CN1159300C - 1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途 - Google Patents

1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途 Download PDF

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Publication number
CN1159300C
CN1159300C CNB988056755A CN98805675A CN1159300C CN 1159300 C CN1159300 C CN 1159300C CN B988056755 A CNB988056755 A CN B988056755A CN 98805675 A CN98805675 A CN 98805675A CN 1159300 C CN1159300 C CN 1159300C
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weak
difluorobenzyl
triazole
carboxamide
moderate
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Chinese (zh)
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CN1259127A (zh
Inventor
R
R·波特曼
÷
U·C·霍夫梅尔
A·布克哈德
W·谢尔
ά
M·司泽拉吉维茨
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB988056755A 1997-06-10 1998-06-08 1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途 Expired - Lifetime CN1159300C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1404/1997 1997-06-10
CH140497 1997-06-10

Related Child Applications (1)

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CNB2004100473675A Division CN1298708C (zh) 1997-06-10 1998-06-08 1－（2，6－二氟苄基）－1h－1，2，3－三唑－4－甲酰胺的结晶改良体及其用途

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CN1259127A CN1259127A (zh) 2000-07-05
CN1159300C true CN1159300C (zh) 2004-07-28

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CNB988056755A Expired - Lifetime CN1159300C (zh) 1997-06-10 1998-06-08 1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途
CNB2004100473675A Expired - Lifetime CN1298708C (zh) 1997-06-10 1998-06-08 1－（2，6－二氟苄基）－1h－1，2，3－三唑－4－甲酰胺的结晶改良体及其用途
CN988000113A Expired - Lifetime CN1132820C (zh) 1997-06-10 1998-06-08 药物的结晶改良体

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CNB2004100473675A Expired - Lifetime CN1298708C (zh) 1997-06-10 1998-06-08 1－（2，6－二氟苄基）－1h－1，2，3－三唑－4－甲酰胺的结晶改良体及其用途
CN988000113A Expired - Lifetime CN1132820C (zh) 1997-06-10 1998-06-08 药物的结晶改良体

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TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
AR040233A1 (es) * 2002-05-31 2005-03-23 Schering Corp Polimorfos inhibidores de xantina fosfodiesterasa v
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
NZ591725A (en) 2008-10-13 2012-09-28 Cipla Ltd PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
KR101597338B1 (ko) * 2009-09-04 2016-02-24 탁티칼 떼라페우틱스 인크. 5-아미노 또는 치환된 아미노 1,2,3-트리아졸 화합물 및 이의 오로트산염 제형들의 신규한 조성물들 및 이의 제조방법
JP2013525413A (ja) * 2010-04-30 2013-06-20 ラボラトリオス レスヴィ，エス．エル． ルフィナマイド中間体の改良された製造方法
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014013511A2 (en) * 2012-07-20 2014-01-23 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
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CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
WO1991001724A1 (en) 1989-07-27 1991-02-21 G.D. Searle & Co. Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
CA2095444C (en) 1990-11-06 2001-06-19 Shuichi Sakamoto Fused pyrazine derivatives
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
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ATE194607T1 (de) 1995-02-22 2000-07-15 Hoechst Japan Amorph piretanide, polymorphe davon, verfahren zur dessen herstellung und ihre verwendung
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HUP0002113A3 (en) 2002-09-30
HK1028241A1 (en) 2001-02-09
CN1259127A (zh) 2000-07-05
JP2000516259A (ja) 2000-12-05
IL125732A0 (en) 1999-04-11
CY2007014I1 (el) 2009-11-04
AR061004A2 (es) 2008-07-30
SK109398A3 (en) 1998-12-02
DE122007000051I2 (de) 2009-02-19
US8076362B2 (en) 2011-12-13
DE69813560T2 (de) 2004-02-05
CZ253498A3 (cs) 1999-04-14
SI0994863T1 (en) 2003-08-31
JP3672574B2 (ja) 2005-07-20
AR012945A1 (es) 2000-11-22
RU2198167C2 (ru) 2003-02-10
US20100310655A1 (en) 2010-12-09
DE69813560D1 (de) 2003-05-22
JP2000516258A (ja) 2000-12-05
ES2197485T3 (es) 2004-01-01
US6740669B1 (en) 2004-05-25
EP0994864A1 (en) 2000-04-26
KR19990087836A (ko) 1999-12-27
US20040167186A1 (en) 2004-08-26
HK1028242A1 (en) 2001-02-09
NO329314B1 (no) 2010-09-27
AU8437298A (en) 1998-12-30
US20030125568A1 (en) 2003-07-03
CN1572789A (zh) 2005-02-02
DE69811500D1 (de) 2003-03-27
EP0994863A1 (en) 2000-04-26
US20010037029A1 (en) 2001-11-01
SI0994864T1 (en) 2003-10-31
DK0994864T3 (da) 2003-07-21
FR07C0037I1 (enExample) 2007-08-17
HUP0000798A3 (en) 2000-10-30
CA2614926A1 (en) 1998-12-17
ATE232852T1 (de) 2003-03-15
IL125733A (en) 2002-12-01
ID21014A (id) 1999-04-08
NO983667L (no) 1998-12-17
KR19990087835A (ko) 1999-12-27
MY125854A (en) 2006-08-30
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WO1998056773A1 (en) 1998-12-17
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CA2256013A1 (en) 1998-12-17
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US7750028B2 (en) 2010-07-06
CN1217716A (zh) 1999-05-26
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NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
TW403740B (en) 2000-09-01
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ID27660A (id) 2001-04-19
NZ331371A (en) 2000-08-25
TR199801631T1 (xx) 1999-06-21
BR9804946A (pt) 1999-08-24
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US6455556B2 (en) 2002-09-24
US20060116520A1 (en) 2006-06-01
AU8437198A (en) 1998-12-30
MY120156A (en) 2005-09-30
HU225153B1 (en) 2006-07-28
CZ253398A3 (cs) 1999-04-14
SK283685B6 (sk) 2003-12-02
AU725528B2 (en) 2000-10-12
CA2256015C (en) 2008-06-03
HU226107B1 (en) 2008-04-28
JP3672575B2 (ja) 2005-07-20
CZ292260B6 (cs) 2003-08-13
ATE237599T1 (de) 2003-05-15
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AU725517B2 (en) 2000-10-12
NL300284I2 (nl) 2007-11-01
KR100425656B1 (ko) 2004-05-17
PT994864E (pt) 2003-07-31

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