DK0975602T3 - Imidazol- og imidazolinderivater samt anvendelse heraf - Google Patents

Imidazol- og imidazolinderivater samt anvendelse heraf

Info

Publication number
DK0975602T3
DK0975602T3 DK98915550T DK98915550T DK0975602T3 DK 0975602 T3 DK0975602 T3 DK 0975602T3 DK 98915550 T DK98915550 T DK 98915550T DK 98915550 T DK98915550 T DK 98915550T DK 0975602 T3 DK0975602 T3 DK 0975602T3
Authority
DK
Denmark
Prior art keywords
imidazoline derivatives
imidazole
compounds
receptors
alpha2
Prior art date
Application number
DK98915550T
Other languages
English (en)
Inventor
Wai C Wong
Charles Gluchowski
Yoon T Jeon
T G Murali Dhar
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK0975602T3 publication Critical patent/DK0975602T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
DK98915550T 1997-04-11 1998-04-10 Imidazol- og imidazolinderivater samt anvendelse heraf DK0975602T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/834,658 US5866579A (en) 1997-04-11 1997-04-11 Imidazole and imidazoline derivatives and uses thereof
PCT/US1998/007453 WO1998046572A1 (en) 1997-04-11 1998-04-10 Imidazole and imidazoline derivatives and uses thereof
EP98915550A EP0975602B1 (en) 1997-04-11 1998-04-10 Imidazole and imidazoline derivatives and uses thereof

Publications (1)

Publication Number Publication Date
DK0975602T3 true DK0975602T3 (da) 2005-10-17

Family

ID=25267478

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98915550T DK0975602T3 (da) 1997-04-11 1998-04-10 Imidazol- og imidazolinderivater samt anvendelse heraf

Country Status (11)

Country Link
US (4) US5866579A (da)
EP (1) EP0975602B1 (da)
AT (1) ATE297899T1 (da)
AU (1) AU6970598A (da)
DE (1) DE69830576T2 (da)
DK (1) DK0975602T3 (da)
ES (1) ES2245029T3 (da)
HK (1) HK1026892A1 (da)
PT (1) PT975602E (da)
SI (1) SI0975602T1 (da)
WO (1) WO1998046572A1 (da)

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US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6410562B1 (en) 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
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FR2846328B1 (fr) * 2002-10-23 2004-12-10 Servier Lab Nouveaux derives de l'imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP1562786A2 (en) * 2002-11-20 2005-08-17 Johnson Controls Technology Company Covered illuminated vanity mirror assembly
US20060293359A1 (en) * 2003-06-25 2006-12-28 Allergan, Inc. Methods and compositions for the treatment of diabetes
US20050059664A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Novel methods for identifying improved, non-sedating alpha-2 agonists
FR2858619B1 (fr) * 2003-08-08 2006-12-22 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US7348434B2 (en) 2003-08-08 2008-03-25 Antony Bigot 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
US20050058696A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
CA2593788A1 (en) * 2005-01-28 2006-08-10 Merck And Co., Inc. Antidiabetic bicyclic compounds
BRPI0615307A2 (pt) * 2005-08-25 2009-08-04 Schering Corp agonistas de adrenorreceptor alfa2c
JP2009524619A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のための２−イミダゾールの使用
EP2076496B1 (en) * 2006-10-19 2010-03-31 F. Hoffmann-Roche AG Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors
CA2666762C (en) * 2006-10-19 2014-12-30 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
JP5064511B2 (ja) 2006-11-02 2012-10-31 エフ．ホフマン−ラ ロシュ アーゲー 痕跡アミン関連受容体調節剤としての置換２−イミダゾール
RU2456281C2 (ru) * 2006-11-16 2012-07-20 Ф. Хоффманн-Ля Рош Аг Замещенные 4-имидазолы, способ их получения и их применение
AU2007332641A1 (en) * 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR)
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US8119807B2 (en) 2007-01-12 2012-02-21 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
US8013169B2 (en) 2007-01-12 2011-09-06 Allergan, Inc Naphthylmethylimidizoles as therapeutic agents
WO2008088936A1 (en) 2007-01-12 2008-07-24 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
RU2473545C2 (ru) * 2007-02-02 2013-01-27 Ф.Хоффманн-Ля Рош Аг Новые 2-аминооксазолины в качестве лигандов taar1 для заболеваний цнс
KR101335845B1 (ko) * 2007-02-15 2013-12-02 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
BRPI0812840A2 (pt) 2007-07-02 2014-12-09 Hoffmann La Roche 2-imidazolinas
JP2010531836A (ja) * 2007-07-03 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー ４−イミダゾリン及びそれらの抗うつ剤としての使用
KR101133862B1 (ko) * 2007-07-27 2012-04-06 에프. 호프만-라 로슈 아게 Ｔａａｒ 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민
CA2695071A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of cns disorders
WO2009019149A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
RU2491284C2 (ru) * 2007-08-15 2013-08-27 Аллерган, Инк. Адренергические соединения
US20090286829A1 (en) * 2008-05-13 2009-11-19 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
PE20110215A1 (es) * 2008-07-24 2011-03-31 Hoffmann La Roche Derivados de 4,5-dihidro-oxazol-2-ilo
AU2010210513A1 (en) * 2009-02-06 2011-09-01 Allergan, Inc. Pyridine compounds as subtype selective modulators of alpha2B and/or alpha 2C adrenergic receptors
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
JP6052685B2 (ja) 2011-07-25 2016-12-27 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ α２アドレナリン受容体の調節因子としてのＮ−（イミダゾリジン−２−イリデン）−ヘテロシクロペンタ［ｂ］ピリジン誘導体
CN104507913B (zh) 2012-07-13 2017-07-28 霍夫曼-拉罗奇有限公司 抗增殖的苯并[b]氮杂*‑2‑酮
MY195528A (en) 2016-03-17 2023-01-30 Hoffmann La Roche 5-Ethyl-4-Methyl-Pyrazole-3-Carboxamide Derivative Having Activity as Agonist of Taar

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Also Published As

Publication number Publication date
US20020019390A1 (en) 2002-02-14
US6777426B2 (en) 2004-08-17
ES2245029T3 (es) 2005-12-16
US6093727A (en) 2000-07-25
WO1998046572A1 (en) 1998-10-22
US5866579A (en) 1999-02-02
EP0975602A1 (en) 2000-02-02
DE69830576D1 (de) 2005-07-21
AU6970598A (en) 1998-11-11
EP0975602B1 (en) 2005-06-15
EP0975602A4 (en) 2003-01-22
DE69830576T2 (de) 2006-05-04
HK1026892A1 (en) 2000-12-29
SI0975602T1 (sl) 2005-12-31
ATE297899T1 (de) 2005-07-15
US6294566B1 (en) 2001-09-25
PT975602E (pt) 2005-10-31

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