TR200101030T2 - İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri - Google Patents

İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri

Info

Publication number
TR200101030T2
TR200101030T2 TR2001/01030T TR200101030T TR200101030T2 TR 200101030 T2 TR200101030 T2 TR 200101030T2 TR 2001/01030 T TR2001/01030 T TR 2001/01030T TR 200101030 T TR200101030 T TR 200101030T TR 200101030 T2 TR200101030 T2 TR 200101030T2
Authority
TR
Turkey
Prior art keywords
uureidopiperidine
receptors
derivatives
human
specific
Prior art date
Application number
TR2001/01030T
Other languages
English (en)
Inventor
Aulombard Alain
Edmonds-Alt Xavier
Proietto Vincenzo
Van Broeck Didiler
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of TR200101030T2 publication Critical patent/TR200101030T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Mevcut bulus; rasemik veya optik olarak saf formdaki, formül (I)'e sahip bilesikler, bahsedilen bilesikleri elde etmek için metotlar ve bu bilesikleri içeren farmasötik kompozisyonlar ile ilgilidir. Söz konusu bilesikler, seçici NK3 reseptör antagonistleridirler.
TR2001/01030T 1998-10-09 1999-10-04 İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri TR200101030T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9812859A FR2784377B3 (fr) 1998-10-09 1998-10-09 Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
TR200101030T2 true TR200101030T2 (tr) 2001-08-21

Family

ID=9531536

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01030T TR200101030T2 (tr) 1998-10-09 1999-10-04 İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri

Country Status (25)

Country Link
US (1) US6465489B1 (tr)
EP (1) EP1119552A1 (tr)
JP (1) JP2002527423A (tr)
KR (1) KR20010085903A (tr)
CN (1) CN1133622C (tr)
AR (1) AR029148A1 (tr)
AU (1) AU751592B2 (tr)
BR (1) BR9914397A (tr)
CA (1) CA2346729A1 (tr)
CO (1) CO5180555A1 (tr)
DZ (1) DZ2905A1 (tr)
EA (1) EA003613B1 (tr)
EE (1) EE200100214A (tr)
FR (1) FR2784377B3 (tr)
HU (1) HUP0201709A3 (tr)
IL (1) IL142362A0 (tr)
IS (1) IS5897A (tr)
NO (1) NO20011779L (tr)
NZ (1) NZ510779A (tr)
PL (1) PL347910A1 (tr)
SK (1) SK4642001A3 (tr)
TR (1) TR200101030T2 (tr)
TW (1) TW539669B (tr)
WO (1) WO2000021931A1 (tr)
YU (1) YU26001A (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068604A2 (en) 2000-03-14 2001-09-20 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
JP2005535650A (ja) * 2002-07-03 2005-11-24 グラクソ　グループ　リミテッド タキキニンアンタゴニストおよびセロトニン再取り込み阻害剤としての置換４−フェニル−ピペリジン−アミド
US20110144081A1 (en) 2009-12-15 2011-06-16 Henner Knust Pyrrolidine derivatives
US9554659B2 (en) 2012-10-22 2017-01-31 Uwm Research Foundation, Inc. Infant sleep pod
WO2020101017A1 (ja) * 2018-11-15 2020-05-22 国立大学法人九州大学 Ｉｌ－３１介在性疾患の予防又は治療剤及び医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99320A (en) 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676055B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2719311B1 (fr) 1994-03-18 1998-06-26 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR2738819B1 (fr) 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
AU4176997A (en) 1996-09-16 1998-04-02 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines

Also Published As

Publication number Publication date
EA003613B1 (ru) 2003-06-26
AR029148A1 (es) 2003-06-18
EP1119552A1 (fr) 2001-08-01
DZ2905A1 (fr) 2004-03-01
HUP0201709A3 (en) 2003-03-28
NZ510779A (en) 2003-07-25
KR20010085903A (ko) 2001-09-07
FR2784377A1 (fr) 2000-04-14
CN1329594A (zh) 2002-01-02
JP2002527423A (ja) 2002-08-27
NO20011779L (no) 2001-06-07
SK4642001A3 (en) 2001-09-11
FR2784377B3 (fr) 2000-11-17
TW539669B (en) 2003-07-01
CA2346729A1 (en) 2000-04-20
IS5897A (is) 2001-03-16
US6465489B1 (en) 2002-10-15
BR9914397A (pt) 2001-06-26
CN1133622C (zh) 2004-01-07
IL142362A0 (en) 2002-03-10
WO2000021931A1 (fr) 2000-04-20
AU5988799A (en) 2000-05-01
NO20011779D0 (no) 2001-04-06
PL347910A1 (en) 2002-04-22
AU751592B2 (en) 2002-08-22
EA200100299A1 (ru) 2001-10-22
CO5180555A1 (es) 2002-07-30
YU26001A (sh) 2003-04-30
EE200100214A (et) 2002-08-15
HUP0201709A2 (en) 2002-09-28

Similar Documents

Publication Publication Date Title
EA200101177A1 (ru) Производные индола в качестве антагонистов прогестерона
TR200101155T2 (tr) 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
IL140622A0 (en) Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
TR200101398T2 (tr) Pirolidin türevleri-CCR-3 reseptörü antagonistleri.
DK1337518T3 (da) Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
TR199801594A2 (tr) CCR-3 reseptör antagonistleri.
TR200101961T2 (tr) 1,2-halkalı kinolin türevleri
MXPA02009773A (es) Derivados de indolin-2-ona y su uso como ligandos de receptores de ocitocina.
PT1274687E (pt) Derivados de 1,2,3,4-tetra-hidroisoquinolina
EA200201179A1 (ru) Производные 2-аминокарбонил-9h-пурина
ATE478664T1 (de) Azaphenanthridone-derivate und deren verwendung als parp-inhibitoren
TR200101397T2 (tr) Piperidin CCR-3 reseptörü antagonistleri
BR0008056A (pt) Pirrolocarbazóis e isoindolonas cìclicas fundidas substituìdas
AR021811A1 (es) Compuestos de piridina fusionados, utiles como inhibidores de gmpc fosfodiesterasa y las composiciones farmaceuticas que las contienen.
EA200300580A1 (ru) Соединения лактама
DE69725825D1 (de) 5-HT1F-Agonisten
TR200101412T2 (tr) Yeni bileşikler.
SE9702773D0 (sv) Novel compounds
ATE374190T1 (de) Tetrahydrochinazolinderivate als cfr-antagonisten
EA200300593A1 (ru) Соединения пиперазинилпиразинов в качестве агонистов или антагонистов серотонин 5-ht2 рецептора
TR200002896T2 (tr) Kalsilitik Bileşimler
TR200402067T4 (tr) 1,3-Dihidro-2H-İndol-2-One türevleri ve bunların arjinin-vasopresin alıcılarının V1B veya V1B ve V1A ligandları olarak kullanımları
TR199902883T2 (tr) NK-2 ve NK-3 reseptör antagonistleri olarak kuinolin-4-karboksamid türevleri.
PL374019A1 (en) Benzoxazine derivatives as 5-ht6 modulators and uses thereof
TR200100462T2 (tr) Muskarinik agonistleri ve antagonistleri