EA200100299A1 - Уреидопиперидиновые производные как селективные антагонисты nk3 - рецепторов человека - Google Patents

Уреидопиперидиновые производные как селективные антагонисты nk3 - рецепторов человека

Info

Publication number
EA200100299A1
EA200100299A1 EA200100299A EA200100299A EA200100299A1 EA 200100299 A1 EA200100299 A1 EA 200100299A1 EA 200100299 A EA200100299 A EA 200100299A EA 200100299 A EA200100299 A EA 200100299A EA 200100299 A1 EA200100299 A1 EA 200100299A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
selective
ureidopiperidine
derivatives
human receptors
Prior art date
Application number
EA200100299A
Other languages
English (en)
Other versions
EA003613B1 (ru
Inventor
Ален Оломбар
Ксавье Эдмонд-Аль
Винченцо Пройетто
Дидье Ван Брук
Original Assignee
Санофи-Синтелябо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Синтелябо filed Critical Санофи-Синтелябо
Publication of EA200100299A1 publication Critical patent/EA200100299A1/ru
Publication of EA003613B1 publication Critical patent/EA003613B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Данное изобретение относится к соединениям формулы (I) в рацемической или оптически чистой форме, к способам их получения и к содержащим их фармацевтическим композициям. Указанные соединения являются селективными антагонистами NK-рецепторов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100299A 1998-10-09 1999-10-04 Уреидопиперидиновые производные как селективные антагонисты nk3-рецепторов человека EA003613B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9812859A FR2784377B3 (fr) 1998-10-09 1998-10-09 Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant
PCT/FR1999/002355 WO2000021931A1 (fr) 1998-10-09 1999-10-04 Derives d'ureidopiperidine comme antagonistes selectifs des recepteurs nk3 humains

Publications (2)

Publication Number Publication Date
EA200100299A1 true EA200100299A1 (ru) 2001-10-22
EA003613B1 EA003613B1 (ru) 2003-06-26

Family

ID=9531536

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100299A EA003613B1 (ru) 1998-10-09 1999-10-04 Уреидопиперидиновые производные как селективные антагонисты nk3-рецепторов человека

Country Status (25)

Country Link
US (1) US6465489B1 (ru)
EP (1) EP1119552A1 (ru)
JP (1) JP2002527423A (ru)
KR (1) KR20010085903A (ru)
CN (1) CN1133622C (ru)
AR (1) AR029148A1 (ru)
AU (1) AU751592B2 (ru)
BR (1) BR9914397A (ru)
CA (1) CA2346729A1 (ru)
CO (1) CO5180555A1 (ru)
DZ (1) DZ2905A1 (ru)
EA (1) EA003613B1 (ru)
EE (1) EE200100214A (ru)
FR (1) FR2784377B3 (ru)
HU (1) HUP0201709A3 (ru)
IL (1) IL142362A0 (ru)
IS (1) IS5897A (ru)
NO (1) NO20011779L (ru)
NZ (1) NZ510779A (ru)
PL (1) PL347910A1 (ru)
SK (1) SK4642001A3 (ru)
TR (1) TR200101030T2 (ru)
TW (1) TW539669B (ru)
WO (1) WO2000021931A1 (ru)
YU (1) YU26001A (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476050B2 (en) 2000-03-14 2002-11-05 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
US20060128752A1 (en) * 2002-07-03 2006-06-15 Giuseppe Alvaro Chemical compounds
US20110144081A1 (en) 2009-12-15 2011-06-16 Henner Knust Pyrrolidine derivatives
US9554659B2 (en) 2012-10-22 2017-01-31 Uwm Research Foundation, Inc. Infant sleep pod
WO2020101017A1 (ja) * 2018-11-15 2020-05-22 国立大学法人九州大学 Ｉｌ－３１介在性疾患の予防又は治療剤及び医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99320A (en) 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676055B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2719311B1 (fr) * 1994-03-18 1998-06-26 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR2738819B1 (fr) 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
AU4176997A (en) * 1996-09-16 1998-04-02 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines

Also Published As

Publication number Publication date
TR200101030T2 (tr) 2001-08-21
US6465489B1 (en) 2002-10-15
CN1329594A (zh) 2002-01-02
EP1119552A1 (fr) 2001-08-01
EA003613B1 (ru) 2003-06-26
KR20010085903A (ko) 2001-09-07
NO20011779L (no) 2001-06-07
AU751592B2 (en) 2002-08-22
WO2000021931A1 (fr) 2000-04-20
IS5897A (is) 2001-03-16
HUP0201709A3 (en) 2003-03-28
AU5988799A (en) 2000-05-01
PL347910A1 (en) 2002-04-22
SK4642001A3 (en) 2001-09-11
CA2346729A1 (en) 2000-04-20
IL142362A0 (en) 2002-03-10
DZ2905A1 (fr) 2004-03-01
BR9914397A (pt) 2001-06-26
CN1133622C (zh) 2004-01-07
YU26001A (sh) 2003-04-30
HUP0201709A2 (en) 2002-09-28
EE200100214A (et) 2002-08-15
CO5180555A1 (es) 2002-07-30
TW539669B (en) 2003-07-01
AR029148A1 (es) 2003-06-18
FR2784377B3 (fr) 2000-11-17
FR2784377A1 (fr) 2000-04-14
NZ510779A (en) 2003-07-25
NO20011779D0 (no) 2001-04-06
JP2002527423A (ja) 2002-08-27

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

TC4A Change in name of a patent proprietor in a eurasian patent

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU