KR20010032147A - 단쇄상 이작용기성 당단백질 호르몬 - Google Patents
단쇄상 이작용기성 당단백질 호르몬 Download PDFInfo
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- KR20010032147A KR20010032147A KR1020007005334A KR20007005334A KR20010032147A KR 20010032147 A KR20010032147 A KR 20010032147A KR 1020007005334 A KR1020007005334 A KR 1020007005334A KR 20007005334 A KR20007005334 A KR 20007005334A KR 20010032147 A KR20010032147 A KR 20010032147A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8/971,439 | 1997-11-17 | ||
| US08/971,439 US6103501A (en) | 1997-11-17 | 1997-11-17 | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
| PCT/US1998/023744 WO1999025849A1 (en) | 1997-11-17 | 1998-11-09 | Single-chain bifunctional glycoprotein hormones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010032147A true KR20010032147A (ko) | 2001-04-16 |
Family
ID=25518394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007005334A Abandoned KR20010032147A (ko) | 1997-11-17 | 1998-11-09 | 단쇄상 이작용기성 당단백질 호르몬 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6103501A (enExample) |
| EP (1) | EP1032688B1 (enExample) |
| JP (1) | JP4255618B2 (enExample) |
| KR (1) | KR20010032147A (enExample) |
| CN (1) | CN1173037C (enExample) |
| AU (1) | AU754296B2 (enExample) |
| BR (1) | BR9814880A (enExample) |
| CA (1) | CA2308571C (enExample) |
| CZ (1) | CZ299742B6 (enExample) |
| DE (1) | DE69839779D1 (enExample) |
| HU (1) | HUP0004394A3 (enExample) |
| IL (2) | IL135995A0 (enExample) |
| NO (1) | NO20002527L (enExample) |
| PL (1) | PL342853A1 (enExample) |
| TR (1) | TR200001406T2 (enExample) |
| WO (1) | WO1999025849A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319504B1 (en) | 1996-06-24 | 2001-11-20 | University Of Maryland Biotechnology Institute | Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin |
| US6583109B1 (en) | 1997-06-24 | 2003-06-24 | Robert C. Gallo | Therapeutic polypeptides from β-hCG and derivatives |
| US6635256B1 (en) * | 1998-10-19 | 2003-10-21 | Washington University | Glycoprotein hormone compositions comprising two β subunits and methods of use thereof |
| US7994278B1 (en) | 1999-08-06 | 2011-08-09 | Nobel Biosciences Llc | Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) |
| AU7546600A (en) * | 1999-10-08 | 2001-04-23 | Biofocus Discovery Limited | Methods and compositions for targeting a cell |
| GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| AU2001255624A1 (en) * | 2000-04-25 | 2001-11-07 | Washington University | Single-chain fertility hormones with variable lh activity |
| JP2001333772A (ja) * | 2000-04-25 | 2001-12-04 | Washington Univ | 可変性の活性を有する単鎖稔性ホルモン |
| US6987172B2 (en) * | 2001-03-05 | 2006-01-17 | Washington University In St. Louis | Multifunctional single chain glycoprotein hormones comprising three or more β subunits |
| US7081446B2 (en) * | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
| US10105417B2 (en) | 2003-03-04 | 2018-10-23 | Aspenbio Pharma, Inc. | Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone |
| JP4412989B2 (ja) * | 2003-12-15 | 2010-02-10 | 株式会社日立製作所 | 複数の記憶システムを有するデータ処理システム |
| US20080039372A1 (en) * | 2005-07-21 | 2008-02-14 | The Trustees Of Columbia University In The City Of New York | Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation |
| ES2534465T3 (es) * | 2005-11-15 | 2015-04-23 | Glycofi, Inc. | Producción de glucoproteínas con O-glucosilación reducida |
| US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US7553941B2 (en) * | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| WO2009143041A1 (en) | 2008-05-20 | 2009-11-26 | Merck & Co., Inc. | Efficient production of heterologous proteins using mannosyl transferase inhibitors |
| JP2011530311A (ja) | 2008-08-12 | 2011-12-22 | グライコフィ， インコーポレイテッド | タンパク質製造のための改良されたベクターおよび酵母株：Ｃａ２＋ＡＴＰアーゼ過剰発現 |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| BR112014001274A2 (pt) | 2011-07-18 | 2017-04-18 | Arts Biologics As | composto de hormônio luteinizante, e, composição farmacêutica |
| SG11201406671RA (en) | 2012-04-19 | 2014-11-27 | Opko Biolog Ltd | Long-acting oxyntomodulin variants and methods of producing same |
| CN112661863A (zh) | 2012-11-20 | 2021-04-16 | 奥普科生物制品有限公司 | 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法 |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| TWI746427B (zh) | 2014-12-10 | 2021-11-21 | 以色列商歐科生物製品有限公司 | 製造長效ｃｔｐ修飾的多肽之方法 |
| EP3310347B1 (en) | 2015-06-19 | 2021-08-04 | OPKO Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| ES2963725T3 (es) | 2016-07-11 | 2024-04-01 | Opko Biologics Ltd | Factor VII de coagulación de acción prolongada y métodos para producir el mismo |
| CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| CN107759697B (zh) * | 2016-08-19 | 2023-03-24 | 安源医药科技（上海）有限公司 | 制备融合蛋白的方法 |
| CN106256835A (zh) * | 2016-08-19 | 2016-12-28 | 安源医药科技（上海）有限公司 | 高糖基化人生长激素融合蛋白及其制备方法与用途 |
| CN106279436B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 活化的人凝血因子vii融合蛋白及其制备方法与用途 |
| CN107827987B (zh) * | 2017-01-04 | 2021-04-27 | 华侨大学 | 一种促黄体激素类似物及其制备方法 |
| CN113105562B (zh) * | 2018-09-26 | 2023-12-01 | 安源医药科技（上海）有限公司 | 突变型单链人凝血因子viii在制备融合蛋白中的应用 |
| BR102019004147A2 (pt) | 2019-02-28 | 2020-10-06 | Ouro Fino Saude Animal Participacoes S.A. | Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso |
| EP3969026A1 (en) | 2019-05-16 | 2022-03-23 | Ceva Santé Animale | Compositions and methods for increasing reproduction performance in non human mammals using recombinant luteinizing hormone |
| KR20220053003A (ko) * | 2019-08-30 | 2022-04-28 | 신텍스 에세.아. | 재조합 융모막 고나도트로핀, 그의 제조방법, 의약 조성물 및 용도 |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3486469T2 (de) * | 1983-11-02 | 1999-04-15 | Applied Research Systems Ars Holding N.V., Curacao | Herstellung heterodimirer menschlicher Fruchtbarkeitshormone |
| CA1213537A (en) * | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
| DE69029799T2 (de) * | 1989-02-21 | 1997-05-28 | Washington University, St. Louis, Mo. | Modifizierte formen von fortpflanzungshormonen |
| CA2082424C (en) * | 1990-05-08 | 2003-09-23 | Robert K. Campbell | Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity |
| FI932477L (fi) * | 1990-12-13 | 1993-06-11 | Immunex Corp | Receptorer foer leukemi-inhiberande faktor |
| ZA942206B (en) * | 1993-04-01 | 1994-10-31 | Amgen Inc | Biologically active polypeptide fusion dimers |
| EP1849802A2 (en) * | 1994-02-18 | 2007-10-31 | Laboratoires Serono SA | Methods for altering fertility |
| PT725795E (pt) * | 1994-08-12 | 2004-05-31 | Univ Washington | Formas de cadeia simples do quarteto de hormonas glicoproteicas |
-
1997
- 1997-11-17 US US08/971,439 patent/US6103501A/en not_active Expired - Lifetime
-
1998
- 1998-11-09 JP JP2000521213A patent/JP4255618B2/ja not_active Expired - Fee Related
- 1998-11-09 EP EP98956662A patent/EP1032688B1/en not_active Expired - Lifetime
- 1998-11-09 KR KR1020007005334A patent/KR20010032147A/ko not_active Abandoned
- 1998-11-09 CA CA2308571A patent/CA2308571C/en not_active Expired - Fee Related
- 1998-11-09 CN CNB988112353A patent/CN1173037C/zh not_active Expired - Fee Related
- 1998-11-09 TR TR2000/01406T patent/TR200001406T2/xx unknown
- 1998-11-09 IL IL13599598A patent/IL135995A0/xx active IP Right Grant
- 1998-11-09 WO PCT/US1998/023744 patent/WO1999025849A1/en not_active Ceased
- 1998-11-09 BR BR9814880-0A patent/BR9814880A/pt not_active Application Discontinuation
- 1998-11-09 HU HU0004394A patent/HUP0004394A3/hu unknown
- 1998-11-09 CZ CZ20001774A patent/CZ299742B6/cs not_active IP Right Cessation
- 1998-11-09 DE DE69839779T patent/DE69839779D1/de not_active Expired - Lifetime
- 1998-11-09 PL PL98342853A patent/PL342853A1/xx not_active IP Right Cessation
- 1998-11-09 AU AU13131/99A patent/AU754296B2/en not_active Ceased
-
2000
- 2000-05-05 IL IL135995A patent/IL135995A/en not_active IP Right Cessation
- 2000-05-16 NO NO20002527A patent/NO20002527L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9814880A (pt) | 2000-10-03 |
| NO20002527D0 (no) | 2000-05-16 |
| HUP0004394A3 (en) | 2003-04-28 |
| EP1032688B1 (en) | 2008-07-23 |
| JP4255618B2 (ja) | 2009-04-15 |
| HUP0004394A2 (hu) | 2001-09-28 |
| AU754296B2 (en) | 2002-11-14 |
| DE69839779D1 (de) | 2008-09-04 |
| CZ20001774A3 (cs) | 2000-10-11 |
| CN1173037C (zh) | 2004-10-27 |
| CA2308571C (en) | 2013-04-23 |
| CZ299742B6 (cs) | 2008-11-05 |
| TR200001406T2 (tr) | 2000-12-21 |
| US6103501A (en) | 2000-08-15 |
| PL342853A1 (en) | 2001-07-16 |
| NO20002527L (no) | 2000-07-10 |
| AU1313199A (en) | 1999-06-07 |
| JP2001523465A (ja) | 2001-11-27 |
| CN1290301A (zh) | 2001-04-04 |
| EP1032688A1 (en) | 2000-09-06 |
| IL135995A0 (en) | 2001-05-20 |
| IL135995A (en) | 2007-03-08 |
| CA2308571A1 (en) | 1999-05-27 |
| WO1999025849A1 (en) | 1999-05-27 |
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