és gyulladásgátló és perifériálisérzéstelenítő aktivitást indukálnak. A találmány tárgya továbbáeljárás magas vérnyomás, gyulladás, fájdalom, gyomor-bél rendszeribetegségek, autoimmun betegségek és tumorok kezelésére, megelőzésérevagy kézben tartására a találmány szerinti vegyületekkel. Az (I)általános képletben A<-B tetszés szerinti kettős kötést jelent; R1jelentése -R'N(R<)2 ahol R' jelentése 1-5 szénatomos alkilcsoport ésR< jelentése hidrogénatom vagy 1-5 szénatomos alkilcsoport vagy -Qahol Q jelentése heterociklusos csoport, vagy -R'X, -R'C(O)(N(R<)2ahol R', R< jelentése azonos a fentiekben megadottakkal; G jelentésehidrogénatom, halogénatom, vagy OR2 ahol R2 jelentése hidrogénatomvagy 1-5 szénatomos alkilcsoport, és R3 jelentése 1-12 szénatomosalkilcsoport vagy -OR< <-ahol R< < jelentése 2-9 szénatomosalkilcsoport vagy -(CH2)n-OR'<, ahol n értéke 1-7 egész szám és R'<jelentése hidrogénatom vagy 1-5 szénatomos alkilcsoport. Ó
HU0203681A 1999-10-31 2000-10-30 Pharmaceutical compositions containing agonists specific for the peripheral cannabinoid receptor and their use HUP0203681A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL132661A IL132661A (en) 1999-10-31 1999-10-31 Agonists specific for peripheral cannabinoid receptors
PCT/US2000/029903 WO2001032169A1 (en) 1999-10-31 2000-10-30 Agonists specific for the peripheral cannabinoid receptor

Publications (2)

Publication Number Publication Date
HUP0203681A2 true HUP0203681A2 (hu) 2003-04-28
HUP0203681A3 HUP0203681A3 (en) 2003-05-28

Family

ID=11073405

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203681A HUP0203681A3 (en) 1999-10-31 2000-10-30 Pharmaceutical compositions containing agonists specific for the peripheral cannabinoid receptor and their use

Country Status (13)

Country Link
US (3) US6864291B1 (hu)
EP (1) EP1244440B1 (hu)
JP (1) JP4231906B2 (hu)
KR (1) KR100770695B1 (hu)
AT (1) ATE286389T1 (hu)
AU (1) AU778149B2 (hu)
CA (1) CA2385928A1 (hu)
DE (1) DE60017287T2 (hu)
HU (1) HUP0203681A3 (hu)
IL (2) IL132661A (hu)
NZ (1) NZ518054A (hu)
WO (1) WO2001032169A1 (hu)
ZA (1) ZA200202181B (hu)

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ATE247097T1 (de) 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
AU778159B2 (en) 1999-10-18 2004-11-18 University Of Connecticut, The Peripheral cannabinoid receptor (CB2) selective ligands
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
IL132661A (en) * 1999-10-31 2008-11-26 Raphael Mechoulam Agonists specific for peripheral cannabinoid receptors
US7329651B2 (en) * 2001-01-26 2008-02-12 University Of Connecticut Cannabimimetic ligands
JP2005503998A (ja) * 2001-01-29 2005-02-10 ユニバーシティ オブ コネチカット 受容体選択性のカンナビミメティックアミノアルキルインドール
JP4312594B2 (ja) * 2001-07-13 2009-08-12 ユニバーシティ オブ コネチカット 新規な二環式及び三環式カンナビノイド
US7666867B2 (en) 2001-10-26 2010-02-23 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
TW200407110A (en) * 2001-11-23 2004-05-16 Astrazeneca Ab New use for the treatment of gastroesophageal reflux disease
WO2003061699A1 (fr) * 2001-12-27 2003-07-31 Japan Tobacco, Inc. Remedes pour affections allergiques
EP1469842A4 (en) * 2002-01-31 2006-04-26 Pharmos Corp BICYCLIC CB2 CANNABINOID RECEPTOR LIGANDS
IL150302A (en) * 2002-01-31 2008-07-08 Naim Menashe Bicyclic cb2 cannabinoid receptor ligands
CN1678303A (zh) 2002-08-23 2005-10-05 康涅狄格大学 具有治疗作用的酮类大麻类
EP1606019A1 (en) * 2003-03-07 2005-12-21 The University Court of The University of Aberdeen Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
AR043633A1 (es) * 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
ATE496901T1 (de) * 2003-05-20 2011-02-15 Univ Tennessee Res Foundation Cannabinoidderivate, verfahren zu deren herstellung und deren verwendung
CA2571679A1 (en) * 2004-06-22 2005-12-29 Pharmos Limited Use of cb2 receptors agonists for the treatment of huntington's disease
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
US20070060638A1 (en) * 2005-08-26 2007-03-15 Olmstead Mary C Methods and therapies for potentiating therapeutic activities of a cannabinoid receptor agonist via administration of a cannabinoid receptor antagonist
US7763607B2 (en) 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
CA2650566A1 (en) * 2006-04-27 2007-11-08 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising cbx cannabinoid receptor modulators and potassium channel modulators
WO2008001369A1 (en) * 2006-06-27 2008-01-03 Pharmos Corporation Use of cb2 receptor agonists for promoting neurogenesis
US9763894B2 (en) * 2006-12-05 2017-09-19 Virginia Commonwealth University Inflammation therapy
GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
WO2008107879A1 (en) * 2007-03-05 2008-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel cannabidiol derivatives and their use as anti-inflammatory agents
WO2009044402A1 (en) 2007-10-02 2009-04-09 Ariel - University Research And Development Company Ltd. Endocannabinoids for enhancing growth and development in infants
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ITMI20122221A1 (it) 2012-12-21 2014-06-22 C4T S C A R L Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende
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IL55274A (en) 1978-08-02 1982-08-31 Yissum Res Dev Co 4-(2,6-dihydroxy-4-(dimethylheptyl)phenyl)substituted 2-pinen-10-ol and pinane derivatives,their preparation and pharmaceutical compositions comprising them
US5434295A (en) * 1994-02-07 1995-07-18 Yissum Research Development Company Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds
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IL132661A (en) * 1999-10-31 2008-11-26 Raphael Mechoulam Agonists specific for peripheral cannabinoid receptors

Also Published As

Publication number Publication date
CA2385928A1 (en) 2001-05-10
DE60017287D1 (de) 2005-02-10
KR100770695B1 (ko) 2007-10-29
DE60017287T2 (de) 2005-12-08
AU1245801A (en) 2001-05-14
NZ518054A (en) 2003-10-31
US20050165118A1 (en) 2005-07-28
JP2004505006A (ja) 2004-02-19
US7214716B2 (en) 2007-05-08
US6864291B1 (en) 2005-03-08
AU778149B2 (en) 2004-11-18
IL148796A (en) 2008-11-26
WO2001032169A1 (en) 2001-05-10
IL132661A0 (en) 2001-03-19
IL132661A (en) 2008-11-26
EP1244440A1 (en) 2002-10-02
US20020173528A1 (en) 2002-11-21
EP1244440A4 (en) 2003-05-14
JP4231906B2 (ja) 2009-03-04
ZA200202181B (en) 2003-05-28
HUP0203681A3 (en) 2003-05-28
KR20030008208A (ko) 2003-01-24
US6903137B2 (en) 2005-06-07
ATE286389T1 (de) 2005-01-15
EP1244440B1 (en) 2005-01-05

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Legal Events

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