ATE297899T1 - Imidazol und imidazolderivate und ihre verwendung - Google Patents
Imidazol und imidazolderivate und ihre verwendungInfo
- Publication number
- ATE297899T1 ATE297899T1 AT98915550T AT98915550T ATE297899T1 AT E297899 T1 ATE297899 T1 AT E297899T1 AT 98915550 T AT98915550 T AT 98915550T AT 98915550 T AT98915550 T AT 98915550T AT E297899 T1 ATE297899 T1 AT E297899T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazole
- derivatives
- compounds
- receptors
- alpha2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epoxy Resins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/834,658 US5866579A (en) | 1997-04-11 | 1997-04-11 | Imidazole and imidazoline derivatives and uses thereof |
PCT/US1998/007453 WO1998046572A1 (en) | 1997-04-11 | 1998-04-10 | Imidazole and imidazoline derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE297899T1 true ATE297899T1 (de) | 2005-07-15 |
Family
ID=25267478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98915550T ATE297899T1 (de) | 1997-04-11 | 1998-04-10 | Imidazol und imidazolderivate und ihre verwendung |
Country Status (11)
Country | Link |
---|---|
US (4) | US5866579A (de) |
EP (1) | EP0975602B1 (de) |
AT (1) | ATE297899T1 (de) |
AU (1) | AU6970598A (de) |
DE (1) | DE69830576T2 (de) |
DK (1) | DK0975602T3 (de) |
ES (1) | ES2245029T3 (de) |
HK (1) | HK1026892A1 (de) |
PT (1) | PT975602E (de) |
SI (1) | SI0975602T1 (de) |
WO (1) | WO1998046572A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
US6410562B1 (en) | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
ES2278016T3 (es) * | 2001-04-09 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r). |
FR2846328B1 (fr) * | 2002-10-23 | 2004-12-10 | Servier Lab | Nouveaux derives de l'imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
JP2006506275A (ja) * | 2002-11-20 | 2006-02-23 | ジョンソン コントロールズ テクノロジー カンパニー | カバー付き照明付きバニティミラー組立体 |
US20060293359A1 (en) * | 2003-06-25 | 2006-12-28 | Allergan, Inc. | Methods and compositions for the treatment of diabetes |
US20050059664A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Novel methods for identifying improved, non-sedating alpha-2 agonists |
US7348434B2 (en) | 2003-08-08 | 2008-03-25 | Antony Bigot | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
FR2858619B1 (fr) * | 2003-08-08 | 2006-12-22 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
US20050058696A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
CN101106991A (zh) * | 2005-01-28 | 2008-01-16 | 默克公司 | 抗糖尿病的双环化合物 |
RU2008110908A (ru) * | 2005-08-25 | 2009-09-27 | Шеринг Корпорейшн (US) | Производные имидазола в качестве функционально селективных агонистов альфа2с адренорецепторов |
KR20080090546A (ko) * | 2006-01-27 | 2008-10-08 | 에프. 호프만-라 로슈 아게 | Cns 장애 치료용 2-이미다졸의 용도 |
KR101176699B1 (ko) * | 2006-10-19 | 2012-08-23 | 에프. 호프만-라 로슈 아게 | 아미노메틸-4-이미다졸 |
RU2009112495A (ru) * | 2006-10-19 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Аминометил-2-имидазолы со сродством к рецепторам, ассоциированным со следовыми аминами |
WO2008052907A1 (en) | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles as modulators of the trace amine associated receptors |
CN101535298A (zh) * | 2006-11-16 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | 取代的4-咪唑类化合物 |
WO2008071574A1 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) |
US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
WO2008086131A1 (en) | 2007-01-12 | 2008-07-17 | Allergan, Inc. | Naphthylmethylimidizoles as therapeutic agents |
WO2008088937A1 (en) * | 2007-01-12 | 2008-07-24 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
US7868020B2 (en) | 2007-01-12 | 2011-01-11 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
CA2675221C (en) * | 2007-02-02 | 2016-02-23 | F. Hoffmann-La Roche Ag | Novel 2-aminooxazolines as taar1 ligands |
CA2676944C (en) * | 2007-02-15 | 2016-01-19 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
CA2691082A1 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (taars) |
WO2009003867A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
KR101133862B1 (ko) * | 2007-07-27 | 2012-04-06 | 에프. 호프만-라 로슈 아게 | Taar 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민 |
CA2695071A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of cns disorders |
EP2185502A1 (de) * | 2007-08-03 | 2010-05-19 | F. Hoffmann-Roche AG | Pyridincarboxamid- und benzamidderivate als taar1-liganden |
KR101642520B1 (ko) * | 2007-08-15 | 2016-07-25 | 알러간, 인코포레이티드 | 아드레날린성 화합물 |
EP2296655A1 (de) * | 2008-05-13 | 2011-03-23 | Allergan, Inc. | Chinolynylmethylimidizole als therapeutika |
BRPI0916363A2 (pt) * | 2008-07-24 | 2018-05-29 | Hoffmann La Roche | derivados de 4,5-di-hidro-oxazol-2-ila |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
CA2751651A1 (en) * | 2009-02-06 | 2010-08-12 | Allergan, Inc. | Pyridine compounds as subtype selective modulators of alpha2b and/or alpha 2c adrenergic receptors |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
RU2014106367A (ru) | 2011-07-25 | 2015-08-27 | Аллерган, Инк. | N-(ИМИДАЗОЛИДИН-2-ИЛИДЕН)-ГЕТЕРОЦИКЛОПЕНТА[b]ПИРИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ АЛЬФА 2 АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ |
WO2014009495A1 (en) | 2012-07-13 | 2014-01-16 | F. Hoffmann-La Roche Ag | Antiproliferative benzo [b] azepin- 2 - ones |
LT3430010T (lt) | 2016-03-17 | 2020-10-12 | F. Hoffmann-La Roche Ag | 5-etil-4-metil-pirazol-3-karboksamido darinys, galintis veikti kaip taar agonistas |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3288805A (en) * | 1966-11-29 | Amino-eviid azoline | ||
US3636219A (en) * | 1964-03-02 | 1972-01-18 | Du Pont | Anticholinergic compositions containing certain thiazolines or imidazolines |
CH632268A5 (de) * | 1977-01-14 | 1982-09-30 | Sandoz Ag | Verfahren zur herstellung von neuen heterocyclylaminoderivaten. |
NL7711390A (nl) * | 1977-10-18 | 1979-04-20 | Philips Nv | Nieuwe 2-arylimino-hexahydopyrimidinen en - imi- dazolidinen, zouten en complexen daarvan, werk- wijze ter bereiding van de nieuwe verbindingen, alsmede fungicide preparaten op basis van de nieuwe verbindingen. |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
JPH06507392A (ja) * | 1991-02-26 | 1994-08-25 | エイアールシー 1,インコーポレイテッド | 交感神経性の持続性疼痛の治療のための組成物および方法 |
US5663189A (en) * | 1993-07-01 | 1997-09-02 | The Procter & Gamble Company | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists |
US5389638A (en) * | 1993-09-10 | 1995-02-14 | Abbott Laboratories | Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors |
JP3805360B2 (ja) * | 1994-01-24 | 2006-08-02 | アラーガン、インコーポレイテッド | α▲下2A▼アドレナリン受容体作動剤としての芳香族2−アミノ−イミダゾール誘導体 |
US5684031A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
JP2001506981A (ja) * | 1996-11-25 | 2001-05-29 | ザ プロクター アンド ギャンブル カンパニー | α―2アドレナリン受容体作動薬として有用な2―イミダゾリニルアミノインドール化合物 |
-
1997
- 1997-04-11 US US08/834,658 patent/US5866579A/en not_active Expired - Fee Related
-
1998
- 1998-04-10 WO PCT/US1998/007453 patent/WO1998046572A1/en active IP Right Grant
- 1998-04-10 EP EP98915550A patent/EP0975602B1/de not_active Expired - Lifetime
- 1998-04-10 ES ES98915550T patent/ES2245029T3/es not_active Expired - Lifetime
- 1998-04-10 AT AT98915550T patent/ATE297899T1/de not_active IP Right Cessation
- 1998-04-10 SI SI9830790T patent/SI0975602T1/sl unknown
- 1998-04-10 AU AU69705/98A patent/AU6970598A/en not_active Abandoned
- 1998-04-10 DE DE69830576T patent/DE69830576T2/de not_active Expired - Fee Related
- 1998-04-10 DK DK98915550T patent/DK0975602T3/da active
- 1998-04-10 PT PT98915550T patent/PT975602E/pt unknown
- 1998-10-20 US US09/175,253 patent/US6093727A/en not_active Expired - Fee Related
-
1999
- 1999-09-20 US US09/398,861 patent/US6294566B1/en not_active Expired - Fee Related
-
2000
- 2000-08-02 HK HK00104824A patent/HK1026892A1/xx not_active IP Right Cessation
-
2001
- 2001-08-20 US US09/933,106 patent/US6777426B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0975602A4 (de) | 2003-01-22 |
SI0975602T1 (sl) | 2005-12-31 |
EP0975602B1 (de) | 2005-06-15 |
ES2245029T3 (es) | 2005-12-16 |
US6294566B1 (en) | 2001-09-25 |
DK0975602T3 (da) | 2005-10-17 |
PT975602E (pt) | 2005-10-31 |
HK1026892A1 (en) | 2000-12-29 |
AU6970598A (en) | 1998-11-11 |
EP0975602A1 (de) | 2000-02-02 |
US20020019390A1 (en) | 2002-02-14 |
WO1998046572A1 (en) | 1998-10-22 |
US5866579A (en) | 1999-02-02 |
US6093727A (en) | 2000-07-25 |
DE69830576D1 (de) | 2005-07-21 |
DE69830576T2 (de) | 2006-05-04 |
US6777426B2 (en) | 2004-08-17 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
Ref document number: 0975602 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |