ES2173477T3 - Derivados de tetrahidronaftaleno y su utilizacion terapeutica. - Google Patents
Derivados de tetrahidronaftaleno y su utilizacion terapeutica.Info
- Publication number
- ES2173477T3 ES2173477T3 ES97939057T ES97939057T ES2173477T3 ES 2173477 T3 ES2173477 T3 ES 2173477T3 ES 97939057 T ES97939057 T ES 97939057T ES 97939057 T ES97939057 T ES 97939057T ES 2173477 T3 ES2173477 T3 ES 2173477T3
- Authority
- ES
- Spain
- Prior art keywords
- tetrahydronaftaleno
- derivatives
- therapeutic use
- compounds
- selectines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R 1 ES UN RESIDUO DE FUCOSA O DE MANOSA. DICHOS COMPUESTOS PRESENTAN UNA UTILIDAD TERAPEUTICA A TRAVES DE LA INHIBICION DE SELECTINAS Y, POR TANTO, DE LA ADHESION CELULAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9618520.2A GB9618520D0 (en) | 1996-09-05 | 1996-09-05 | Compounds and their therapeutic use |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173477T3 true ES2173477T3 (es) | 2002-10-16 |
Family
ID=10799452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97939057T Expired - Lifetime ES2173477T3 (es) | 1996-09-05 | 1997-09-05 | Derivados de tetrahidronaftaleno y su utilizacion terapeutica. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6133240A (es) |
EP (1) | EP0931086B1 (es) |
JP (1) | JP2001500490A (es) |
AT (1) | ATE217006T1 (es) |
AU (1) | AU707160B2 (es) |
CA (1) | CA2264737A1 (es) |
DE (1) | DE69712351T2 (es) |
ES (1) | ES2173477T3 (es) |
GB (1) | GB9618520D0 (es) |
WO (1) | WO1998009977A1 (es) |
ZA (1) | ZA978015B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7060685B2 (en) | 2002-05-16 | 2006-06-13 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
CA2490703A1 (en) * | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス, インコーポレイテッド | E−およびp−セレクチンの両方のための糖模倣物アンタゴニスト |
WO2005051920A2 (en) * | 2003-11-19 | 2005-06-09 | Glycomimetics, Inc. | Specific antagonist for both e- and p-selectins |
WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
CA2618638C (en) * | 2005-08-09 | 2014-03-11 | Glycomimetics, Inc. | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
JP5209476B2 (ja) | 2005-09-02 | 2013-06-12 | グリコミメティクス, インコーポレイテッド | ヘテロ二官能性全セレクチン阻害剤 |
US20090176717A1 (en) * | 2006-06-01 | 2009-07-09 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
JP5298020B2 (ja) | 2006-10-12 | 2013-09-25 | グリコミメティクス, インコーポレイテッド | ヘキソースおよびn−アセチルヘキソサミンの糖模倣体置換 |
NZ598863A (en) * | 2007-02-09 | 2013-11-29 | Glycomimetics Inc | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
WO2009152245A1 (en) | 2008-06-13 | 2009-12-17 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
WO2010126888A1 (en) * | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
ES2655443T7 (es) | 2011-12-22 | 2021-03-22 | Glycomimetics Inc | Compuestos antagonistas de E-selectina |
CA2891514C (en) | 2012-12-07 | 2020-08-25 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
CN107108679B (zh) | 2014-12-03 | 2020-10-23 | 糖模拟物有限公司 | E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂 |
CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
JP7069136B2 (ja) | 2016-10-07 | 2022-05-17 | グリコミメティクス, インコーポレイテッド | 極めて強力な多量体e-セレクチンアンタゴニスト |
JP7272956B2 (ja) | 2017-03-15 | 2023-05-12 | グリコミメティクス, インコーポレイテッド | E-セレクチンアンタゴニストとしてのガラクトピラノシル-シクロヘキシル誘導体 |
US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
AU2019230013A1 (en) | 2018-03-05 | 2020-09-10 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
USD936390S1 (en) * | 2021-04-23 | 2021-11-23 | Qingdao Jinxiang Tongzhen Textile Co., Ltd. | Wedge pillow set |
USD936391S1 (en) * | 2021-04-26 | 2021-11-23 | Qingdao Jinxiang Tongzhen Textile Co., Ltd. | Wedge pillow set |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639734A (en) * | 1994-12-20 | 1997-06-17 | Esko; Jeffrey D. | Disaccharide inflammation inhibitors and uses thereof |
-
1996
- 1996-09-05 GB GBGB9618520.2A patent/GB9618520D0/en active Pending
-
1997
- 1997-09-05 DE DE69712351T patent/DE69712351T2/de not_active Expired - Fee Related
- 1997-09-05 WO PCT/GB1997/002406 patent/WO1998009977A1/en active IP Right Grant
- 1997-09-05 ZA ZA978015A patent/ZA978015B/xx unknown
- 1997-09-05 AU AU41282/97A patent/AU707160B2/en not_active Ceased
- 1997-09-05 JP JP10512372A patent/JP2001500490A/ja active Pending
- 1997-09-05 CA CA002264737A patent/CA2264737A1/en not_active Abandoned
- 1997-09-05 US US08/924,688 patent/US6133240A/en not_active Expired - Fee Related
- 1997-09-05 ES ES97939057T patent/ES2173477T3/es not_active Expired - Lifetime
- 1997-09-05 AT AT97939057T patent/ATE217006T1/de not_active IP Right Cessation
- 1997-09-05 EP EP97939057A patent/EP0931086B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ZA978015B (en) | 1998-09-07 |
GB9618520D0 (en) | 1996-10-16 |
ATE217006T1 (de) | 2002-05-15 |
AU707160B2 (en) | 1999-07-01 |
DE69712351D1 (de) | 2002-06-06 |
DE69712351T2 (de) | 2002-11-07 |
EP0931086A1 (en) | 1999-07-28 |
CA2264737A1 (en) | 1998-03-12 |
AU4128297A (en) | 1998-03-26 |
US6133240A (en) | 2000-10-17 |
WO1998009977A1 (en) | 1998-03-12 |
EP0931086B1 (en) | 2002-05-02 |
JP2001500490A (ja) | 2001-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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