DE69739998D1 - Verfahren zur Herstellung von 1-Alkoxycarbonyl-3-phenylpropylderivaten - Google Patents

Verfahren zur Herstellung von 1-Alkoxycarbonyl-3-phenylpropylderivaten

Info

Publication number
DE69739998D1
DE69739998D1 DE69739998T DE69739998T DE69739998D1 DE 69739998 D1 DE69739998 D1 DE 69739998D1 DE 69739998 T DE69739998 T DE 69739998T DE 69739998 T DE69739998 T DE 69739998T DE 69739998 D1 DE69739998 D1 DE 69739998D1
Authority
DE
Germany
Prior art keywords
formula
alkoxycarbonyl
phenylpropyl
preparation
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739998T
Other languages
German (de)
English (en)
Inventor
Yasuyoshi Ueda
Akira Matsumoto
Hajime Manabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of DE69739998D1 publication Critical patent/DE69739998D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69739998T 1996-05-10 1997-05-08 Verfahren zur Herstellung von 1-Alkoxycarbonyl-3-phenylpropylderivaten Expired - Lifetime DE69739998D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11654596A JP3792777B2 (ja) 1996-05-10 1996-05-10 １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法

Publications (1)

Publication Number Publication Date
DE69739998D1 true DE69739998D1 (de) 2010-10-28

Family

ID=14689775

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69739998T Expired - Lifetime DE69739998D1 (de) 1996-05-10 1997-05-08 Verfahren zur Herstellung von 1-Alkoxycarbonyl-3-phenylpropylderivaten
DE69735667T Expired - Lifetime DE69735667T2 (de) 1996-05-10 1997-05-08 Verfahren zur herstellung von 1-alkoxycarbonyl-3-phenylpropylderivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69735667T Expired - Lifetime DE69735667T2 (de) 1996-05-10 1997-05-08 Verfahren zur herstellung von 1-alkoxycarbonyl-3-phenylpropylderivaten

Country Status (13)

Country Link
US (1) US6118010A (enExample)
EP (2) EP0903337B1 (enExample)
JP (1) JP3792777B2 (enExample)
KR (1) KR100382633B1 (enExample)
CN (1) CN1159286C (enExample)
AT (1) ATE481378T1 (enExample)
CA (1) CA2254972C (enExample)
DE (2) DE69739998D1 (enExample)
ES (2) ES2353151T3 (enExample)
HU (1) HU227430B1 (enExample)
IN (2) IN183558B (enExample)
SI (1) SI9720039B (enExample)
WO (1) WO1997043246A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL340685A1 (en) * 1998-09-22 2001-02-26 Kaneka Corp Method of obtaining n2-(1(s)-carboxy-3-phenylpropyl)-l-lysil-l-proline
AU2000239828A1 (en) * 2000-04-18 2001-10-30 Scinopharm Singapore Pte Ltd Process for preparation of 3-((1'-(alkoxycarbonyl)-3'-phenylpropyl)amino)-2-oxo-(1)- benzazepine and its derivatives
AR033048A1 (es) 2001-03-19 2003-12-03 Kaneka Corp Metodo para la purificacion de la n-(1(s)-etoxicarbonil-3-fenilpropil) -l-alanina
JP2003026644A (ja) * 2001-07-11 2003-01-29 Kanegafuchi Chem Ind Co Ltd Ｎ２−（１（ｓ）−エトキシカルボニル−３−フェニルプロピル）−ｎ６−トリフルオロアセチル−ｌ−リジンの精製方法
SI21101A (sl) * 2001-11-26 2003-06-30 LEK farmacevtska dru�ba d.d. Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo
ATE335757T1 (de) * 2002-06-19 2006-09-15 Eos Eczacibasi Ozgun Kimyasal Verfahren zur herstellung von lisinopril
JP4744979B2 (ja) * 2005-08-24 2011-08-10 独立行政法人理化学研究所 ゼオライトを用いたタンパク質結晶化方法
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
CN101239923B (zh) * 2007-12-31 2010-09-15 浙江工业大学 (s,s)n-(1-乙氧羰基-3-苯丙基)-l-氨基酸衍生物的制备方法与精制方法
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
CN101973904B (zh) 2010-09-28 2014-01-01 雅本化学股份有限公司 一种具有高光学纯度的n2-[1-(s)-乙氧羰基-3-苯丙基]-n6-三氟乙酰基-l-赖氨酸的制备方法
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
WO2014071241A1 (en) * 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN105294827A (zh) * 2014-07-21 2016-02-03 常州制药厂有限公司 一种马来酸依那普利的制备方法
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN106220545B (zh) * 2016-07-21 2019-08-13 成都摩尔生物医药有限公司 一种acei药物环己基杂质的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1327787A3 (ru) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3660868D1 (en) * 1985-02-04 1988-11-10 Kanegafuchi Chemical Ind Process for preparing ethyl-alpha-(1-carboxyethyl)-amino-gamma-oxo-gamma-phenylbutyrate
JPH01104034A (ja) * 1986-03-27 1989-04-21 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体の製造法
DE3770301D1 (de) * 1986-03-27 1991-07-04 Kanegafuchi Chemical Ind N2-(1-carboxy-3-oxo-3-phenylpropyl)-l-lysinverbindungen und deren abkoemmlinge.
JPS62239062A (ja) * 1986-04-11 1987-10-19 Matsushita Electric Ind Co Ltd 交差コイル式メ−タの駆動回路
JPH03115254A (ja) * 1990-09-12 1991-05-16 Kanegafuchi Chem Ind Co Ltd α―（１―カルボキシエチル）アミノ―γ―フエニル酪酸エチルの製造法
JPH06336495A (ja) * 1993-05-28 1994-12-06 Kyowa Hakko Kogyo Co Ltd Ｌ−アラニル−ｌ−プロリン誘導体の製造法

Also Published As

Publication number Publication date
IN187140B (enExample) 2002-02-09
CA2254972A1 (en) 1997-11-20
SI9720039A (sl) 1999-08-31
CN1159286C (zh) 2004-07-28
KR20000010840A (ko) 2000-02-25
JP3792777B2 (ja) 2006-07-05
ES2257775T3 (es) 2006-08-01
EP0903337B1 (en) 2006-04-12
US6118010A (en) 2000-09-12
HU227430B1 (hu) 2011-06-28
SI9720039B (sl) 2002-02-28
EP1679303B1 (en) 2010-09-15
EP1679303A1 (en) 2006-07-12
KR100382633B1 (ko) 2003-07-12
CA2254972C (en) 2005-08-02
IN183558B (enExample) 2000-02-12
DE69735667D1 (de) 2006-05-24
ES2353151T3 (es) 2011-02-25
EP0903337A4 (en) 2001-02-28
DE69735667T2 (de) 2007-04-26
ATE481378T1 (de) 2010-10-15
HUP9903214A3 (en) 2002-12-28
EP0903337A1 (en) 1999-03-24
CN1218454A (zh) 1999-06-02
WO1997043246A1 (fr) 1997-11-20
JPH09301938A (ja) 1997-11-25

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