CN1159300C - 1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途 - Google Patents

1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途 Download PDF

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Publication number
CN1159300C
CN1159300C CNB988056755A CN98805675A CN1159300C CN 1159300 C CN1159300 C CN 1159300C CN B988056755 A CNB988056755 A CN B988056755A CN 98805675 A CN98805675 A CN 98805675A CN 1159300 C CN1159300 C CN 1159300C
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weak
difluorobenzyl
triazole
carboxamide
moderate
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Expired - Lifetime
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Chinese (zh)
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CN1259127A (zh
Inventor
R
R·波特曼
÷
U·C·霍夫梅尔
A·布克哈德
W·谢尔
ά
M·司泽拉吉维茨
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB988056755A 1997-06-10 1998-06-08 1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途 Expired - Lifetime CN1159300C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
CH1404/1997 1997-06-10

Related Child Applications (1)

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CNB2004100473675A Division CN1298708C (zh) 1997-06-10 1998-06-08 1－（2，6－二氟苄基）－1h－1，2，3－三唑－4－甲酰胺的结晶改良体及其用途

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CN1259127A CN1259127A (zh) 2000-07-05
CN1159300C true CN1159300C (zh) 2004-07-28

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ID=4209650

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB988056755A Expired - Lifetime CN1159300C (zh) 1997-06-10 1998-06-08 1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的结晶改良体及其用作抗癫痫药的用途
CN988000113A Expired - Lifetime CN1132820C (zh) 1997-06-10 1998-06-08 药物的结晶改良体
CNB2004100473675A Expired - Lifetime CN1298708C (zh) 1997-06-10 1998-06-08 1－（2，6－二氟苄基）－1h－1，2，3－三唑－4－甲酰胺的结晶改良体及其用途

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CN988000113A Expired - Lifetime CN1132820C (zh) 1997-06-10 1998-06-08 药物的结晶改良体
CNB2004100473675A Expired - Lifetime CN1298708C (zh) 1997-06-10 1998-06-08 1－（2，6－二氟苄基）－1h－1，2，3－三唑－4－甲酰胺的结晶改良体及其用途

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Country Link
US (6) US6740669B1 (OSRAM)
EP (2) EP0994863B1 (OSRAM)
JP (2) JP3672575B2 (OSRAM)
KR (2) KR100409168B1 (OSRAM)
CN (3) CN1159300C (OSRAM)
AR (4) AR012945A1 (OSRAM)
AT (2) ATE237599T1 (OSRAM)
AU (2) AU725517B2 (OSRAM)
BR (2) BR9804947A (OSRAM)
CA (3) CA2256015C (OSRAM)
CO (2) CO4940448A1 (OSRAM)
CY (1) CY2007014I1 (OSRAM)
CZ (2) CZ292260B6 (OSRAM)
DE (3) DE69813560T2 (OSRAM)
DK (2) DK0994863T3 (OSRAM)
ES (2) ES2192779T3 (OSRAM)
FR (1) FR07C0037I2 (OSRAM)
HU (2) HU225153B1 (OSRAM)
ID (2) ID27660A (OSRAM)
IL (2) IL125733A (OSRAM)
LU (1) LU91345I2 (OSRAM)
MY (2) MY120156A (OSRAM)
NL (1) NL300284I2 (OSRAM)
NO (2) NO329315B1 (OSRAM)
NZ (2) NZ331371A (OSRAM)
PE (2) PE79799A1 (OSRAM)
PL (2) PL191943B1 (OSRAM)
PT (1) PT994864E (OSRAM)
RU (2) RU2198167C2 (OSRAM)
SI (2) SI0994864T1 (OSRAM)
SK (2) SK283734B6 (OSRAM)
TR (2) TR199801630T1 (OSRAM)
TW (2) TW526195B (OSRAM)
UY (1) UY25844A1 (OSRAM)
WO (2) WO1998056773A1 (OSRAM)
ZA (2) ZA984967B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
MXPA04011865A (es) * 2002-05-31 2005-03-31 Schering Corp Polimorfos inhibidores de xantina fosfodiesterasa v.
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
CA2736703A1 (en) 2008-10-13 2010-04-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
KR101597338B1 (ko) * 2009-09-04 2016-02-24 탁티칼 떼라페우틱스 인크. 5-아미노 또는 치환된 아미노 1,2,3-트리아졸 화합물 및 이의 오로트산염 제형들의 신규한 조성물들 및 이의 제조방법
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
WO2011135105A1 (en) * 2010-04-30 2011-11-03 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
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US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
ES2150417T3 (es) 1990-11-06 2000-12-01 Yamanouchi Pharma Co Ltd Derivados de pirazina fusionados.
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
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CA2614926C (en) 2010-02-09
SI0994864T1 (en) 2003-10-31
US20060116520A1 (en) 2006-06-01
IL125732A0 (en) 1999-04-11
MY125854A (en) 2006-08-30
AR012945A1 (es) 2000-11-22
CZ253498A3 (cs) 1999-04-14
SI0994863T1 (en) 2003-08-31
ATE237599T1 (de) 2003-05-15
HK1028242A1 (en) 2001-02-09
PE80999A1 (es) 1999-09-06
JP2000516259A (ja) 2000-12-05
DK0994863T3 (da) 2003-05-26
AU725517B2 (en) 2000-10-12
IL125733A0 (en) 1999-04-11
HUP0002113A2 (hu) 2001-02-28
HK1028031A1 (en) 2001-02-02
NO329315B1 (no) 2010-09-27
NO983666D0 (no) 1998-08-11
CN1572789A (zh) 2005-02-02
JP3672574B2 (ja) 2005-07-20
SK283685B6 (sk) 2003-12-02
AR061005A2 (es) 2008-07-30
ZA984967B (en) 1999-01-11
JP2000516258A (ja) 2000-12-05
KR100409168B1 (ko) 2004-01-31
ID27660A (id) 2001-04-19
US20030125568A1 (en) 2003-07-03
ES2192779T3 (es) 2003-10-16
CY2007014I2 (el) 2009-11-04
MY120156A (en) 2005-09-30
CN1259127A (zh) 2000-07-05
KR19990087835A (ko) 1999-12-27
LU91345I9 (OSRAM) 2018-12-31
NO983667L (no) 1998-12-17
PL330764A1 (en) 1999-05-24
PL191943B1 (pl) 2006-07-31
ATE232852T1 (de) 2003-03-15
CA2256015A1 (en) 1998-12-17
ID21014A (id) 1999-04-08
PT994864E (pt) 2003-07-31
DE122007000051I1 (de) 2007-11-08
HUP0002113A3 (en) 2002-09-30
DE122007000051I2 (de) 2009-02-19
HU226107B1 (en) 2008-04-28
CY2007014I1 (el) 2009-11-04
TR199801630T1 (xx) 1999-06-21
AU8437298A (en) 1998-12-30
TR199801631T1 (xx) 1999-06-21
CA2256013C (en) 2007-10-16
CZ292260B6 (cs) 2003-08-13
TW403740B (en) 2000-09-01
NZ331370A (en) 2000-08-25
US7750028B2 (en) 2010-07-06
ZA984966B (en) 1999-01-11
NZ331371A (en) 2000-08-25
KR100425656B1 (ko) 2004-05-17
CN1132820C (zh) 2003-12-31
JP3672575B2 (ja) 2005-07-20
CO4940452A1 (es) 2000-07-24
EP0994864B1 (en) 2003-04-16
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HU225153B1 (en) 2006-07-28
US8076362B2 (en) 2011-12-13
ES2197485T3 (es) 2004-01-01
CA2256015C (en) 2008-06-03
CA2256013A1 (en) 1998-12-17
RU2198167C2 (ru) 2003-02-10
HUP0000798A2 (hu) 2000-10-30
DE69811500D1 (de) 2003-03-27
CN1217716A (zh) 1999-05-26
US20010037029A1 (en) 2001-11-01
LU91345I2 (fr) 2007-09-04
WO1998056772A1 (en) 1998-12-17
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
IL125732A (en) 2002-12-01
AU725528B2 (en) 2000-10-12
DK0994864T3 (da) 2003-07-21
DE69813560T2 (de) 2004-02-05
CZ292481B6 (cs) 2003-09-17
BR9804947A (pt) 1999-08-24
PL330798A1 (en) 1999-06-07
CO4940448A1 (es) 2000-07-24
FR07C0037I1 (OSRAM) 2007-08-17
PL192114B1 (pl) 2006-08-31
NO983666L (no) 1998-12-17
BR9804946A (pt) 1999-08-24
HK1028241A1 (en) 2001-02-09
CZ253398A3 (cs) 1999-04-14
HUP0000798A3 (en) 2000-10-30
AR061004A2 (es) 2008-07-30
CN1298708C (zh) 2007-02-07
EP0994864A1 (en) 2000-04-26
SK109498A3 (en) 1998-12-02
UY25844A1 (es) 2001-08-27
KR19990087836A (ko) 1999-12-27
IL125733A (en) 2002-12-01
US20100310655A1 (en) 2010-12-09
RU2194041C2 (ru) 2002-12-10
DE69811500T2 (de) 2004-04-01
DE69813560D1 (de) 2003-05-22
EP0994863B1 (en) 2003-02-19
US6740669B1 (en) 2004-05-25
PE79799A1 (es) 1999-09-03
NO329314B1 (no) 2010-09-27
SK109398A3 (en) 1998-12-02
US6455556B2 (en) 2002-09-24
US20040167186A1 (en) 2004-08-26
CA2614926A1 (en) 1998-12-17
FR07C0037I2 (OSRAM) 2008-05-16
TW526195B (en) 2003-04-01
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
AU8437198A (en) 1998-12-30
NL300284I2 (nl) 2007-11-01
AR012946A1 (es) 2000-11-22

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