IT1255258B - Composizioni farmaceutiche per l'applicazione per via nasale. - Google Patents

Composizioni farmaceutiche per l'applicazione per via nasale.

Info

Publication number
IT1255258B
IT1255258B ITRM910696A ITRM910696A IT1255258B IT 1255258 B IT1255258 B IT 1255258B IT RM910696 A ITRM910696 A IT RM910696A IT RM910696 A ITRM910696 A IT RM910696A IT 1255258 B IT1255258 B IT 1255258B
Authority
IT
Italy
Prior art keywords
pharmaceutical compositions
nasal application
nasal
application
hpth
Prior art date
Application number
ITRM910696A
Other languages
English (en)
Inventor
Francois Cardinaux
Christine Oechslein
Andreas Rummelt
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of ITRM910696A0 publication Critical patent/ITRM910696A0/it
Publication of ITRM910696A1 publication Critical patent/ITRM910696A1/it
Application granted granted Critical
Publication of IT1255258B publication Critical patent/IT1255258B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invenzione riguarda una composizione farmaceutica adattata per la somministrazione per via nasale e comprendente l'hPTH o un frammento N-terminale di questo composto. I veicoli preferiti sono le cellulose eventualmente rivestite.
ITRM910696A 1990-09-20 1991-09-18 Composizioni farmaceutiche per l'applicazione per via nasale. IT1255258B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909020544A GB9020544D0 (en) 1990-09-20 1990-09-20 Improvements in or relating to organic compounds

Publications (3)

Publication Number Publication Date
ITRM910696A0 ITRM910696A0 (it) 1991-09-18
ITRM910696A1 ITRM910696A1 (it) 1993-03-18
IT1255258B true IT1255258B (it) 1995-10-20

Family

ID=10682494

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910696A IT1255258B (it) 1990-09-20 1991-09-18 Composizioni farmaceutiche per l'applicazione per via nasale.

Country Status (21)

Country Link
US (1) US5578567A (it)
EP (2) EP0672682A1 (it)
JP (1) JPH04247034A (it)
KR (1) KR920006003A (it)
AT (1) ATA189691A (it)
AU (1) AU8464791A (it)
CA (1) CA2051721A1 (it)
CH (1) CH683749A5 (it)
CS (1) CS285491A3 (it)
DE (1) DE4131232A1 (it)
FI (1) FI914398A7 (it)
FR (2) FR2666987A1 (it)
GB (2) GB9020544D0 (it)
IE (1) IE913296A1 (it)
IL (1) IL99521A0 (it)
IT (1) IT1255258B (it)
LU (1) LU88006A1 (it)
MX (1) MX9101175A (it)
NO (1) NO913668D0 (it)
PT (1) PT99007A (it)
ZA (1) ZA917528B (it)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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JP3090353B2 (ja) * 1991-09-17 2000-09-18 旭化成工業株式会社 パラチロイドホルモン類含有経鼻投与用乳剤
KR0131678B1 (ko) * 1991-12-09 1998-04-17 유미꾸라 레이이찌 파라티로이드 호르몬류의 안정화 조성물
DE4203040A1 (de) * 1992-02-04 1993-08-05 Boehringer Mannheim Gmbh Neue parathormonfragmente, deren herstellung und diese enthaltende arzneimittel
CA2094217A1 (en) * 1992-04-17 1993-10-18 Yasutaka Igari Transmucosal therapeutic composition
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
GB2269992A (en) * 1992-08-14 1994-03-02 Rh Ne Poulenc Rorer Limited Powder inhalation formulations
NZ257212A (en) 1992-09-29 1996-11-26 Inhale Therapeutic Syst Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
HU218940B (hu) * 1994-12-22 2001-01-29 Astra Aktiebolag Paratiroid hormont (PHT) tartalmazó, inhalációs célra szolgáló gyógyszerkészítmény, eljárás előállítására, alkalmazása inhalációs készülék töltésére és ezt tartalmazó inhalációs készülék
JP3098401B2 (ja) * 1995-07-12 2000-10-16 株式会社エルティーティー研究所 経鼻投与用製剤
JP3263598B2 (ja) * 1995-11-01 2002-03-04 有限会社ドット 経鼻吸収用生理活性ペプチド組成物
CA2208336A1 (en) * 1996-06-20 1997-12-20 Hisamitsu Pharmaceuticals Co., Inc. A device structure for iontophoresis
TW505654B (en) * 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
AU8356198A (en) * 1997-07-22 1999-02-16 Chugai Seiyaku Kabushiki Kaisha Dental remedies containing pth
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
WO1999006563A1 (en) 1997-07-30 1999-02-11 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
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US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
DE19756314C2 (de) * 1997-12-12 2000-06-29 Roland Bodmeier Zubereitung mit verlängerter Verweildauer am Applikationsort
JPH11246439A (ja) * 1998-03-02 1999-09-14 Hisamitsu Pharmaceut Co Inc 経粘膜用吸収促進剤
EP1079801A1 (en) * 1998-05-20 2001-03-07 Highchem Company., Ltd. A pharmaceutical formulation for nasal administration
CN1065141C (zh) * 1998-05-20 2001-05-02 北京金源东和化学有限责任公司 通过鼻粘膜给药的药物制剂
US6150420A (en) * 1998-06-01 2000-11-21 Theramax, Inc. Method for enhanced brain delivery of bupropion
AU762145C (en) * 1998-08-26 2005-03-17 Teijin Limited Powdery pernasal compositions
JP2000239187A (ja) 1999-02-22 2000-09-05 Dotto:Kk 経鼻吸収用組成物
JP2000247911A (ja) 1999-02-26 2000-09-12 Hisamitsu Pharmaceut Co Inc 大腸用吸収促進剤
ES2226843T3 (es) * 1999-05-03 2005-04-01 Battelle Memorial Institute Composiciones para dispersion por aerosol e inhalacion.
US6197328B1 (en) * 1999-08-20 2001-03-06 Dott Research Laboratory Nasally administrable compositions
ES2166278B2 (es) * 1999-09-14 2003-06-16 Univ Madrid Complutense Procedimiento de preparacion de polvos nasales por atomizacion utilizando excipientes insolubles y absorbentes como promotores de absorcion nasal.
CA2405169C (en) * 2000-04-03 2011-07-26 Battelle Memorial Institute Devices and formulations
AU2001267887B2 (en) 2000-06-30 2007-02-15 Asubio Pharma Co., Ltd. Medicinal components comprising human parathyroid hormone and medicinal compositions for nasal administration containing the components
EP1343521A2 (en) 2000-12-01 2003-09-17 Battelle Memorial Institute Method for the stabilizing biomolecules (e.g. insulin) in liquid formulations
DE10120200B4 (de) * 2001-04-24 2005-12-22 Infood Gmbh Schnupfpulver als Schnupftabakersatz
JP2005531570A (ja) * 2002-05-23 2005-10-20 ユーエムディー， インコーポレイテッド 貫粘膜薬物送達及び凍結保護のための組成物及び方法
US7273889B2 (en) * 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
AU2003286472A1 (en) * 2002-10-17 2004-05-04 Alkermes Controlled Therapeutics, Inc. Ii Microencapsulation and sustained release of biologically active polypeptides
GB0304636D0 (en) * 2003-02-28 2003-04-02 Britannia Pharmaceuticals Ltd Pharmaceutical composition for nasal delivery
US7683029B2 (en) * 2003-05-07 2010-03-23 Philip Morris Usa Inc. Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin
US20060052306A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. GRAS composition for enhanced mucosal delivery of parathyroid hormone
EP1750756A2 (en) 2004-05-10 2007-02-14 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
US20060189533A1 (en) * 2004-05-10 2006-08-24 Nastech Pharmaceutical Company Inc. Stable pharmaceutical dosage forms of teriparatide
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US7906137B2 (en) * 2004-05-21 2011-03-15 Mediplex Corporation, Korea Delivery agents for enhancing mucosal absorption of therapeutic agents
AU2005260834A1 (en) * 2004-07-14 2006-01-19 Chugai Seiyaku Kabushiki Kaisha PTH-containing preparation for transmucosal administration
US20060069021A1 (en) * 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
US20090136505A1 (en) 2005-02-23 2009-05-28 Johanna Bentz Intranasal Administration of Active Agents to the Central Nervous System
JP2008531560A (ja) * 2005-02-23 2008-08-14 アルザ・コーポレーシヨン 中枢神経系への有効成分の鼻内投与
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WO2007044375A2 (en) * 2005-10-06 2007-04-19 Nastech Pharmaceutical Company Inc. Pth formulations and methods of use
WO2007044069A2 (en) * 2005-10-06 2007-04-19 Nastech Pharmaceutical Company Inc. Pth formulations and methods of use
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
CN101355959B (zh) 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20080119408A1 (en) * 2006-07-07 2008-05-22 Nastech Pharmaceutical Company Inc. Pth formulations for intranasal delivery
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US8987201B2 (en) 2009-12-07 2015-03-24 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
KR20130010462A (ko) * 2010-03-19 2013-01-28 다이이찌 산쿄 가부시키가이샤 경비 투여용 조성물 및 그 제조 방법
US10723716B2 (en) 2016-12-21 2020-07-28 New York University Alpha-helix mimetics as modulators of Abeta self-assembly
US11124479B2 (en) 2017-07-14 2021-09-21 New York University Oligopyrroles as antagonists of islet amyloid polypeptide oligomerization
US10500197B2 (en) 2017-07-18 2019-12-10 New York University Use of oligopyridylamides to inhibit mutant p53 amyloid formation and restore its tumor suppressor function
WO2021229835A1 (ja) * 2020-05-11 2021-11-18 旭化成ファーマ株式会社 テリパラチド又はその塩を含有する安定な液状医薬製剤
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Also Published As

Publication number Publication date
GB9120024D0 (en) 1991-11-06
US5578567A (en) 1996-11-26
PT99007A (pt) 1992-08-31
DE4131232A1 (de) 1992-03-26
CA2051721A1 (en) 1992-03-21
IL99521A0 (en) 1992-08-18
LU88006A1 (fr) 1993-04-15
FI914398A0 (fi) 1991-09-18
EP0490806A2 (en) 1992-06-17
ITRM910696A0 (it) 1991-09-18
CH683749A5 (de) 1994-05-13
ZA917528B (en) 1993-03-22
FR2681326B1 (fr) 1995-06-16
GB9020544D0 (en) 1990-10-31
IE913296A1 (en) 1992-02-25
AU8464791A (en) 1992-03-26
EP0672682A1 (en) 1995-09-20
MX9101175A (es) 1992-05-04
NO913668D0 (no) 1991-09-18
ITRM910696A1 (it) 1993-03-18
EP0490806A3 (en) 1992-09-23
FI914398L (fi) 1992-03-21
JPH04247034A (ja) 1992-09-03
FR2666987A1 (fr) 1992-03-27
KR920006003A (ko) 1992-04-27
ATA189691A (de) 1997-10-15
GB2248550B (en) 1995-04-05
CS285491A3 (en) 1992-04-15
GB2248550A (en) 1992-04-15
FI914398A7 (fi) 1992-03-21
FR2681326A1 (fr) 1993-03-19

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Effective date: 19970714