DK0994863T3 - Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel - Google Patents

Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel

Info

Publication number
DK0994863T3
DK0994863T3 DK98934929T DK98934929T DK0994863T3 DK 0994863 T3 DK0994863 T3 DK 0994863T3 DK 98934929 T DK98934929 T DK 98934929T DK 98934929 T DK98934929 T DK 98934929T DK 0994863 T3 DK0994863 T3 DK 0994863T3
Authority
DK
Denmark
Prior art keywords
difluorobenzyl
carboxamide
triazole
crystal modification
antiepileptic agent
Prior art date
Application number
DK98934929T
Other languages
English (en)
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0994863(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0994863T3 publication Critical patent/DK0994863T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98934929T 1997-06-10 1998-06-08 Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel DK0994863T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003427 WO1998056772A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic

Publications (1)

Publication Number Publication Date
DK0994863T3 true DK0994863T3 (da) 2003-05-26

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
DK98934929T DK0994863T3 (da) 1997-06-10 1998-06-08 Krystalmodifikation af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptisk middel
DK98934930T DK0994864T3 (da) 1997-06-10 1998-06-08 Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98934930T DK0994864T3 (da) 1997-06-10 1998-06-08 Krystalmodificering af 1-(2,6-difluorbenzyl)-1H-1,2,3-triazol-4-carboxamid og dets anvendelse som antiepileptikum

Country Status (37)

Country Link
US (6) US6740669B1 (da)
EP (2) EP0994863B1 (da)
JP (2) JP3672574B2 (da)
KR (2) KR100425656B1 (da)
CN (3) CN1298708C (da)
AR (4) AR012946A1 (da)
AT (2) ATE232852T1 (da)
AU (2) AU725528B2 (da)
BR (2) BR9804947A (da)
CA (3) CA2256013C (da)
CO (2) CO4940448A1 (da)
CY (1) CY2007014I1 (da)
CZ (2) CZ292481B6 (da)
DE (3) DE122007000051I2 (da)
DK (2) DK0994863T3 (da)
ES (2) ES2192779T3 (da)
FR (1) FR07C0037I2 (da)
HK (3) HK1028242A1 (da)
HU (2) HU225153B1 (da)
ID (2) ID27660A (da)
IL (2) IL125732A (da)
LU (1) LU91345I2 (da)
MY (2) MY120156A (da)
NL (1) NL300284I2 (da)
NO (2) NO329314B1 (da)
NZ (2) NZ331370A (da)
PE (2) PE79799A1 (da)
PL (2) PL192114B1 (da)
PT (1) PT994864E (da)
RU (2) RU2198167C2 (da)
SI (2) SI0994864T1 (da)
SK (2) SK283734B6 (da)
TR (2) TR199801631T1 (da)
TW (2) TW526195B (da)
UY (1) UY25844A1 (da)
WO (2) WO1998056772A1 (da)
ZA (2) ZA984967B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
DE60319980T2 (de) * 2002-05-31 2009-04-16 Schering Corporation Xanthin-phosphodiesterase-v-hemmer polymorphe
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
CA2736703A1 (en) 2008-10-13 2010-04-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
CN104817507A (zh) * 2009-09-04 2015-08-05 巧妙疗法股份有限公司 用于制备5-氨基或取代的氨基1,2,3-三唑和三唑乳清酸盐制剂的新组合物和方法
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
JP2013525413A (ja) * 2010-04-30 2013-06-20 ラボラトリオス レスヴィ，エス．エル． ルフィナマイド中間体の改良された製造方法
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
FI834666A (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
US5283244A (en) 1990-11-06 1994-02-01 Yamanouchi Pharmaceutical Co., Ltd. Fused pyrazine derivatives
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
DK0812320T3 (da) 1995-02-22 2003-04-14 Aventis Pharma Ltd Amorft piretanid, polymorfe former deraf, fremgangsmåde til fremstilling deraf og deres anvendelse
SK283990B6 (sk) * 1996-07-11 2004-07-07 Novartis Ag Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
CA2256015A1 (en) 1998-12-17
SK109498A3 (en) 1998-12-02
TR199801631T1 (xx) 1999-06-21
LU91345I2 (fr) 2007-09-04
HU225153B1 (en) 2006-07-28
WO1998056772A1 (en) 1998-12-17
ES2197485T3 (es) 2004-01-01
EP0994863A1 (en) 2000-04-26
KR100409168B1 (ko) 2004-01-31
PL330798A1 (en) 1999-06-07
DE122007000051I2 (de) 2009-02-19
DE122007000051I1 (de) 2007-11-08
CZ292260B6 (cs) 2003-08-13
CZ253498A3 (cs) 1999-04-14
IL125732A (en) 2002-12-01
ZA984966B (en) 1999-01-11
MY125854A (en) 2006-08-30
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
NO983666L (no) 1998-12-17
HUP0000798A2 (hu) 2000-10-30
CN1217716A (zh) 1999-05-26
CA2614926C (en) 2010-02-09
US20010037029A1 (en) 2001-11-01
HK1028242A1 (en) 2001-02-09
HU226107B1 (en) 2008-04-28
TW403740B (en) 2000-09-01
CZ292481B6 (cs) 2003-09-17
CA2256013C (en) 2007-10-16
IL125733A (en) 2002-12-01
AR061005A2 (es) 2008-07-30
US20060116520A1 (en) 2006-06-01
US6740669B1 (en) 2004-05-25
TR199801630T1 (xx) 1999-06-21
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
CN1298708C (zh) 2007-02-07
KR19990087835A (ko) 1999-12-27
IL125733A0 (en) 1999-04-11
ATE232852T1 (de) 2003-03-15
US6455556B2 (en) 2002-09-24
HK1028241A1 (en) 2001-02-09
NO329315B1 (no) 2010-09-27
KR100425656B1 (ko) 2004-05-17
HUP0002113A2 (hu) 2001-02-28
AR012945A1 (es) 2000-11-22
JP2000516258A (ja) 2000-12-05
KR19990087836A (ko) 1999-12-27
CA2614926A1 (en) 1998-12-17
RU2194041C2 (ru) 2002-12-10
IL125732A0 (en) 1999-04-11
ES2192779T3 (es) 2003-10-16
CZ253398A3 (cs) 1999-04-14
US20100310655A1 (en) 2010-12-09
BR9804946A (pt) 1999-08-24
ID27660A (id) 2001-04-19
SI0994864T1 (en) 2003-10-31
DE69813560D1 (de) 2003-05-22
AR061004A2 (es) 2008-07-30
DE69813560T2 (de) 2004-02-05
CN1572789A (zh) 2005-02-02
HK1028031A1 (en) 2001-02-02
LU91345I9 (da) 2018-12-31
SK283685B6 (sk) 2003-12-02
CN1132820C (zh) 2003-12-31
TW526195B (en) 2003-04-01
ZA984967B (en) 1999-01-11
FR07C0037I1 (da) 2007-08-17
AU8437198A (en) 1998-12-30
CY2007014I2 (el) 2009-11-04
AU725528B2 (en) 2000-10-12
EP0994864A1 (en) 2000-04-26
PL330764A1 (en) 1999-05-24
CO4940452A1 (es) 2000-07-24
PT994864E (pt) 2003-07-31
EP0994863B1 (en) 2003-02-19
EP0994864B1 (en) 2003-04-16
US20040167186A1 (en) 2004-08-26
JP3672574B2 (ja) 2005-07-20
SI0994863T1 (en) 2003-08-31
SK109398A3 (en) 1998-12-02
NZ331370A (en) 2000-08-25
ATE237599T1 (de) 2003-05-15
NO983667L (no) 1998-12-17
MY120156A (en) 2005-09-30
CN1259127A (zh) 2000-07-05
DE69811500D1 (de) 2003-03-27
PL191943B1 (pl) 2006-07-31
PE79799A1 (es) 1999-09-03
HUP0000798A3 (en) 2000-10-30
DE69811500T2 (de) 2004-04-01
AU725517B2 (en) 2000-10-12
US8076362B2 (en) 2011-12-13
PE80999A1 (es) 1999-09-06
US20030125568A1 (en) 2003-07-03
RU2198167C2 (ru) 2003-02-10
ID21014A (id) 1999-04-08
FR07C0037I2 (da) 2008-05-16
CN1159300C (zh) 2004-07-28
NL300284I2 (nl) 2007-11-01
NO329314B1 (no) 2010-09-27
NZ331371A (en) 2000-08-25
NO983666D0 (no) 1998-08-11
CY2007014I1 (el) 2009-11-04
CO4940448A1 (es) 2000-07-24
AU8437298A (en) 1998-12-30
JP3672575B2 (ja) 2005-07-20
DK0994864T3 (da) 2003-07-21
HUP0002113A3 (en) 2002-09-30
UY25844A1 (es) 2001-08-27
BR9804947A (pt) 1999-08-24
CA2256015C (en) 2008-06-03
PL192114B1 (pl) 2006-08-31
JP2000516259A (ja) 2000-12-05
CA2256013A1 (en) 1998-12-17
US7750028B2 (en) 2010-07-06
AR012946A1 (es) 2000-11-22

Similar Documents

Publication Publication Date Title
NL300284I1 (nl) Kristalmodificatie van 1-(2,6-difluorbenzyl)1H-1,2,3-triazool-4-carboxamide en de toepassing daarvanals anti-epilepticum.
NO993522D0 (no) 4-(3-heterocyclyl-1-benzoyl)pyrazoler og anvendelse derav som herbisider
NO993646D0 (no) Tiazol benzensulfonamider som <beta>3-agonister for behandling av diabetes og fedme
DZ2936A1 (fr) Composition nouvelle à libération modifiée pour letraitement du diabète.
NO986024L (no) Substituerte 3,5-difenyl-1,2,4-triazoler og deres anvendelse som farmas°ytiske metallchelatorer
DK2036581T3 (da) Sårforbindinger og egnede materialer til anvendelse deri
ZA200306488B (en) Benzamides and related inhibitors of factor Xa.
NO996266D0 (no) Behandling av diabetes tiazolidindion og metformin
NO20001602L (no) Visittkortagent
DE59904547D1 (de) Diacylhydrazinderivate als integrin-inhibitoren
NO20002181D0 (no) Steriliseringsinnpakning, anvendelse derav og fremgangsmÕte for sterilisering
DK0984960T3 (da) N-triazol-2-indolcarboxamider og deres anvendelse som CCK-A-agonister
NO20012727D0 (no) 3,4,5-trisubstituerte arylnitronforbindelser og farmasöytiske sammensetninger som inneholder samme
NO20001196D0 (no) Nootropisk middel
DK1140952T3 (da) Phosphororganiske forbindelser og anvendelse heraf
NO981253L (no) Forsterkende middel
NO932315D0 (no) Overflateaktivt middel, fremgangsmaate ved dets fremstilling og anvendelse
FR2720276B1 (fr) Nouvelle utilisation thérapeutique des agents bétamimétiques et médicament en contenant.
IT237481Y1 (it) Aggiuntivi intercambiabili e ribaltabili per occhiali
NO20014300D0 (no) Nytt protein og dets anvendelse
IL137738A0 (en) 1-(cbz-leucinyl-amino)-3-(n-sulfonyl-amino)-propan-2-one cysteine protease inhibitors
DK1009400T3 (da) Kombinationsterapi, der omfatter atorvastatin og et antihypertensivt middel