CN1155579C - 二盐酸组胺的合成 - Google Patents

二盐酸组胺的合成 Download PDF

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Publication number
CN1155579C
CN1155579C CNB998149063A CN99814906A CN1155579C CN 1155579 C CN1155579 C CN 1155579C CN B998149063 A CNB998149063 A CN B998149063A CN 99814906 A CN99814906 A CN 99814906A CN 1155579 C CN1155579 C CN 1155579C
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CN
China
Prior art keywords
histamine
methanol
hydrochloric acid
dihydrochloride
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB998149063A
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English (en)
Chinese (zh)
Other versions
CN1331681A (zh
Inventor
W��-L��Ҷ
W·－L·叶
�����ز��
C·安特查克
J·D·麦戈尔里克
M·J·罗斯
M·罗纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Martha Pharmaceutical Co ltd
Original Assignee
Maxim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxim Pharmaceuticals Inc filed Critical Maxim Pharmaceuticals Inc
Publication of CN1331681A publication Critical patent/CN1331681A/zh
Application granted granted Critical
Publication of CN1155579C publication Critical patent/CN1155579C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB998149063A 1998-12-23 1999-12-20 二盐酸组胺的合成 Expired - Lifetime CN1155579C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11393398P 1998-12-23 1998-12-23
US60/113,933 1998-12-23
US09/467,652 US6403806B1 (en) 1998-12-23 1999-12-20 Synthesis of histamine dihydrochloride

Publications (2)

Publication Number Publication Date
CN1331681A CN1331681A (zh) 2002-01-16
CN1155579C true CN1155579C (zh) 2004-06-30

Family

ID=26811642

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998149063A Expired - Lifetime CN1155579C (zh) 1998-12-23 1999-12-20 二盐酸组胺的合成

Country Status (17)

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US (3) US6403806B1 (enExample)
EP (1) EP1140857B1 (enExample)
JP (1) JP4139082B2 (enExample)
CN (1) CN1155579C (enExample)
AT (1) ATE399769T1 (enExample)
AU (1) AU763523B2 (enExample)
CA (1) CA2356871C (enExample)
DE (1) DE69939027D1 (enExample)
DK (1) DK1140857T3 (enExample)
ES (1) ES2310056T3 (enExample)
HK (1) HK1040998B (enExample)
IL (2) IL143570A0 (enExample)
NZ (1) NZ512935A (enExample)
PT (1) PT1140857E (enExample)
TW (1) TWI243166B (enExample)
WO (1) WO2000039098A1 (enExample)
ZA (1) ZA200104552B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101205160B (zh) * 2006-12-20 2012-01-18 赢创德固赛有限责任公司 用于使羧酸脱羧的连续方法

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6590106B2 (en) * 1997-05-09 2003-07-08 Pharm-Eco Laboratories, Inc. Amino acid derivatives and methods of making the same
US7728015B2 (en) * 2004-04-22 2010-06-01 Mor Research Applications Ltd. Compositions for weight management
WO2005101979A2 (en) * 2004-04-22 2005-11-03 Mor Research Applications Ltd. Method of food intake management
US20080051440A1 (en) * 2004-04-22 2008-02-28 Mor Research Applications Ltd. Compositions for weight management
US20060188528A1 (en) * 2005-02-23 2006-08-24 Ansell Healthcare Products Llc Spreadable warming lubricant
US7709428B2 (en) * 2005-02-23 2010-05-04 Ansell Healthcare Products Llc Thickened spreadable warming lubricant
US8770201B2 (en) * 2007-10-26 2014-07-08 Glycobiosciences Inc. Condom with multifunctional coating
CN102477014B (zh) * 2010-11-27 2015-08-19 山东新时代药业有限公司 二盐酸组胺的制备方法
ITMI20110379A1 (it) * 2011-03-10 2012-09-11 Erregierre Spa Procedimento per la preparazione di istamina dicloridrato con elevato grado di purezza
US9452954B2 (en) 2013-03-14 2016-09-27 University Of Georgia Research Foundation, Inc. Method for decarboxylation of amino acids via imine formation
US10487042B2 (en) 2013-03-14 2019-11-26 University Of Georgia Research Foundation, Inc. Method for solvent-free decarboxylation of amino acids via imine formation
US10118898B2 (en) 2013-03-14 2018-11-06 University Of Georgia Research Foundation, Inc. Method for decarboxylation of amino acids via imine formation
CN103288742A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种高纯度英加韦林原料的制备方法
CN103739551B (zh) * 2013-09-24 2016-03-23 国药一心制药有限公司 一种二盐酸组胺的纯化方法
JP6495288B2 (ja) 2013-12-17 2019-04-03 サイモン フレーザー ユニバーシティー トコジラミを誘引および／または拘束するための化合物、組成物、および方法
CN103739552B (zh) * 2014-01-24 2015-08-26 国药一心制药有限公司 二盐酸组胺的制备方法
CN104402825B (zh) * 2014-12-13 2017-03-15 济南诚汇双达化工有限公司 一种组胺二盐酸盐的合成方法
CN106432089B (zh) * 2016-09-12 2018-09-07 开封制药(集团)有限公司 二盐酸组胺的合成方法
US10889549B2 (en) 2017-07-03 2021-01-12 Jubilant Generics Limited Continuous process for the preparation of 2-(1H-imidazol-4-yl) ethanamine and pharmaceutically acceptable salts thereof
WO2019008594A1 (en) * 2017-07-03 2019-01-10 Jubilant Generics Limited CONTINUOUS PROCESS FOR THE PREPARATION OF 2- (1H-IMIDAZOL-4-YL) ETHANAMINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
CN112266360B (zh) * 2020-10-26 2022-06-10 武汉桀升生物科技有限公司 一种高纯度组胺二盐酸盐的合成方法
CN113045500A (zh) * 2021-03-31 2021-06-29 苏州园方生物科技有限公司 一种组胺二盐酸盐的制备方法
JP7193815B1 (ja) 2021-12-28 2022-12-21 Ｋｍバイオロジクス株式会社 ヒスタミンの製造方法及び医薬品としてのその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE57638C (de) O. ECKARDT in Berlin j N.W., Bandelslr. 14 Verfahren zur Herstellung von Steinkohlenbriquettes auf kaltem Wege
GB430108A (en) * 1934-02-23 1935-06-13 Boot S Pure Drug Company Ltd Improvements relating to the preparation of histamine and its derivatives
GB1008594A (en) 1963-07-03 1965-10-27 Nat Res Dev Process for the production of amines
SU557755A3 (ru) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Способ получени производных имидазола
DE3322117A1 (de) * 1983-06-20 1984-12-20 Diamalt AG, 8000 München Verfahren zur herstellung von n(pfeil hoch)(tau)(pfeil hoch)-substituierten histidinderivaten, n(pfeil hoch)(tau)(pfeil hoch)-substituierten histidinderivate und ihre verwendung
NL8800998A (nl) * 1988-04-18 1989-11-16 Cedona Pharm Bv Werkwijze voor het bereiden van een al of niet gesubstitueerd 4(5)-(omega-aminoalkyl) imidazool.
JPH05255204A (ja) * 1992-03-11 1993-10-05 Kanegafuchi Chem Ind Co Ltd アミン類の製造法
SE513429C2 (sv) 1992-06-03 2000-09-11 Syntello Inc Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101205160B (zh) * 2006-12-20 2012-01-18 赢创德固赛有限责任公司 用于使羧酸脱羧的连续方法

Also Published As

Publication number Publication date
US6528654B2 (en) 2003-03-04
EP1140857A1 (en) 2001-10-10
ZA200104552B (en) 2002-01-16
US6620942B2 (en) 2003-09-16
CA2356871A1 (en) 2000-07-06
DK1140857T3 (da) 2008-10-20
TWI243166B (en) 2005-11-11
AU763523B2 (en) 2003-07-24
HK1040998B (en) 2009-04-24
EP1140857B1 (en) 2008-07-02
CA2356871C (en) 2010-09-14
US6403806B1 (en) 2002-06-11
AU2482500A (en) 2000-07-31
IL143570A (en) 2006-08-20
CN1331681A (zh) 2002-01-16
JP2002533445A (ja) 2002-10-08
IL143570A0 (en) 2002-04-21
ATE399769T1 (de) 2008-07-15
NZ512935A (en) 2003-08-29
PT1140857E (pt) 2008-10-06
HK1040998A1 (en) 2002-06-28
US20020035268A1 (en) 2002-03-21
ES2310056T3 (es) 2008-12-16
WO2000039098A9 (en) 2001-05-17
DE69939027D1 (de) 2008-08-14
JP4139082B2 (ja) 2008-08-27
WO2000039098A1 (en) 2000-07-06
US20030138964A1 (en) 2003-07-24

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C06 Publication
C10 Entry into substantive examination
PB01 Publication
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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Effective date of registration: 20160919

Address after: Luxemburg Luxemburg

Patentee after: Martha Pharmaceutical Co.,Ltd.

Address before: California, USA

Patentee before: Maxim Pharmaceuticals, Inc.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20040630