JP4139082B2 - ヒスタミンジヒドロクロリドの合成 - Google Patents

ヒスタミンジヒドロクロリドの合成 Download PDF

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Publication number
JP4139082B2
JP4139082B2 JP2000591009A JP2000591009A JP4139082B2 JP 4139082 B2 JP4139082 B2 JP 4139082B2 JP 2000591009 A JP2000591009 A JP 2000591009A JP 2000591009 A JP2000591009 A JP 2000591009A JP 4139082 B2 JP4139082 B2 JP 4139082B2
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JP
Japan
Prior art keywords
histamine
dihydrochloride
methylacetophenone
solvent
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2000591009A
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English (en)
Japanese (ja)
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JP2002533445A5 (enExample
JP2002533445A (ja
Inventor
イエ，ウェン−ラン
アントクザック，カシミール
デイビット マクゴルリック，ジェフリー
ジョセフ ロス，マイケル
ロナ，マーク
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Maxim Pharmaceuticals Inc
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Maxim Pharmaceuticals Inc
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Publication date
Application filed by Maxim Pharmaceuticals Inc filed Critical Maxim Pharmaceuticals Inc
Publication of JP2002533445A publication Critical patent/JP2002533445A/ja
Publication of JP2002533445A5 publication Critical patent/JP2002533445A5/ja
Application granted granted Critical
Publication of JP4139082B2 publication Critical patent/JP4139082B2/ja
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2000591009A 1998-12-23 1999-12-20 ヒスタミンジヒドロクロリドの合成 Expired - Fee Related JP4139082B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11393398P 1998-12-23 1998-12-23
US60/113,933 1998-12-23
PCT/US1999/030379 WO2000039098A1 (en) 1998-12-23 1999-12-20 Synthesis of histamine dihydrochloride
US09/467,652 US6403806B1 (en) 1998-12-23 1999-12-20 Synthesis of histamine dihydrochloride

Publications (3)

Publication Number Publication Date
JP2002533445A JP2002533445A (ja) 2002-10-08
JP2002533445A5 JP2002533445A5 (enExample) 2005-11-17
JP4139082B2 true JP4139082B2 (ja) 2008-08-27

Family

ID=26811642

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000591009A Expired - Fee Related JP4139082B2 (ja) 1998-12-23 1999-12-20 ヒスタミンジヒドロクロリドの合成

Country Status (17)

Country Link
US (3) US6403806B1 (enExample)
EP (1) EP1140857B1 (enExample)
JP (1) JP4139082B2 (enExample)
CN (1) CN1155579C (enExample)
AT (1) ATE399769T1 (enExample)
AU (1) AU763523B2 (enExample)
CA (1) CA2356871C (enExample)
DE (1) DE69939027D1 (enExample)
DK (1) DK1140857T3 (enExample)
ES (1) ES2310056T3 (enExample)
HK (1) HK1040998B (enExample)
IL (2) IL143570A0 (enExample)
NZ (1) NZ512935A (enExample)
PT (1) PT1140857E (enExample)
TW (1) TWI243166B (enExample)
WO (1) WO2000039098A1 (enExample)
ZA (1) ZA200104552B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6590106B2 (en) * 1997-05-09 2003-07-08 Pharm-Eco Laboratories, Inc. Amino acid derivatives and methods of making the same
CA2553309A1 (en) * 2004-04-22 2005-11-03 Mor Research Applications Ltd. Method of food intake management
US20080051440A1 (en) * 2004-04-22 2008-02-28 Mor Research Applications Ltd. Compositions for weight management
US7728015B2 (en) * 2004-04-22 2010-06-01 Mor Research Applications Ltd. Compositions for weight management
US20060188528A1 (en) * 2005-02-23 2006-08-24 Ansell Healthcare Products Llc Spreadable warming lubricant
US7709428B2 (en) * 2005-02-23 2010-05-04 Ansell Healthcare Products Llc Thickened spreadable warming lubricant
DE102006060908A1 (de) 2006-12-20 2008-07-03 Evonik Degussa Gmbh Kontinuierliches Verfahren zur Decarboxylierung von Carbonsäuren
US8770201B2 (en) * 2007-10-26 2014-07-08 Glycobiosciences Inc. Condom with multifunctional coating
CN102477014B (zh) * 2010-11-27 2015-08-19 山东新时代药业有限公司 二盐酸组胺的制备方法
ITMI20110379A1 (it) * 2011-03-10 2012-09-11 Erregierre Spa Procedimento per la preparazione di istamina dicloridrato con elevato grado di purezza
US10487042B2 (en) 2013-03-14 2019-11-26 University Of Georgia Research Foundation, Inc. Method for solvent-free decarboxylation of amino acids via imine formation
US10118898B2 (en) 2013-03-14 2018-11-06 University Of Georgia Research Foundation, Inc. Method for decarboxylation of amino acids via imine formation
US9452954B2 (en) 2013-03-14 2016-09-27 University Of Georgia Research Foundation, Inc. Method for decarboxylation of amino acids via imine formation
CN103288742A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种高纯度英加韦林原料的制备方法
CN103739551B (zh) * 2013-09-24 2016-03-23 国药一心制药有限公司 一种二盐酸组胺的纯化方法
JP6495288B2 (ja) * 2013-12-17 2019-04-03 サイモン フレーザー ユニバーシティー トコジラミを誘引および／または拘束するための化合物、組成物、および方法
CN103739552B (zh) * 2014-01-24 2015-08-26 国药一心制药有限公司 二盐酸组胺的制备方法
CN104402825B (zh) * 2014-12-13 2017-03-15 济南诚汇双达化工有限公司 一种组胺二盐酸盐的合成方法
CN106432089B (zh) * 2016-09-12 2018-09-07 开封制药(集团)有限公司 二盐酸组胺的合成方法
US10889549B2 (en) 2017-07-03 2021-01-12 Jubilant Generics Limited Continuous process for the preparation of 2-(1H-imidazol-4-yl) ethanamine and pharmaceutically acceptable salts thereof
WO2019008594A1 (en) * 2017-07-03 2019-01-10 Jubilant Generics Limited CONTINUOUS PROCESS FOR THE PREPARATION OF 2- (1H-IMIDAZOL-4-YL) ETHANAMINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
CN112266360B (zh) * 2020-10-26 2022-06-10 武汉桀升生物科技有限公司 一种高纯度组胺二盐酸盐的合成方法
CN113045500A (zh) * 2021-03-31 2021-06-29 苏州园方生物科技有限公司 一种组胺二盐酸盐的制备方法
JP7193815B1 (ja) 2021-12-28 2022-12-21 Ｋｍバイオロジクス株式会社 ヒスタミンの製造方法及び医薬品としてのその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE56793C (de) O. ECKARDT in Berlin Verfahren zur Herstellung von Steinkohlenbriquets auf kaltem Wege
GB430108A (en) * 1934-02-23 1935-06-13 Boot S Pure Drug Company Ltd Improvements relating to the preparation of histamine and its derivatives
GB1008594A (en) 1963-07-03 1965-10-27 Nat Res Dev Process for the production of amines
SU557755A3 (ru) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Способ получени производных имидазола
DE3322117A1 (de) * 1983-06-20 1984-12-20 Diamalt AG, 8000 München Verfahren zur herstellung von n(pfeil hoch)(tau)(pfeil hoch)-substituierten histidinderivaten, n(pfeil hoch)(tau)(pfeil hoch)-substituierten histidinderivate und ihre verwendung
NL8800998A (nl) * 1988-04-18 1989-11-16 Cedona Pharm Bv Werkwijze voor het bereiden van een al of niet gesubstitueerd 4(5)-(omega-aminoalkyl) imidazool.
JPH05255204A (ja) 1992-03-11 1993-10-05 Kanegafuchi Chem Ind Co Ltd アミン類の製造法
SE513429C2 (sv) 1992-06-03 2000-09-11 Syntello Inc Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer

Also Published As

Publication number Publication date
CN1155579C (zh) 2004-06-30
CA2356871C (en) 2010-09-14
DK1140857T3 (da) 2008-10-20
US6528654B2 (en) 2003-03-04
AU763523B2 (en) 2003-07-24
HK1040998B (en) 2009-04-24
ES2310056T3 (es) 2008-12-16
US6620942B2 (en) 2003-09-16
HK1040998A1 (en) 2002-06-28
ATE399769T1 (de) 2008-07-15
US20020035268A1 (en) 2002-03-21
WO2000039098A9 (en) 2001-05-17
WO2000039098A1 (en) 2000-07-06
IL143570A (en) 2006-08-20
TWI243166B (en) 2005-11-11
US6403806B1 (en) 2002-06-11
NZ512935A (en) 2003-08-29
EP1140857A1 (en) 2001-10-10
ZA200104552B (en) 2002-01-16
CA2356871A1 (en) 2000-07-06
DE69939027D1 (de) 2008-08-14
IL143570A0 (en) 2002-04-21
CN1331681A (zh) 2002-01-16
US20030138964A1 (en) 2003-07-24
EP1140857B1 (en) 2008-07-02
JP2002533445A (ja) 2002-10-08
AU2482500A (en) 2000-07-31
PT1140857E (pt) 2008-10-06

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