HUP0002113A2 - 1-(2,6-Difluor-benzil)-14-1,2,3-triazolil-4-karboxamid kristálymódosulatai, alkalmazásuk és az azokat tartalmazó gyógyszerkészítmények - Google Patents

1-(2,6-Difluor-benzil)-14-1,2,3-triazolil-4-karboxamid kristálymódosulatai, alkalmazásuk és az azokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0002113A2
HUP0002113A2 HU0002113A HUP0002113A HUP0002113A2 HU P0002113 A2 HUP0002113 A2 HU P0002113A2 HU 0002113 A HU0002113 A HU 0002113A HU P0002113 A HUP0002113 A HU P0002113A HU P0002113 A2 HUP0002113 A2 HU P0002113A2
Authority
HU
Hungary
Prior art keywords
carboxamide
triazole
difluorobenzyl
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0002113A
Other languages
English (en)
Inventor
Andreas Burkhard
Urs Christoph Hofmeier
Robert Portmann
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0002113(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of HUP0002113A2 publication Critical patent/HUP0002113A2/hu
Publication of HUP0002113A3 publication Critical patent/HUP0002113A3/hu
Publication of HU225153B1 publication Critical patent/HU225153B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgyát 1-(2,6-difluor-benzil)-1H-1,2,3-triazol-4-karboxamid új B és C módosulatai, ezek felhasználása és az ezeket akristálymódosulatokat tartalmazó gyógyszerkészítmények képezik. Ó
HU0002113A 1997-06-10 1998-06-08 Crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide, their use and pharmaceutical compositions containing them HU225153B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (3)

Publication Number Publication Date
HUP0002113A2 true HUP0002113A2 (hu) 2001-02-28
HUP0002113A3 HUP0002113A3 (en) 2002-09-30
HU225153B1 HU225153B1 (en) 2006-07-28

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0000798A HU226107B1 (en) 1997-06-10 1998-06-08 New crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and pharmaceutical compositions containing them
HU0002113A HU225153B1 (en) 1997-06-10 1998-06-08 Crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide, their use and pharmaceutical compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0000798A HU226107B1 (en) 1997-06-10 1998-06-08 New crystal modifications of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and pharmaceutical compositions containing them

Country Status (37)

Country Link
US (6) US6740669B1 (hu)
EP (2) EP0994863B1 (hu)
JP (2) JP3672575B2 (hu)
KR (2) KR100425656B1 (hu)
CN (3) CN1132820C (hu)
AR (4) AR012945A1 (hu)
AT (2) ATE232852T1 (hu)
AU (2) AU725528B2 (hu)
BR (2) BR9804946A (hu)
CA (3) CA2256013C (hu)
CO (2) CO4940452A1 (hu)
CY (1) CY2007014I2 (hu)
CZ (2) CZ292481B6 (hu)
DE (3) DE69811500T2 (hu)
DK (2) DK0994863T3 (hu)
ES (2) ES2197485T3 (hu)
FR (1) FR07C0037I2 (hu)
HK (3) HK1028241A1 (hu)
HU (2) HU226107B1 (hu)
ID (2) ID21014A (hu)
IL (2) IL125733A (hu)
LU (1) LU91345I2 (hu)
MY (2) MY125854A (hu)
NL (1) NL300284I2 (hu)
NO (2) NO329314B1 (hu)
NZ (2) NZ331371A (hu)
PE (2) PE80999A1 (hu)
PL (2) PL191943B1 (hu)
PT (1) PT994864E (hu)
RU (2) RU2198167C2 (hu)
SI (2) SI0994863T1 (hu)
SK (2) SK283685B6 (hu)
TR (2) TR199801631T1 (hu)
TW (2) TW526195B (hu)
UY (1) UY25844A1 (hu)
WO (2) WO1998056772A1 (hu)
ZA (2) ZA984966B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
ATE390425T1 (de) * 2002-05-31 2008-04-15 Schering Corp Xanthin-phosphodiesterase-v-hemmer polymorphe
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
AU2009305255B2 (en) 2008-10-13 2014-02-06 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
RU2594155C2 (ru) * 2009-09-04 2016-08-10 Тэктикал Терапеутикс, Инк Новые композиции и способы получения 5-амино- или замещенных амино-1,2,3-триазолов и триазол-оротатных композиций
EP2563766B1 (en) * 2010-04-30 2014-06-25 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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JP2550456B2 (ja) 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
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US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
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Also Published As

Publication number Publication date
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
DE122007000051I2 (de) 2009-02-19
HU226107B1 (en) 2008-04-28
RU2198167C2 (ru) 2003-02-10
CA2256015C (en) 2008-06-03
PE79799A1 (es) 1999-09-03
ATE237599T1 (de) 2003-05-15
MY120156A (en) 2005-09-30
CO4940448A1 (es) 2000-07-24
CN1217716A (zh) 1999-05-26
AR061005A2 (es) 2008-07-30
IL125733A0 (en) 1999-04-11
KR19990087836A (ko) 1999-12-27
EP0994864A1 (en) 2000-04-26
WO1998056772A1 (en) 1998-12-17
CA2256015A1 (en) 1998-12-17
CA2614926C (en) 2010-02-09
PL330764A1 (en) 1999-05-24
HU225153B1 (en) 2006-07-28
US7750028B2 (en) 2010-07-06
FR07C0037I2 (hu) 2008-05-16
HUP0002113A3 (en) 2002-09-30
HUP0000798A3 (en) 2000-10-30
RU2194041C2 (ru) 2002-12-10
PL192114B1 (pl) 2006-08-31
JP3672575B2 (ja) 2005-07-20
AU8437198A (en) 1998-12-30
DE122007000051I1 (de) 2007-11-08
CN1298708C (zh) 2007-02-07
NZ331370A (en) 2000-08-25
TR199801630T1 (xx) 1999-06-21
NO983666L (no) 1998-12-17
CN1159300C (zh) 2004-07-28
TW526195B (en) 2003-04-01
AU725528B2 (en) 2000-10-12
SK109398A3 (en) 1998-12-02
KR100409168B1 (ko) 2004-01-31
LU91345I9 (hu) 2018-12-31
KR19990087835A (ko) 1999-12-27
ID21014A (id) 1999-04-08
NL300284I2 (nl) 2007-11-01
ES2192779T3 (es) 2003-10-16
CZ253498A3 (cs) 1999-04-14
DE69813560T2 (de) 2004-02-05
JP2000516259A (ja) 2000-12-05
EP0994864B1 (en) 2003-04-16
US6740669B1 (en) 2004-05-25
HK1028241A1 (en) 2001-02-09
EP0994863A1 (en) 2000-04-26
IL125732A0 (en) 1999-04-11
US8076362B2 (en) 2011-12-13
MY125854A (en) 2006-08-30
DK0994863T3 (da) 2003-05-26
US20060116520A1 (en) 2006-06-01
AR012945A1 (es) 2000-11-22
SK283685B6 (sk) 2003-12-02
CN1259127A (zh) 2000-07-05
ID27660A (id) 2001-04-19
NO329314B1 (no) 2010-09-27
NO329315B1 (no) 2010-09-27
ES2197485T3 (es) 2004-01-01
AU8437298A (en) 1998-12-30
US20040167186A1 (en) 2004-08-26
AR061004A2 (es) 2008-07-30
AU725517B2 (en) 2000-10-12
SI0994863T1 (en) 2003-08-31
EP0994863B1 (en) 2003-02-19
BR9804946A (pt) 1999-08-24
US6455556B2 (en) 2002-09-24
DE69811500T2 (de) 2004-04-01
DE69813560D1 (de) 2003-05-22
US20030125568A1 (en) 2003-07-03
TR199801631T1 (xx) 1999-06-21
PL330798A1 (en) 1999-06-07
IL125732A (en) 2002-12-01
KR100425656B1 (ko) 2004-05-17
SI0994864T1 (en) 2003-10-31
DE69811500D1 (de) 2003-03-27
CO4940452A1 (es) 2000-07-24
TW403740B (en) 2000-09-01
CY2007014I1 (el) 2009-11-04
AR012946A1 (es) 2000-11-22
NO983667L (no) 1998-12-17
PE80999A1 (es) 1999-09-06
JP2000516258A (ja) 2000-12-05
LU91345I2 (fr) 2007-09-04
CZ253398A3 (cs) 1999-04-14
CN1572789A (zh) 2005-02-02
UY25844A1 (es) 2001-08-27
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
CY2007014I2 (el) 2009-11-04
CA2256013C (en) 2007-10-16
BR9804947A (pt) 1999-08-24
ZA984967B (en) 1999-01-11
CA2256013A1 (en) 1998-12-17
NO983666D0 (no) 1998-08-11
HUP0000798A2 (hu) 2000-10-30
US20100310655A1 (en) 2010-12-09
HK1028031A1 (en) 2001-02-02
HK1028242A1 (en) 2001-02-09
FR07C0037I1 (hu) 2007-08-17
ATE232852T1 (de) 2003-03-15
PT994864E (pt) 2003-07-31
US20010037029A1 (en) 2001-11-01
PL191943B1 (pl) 2006-07-31
CN1132820C (zh) 2003-12-31
NZ331371A (en) 2000-08-25
SK109498A3 (en) 1998-12-02
JP3672574B2 (ja) 2005-07-20
CA2614926A1 (en) 1998-12-17
CZ292481B6 (cs) 2003-09-17
ZA984966B (en) 1999-01-11
IL125733A (en) 2002-12-01
DK0994864T3 (da) 2003-07-21
CZ292260B6 (cs) 2003-08-13

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