AR012945A1 - Formas cristalinas b y c del compuesto 1-(2,6-difluorbencil)-1h-1,2,3- triazol-4 carboxamida, un preparado farmaceutico y uso para la obtenciondel mismo y para la manufactura de un medicamento - Google Patents

Formas cristalinas b y c del compuesto 1-(2,6-difluorbencil)-1h-1,2,3- triazol-4 carboxamida, un preparado farmaceutico y uso para la obtenciondel mismo y para la manufactura de un medicamento

Info

Publication number
AR012945A1
AR012945A1 ARP980102707A ARP980102707A AR012945A1 AR 012945 A1 AR012945 A1 AR 012945A1 AR P980102707 A ARP980102707 A AR P980102707A AR P980102707 A ARP980102707 A AR P980102707A AR 012945 A1 AR012945 A1 AR 012945A1
Authority
AR
Argentina
Prior art keywords
carboxamide
compound
manufacture
obtaining
same
Prior art date
Application number
ARP980102707A
Other languages
English (en)
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4209650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR012945(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR012945A1 publication Critical patent/AR012945A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP980102707A 1997-06-10 1998-06-09 Formas cristalinas b y c del compuesto 1-(2,6-difluorbencil)-1h-1,2,3- triazol-4 carboxamida, un preparado farmaceutico y uso para la obtenciondel mismo y para la manufactura de un medicamento AR012945A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10

Publications (1)

Publication Number Publication Date
AR012945A1 true AR012945A1 (es) 2000-11-22

Family

ID=4209650

Family Applications (4)

Application Number Title Priority Date Filing Date
ARP980102707A AR012945A1 (es) 1997-06-10 1998-06-09 Formas cristalinas b y c del compuesto 1-(2,6-difluorbencil)-1h-1,2,3- triazol-4 carboxamida, un preparado farmaceutico y uso para la obtenciondel mismo y para la manufactura de un medicamento
ARP980102708A AR012946A1 (es) 1997-06-10 1998-06-09 Forma cristalina a de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos
ARP070102131A AR061004A2 (es) 1997-06-10 2007-05-17 Formas cristalinas b y c del compuesto 1-(2,6-difluorobencil)-1h-1,2,3-triazol-4- carboxamida, un preparado farmaceutico y uso para la obtencion del mismo y para la manufactura de un medicamento
ARP070102132A AR061005A2 (es) 1997-06-10 2007-05-17 Forma cristalina a de 1-(2,6- difluorobencil)-1h-1,2,3- triazol-4-carboxamida, preparaciones farmaceuticas que las contienen y su uso para la preparacion de medicamentos

Family Applications After (3)

Application Number Title Priority Date Filing Date
ARP980102708A AR012946A1 (es) 1997-06-10 1998-06-09 Forma cristalina a de 1-(2,6-difluorbencil)-1h-1,2,3-triazol-4-carboxamida, preparaciones farmaceuticas que los contienen y su uso para la preparacion de medicamentos
ARP070102131A AR061004A2 (es) 1997-06-10 2007-05-17 Formas cristalinas b y c del compuesto 1-(2,6-difluorobencil)-1h-1,2,3-triazol-4- carboxamida, un preparado farmaceutico y uso para la obtencion del mismo y para la manufactura de un medicamento
ARP070102132A AR061005A2 (es) 1997-06-10 2007-05-17 Forma cristalina a de 1-(2,6- difluorobencil)-1h-1,2,3- triazol-4-carboxamida, preparaciones farmaceuticas que las contienen y su uso para la preparacion de medicamentos

Country Status (36)

Country Link
US (6) US6740669B1 (OSRAM)
EP (2) EP0994863B1 (OSRAM)
JP (2) JP3672574B2 (OSRAM)
KR (2) KR100425656B1 (OSRAM)
CN (3) CN1298708C (OSRAM)
AR (4) AR012945A1 (OSRAM)
AT (2) ATE237599T1 (OSRAM)
AU (2) AU725528B2 (OSRAM)
BR (2) BR9804946A (OSRAM)
CA (3) CA2256013C (OSRAM)
CO (2) CO4940448A1 (OSRAM)
CY (1) CY2007014I2 (OSRAM)
CZ (2) CZ292481B6 (OSRAM)
DE (3) DE122007000051I2 (OSRAM)
DK (2) DK0994863T3 (OSRAM)
ES (2) ES2192779T3 (OSRAM)
FR (1) FR07C0037I2 (OSRAM)
HU (2) HU226107B1 (OSRAM)
ID (2) ID27660A (OSRAM)
IL (2) IL125733A (OSRAM)
LU (1) LU91345I2 (OSRAM)
MY (2) MY125854A (OSRAM)
NL (1) NL300284I2 (OSRAM)
NO (2) NO329314B1 (OSRAM)
NZ (2) NZ331370A (OSRAM)
PE (2) PE79799A1 (OSRAM)
PL (2) PL192114B1 (OSRAM)
PT (1) PT994864E (OSRAM)
RU (2) RU2194041C2 (OSRAM)
SI (2) SI0994863T1 (OSRAM)
SK (2) SK283685B6 (OSRAM)
TR (2) TR199801630T1 (OSRAM)
TW (2) TW526195B (OSRAM)
UY (1) UY25844A1 (OSRAM)
WO (2) WO1998056772A1 (OSRAM)
ZA (2) ZA984967B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526195B (en) * 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
WO2003101991A1 (en) * 2002-05-31 2003-12-11 Schering Corporation Xanthine phosphodiesterase v inhibitor polymorphs
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
WO2010043849A1 (en) * 2008-10-13 2010-04-22 Cipla Limited Process for the preparation of rufinamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
BR112012004539A2 (pt) * 2009-09-04 2020-09-15 Tactical Therapeutics, Inc. composto, composto de orotato, polimorfo de forma 1 e poliformo de forma 2
EP2465853A1 (en) 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
US8884026B2 (en) 2010-04-30 2014-11-11 Laboratorios Lesvi, S.L. Process for preparing rufinamide intermediate
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992378A (en) 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
FI834666A7 (fi) 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.
US4511572A (en) * 1983-03-18 1985-04-16 The University Of Kentucky Research Foundation Triazoline anticonvulsant drugs
PH22568A (en) * 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
HU221425B (en) 1990-11-06 2002-10-28 Yamanouchi Pharma Co Ltd Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
GB9419318D0 (en) 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
CA2213693C (en) 1995-02-22 2008-04-15 Hoechst Pharmaceuticals & Chemicals K.K. Amorphous piretanide, piretanide polymorphs, process for their preparation and their use
RU2177942C2 (ru) * 1996-07-11 2002-01-10 Новартис Аг Способ получения 1-замещенных-4-циано-1,2,3-триазолов и 4-циано-1-(2,6-дифторбензил)-1h-1,2,3-триазол
TW526195B (en) 1997-06-10 2003-04-01 Novartis Ag Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use

Also Published As

Publication number Publication date
US20030125568A1 (en) 2003-07-03
HK1028031A1 (en) 2001-02-02
EP0994863B1 (en) 2003-02-19
US20010037029A1 (en) 2001-11-01
SK283685B6 (sk) 2003-12-02
CN1259127A (zh) 2000-07-05
CN1217716A (zh) 1999-05-26
PL330798A1 (en) 1999-06-07
CA2256013A1 (en) 1998-12-17
CO4940448A1 (es) 2000-07-24
FR07C0037I2 (OSRAM) 2008-05-16
DE69811500T2 (de) 2004-04-01
WO1998056772A1 (en) 1998-12-17
AU725528B2 (en) 2000-10-12
NO983666D0 (no) 1998-08-11
RU2198167C2 (ru) 2003-02-10
CZ253398A3 (cs) 1999-04-14
CA2256015A1 (en) 1998-12-17
JP2000516258A (ja) 2000-12-05
CY2007014I1 (el) 2009-11-04
DK0994864T3 (da) 2003-07-21
TR199801631T1 (xx) 1999-06-21
NO329315B1 (no) 2010-09-27
AR061004A2 (es) 2008-07-30
ZA984967B (en) 1999-01-11
LU91345I2 (fr) 2007-09-04
US8076362B2 (en) 2011-12-13
NO329314B1 (no) 2010-09-27
TR199801630T1 (xx) 1999-06-21
PE79799A1 (es) 1999-09-03
NZ331371A (en) 2000-08-25
TW526195B (en) 2003-04-01
IL125732A0 (en) 1999-04-11
SK109398A3 (en) 1998-12-02
US20060116520A1 (en) 2006-06-01
JP3672575B2 (ja) 2005-07-20
AU8437298A (en) 1998-12-30
CA2256015C (en) 2008-06-03
ES2192779T3 (es) 2003-10-16
HUP0000798A3 (en) 2000-10-30
CN1159300C (zh) 2004-07-28
MY125854A (en) 2006-08-30
FR07C0037I1 (OSRAM) 2007-08-17
KR100409168B1 (ko) 2004-01-31
DE69811500D1 (de) 2003-03-27
SI0994864T1 (en) 2003-10-31
CN1132820C (zh) 2003-12-31
PT994864E (pt) 2003-07-31
LU91345I9 (OSRAM) 2018-12-31
RU2194041C2 (ru) 2002-12-10
HUP0000798A2 (hu) 2000-10-30
CA2256013C (en) 2007-10-16
JP2000516259A (ja) 2000-12-05
ES2197485T3 (es) 2004-01-01
HU226107B1 (en) 2008-04-28
NL300284I2 (nl) 2007-11-01
PL330764A1 (en) 1999-05-24
BR9804947A (pt) 1999-08-24
AU725517B2 (en) 2000-10-12
ZA984966B (en) 1999-01-11
TW403740B (en) 2000-09-01
ID27660A (id) 2001-04-19
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
US20040167186A1 (en) 2004-08-26
CZ292260B6 (cs) 2003-08-13
CZ292481B6 (cs) 2003-09-17
ATE237599T1 (de) 2003-05-15
KR100425656B1 (ko) 2004-05-17
HUP0002113A3 (en) 2002-09-30
CA2614926C (en) 2010-02-09
NO983666L (no) 1998-12-17
ATE232852T1 (de) 2003-03-15
IL125733A (en) 2002-12-01
US7750028B2 (en) 2010-07-06
US20100310655A1 (en) 2010-12-09
DE122007000051I1 (de) 2007-11-08
PL191943B1 (pl) 2006-07-31
AR061005A2 (es) 2008-07-30
US6740669B1 (en) 2004-05-25
NO983667L (no) 1998-12-17
MY120156A (en) 2005-09-30
CO4940452A1 (es) 2000-07-24
DE122007000051I2 (de) 2009-02-19
HK1028242A1 (en) 2001-02-09
KR19990087836A (ko) 1999-12-27
UY25844A1 (es) 2001-08-27
BR9804946A (pt) 1999-08-24
CA2614926A1 (en) 1998-12-17
ID21014A (id) 1999-04-08
CZ253498A3 (cs) 1999-04-14
JP3672574B2 (ja) 2005-07-20
DE69813560T2 (de) 2004-02-05
DE69813560D1 (de) 2003-05-22
SI0994863T1 (en) 2003-08-31
CN1298708C (zh) 2007-02-07
HU225153B1 (en) 2006-07-28
IL125732A (en) 2002-12-01
EP0994863A1 (en) 2000-04-26
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
PE80999A1 (es) 1999-09-06
PL192114B1 (pl) 2006-08-31
US6455556B2 (en) 2002-09-24
AU8437198A (en) 1998-12-30
EP0994864A1 (en) 2000-04-26
NZ331370A (en) 2000-08-25
DK0994863T3 (da) 2003-05-26
AR012946A1 (es) 2000-11-22
KR19990087835A (ko) 1999-12-27
EP0994864B1 (en) 2003-04-16
HUP0002113A2 (hu) 2001-02-28
SK109498A3 (en) 1998-12-02
IL125733A0 (en) 1999-04-11
CN1572789A (zh) 2005-02-02
CY2007014I2 (el) 2009-11-04
HK1028241A1 (en) 2001-02-09

Similar Documents

Publication Publication Date Title
AR061004A2 (es) Formas cristalinas b y c del compuesto 1-(2,6-difluorobencil)-1h-1,2,3-triazol-4- carboxamida, un preparado farmaceutico y uso para la obtencion del mismo y para la manufactura de un medicamento
AR019853A1 (es) Derivado del acido 3-aril-2-hidroxipropionico, proceso e intermediario para su preparacion, formulaciones farmaceuticas, uso de dicho compuesto en laelaboracion de un medicamento, metodo para la profilaxis y/o tratamiento de trastornos clinicos asociados con la resistencia a la insulina, y formulaci
AR011069A1 (es) Compuestos amidino, proceso para su preparacion, compuestos intermediarios, formulaciones farmaceuticas que los comprenden, y su uso en la fabricacion de un medicamento como inhibidor de la oxido nitrico sintasa inducible.
ES2145774T3 (es) Derivados de adenosina que tienen actividad agonista en a2.
IT1256450B (it) Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
GEP20043237B (en) Pyrazoline Derivatives, Method for Their Preparation and Compositions Containing Them for Treatment of Diseases Mediated by Cyclooxygenase-2
AR020001A1 (es) COMPUESTOS ACTIVADORES DE hPPARGAMMA Y hPPARALFA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN, METODO PARA EL TRATAMIENTO Y/O PREVENCION DE UNAENFERMEDAD MEDIADA POR LOS MISMOS, Y SU USO PARA LA ELABORACION DE UN MEDICAMENTO
AR003415A1 (es) Compuestos analogos de lactacistina, metodo para inhibir la proteolisis dependiente de proteasoma, metodo para identificar un proceso biologico mediado por proteolisis dependiente de proteasoma, uso de dichos compuestos para preparar un medicamento para tratar una condicion mediada por proteolisis dependiente de proteasoma.
WO1994027587A3 (en) Sustained antiepileptic therapy
HUT76511A (en) Benzoyl derivatives, preparation and use thereot
MX9400175A (es) Derivados de fenil tri-substituidos y proceso para su preparacion.
ES2095432T3 (es) Derivados de 2,4-tiazolidin-diona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2102475T3 (es) Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
CO4290417A1 (es) Nuevas benzoilguanidinas como medicamentos y su preparacion .
MX9803629A (es) 5-amino isotiazoles acilados con efecto insecticida, productos intermedios y proceso para su preparacion.
ES2062610T3 (es) Compuesto diarilico anti-ateroesclerotico.
AR019496A1 (es) Azalidas de 13 miembros, composiciones farmaceuticas, uso en la preparacion de medicamentos y preparacion de los mismos
BR9101121A (pt) Composto,processo para sua preparacao,suas aplicacoes,e preparado farmaceutico
EP0137441A3 (de) Cephalosporinderivate und Verfahren zu ihrer Herstellung
MX9303123A (es) Ciclopentano-y-penteno-beta-aminoacidos, procedimiento para su preparacion y medicamentos que los contienen.
MX9300558A (es) Nueva sulfonilurea, procedimiento para su preparacion y formulado farmaceutico que la contiene.
IT1250636B (it) Sale del diclofenac, metodo di preparazione e composizioni farmaceutiche che lo contengono.
HUP9700661A2 (hu) Alfa1-adrenoreceptor antagonisták felhasználása rák megelőzésére és kezelésére alkalmas gyógyszerkészítmények előállítására
ATE40987T1 (de) Acetylenische phenoxypropanolderivate und pharmazeutische zusammensetzungen fuer die behandlung von bluthochdruck.
ES2118248T3 (es) Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.

Legal Events

Date Code Title Description
FC Refusal