ES2128427T3 - Derivados condensados de imidazol y triazol como agonistas de receptores de 5-ht1. - Google Patents

Derivados condensados de imidazol y triazol como agonistas de receptores de 5-ht1.

Info

Publication number
ES2128427T3
ES2128427T3 ES93911925T ES93911925T ES2128427T3 ES 2128427 T3 ES2128427 T3 ES 2128427T3 ES 93911925 T ES93911925 T ES 93911925T ES 93911925 T ES93911925 T ES 93911925T ES 2128427 T3 ES2128427 T3 ES 2128427T3
Authority
ES
Spain
Prior art keywords
pct
condensated
triazole
imidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93911925T
Other languages
English (en)
Inventor
Leslie Joseph Street
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2128427T3 publication Critical patent/ES2128427T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

LOS COMPUESTOS DE LA FORMULA (I) EN LA QUE Q REPRESENTA EL RESIDUO DE UN NUCLEO HETEROAROMATICO O AROMATICO DE SEIS MIEMBROS QUE CONTIENE CERO, UNO O DOS ATOMOS DE NITROGENO; V REPRESENTA NITROGENO O C-A2; E REPRESENTA UN ENLACE O UNA CADENA DE ALKILENO RECTA O RAMIFICADA QUE CONTIENE DE 1 A 4 ATOMOS DE CARBONO; F REPRESENTA UN GRUPO DE LA FORMULA (Q); U REPRESENTA NITROGENO O C-R2; B REPRESENTA OXIGENO, AZUFRE O N-R3; R1 REPRESENTA -CH2.CHR4.NR6R7 O UN GRUPO DE LA FORMULA (I), (II), (III) O (IV); SON AGONISTAS SELECTIVOS DE LOS RECEPTORES TIPO 5-HT1 Y POR TANTO SON UTILES PARA EL TRATAMIENTO DE ESTADOS CLINICOS, EN PARTICULAR DE LA JAQUECA Y TRASTORNOS ASOCIADOS, PARA LOS QUE SE INDICA UN AGONISTA SELECTIVO DE ESTOS RECEPTORES.
ES93911925T 1992-05-15 1993-05-06 Derivados condensados de imidazol y triazol como agonistas de receptores de 5-ht1. Expired - Lifetime ES2128427T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929210400A GB9210400D0 (en) 1992-05-15 1992-05-15 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2128427T3 true ES2128427T3 (es) 1999-05-16

Family

ID=10715527

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93911925T Expired - Lifetime ES2128427T3 (es) 1992-05-15 1993-05-06 Derivados condensados de imidazol y triazol como agonistas de receptores de 5-ht1.

Country Status (10)

Country Link
US (1) US5514682A (es)
EP (1) EP0640085B1 (es)
JP (1) JP3283260B2 (es)
AT (1) ATE178065T1 (es)
AU (1) AU671836B2 (es)
CA (1) CA2134986A1 (es)
DE (1) DE69324140T2 (es)
ES (1) ES2128427T3 (es)
GB (1) GB9210400D0 (es)
WO (1) WO1993023396A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
TW251284B (es) * 1992-11-02 1995-07-11 Pfizer
US5849739A (en) * 1993-08-31 1998-12-15 Pfizer Inc. 5-arylindole derivatives
US5688809A (en) * 1994-02-10 1997-11-18 Pfizer Inc. 5-heteroarylindole derivatives
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
US5484763A (en) * 1995-02-10 1996-01-16 American Cyanamid Company Substituted benzisoxazole and benzisothiazole herbicidal agents
HUP0100179A3 (en) 1997-07-03 2002-12-28 Bristol Myers Squibb Pharma Co Imidazopyrimidine and imidazopyridine derivatives and pharmaceutical compositions thereof
US6465484B1 (en) * 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
EP1109555A4 (en) * 1998-08-31 2001-11-21 Merck & Co Inc NEW ANGIOGENIC INHIBITORS
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
DK1523486T3 (da) 2002-06-21 2008-03-03 Suven Life Sciences Ltd Tetracykliske arylsulfonylindoler med serotoninreceptor-affinitet
WO2004000845A1 (en) 2002-06-21 2003-12-31 Suven Life Sciences Limited Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
BRPI0315959C1 (pt) 2002-11-28 2021-05-25 Suven Life Sciences Ltd composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto
ES2425143T3 (es) 2002-11-28 2013-10-11 Suven Life Sciences Limited N-Arilsulfonil-3-aminoalcoxiindoles
ATE355292T1 (de) 2002-12-18 2006-03-15 Suven Life Sciences Ltd Tetrazyklische 3-substituierte indole mit serotoninrezeptoraffinität
EP1724271A4 (en) * 2004-02-26 2013-01-23 Kyowa Hakko Kirin Co Ltd PREVENTIVE AND / OR THERAPEUTIC AGENT AGAINST NEUTROPHIC INFLAMMATORY DISEASE
LT2624696T (lt) 2010-10-06 2017-03-10 Glaxosmithkline Llc Benzimidazolo deriniai kaip pi3 kinazės inhibitoriai
EP3901153A1 (en) * 2015-04-29 2021-10-27 Janssen Pharmaceutica NV Azabenzimidazoles and their use as ampa receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
HU225055B1 (en) * 1990-10-15 2006-05-29 Pfizer Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW251284B (es) * 1992-11-02 1995-07-11 Pfizer

Also Published As

Publication number Publication date
DE69324140D1 (de) 1999-04-29
WO1993023396A1 (en) 1993-11-25
CA2134986A1 (en) 1993-11-25
DE69324140T2 (de) 1999-10-28
EP0640085B1 (en) 1999-03-24
JPH07506825A (ja) 1995-07-27
US5514682A (en) 1996-05-07
GB9210400D0 (en) 1992-07-01
AU4269793A (en) 1993-12-13
AU671836B2 (en) 1996-09-12
EP0640085A1 (en) 1995-03-01
JP3283260B2 (ja) 2002-05-20
ATE178065T1 (de) 1999-04-15

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