CN1152863C - 作为环氧合酶-2选择性抑制剂的取代的吡啶类化合物及其组合物 - Google Patents

作为环氧合酶-2选择性抑制剂的取代的吡啶类化合物及其组合物 Download PDF

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Publication number
CN1152863C
CN1152863C CNB971963770A CN97196377A CN1152863C CN 1152863 C CN1152863 C CN 1152863C CN B971963770 A CNB971963770 A CN B971963770A CN 97196377 A CN97196377 A CN 97196377A CN 1152863 C CN1152863 C CN 1152863C
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methylsulfonyl
phenyl
acid
pyridyl
cox
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Expired - Lifetime
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CNB971963770A
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Chinese (zh)
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CN1225085A (zh
Inventor
D���ű�
D·杜贝
R·福廷
�������ɭ
R·弗里森
王召印
J·Y·戈捷
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Merck Canada Inc
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Merck Frosst Canada Ltd
Merck Frosst Canada and Co
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Priority claimed from GBGB9616126.0A external-priority patent/GB9616126D0/en
Priority claimed from GBGB9621420.0A external-priority patent/GB9621420D0/en
Priority claimed from GBGB9709291.0A external-priority patent/GB9709291D0/en
Application filed by Merck Frosst Canada Ltd, Merck Frosst Canada and Co filed Critical Merck Frosst Canada Ltd
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • Health & Medical Sciences (AREA)
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CNB971963770A 1996-07-18 1997-07-08 作为环氧合酶-2选择性抑制剂的取代的吡啶类化合物及其组合物 Expired - Lifetime CN1152863C (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US2212896P 1996-07-18 1996-07-18
US60/022,128 1996-07-18
GBGB9616126.0A GB9616126D0 (en) 1996-08-01 1996-08-01 Substituted pyridines as selective cyclooxygenase-2 inhibitors
GB9616126.0 1996-08-01
US2713996P 1996-10-01 1996-10-01
US60/027,139 1996-10-01
GBGB9621420.0A GB9621420D0 (en) 1996-10-15 1996-10-15 Substituted pyridines as selective cyclooxygenase-2 inhibitors
GB9621420.0 1996-10-15
US4181497P 1997-04-08 1997-04-08
US60/041,814 1997-04-08
GBGB9709291.0A GB9709291D0 (en) 1997-05-07 1997-05-07 Substituted pyridines as selective cyclooxygenase-2 inhibitors
GB9709291.0 1997-05-07

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CN1225085A CN1225085A (zh) 1999-08-04
CN1152863C true CN1152863C (zh) 2004-06-09

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CN107286085B (zh) * 2017-05-25 2020-06-16 华东师范大学 一种吡啶类衍生物及其合成方法
CN107556232A (zh) * 2017-09-26 2018-01-09 江苏正大清江制药有限公司 一种依托考昔与盐酸形成盐的新晶型及制备方法

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