CN113710229B - 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物 - Google Patents

用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物

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Publication number
CN113710229B
CN113710229B CN202080030419.5A CN202080030419A CN113710229B CN 113710229 B CN113710229 B CN 113710229B CN 202080030419 A CN202080030419 A CN 202080030419A CN 113710229 B CN113710229 B CN 113710229B
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inflammatory
peptide
composition
antibody
autoimmune
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CN113710229A (zh
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杰弗里·A·哈贝尔
胜俣清光
石原亚香
石原纯
阿斯兰·曼苏罗夫
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University of Chicago
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University of Chicago
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202080030419.5A 2019-02-25 2020-02-25 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物 Active CN113710229B (zh)

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US201962809988P 2019-02-25 2019-02-25
US62/809,988 2019-02-25
PCT/US2020/019668 WO2020176478A1 (en) 2019-02-25 2020-02-25 Methods and compositions for treating inflammatory and autoimmune conditions with ecm-affinity peptides linked to anti-inflammatory agents

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CN202511945876.8A Division CN121971599A (en) 2019-02-25 2020-02-25 Methods and compositions for treating inflammatory and autoimmune disorders with ECM-affinity peptides linked to anti-inflammatory agents

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CN113710229A CN113710229A (zh) 2021-11-26
CN113710229B true CN113710229B (zh) 2026-01-06

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US (2) US12465640B2 (https=)
EP (1) EP3930687A4 (https=)
JP (2) JP2022521428A (https=)
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WO (1) WO2020176478A1 (https=)

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AU2019232729B2 (en) * 2018-03-05 2024-08-08 The University Of Chicago Methods and compositions for treating cancer with ECM-affinity peptides linked to cytokines
CN113710229B (zh) 2019-02-25 2026-01-06 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
WO2020212598A1 (en) 2019-04-19 2020-10-22 Synerkine Pharma B.V. A fusion protein comprising il13
SE545148C2 (en) * 2020-06-29 2023-04-18 Antaros Tracer Ab Novel compounds for use in diagnosis and/or monitoring of fibrosis
JP2023543266A (ja) * 2020-09-25 2023-10-13 ザ・ユニバーシティ・オブ・シカゴ 抗炎症性サイトカインおよび使用の方法
CN112225820B (zh) * 2020-10-21 2023-01-17 中美福源生物技术(北京)股份有限公司 肿瘤特异靶向性基质的重组人血清白蛋白-胶原结合域融合蛋白和应用
US20240044915A1 (en) * 2020-12-22 2024-02-08 Ann And Robert H. Lurie Children's Hospital Of Chicago Use of stromal cell-derived factor 1 (sdf1) as a biomarker for diagnosing and treating severe acute respiratory distress syndrome (ards)
WO2022256824A1 (en) * 2021-06-03 2022-12-08 The University Of Chicago Methods and compositions for treating fibrosis
CN116987202B (zh) * 2023-09-27 2023-12-01 英特菲尔(成都)生物制品有限责任公司 一种具有抗炎舒缓活性的融合蛋白及其制备方法与应用
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