SK283685B6 - Kryštálová modifikácia 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ju obsahujú, a jej použitie - Google Patents

Kryštálová modifikácia 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ju obsahujú, a jej použitie Download PDF

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Publication number
SK283685B6
SK283685B6 SK1093-98A SK109398A SK283685B6 SK 283685 B6 SK283685 B6 SK 283685B6 SK 109398 A SK109398 A SK 109398A SK 283685 B6 SK283685 B6 SK 283685B6
Authority
SK
Slovakia
Prior art keywords
weak
modification
difluorobenzyl
triazole
carboxamide
Prior art date
Application number
SK1093-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK109398A3 (en
Inventor
Robert Portmann
Urs Christoph Hofmeier
Andreas Burkhard
Walter Scherrer
Martin Szelagiewicz
Original Assignee
Novartis Ag
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Publication date
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK109398A3 publication Critical patent/SK109398A3/sk
Publication of SK283685B6 publication Critical patent/SK283685B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1093-98A 1997-06-10 1998-06-08 Kryštálová modifikácia 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ju obsahujú, a jej použitie SK283685B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140497 1997-06-10
PCT/EP1998/003427 WO1998056772A1 (en) 1997-06-10 1998-06-08 Crystal modification of 1-(2,6-difluorobenzyl)-1h-1,2,3--triazole-4-carboxamide and its use as antiepileptic

Publications (2)

Publication Number Publication Date
SK109398A3 SK109398A3 (en) 1998-12-02
SK283685B6 true SK283685B6 (sk) 2003-12-02

Family

ID=4209650

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1094-98A SK283734B6 (sk) 1997-06-10 1998-06-08 Kryštálové modifikácie 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ich obsahujú, a ich použitie
SK1093-98A SK283685B6 (sk) 1997-06-10 1998-06-08 Kryštálová modifikácia 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ju obsahujú, a jej použitie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK1094-98A SK283734B6 (sk) 1997-06-10 1998-06-08 Kryštálové modifikácie 1-(2,6-difluórbenzyl)-1H-1,2,3-triazol-4- karboxamidu, farmaceutické prípravky, ktoré ich obsahujú, a ich použitie

Country Status (36)

Country Link
US (6) US6740669B1 (OSRAM)
EP (2) EP0994864B1 (OSRAM)
JP (2) JP3672574B2 (OSRAM)
KR (2) KR100425656B1 (OSRAM)
CN (3) CN1298708C (OSRAM)
AR (4) AR012946A1 (OSRAM)
AT (2) ATE232852T1 (OSRAM)
AU (2) AU725517B2 (OSRAM)
BR (2) BR9804946A (OSRAM)
CA (3) CA2256013C (OSRAM)
CO (2) CO4940452A1 (OSRAM)
CY (1) CY2007014I2 (OSRAM)
CZ (2) CZ292481B6 (OSRAM)
DE (3) DE122007000051I2 (OSRAM)
DK (2) DK0994864T3 (OSRAM)
ES (2) ES2197485T3 (OSRAM)
FR (1) FR07C0037I2 (OSRAM)
HU (2) HU226107B1 (OSRAM)
ID (2) ID27660A (OSRAM)
IL (2) IL125732A (OSRAM)
LU (1) LU91345I2 (OSRAM)
MY (2) MY125854A (OSRAM)
NL (1) NL300284I2 (OSRAM)
NO (2) NO329314B1 (OSRAM)
NZ (2) NZ331370A (OSRAM)
PE (2) PE80999A1 (OSRAM)
PL (2) PL192114B1 (OSRAM)
PT (1) PT994864E (OSRAM)
RU (2) RU2198167C2 (OSRAM)
SI (2) SI0994864T1 (OSRAM)
SK (2) SK283734B6 (OSRAM)
TR (2) TR199801631T1 (OSRAM)
TW (2) TW403740B (OSRAM)
UY (1) UY25844A1 (OSRAM)
WO (2) WO1998056772A1 (OSRAM)
ZA (2) ZA984967B (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
AR040233A1 (es) * 2002-05-31 2005-03-23 Schering Corp Polimorfos inhibidores de xantina fosfodiesterasa v
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20090069390A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched rufinamide
NZ591725A (en) 2008-10-13 2012-09-28 Cipla Ltd PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
CN101768124B (zh) * 2008-12-30 2012-01-04 北京本草天源药物研究院 一种药物晶体及其制备方法和用途
IT1395736B1 (it) * 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
MX2012002730A (es) * 2009-09-04 2012-07-20 Tactical Therapeutics Inc Nuevas composiciones y procesos para preparar formulaciones de 1,2,3-triazoles 5-amino o amino sustituidos y triazol orotato.
EP2465853A1 (en) * 2010-12-14 2012-06-20 Laboratorios Lesvi, S.L. Polymorph of rufinamide and process for obtaining it
EP2563766B1 (en) * 2010-04-30 2014-06-25 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
ITMI20110718A1 (it) * 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
US10206874B2 (en) 2012-07-20 2019-02-19 Hetero Research Foundation Rufinamide solid dispersion
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

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US4156734A (en) * 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
GB1511195A (en) 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
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JPH02214504A (ja) 1989-02-15 1990-08-27 Nissan Chem Ind Ltd 光学活性キノキサリン化合物の晶析法
EP0484437A4 (en) 1989-07-27 1994-06-01 Searle & Co Renal-selective prodrugs for the treatment of hypertension
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
DE69132340T2 (de) 1990-11-06 2001-02-08 Yamanouchi Pharmaceutical Co., Ltd. Kondensiertes pyrazinderivat
JP2753911B2 (ja) 1991-12-06 1998-05-20 キッセイ薬品工業株式会社 Ｎ−ｔｅｒｔ−ブチル−１−メチル−３，３−ジフェニルプロピルアミン塩酸塩の結晶多形およびその製造方法
DE4217952A1 (de) 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
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TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Also Published As

Publication number Publication date
SI0994864T1 (en) 2003-10-31
HK1028031A1 (en) 2001-02-02
AU725517B2 (en) 2000-10-12
ZA984967B (en) 1999-01-11
LU91345I9 (OSRAM) 2018-12-31
NZ331370A (en) 2000-08-25
CA2614926A1 (en) 1998-12-17
AR061004A2 (es) 2008-07-30
ATE237599T1 (de) 2003-05-15
TR199801631T1 (xx) 1999-06-21
SK109398A3 (en) 1998-12-02
AR012945A1 (es) 2000-11-22
SI0994863T1 (en) 2003-08-31
RU2194041C2 (ru) 2002-12-10
IL125733A (en) 2002-12-01
IL125732A (en) 2002-12-01
CN1572789A (zh) 2005-02-02
CN1259127A (zh) 2000-07-05
CA2256015A1 (en) 1998-12-17
KR100409168B1 (ko) 2004-01-31
ATE232852T1 (de) 2003-03-15
HUP0002113A2 (hu) 2001-02-28
DE69811500T2 (de) 2004-04-01
PL192114B1 (pl) 2006-08-31
ID21014A (id) 1999-04-08
NO983666D0 (no) 1998-08-11
AU8437198A (en) 1998-12-30
CY2007014I1 (el) 2009-11-04
CN1132820C (zh) 2003-12-31
PL330798A1 (en) 1999-06-07
PL191943B1 (pl) 2006-07-31
SK109498A3 (en) 1998-12-02
US20040167186A1 (en) 2004-08-26
KR100425656B1 (ko) 2004-05-17
CA2614926C (en) 2010-02-09
CA2256015C (en) 2008-06-03
PT994864E (pt) 2003-07-31
PE79799A1 (es) 1999-09-03
US7750028B2 (en) 2010-07-06
NO329314B1 (no) 2010-09-27
DE69813560D1 (de) 2003-05-22
CO4940452A1 (es) 2000-07-24
RU2198167C2 (ru) 2003-02-10
HUP0002113A3 (en) 2002-09-30
DK0994864T3 (da) 2003-07-21
ES2197485T3 (es) 2004-01-01
PE80999A1 (es) 1999-09-06
BR9804947A (pt) 1999-08-24
CZ292260B6 (cs) 2003-08-13
DE69811500D1 (de) 2003-03-27
EP0994863B1 (en) 2003-02-19
UY25844A1 (es) 2001-08-27
JP2000516258A (ja) 2000-12-05
MY125854A (en) 2006-08-30
CA2256013A1 (en) 1998-12-17
ID27660A (id) 2001-04-19
ZA984966B (en) 1999-01-11
DE122007000051I2 (de) 2009-02-19
CN1159300C (zh) 2004-07-28
AR012946A1 (es) 2000-11-22
CN1217716A (zh) 1999-05-26
AU725528B2 (en) 2000-10-12
IL125733A0 (en) 1999-04-11
CZ253498A3 (cs) 1999-04-14
US20010037029A1 (en) 2001-11-01
FR07C0037I1 (OSRAM) 2007-08-17
SK283734B6 (sk) 2003-12-02
WO1998056773A1 (en) 1998-12-17
CN1298708C (zh) 2007-02-07
WO1998056772A1 (en) 1998-12-17
IL125732A0 (en) 1999-04-11
CZ292481B6 (cs) 2003-09-17
CA2256013C (en) 2007-10-16
EP0994863A1 (en) 2000-04-26
NO983667L (no) 1998-12-17
US20060116520A1 (en) 2006-06-01
CY2007014I2 (el) 2009-11-04
KR19990087835A (ko) 1999-12-27
CO4940448A1 (es) 2000-07-24
DK0994863T3 (da) 2003-05-26
EP0994864B1 (en) 2003-04-16
HUP0000798A2 (hu) 2000-10-30
DE122007000051I1 (de) 2007-11-08
NZ331371A (en) 2000-08-25
HK1028241A1 (en) 2001-02-09
US8076362B2 (en) 2011-12-13
LU91345I2 (fr) 2007-09-04
PL330764A1 (en) 1999-05-24
US6455556B2 (en) 2002-09-24
AR061005A2 (es) 2008-07-30
TW403740B (en) 2000-09-01
TR199801630T1 (xx) 1999-06-21
KR19990087836A (ko) 1999-12-27
NO329315B1 (no) 2010-09-27
US20030125568A1 (en) 2003-07-03
CZ253398A3 (cs) 1999-04-14
NL300284I2 (nl) 2007-11-01
NL300284I1 (nl) 2007-10-01
NO983667D0 (no) 1998-08-11
US20100310655A1 (en) 2010-12-09
AU8437298A (en) 1998-12-30
NO983666L (no) 1998-12-17
DE69813560T2 (de) 2004-02-05
JP2000516259A (ja) 2000-12-05
HUP0000798A3 (en) 2000-10-30
MY120156A (en) 2005-09-30
ES2192779T3 (es) 2003-10-16
BR9804946A (pt) 1999-08-24
HU225153B1 (en) 2006-07-28
JP3672575B2 (ja) 2005-07-20
US6740669B1 (en) 2004-05-25
FR07C0037I2 (OSRAM) 2008-05-16
HK1028242A1 (en) 2001-02-09
JP3672574B2 (ja) 2005-07-20
EP0994864A1 (en) 2000-04-26
HU226107B1 (en) 2008-04-28
TW526195B (en) 2003-04-01

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SPCM Change of validity term of an spc as amended by art. 17 (2) of ec reg. no. 1610/96 and art. 18 of ec reg. no. 469/2009

Free format text: FIRST REGISTRATION NO/DATE: EU/1/06/378/001, EU/1/06/378/002, EU/1/06/378/003, EU/1/06/378/004, EU/1/06/378/005, EU/1/06/378/006, EU/1/06/378/007, EU/1/06/378/008, EU/1/06/378/009, EU/1/06/378/010, EU/1/06/378/011, EU/1/06/378/012, EU/1/06/378/013, EU/1/06/378/014, EU/1/06/378/015, 20070116

Spc suppl protection certif: 63 5005-2007

Filing date: 20070716

Extension date: 20220118

MK4A Patent expired

Expiry date: 20180608