CN1159076C - 粉状药物吸入器 - Google Patents

粉状药物吸入器 Download PDF

Info

Publication number
CN1159076C
CN1159076C CNB971939640A CN97193964A CN1159076C CN 1159076 C CN1159076 C CN 1159076C CN B971939640 A CNB971939640 A CN B971939640A CN 97193964 A CN97193964 A CN 97193964A CN 1159076 C CN1159076 C CN 1159076C
Authority
CN
China
Prior art keywords
powder
counter ring
metering plate
pawl
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB971939640A
Other languages
English (en)
Chinese (zh)
Other versions
CN1216476A (zh
Inventor
T��J��������ķ
T·J·阿姆布罗斯奥
�������ɭ
小W·A·本森
K·C·岛
D·J·肯杨
I���¶�
W·J·克雷瑟德尔
Ф�ɱ�ķ
T·J·肖纳鲍姆
�ָ���
A·J·沃格尔
L·B·瓦尔克尔
杨宗德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1216476A publication Critical patent/CN1216476A/zh
Application granted granted Critical
Publication of CN1159076C publication Critical patent/CN1159076C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/14—Design features of general application for transferring a condition from one stage to a higher stage
    • G06M1/16—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism
    • G06M1/163—Design features of general application for transferring a condition from one stage to a higher stage self-operating, e.g. by Geneva mechanism with drums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Coating Apparatus (AREA)
  • Nozzles (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Closures For Containers (AREA)
  • Cosmetics (AREA)
  • Filling Or Emptying Of Bunkers, Hoppers, And Tanks (AREA)
CNB971939640A 1996-02-21 1997-02-13 粉状药物吸入器 Expired - Lifetime CN1159076C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60454996A 1996-02-21 1996-02-21
US08/604,549 1996-02-21

Publications (2)

Publication Number Publication Date
CN1216476A CN1216476A (zh) 1999-05-12
CN1159076C true CN1159076C (zh) 2004-07-28

Family

ID=24420048

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB971939640A Expired - Lifetime CN1159076C (zh) 1996-02-21 1997-02-13 粉状药物吸入器

Country Status (28)

Country Link
US (1) US6240918B1 (cg-RX-API-DMAC10.html)
EP (1) EP0883415B1 (cg-RX-API-DMAC10.html)
JP (2) JP3830972B2 (cg-RX-API-DMAC10.html)
KR (1) KR100453610B1 (cg-RX-API-DMAC10.html)
CN (1) CN1159076C (cg-RX-API-DMAC10.html)
AR (1) AR005888A1 (cg-RX-API-DMAC10.html)
AT (1) ATE216903T1 (cg-RX-API-DMAC10.html)
AU (1) AU714886B2 (cg-RX-API-DMAC10.html)
BR (1) BR9707660A (cg-RX-API-DMAC10.html)
CA (1) CA2245799C (cg-RX-API-DMAC10.html)
CZ (1) CZ298885B6 (cg-RX-API-DMAC10.html)
DE (1) DE69712324T2 (cg-RX-API-DMAC10.html)
DK (1) DK0883415T3 (cg-RX-API-DMAC10.html)
ES (1) ES2172763T3 (cg-RX-API-DMAC10.html)
HU (1) HU221033B1 (cg-RX-API-DMAC10.html)
ID (1) ID19343A (cg-RX-API-DMAC10.html)
IL (1) IL120246A (cg-RX-API-DMAC10.html)
MY (1) MY115064A (cg-RX-API-DMAC10.html)
NO (1) NO316787B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ331361A (cg-RX-API-DMAC10.html)
PL (1) PL185384B1 (cg-RX-API-DMAC10.html)
PT (1) PT883415E (cg-RX-API-DMAC10.html)
RU (1) RU2195965C2 (cg-RX-API-DMAC10.html)
SK (1) SK287878B6 (cg-RX-API-DMAC10.html)
TW (1) TW333459B (cg-RX-API-DMAC10.html)
UA (1) UA49878C2 (cg-RX-API-DMAC10.html)
WO (1) WO1997030743A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA971324B (cg-RX-API-DMAC10.html)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2199858A1 (en) * 1994-09-16 1996-03-21 Alain Emile Edward Schaeffer Inhalation device
EP0995457B1 (de) 1995-12-07 2004-03-10 Jago Research Ag Mundstück für einen Inhalator zur mehrfachen dosisweisen Abgabe eines pharmakologischen Trockenpulvers
US7131441B1 (en) 1995-12-07 2006-11-07 Skyepharma Ag Inhaler for multiple dosed administration of a pharmacological dry powder
GB9626263D0 (en) * 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
TW469832U (en) 1997-03-14 2001-12-21 Astra Ab Inhalation device
SE9700938D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Powder inhaler II and a method of construction thereof
US7143764B1 (en) * 1998-03-13 2006-12-05 Astrazeneca Ab Inhalation device
DE29814647U1 (de) * 1998-08-14 1999-12-23 Josef Wischerath Gmbh & Co. Kg, 50259 Pulheim Inhalator mit einer Dosierzähleinrichtung
DE29908593U1 (de) 1999-05-14 1999-07-22 Jago Research AG, Hergiswil Mundstück für einen Inhalator zur Abgabe eines Medikaments
PL352615A1 (en) 1999-06-05 2003-08-25 Innovata Biomed Ltd Delivery system
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
US7089934B2 (en) * 2000-02-28 2006-08-15 Vectura Limited Delivery of oral drugs
AU2001263098A1 (en) * 2000-05-12 2001-11-26 Iep Pharmaceutical Devices, Inc. Powder/liquid metering valve
GB2364649A (en) * 2000-05-17 2002-02-06 Orion Corp Inhaler with Dose Counter
TWI224513B (en) * 2000-06-23 2004-12-01 Norton Healthcare Ltd Dose counter for medicament inhaler
FR2811576B1 (fr) * 2000-07-13 2003-01-24 Henri Bocquee Disposits ou appareils d'administration de produits actifs pulverurents du type medicaments ou vaccins, par voie pulmonaire
US6595210B2 (en) * 2000-11-27 2003-07-22 Unisia Jecs Corporation Inhalator for administering powder composition
DE60221640T2 (de) * 2001-02-06 2008-05-21 Innovata Biomed Ltd., St. Albans Bimodale trockenpulverzusammensetzung zur inhalation
SE0101233L (sv) * 2001-04-05 2002-10-01 Microdrug Ag Förfarande och anordning för frigörande av pulver och inhalatoranordning för administrering av medicinskt pulver
US6766799B2 (en) * 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
GB0128148D0 (en) * 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
US6772756B2 (en) 2002-02-09 2004-08-10 Advanced Inhalation Revolutions Inc. Method and system for vaporization of a substance
GB0204829D0 (en) * 2002-03-01 2002-04-17 Glaxo Group Ltd A fluid dispensing device
PT1494732E (pt) * 2002-03-20 2008-03-20 Mannkind Corp Aparelho de inalação
US7814900B2 (en) 2002-03-22 2010-10-19 Clinical Designs Limited Can fixture
EP2497514B8 (de) * 2002-09-16 2015-12-16 Sanofi SA Inhalator für pulverförmige, insbesondere medizinische Substanzen
US7322352B2 (en) 2002-09-21 2008-01-29 Aventis Pharma Limited Inhaler
GB0222023D0 (en) * 2002-09-21 2002-10-30 Aventis Pharma Ltd Inhaler
AU2003272935C1 (en) * 2002-10-11 2009-06-25 Otsuka Pharmaceutical Co., Ltd. Powder inhalation device
WO2004064705A2 (en) 2003-01-17 2004-08-05 Schering Corporation Training device for medicament inhalers
GB0304000D0 (en) 2003-02-21 2003-03-26 Clinical Designs Ltd Dispenser
US20040177848A1 (en) * 2003-03-12 2004-09-16 Alley Kenneth A. Multi-compartment inhaler
GB0313604D0 (en) * 2003-06-12 2003-07-16 Britannia Pharmaceuticals Ltd Delivery device for powdered medicament
GB0327112D0 (en) 2003-11-21 2003-12-24 Clincial Designs Ltd Dispenser and reservoir
GB0328859D0 (en) 2003-12-12 2004-01-14 Clinical Designs Ltd Dispenser and counter
GB0403394D0 (en) * 2004-02-16 2004-03-17 Glaxo Group Ltd Counter for use with a medicament dispenser
PL1730676T3 (pl) * 2004-02-16 2014-04-30 Glaxo Group Ltd Licznik do stosowania z dozownikiem leku
JP4940127B2 (ja) * 2004-03-10 2012-05-30 グラクソ グループ リミテッド 投与装置
US7246728B2 (en) * 2004-03-31 2007-07-24 The Sherwin-Williams Company Container and lid assembly
JP2007533387A (ja) * 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
GB0409197D0 (en) * 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
GB0410712D0 (en) * 2004-05-13 2004-06-16 Novartis Ag Organic compounds
AU2005263486B2 (en) * 2004-07-16 2011-05-12 Astrazeneca Ab Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler
AU2005272309B2 (en) * 2004-08-12 2010-08-19 Teijin Limited Counter mechanism of feeder and feeder having counter mechanism
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
GB0425518D0 (en) 2004-11-19 2004-12-22 Clinical Designs Ltd Substance source
GB0428204D0 (en) 2004-12-23 2005-01-26 Clinical Designs Ltd Medicament container
TWI372749B (en) 2005-03-10 2012-09-21 Theravance Inc Crystalline forms of a biphenyl compound
FR2883400B1 (fr) 2005-03-16 2007-06-15 Valois Sas Dispositif d'indication de doses pour distribuer des produits fluides ou pulverulents
EP1879620A2 (en) 2005-03-30 2008-01-23 Schering Corporation Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist
USD550835S1 (en) * 2005-07-22 2007-09-11 Omron Healthcare Co., Ltd. Atomizer for inhaler
GB0518400D0 (en) * 2005-09-09 2005-10-19 Clinical Designs Ltd Dispenser
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
GB0519151D0 (en) 2005-09-20 2005-10-26 Aventis Pharma Ltd Inhaler
KR100709270B1 (ko) 2005-09-28 2007-04-19 문찬식 휴대가 가능한 액상향료 흡입 장치
US20070099883A1 (en) * 2005-10-07 2007-05-03 Cheryl Lynn Calis Anhydrous mometasone furoate formulation
CA2881155A1 (en) 2005-11-21 2007-05-31 Mannkind Corporation Powder dispensing and sensing apparatus and methods
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
GB0605150D0 (en) * 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
NZ573910A (en) * 2006-06-16 2011-07-29 Cipla Ltd Dry powder inhaler in which the turbulent flow causes the vibration of capsule assisting in release of medicament
DE102006045788A1 (de) * 2006-09-26 2008-03-27 Alfred Von Schuckmann Spender für pulverförmige Massen
WO2008081132A2 (fr) * 2006-12-11 2008-07-10 Valois Sas Dispositif de distribution de produit fluide
WO2008091355A2 (en) * 2007-01-24 2008-07-31 Breathe Pharmaceuticals, Inc. Drug transfer device
AP2007000277S (en) * 2007-03-28 2007-10-04 Xerxes Rao Cartridge for multidose inhaler
GB2448183A (en) * 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
GB0713876D0 (en) * 2007-07-18 2007-08-29 3M Innovative Properties Co Manufacture of components for medicinal dispensers
CN101827844B (zh) 2007-10-17 2013-08-14 诺瓦提斯公司 可用作ALK抑制剂的咪唑并[1,2-a]吡啶衍生物
CN201337727Y (zh) * 2007-12-28 2009-11-04 国家纳米技术与工程研究院 一种肺部给药的干粉吸入器装置
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
KR20100129728A (ko) * 2008-01-23 2010-12-09 아스트라제네카 아베 사용자에게 표시부를 제공하는 디스플레이가 제공되는 의약-수용 분배기
CA2722727C (en) 2008-05-02 2016-06-07 Boehringer Ingelheim International Gmbh Inhaler with blocking device based on number of operations or uses
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
RU2608439C2 (ru) 2008-06-13 2017-01-18 Маннкайнд Корпорейшн Ингалятор для сухого порошка и система для доставки лекарственных средств
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
EP2684801B1 (en) * 2008-08-05 2015-07-08 MannKind Corporation Powder dispensing and sensing apparatus and method of dispensing and sensing powder
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
GB0904040D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
GB0904059D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101290893B1 (ko) 2009-04-09 2013-07-29 노파르티스 아게 피롤리디늄 염의 제조 방법
CN102647979B (zh) 2009-06-12 2015-03-04 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
CN102711885B (zh) * 2009-11-13 2014-10-29 默沙东公司 药品用产品和具有多个贮存器的干粉吸入器
USD665073S1 (en) * 2010-02-26 2012-08-07 Omron Healthcare Co., Ltd. Atomizer for inhaler
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US9202164B2 (en) 2011-09-26 2015-12-01 Trudell Medical International Dose counter and medication delivery device
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
GB201118842D0 (en) * 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser cap arrangement
WO2013105066A1 (en) 2012-01-13 2013-07-18 Novartis Ag Salts of an ip receptor agonist
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
RU2627380C2 (ru) * 2012-04-26 2017-08-08 Конинклейке Филипс Н.В. Ингалятор и способ изготовления ингалятора
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
EP2879743B1 (en) * 2012-07-31 2016-12-07 Sanofi SA Arrangement for a drug delivery device
CN103656811B (zh) * 2012-09-19 2015-06-17 上海理工大学 粉剂定量给药装置
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
USD727492S1 (en) * 2012-12-06 2015-04-21 Koninklijke Philips N.V. Disposable airway adapter for respiratory gas monitoring
CN104968656B (zh) 2012-12-19 2017-08-11 诺华股份有限公司 自分泌运动因子抑制剂
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
BR112015020443A8 (pt) 2013-03-14 2019-11-12 Novartis Ag formulação em pó para inalação, seus usos e seu processo de preparação, e composição farmacêutica
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
EP3022201A1 (en) 2013-07-18 2016-05-25 Novartis AG Autotaxin inhibitors
CA2918369C (en) 2013-07-18 2021-06-29 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EA035256B1 (ru) 2013-07-18 2020-05-21 Новартис Аг Ингибиторы аутотаксинов, содержащие гетероарил-бензил-амидное ядро
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
GB201319265D0 (en) * 2013-10-31 2013-12-18 Norton Waterford Ltd Medicament inhaler
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
JP6433509B2 (ja) 2014-04-24 2018-12-05 ノバルティス アーゲー ホスファチジルイノシトール３−キナーゼ阻害薬としてのアミノピラジン誘導体
WO2015162558A1 (en) 2014-04-24 2015-10-29 Novartis Ag Autotaxin inhibitors
BR112016024484A2 (pt) 2014-04-24 2017-08-15 Novartis Ag derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase
PL3134395T3 (pl) 2014-04-24 2018-07-31 Novartis Ag Pochodne pirazyny jako inhibitory 3-kinazy fosfatydyloinozytolu
US20170088545A1 (en) 2014-05-14 2017-03-30 Novartis Ag Carboxamide inhibitors
WO2015173659A2 (en) 2014-05-14 2015-11-19 Novartis Ag Carboxamide derivatives
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
TW201636068A (zh) * 2015-01-13 2016-10-16 賽諾菲股份有限公司 藥物輸送裝置之組件
ES2932770T3 (es) 2015-05-08 2023-01-26 Iconovo Ab Inhalador de polvo seco
JP6942057B2 (ja) * 2015-05-08 2021-09-29 イコノヴォ アーベー ロック機構、投薬表示部、釣り合いおもり機構、またはそれらの組合せを備える乾燥粉末吸入器
WO2017040773A1 (en) * 2015-09-02 2017-03-09 Mylan Inc. Medication packaging and dose regimen system
WO2017112451A1 (en) 2015-12-21 2017-06-29 3M Innovative Properties Company Auto-reset dose release firing systems, medicinal inhalers comprising same, and methods of using same
WO2017112476A2 (en) * 2015-12-21 2017-06-29 3M Innovative Properties Company Dose release firing systems and medicinal inhalers comprising same
WO2017112400A1 (en) 2015-12-21 2017-06-29 3M Innovative Properties Company Medicinal inhalers
EP4253273A3 (en) 2016-11-21 2024-03-27 Ecolab USA Inc. Material supply system with valve assembly with improved sealing capabilities
WO2018093995A1 (en) 2016-11-21 2018-05-24 Ecolab Usa Inc. Material supply system with a valve assembly and a base assembly provided with an actuator
EP4147771A1 (en) 2017-12-04 2023-03-15 Ecolab Usa Inc. Material wetting system with shroud assembly
MX2020005768A (es) 2017-12-04 2020-08-20 Ecolab Usa Inc Sistema de tolva de material en polvo con carga desplazada.
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
US11206864B2 (en) * 2018-03-26 2021-12-28 Rai Strategic Holdings, Inc. Aerosol delivery device providing flavor control
CN108741239B (zh) * 2018-09-17 2021-01-12 杭州清大科瑞生物科技有限公司 一种电子烟式烟弹可替换的干细胞吸入装置
FR3098420B1 (fr) * 2019-07-10 2021-07-09 Aptar France Sas Dispositif de distribution nasale de poudre
IL295115A (en) 2020-01-31 2022-09-01 Advita Lifescience Gmbh Human anti-inflammatory peptides for the inhalatory treatment of inflammatory pulmonary diseases
CN113262365B (zh) * 2021-05-19 2023-06-23 西安交通大学医学院第二附属医院 一种急诊科雾化装置
CN114432546B (zh) * 2021-12-31 2024-04-16 上海成煜医疗科技有限公司 吸入式给药器的计数装置
US20230372646A1 (en) * 2022-05-19 2023-11-23 Willie Tsang Inhaling device

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2432641A (en) * 1944-06-20 1947-12-16 Wilsons Sons Inc William M Dispensing nozzle or faucet
US2456451A (en) * 1946-05-31 1948-12-14 Scovill Manufacturing Co Inhaler
US2604094A (en) 1949-06-25 1952-07-22 Schenley Ind Inc Inhaler
US3024787A (en) * 1957-03-20 1962-03-13 Herbert M Birch Means for administering pressurized medicaments, gases, combination thereof and liquids into body cavities
US3587573A (en) * 1969-06-20 1971-06-28 John Gene Flack Inhalation device with rupturable microscopic capsules
GB1283205A (en) * 1969-09-30 1972-07-26 Griffiths Fuel Injection Dev L Improvements relating to fuel injection apparatus for internal combustion engines
SE448277B (sv) 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
DK479189D0 (da) 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
SE466684B (sv) * 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
DE4004904A1 (de) * 1990-02-16 1990-09-13 Gerhard Brendel Trommel-applikator
IT1240750B (it) 1990-04-12 1993-12-17 Chiesi Farma Spa Dispositivo per la somministrazione di sostanze medicamentose in polvere
US5429122A (en) * 1990-09-26 1995-07-04 Zanen; Pieter Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
GB9027234D0 (en) * 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
US5129582A (en) * 1990-12-26 1992-07-14 General Turbine Systems, Inc. Turbine injector device and method
DE4142238A1 (de) * 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen
SE9201411D0 (sv) 1992-05-05 1992-05-05 Astra Ab Dosage inhalator with indicating/interupting means
US5394868A (en) * 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
SE9203570D0 (sv) 1992-11-27 1992-11-27 Astra Ab Inhaler for multiple use
JP2924924B2 (ja) * 1992-12-18 1999-07-26 シェリング・コーポレーション 粉末薬物のための吸入器
AU684779B2 (en) * 1993-05-12 1998-01-08 Teijin Limited Device and method for dispensing powdered medicine in multiple doses
US5415162A (en) * 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device

Also Published As

Publication number Publication date
CN1216476A (zh) 1999-05-12
MY115064A (en) 2003-03-31
AU714886B2 (en) 2000-01-13
ZA971324B (en) 1997-08-18
HU221033B1 (hu) 2002-07-29
CA2245799A1 (en) 1997-08-28
WO1997030743A2 (en) 1997-08-28
TW333459B (en) 1998-06-11
DE69712324D1 (de) 2002-06-06
CZ259998A3 (cs) 1999-09-15
ID19343A (id) 1998-07-02
DE69712324T2 (de) 2002-08-29
PL185384B1 (pl) 2003-04-30
CZ298885B6 (cs) 2008-03-05
AU1850897A (en) 1997-09-10
NO983832D0 (no) 1998-08-20
IL120246A (en) 2001-05-20
JP3830972B2 (ja) 2006-10-11
WO1997030743A3 (en) 1997-11-13
UA49878C2 (uk) 2002-10-15
JP2000504955A (ja) 2000-04-25
DK0883415T3 (da) 2002-08-19
NO983832L (no) 1998-10-20
PL328485A1 (en) 1999-02-01
SK115498A3 (en) 2000-02-14
BR9707660A (pt) 2001-10-30
US6240918B1 (en) 2001-06-05
SK287878B6 (sk) 2012-02-03
KR100453610B1 (ko) 2005-01-13
EP0883415B1 (en) 2002-05-02
HK1015718A1 (en) 1999-10-22
RU2195965C2 (ru) 2003-01-10
NO316787B1 (no) 2004-05-10
NZ331361A (en) 2000-01-28
CA2245799C (en) 2006-03-21
EP0883415A1 (en) 1998-12-16
PT883415E (pt) 2002-10-31
ES2172763T3 (es) 2002-10-01
KR19990087128A (ko) 1999-12-15
ATE216903T1 (de) 2002-05-15
HUP9902899A3 (en) 2000-03-28
JP2006263478A (ja) 2006-10-05
AR005888A1 (es) 1999-07-21
IL120246A0 (en) 1997-06-10
HUP9902899A2 (hu) 1999-12-28

Similar Documents

Publication Publication Date Title
CN1159076C (zh) 粉状药物吸入器
CN1120024C (zh) 粉料药物吸入器
CN1181896C (zh) 带整体计量装置的药筒和药粉吸入器
CN1871044A (zh) 分发装置
RU2468831C2 (ru) Дозировочное устройство для ингаляции порошкообразной субстанции
CN1787879A (zh) 具有封堵器的流体分配装置
HK1052312A1 (zh) 粉末药剂多次投药器
CN1286638A (zh) 吸药装置
CN1217713C (zh) 雾化药物制剂的系统和方法
JP3293722B2 (ja) 吸入装置
CN1204935C (zh) 粉末药物多剂量给药器
CN102711885B (zh) 药品用产品和具有多个贮存器的干粉吸入器
CN1067822A (zh) 粉末药物的吸入装置
CN1462196A (zh) 静电定剂量干粉末吸入器的最优化
CN1942251A (zh) 抗静电油漆杯
CN116603139B (zh) 一种可便捷拆装的药粉吸入装置
HK1015718B (en) Powdered medication inhaler
HK1018011B (en) Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: MSD CORP.

Free format text: FORMER NAME: SCHERING CORP (US)

CP01 Change in the name or title of a patent holder

Address after: new jersey

Patentee after: Schering Corporation

Address before: new jersey

Patentee before: SCHERING CORP (US)

CX01 Expiry of patent term

Granted publication date: 20040728

CX01 Expiry of patent term