SI0994864T1 - Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic - Google Patents

Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Info

Publication number
SI0994864T1
SI0994864T1 SI9830450T SI9830450T SI0994864T1 SI 0994864 T1 SI0994864 T1 SI 0994864T1 SI 9830450 T SI9830450 T SI 9830450T SI 9830450 T SI9830450 T SI 9830450T SI 0994864 T1 SI0994864 T1 SI 0994864T1
Authority
SI
Slovenia
Prior art keywords
antiepileptic
difluorobenzyl
carboxamide
triazole
crystal modification
Prior art date
Application number
SI9830450T
Other languages
English (en)
Slovenian (sl)
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0994864(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI0994864T1 publication Critical patent/SI0994864T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI9830450T 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic SI0994864T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003428 WO1998056773A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic
EP98934930A EP0994864B1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Publications (1)

Publication Number Publication Date
SI0994864T1 true SI0994864T1 (en) 2003-10-31

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9830450T SI0994864T1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic
SI9830405T SI0994863T1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9830405T SI0994863T1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide and its use as antiepileptic

Country Status (36)

Country Link
US (6) US6740669B1 (enExample)
EP (2) EP0994863B1 (enExample)
JP (2) JP3672575B2 (enExample)
KR (2) KR100409168B1 (enExample)
CN (3) CN1159300C (enExample)
AR (4) AR012946A1 (enExample)
AT (2) ATE237599T1 (enExample)
AU (2) AU725528B2 (enExample)
BR (2) BR9804947A (enExample)
CA (3) CA2256015C (enExample)
CO (2) CO4940452A1 (enExample)
CY (1) CY2007014I2 (enExample)
CZ (2) CZ292481B6 (enExample)
DE (3) DE69811500T2 (enExample)
DK (2) DK0994863T3 (enExample)
ES (2) ES2197485T3 (enExample)
FR (1) FR07C0037I2 (enExample)
HU (2) HU225153B1 (enExample)
ID (2) ID21014A (enExample)
IL (2) IL125733A (enExample)
LU (1) LU91345I2 (enExample)
MY (2) MY125854A (enExample)
NL (1) NL300284I2 (enExample)
NO (2) NO329315B1 (enExample)
NZ (2) NZ331371A (enExample)
PE (2) PE80999A1 (enExample)
PL (2) PL192114B1 (enExample)
PT (1) PT994864E (enExample)
RU (2) RU2194041C2 (enExample)
SI (2) SI0994864T1 (enExample)
SK (2) SK283685B6 (enExample)
TR (2) TR199801630T1 (enExample)
TW (2) TW403740B (enExample)
UY (1) UY25844A1 (enExample)
WO (2) WO1998056772A1 (enExample)
ZA (2) ZA984967B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
AR040233A1 (es) * 2002-05-31 2005-03-23 Schering Corp Polimorfos inhibidores de xantina fosfodiesterasa v
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
NZ591725A (en) 2008-10-13 2012-09-28 Cipla Ltd PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
KR101597338B1 (ko) * 2009-09-04 2016-02-24 탁티칼 떼라페우틱스 인크. 5-아미노 또는 치환된 아미노 1,2,3-트리아졸 화합물 및 이의 오로트산염 제형들의 신규한 조성물들 및 이의 제조방법
JP2013525413A (ja) * 2010-04-30 2013-06-20 ラボラトリオス レスヴィ，エス．エル． ルフィナマイド中間体の改良された製造方法
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014013511A2 (en) * 2012-07-20 2014-01-23 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
WO1991001724A1 (en) 1989-07-27 1991-02-21 G.D. Searle & Co. Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
CA2095444C (en) 1990-11-06 2001-06-19 Shuichi Sakamoto Fused pyrazine derivatives
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
ATE194607T1 (de) 1995-02-22 2000-07-15 Hoechst Japan Amorph piretanide, polymorphe davon, verfahren zur dessen herstellung und ihre verwendung
SI0918758T1 (en) * 1996-07-11 2002-10-31 Novartis Ag Process for preparing 1-substituted 4-cyano-1,2,3-triazoles
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
HUP0002113A3 (en) 2002-09-30
HK1028241A1 (en) 2001-02-09
CN1259127A (zh) 2000-07-05
JP2000516259A (ja) 2000-12-05
IL125732A0 (en) 1999-04-11
CY2007014I1 (el) 2009-11-04
AR061004A2 (es) 2008-07-30
SK109398A3 (en) 1998-12-02
DE122007000051I2 (de) 2009-02-19
US8076362B2 (en) 2011-12-13
DE69813560T2 (de) 2004-02-05
CZ253498A3 (cs) 1999-04-14
SI0994863T1 (en) 2003-08-31
JP3672574B2 (ja) 2005-07-20
AR012945A1 (es) 2000-11-22
RU2198167C2 (ru) 2003-02-10
US20100310655A1 (en) 2010-12-09
DE69813560D1 (de) 2003-05-22
JP2000516258A (ja) 2000-12-05
ES2197485T3 (es) 2004-01-01
US6740669B1 (en) 2004-05-25
EP0994864A1 (en) 2000-04-26
KR19990087836A (ko) 1999-12-27
US20040167186A1 (en) 2004-08-26
HK1028242A1 (en) 2001-02-09
NO329314B1 (no) 2010-09-27
AU8437298A (en) 1998-12-30
US20030125568A1 (en) 2003-07-03
CN1572789A (zh) 2005-02-02
DE69811500D1 (de) 2003-03-27
EP0994863A1 (en) 2000-04-26
US20010037029A1 (en) 2001-11-01
DK0994864T3 (da) 2003-07-21
FR07C0037I1 (enExample) 2007-08-17
HUP0000798A3 (en) 2000-10-30
CA2614926A1 (en) 1998-12-17
ATE232852T1 (de) 2003-03-15
IL125733A (en) 2002-12-01
ID21014A (id) 1999-04-08
NO983667L (no) 1998-12-17
KR19990087835A (ko) 1999-12-27
MY125854A (en) 2006-08-30
PL330764A1 (en) 1999-05-24
NO983666D0 (no) 1998-08-11
CN1159300C (zh) 2004-07-28
AR012946A1 (es) 2000-11-22
SK109498A3 (en) 1998-12-02
CZ292481B6 (cs) 2003-09-17
NO329315B1 (no) 2010-09-27
DE122007000051I1 (de) 2007-11-08
LU91345I9 (enExample) 2018-12-31
CA2256015A1 (en) 1998-12-17
KR100409168B1 (ko) 2004-01-31
ES2192779T3 (es) 2003-10-16
TW526195B (en) 2003-04-01
CY2007014I2 (el) 2009-11-04
NO983666L (no) 1998-12-17
CO4940448A1 (es) 2000-07-24
PE80999A1 (es) 1999-09-06
ZA984966B (en) 1999-01-11
LU91345I2 (fr) 2007-09-04
WO1998056773A1 (en) 1998-12-17
CN1298708C (zh) 2007-02-07
CA2256013A1 (en) 1998-12-17
PL192114B1 (pl) 2006-08-31
DE69811500T2 (de) 2004-04-01
HUP0000798A2 (hu) 2000-10-30
ZA984967B (en) 1999-01-11
PE79799A1 (es) 1999-09-03
EP0994863B1 (en) 2003-02-19
EP0994864B1 (en) 2003-04-16
HUP0002113A2 (hu) 2001-02-28
AR061005A2 (es) 2008-07-30
US7750028B2 (en) 2010-07-06
CN1217716A (zh) 1999-05-26
CA2256013C (en) 2007-10-16
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
TW403740B (en) 2000-09-01
RU2194041C2 (ru) 2002-12-10
ID27660A (id) 2001-04-19
NZ331371A (en) 2000-08-25
TR199801631T1 (xx) 1999-06-21
BR9804946A (pt) 1999-08-24
IL125733A0 (en) 1999-04-11
HK1028031A1 (en) 2001-02-02
NZ331370A (en) 2000-08-25
PL191943B1 (pl) 2006-07-31
SK283734B6 (sk) 2003-12-02
BR9804947A (pt) 1999-08-24
IL125732A (en) 2002-12-01
DK0994863T3 (da) 2003-05-26
CN1132820C (zh) 2003-12-31
WO1998056772A1 (en) 1998-12-17
CA2614926C (en) 2010-02-09
CO4940452A1 (es) 2000-07-24
PL330798A1 (en) 1999-06-07
UY25844A1 (es) 2001-08-27
FR07C0037I2 (enExample) 2008-05-16
US6455556B2 (en) 2002-09-24
US20060116520A1 (en) 2006-06-01
AU8437198A (en) 1998-12-30
MY120156A (en) 2005-09-30
HU225153B1 (en) 2006-07-28
CZ253398A3 (cs) 1999-04-14
SK283685B6 (sk) 2003-12-02
AU725528B2 (en) 2000-10-12
CA2256015C (en) 2008-06-03
HU226107B1 (en) 2008-04-28
JP3672575B2 (ja) 2005-07-20
CZ292260B6 (cs) 2003-08-13
ATE237599T1 (de) 2003-05-15
TR199801630T1 (xx) 1999-06-21
AU725517B2 (en) 2000-10-12
NL300284I2 (nl) 2007-11-01
KR100425656B1 (ko) 2004-05-17
PT994864E (pt) 2003-07-31

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