CN1159286C - 1-烷氧羰基-3-苯丙基衍生物的制备方法 - Google Patents

1-烷氧羰基-3-苯丙基衍生物的制备方法 Download PDF

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Publication number
CN1159286C
CN1159286C CNB971945292A CN97194529A CN1159286C CN 1159286 C CN1159286 C CN 1159286C CN B971945292 A CNB971945292 A CN B971945292A CN 97194529 A CN97194529 A CN 97194529A CN 1159286 C CN1159286 C CN 1159286C
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China
Prior art keywords
phenylpropyl
alkoxycarbonyl
alanine
reaction
ethoxycarbonyl
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Expired - Lifetime
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CNB971945292A
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English (en)
Chinese (zh)
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CN1218454A (zh
Inventor
上田恭义
松本昭
真锅肇
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Kanegafuchi Chemical Industry Co Ltd
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Kanegafuchi Chemical Industry Co Ltd
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Publication of CN1218454A publication Critical patent/CN1218454A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB971945292A 1996-05-10 1997-05-08 1-烷氧羰基-3-苯丙基衍生物的制备方法 Expired - Lifetime CN1159286C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11654596A JP3792777B2 (ja) 1996-05-10 1996-05-10 １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法
JP116545/96 1996-05-10
JP116545/1996 1996-05-10

Publications (2)

Publication Number Publication Date
CN1218454A CN1218454A (zh) 1999-06-02
CN1159286C true CN1159286C (zh) 2004-07-28

Family

ID=14689775

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB971945292A Expired - Lifetime CN1159286C (zh) 1996-05-10 1997-05-08 1-烷氧羰基-3-苯丙基衍生物的制备方法

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Country Link
US (1) US6118010A (enExample)
EP (2) EP1679303B1 (enExample)
JP (1) JP3792777B2 (enExample)
KR (1) KR100382633B1 (enExample)
CN (1) CN1159286C (enExample)
AT (1) ATE481378T1 (enExample)
CA (1) CA2254972C (enExample)
DE (2) DE69739998D1 (enExample)
ES (2) ES2353151T3 (enExample)
HU (1) HU227430B1 (enExample)
IN (2) IN183558B (enExample)
SI (1) SI9720039B (enExample)
WO (1) WO1997043246A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101239923B (zh) * 2007-12-31 2010-09-15 浙江工业大学 (s,s)n-(1-乙氧羰基-3-苯丙基)-l-氨基酸衍生物的制备方法与精制方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE346086T1 (de) 1998-09-22 2006-12-15 Kaneka Corp Verfahren zur herstellung von n2-(1(s)-carboxy-3- phenylpropyl)-l-lysyl-l-prolin
AU2000239828A1 (en) * 2000-04-18 2001-10-30 Scinopharm Singapore Pte Ltd Process for preparation of 3-((1'-(alkoxycarbonyl)-3'-phenylpropyl)amino)-2-oxo-(1)- benzazepine and its derivatives
AR033048A1 (es) 2001-03-19 2003-12-03 Kaneka Corp Metodo para la purificacion de la n-(1(s)-etoxicarbonil-3-fenilpropil) -l-alanina
JP2003026644A (ja) * 2001-07-11 2003-01-29 Kanegafuchi Chem Ind Co Ltd Ｎ２−（１（ｓ）−エトキシカルボニル−３−フェニルプロピル）−ｎ６−トリフルオロアセチル−ｌ−リジンの精製方法
SI21101A (sl) * 2001-11-26 2003-06-30 LEK farmacevtska dru�ba d.d. Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo
EP1513868B1 (en) * 2002-06-19 2006-08-09 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Process for the production of lisinopril
JP4744979B2 (ja) * 2005-08-24 2011-08-10 独立行政法人理化学研究所 ゼオライトを用いたタンパク質結晶化方法
EP2118123B1 (en) 2007-01-31 2015-10-14 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP3159352B1 (en) 2007-03-28 2023-08-02 President and Fellows of Harvard College Stitched polypeptides
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
CN101973904B (zh) * 2010-09-28 2014-01-01 雅本化学股份有限公司 一种具有高光学纯度的n2-[1-(s)-乙氧羰基-3-苯丙基]-n6-三氟乙酰基-l-赖氨酸的制备方法
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
BR112015009470A2 (pt) * 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
CN105294827A (zh) * 2014-07-21 2016-02-03 常州制药厂有限公司 一种马来酸依那普利的制备方法
MX389354B (es) 2014-09-24 2025-03-20 Aileron Therapeutics Inc Macrociclos peptidomimeticos y formulaciones de los mismos.
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
CN106220545B (zh) * 2016-07-21 2019-08-13 成都摩尔生物医药有限公司 一种acei药物环己基杂质的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1327787A3 (ru) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0190687B1 (en) * 1985-02-04 1988-10-05 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing ethyl-alpha-(1-carboxyethyl)-amino-gamma-oxo-gamma-phenylbutyrate
ES2028812T3 (es) * 1986-03-27 1992-07-16 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Un procedimiento para la preparacion de un derivado de n2-(1-carboxi-3-oxo-3-fenilpropil)-l-lisina.
JPH01104034A (ja) * 1986-03-27 1989-04-21 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体の製造法
JPS62239062A (ja) * 1986-04-11 1987-10-19 Matsushita Electric Ind Co Ltd 交差コイル式メ−タの駆動回路
JPH03115254A (ja) * 1990-09-12 1991-05-16 Kanegafuchi Chem Ind Co Ltd α―（１―カルボキシエチル）アミノ―γ―フエニル酪酸エチルの製造法
JPH06336495A (ja) * 1993-05-28 1994-12-06 Kyowa Hakko Kogyo Co Ltd Ｌ−アラニル−ｌ−プロリン誘導体の製造法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101239923B (zh) * 2007-12-31 2010-09-15 浙江工业大学 (s,s)n-(1-乙氧羰基-3-苯丙基)-l-氨基酸衍生物的制备方法与精制方法

Also Published As

Publication number Publication date
EP0903337A1 (en) 1999-03-24
JP3792777B2 (ja) 2006-07-05
CN1218454A (zh) 1999-06-02
IN183558B (enExample) 2000-02-12
ES2257775T3 (es) 2006-08-01
DE69735667T2 (de) 2007-04-26
EP0903337A4 (en) 2001-02-28
EP0903337B1 (en) 2006-04-12
EP1679303A1 (en) 2006-07-12
KR20000010840A (ko) 2000-02-25
CA2254972C (en) 2005-08-02
EP1679303B1 (en) 2010-09-15
HU227430B1 (hu) 2011-06-28
ATE481378T1 (de) 2010-10-15
CA2254972A1 (en) 1997-11-20
WO1997043246A1 (fr) 1997-11-20
DE69735667D1 (de) 2006-05-24
ES2353151T3 (es) 2011-02-25
DE69739998D1 (de) 2010-10-28
HUP9903214A3 (en) 2002-12-28
JPH09301938A (ja) 1997-11-25
SI9720039A (sl) 1999-08-31
SI9720039B (sl) 2002-02-28
KR100382633B1 (ko) 2003-07-12
IN187140B (enExample) 2002-02-09
US6118010A (en) 2000-09-12

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