CN1120157C - 取代的喹啉－2－甲酰胺、其制备方法和其作为药物的应用以及其中间体 - Google Patents

取代的喹啉－2－甲酰胺、其制备方法和其作为药物的应用以及其中间体 Download PDF

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Publication number
CN1120157C
CN1120157C CN96122806A CN96122806A CN1120157C CN 1120157 C CN1120157 C CN 1120157C CN 96122806 A CN96122806 A CN 96122806A CN 96122806 A CN96122806 A CN 96122806A CN 1120157 C CN1120157 C CN 1120157C
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CN
China
Prior art keywords
formula
alkyl
compound
hydrogen
mmol
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN96122806A
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English (en)
Chinese (zh)
Other versions
CN1154365A (zh
Inventor
K·维德曼
K·H·巴伦格哈斯
G·施安克
M·比凯尔
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FIBRE GENE Inc
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Hoechst AG
Fiber Genetics
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Priority claimed from DE19536263A external-priority patent/DE19536263A1/de
Application filed by Hoechst AG, Fiber Genetics filed Critical Hoechst AG
Publication of CN1154365A publication Critical patent/CN1154365A/zh
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Publication of CN1120157C publication Critical patent/CN1120157C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN96122806A 1995-09-28 1996-09-26 取代的喹啉－2－甲酰胺、其制备方法和其作为药物的应用以及其中间体 Expired - Lifetime CN1120157C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19536263.2 1995-09-28
DE19536263A DE19536263A1 (de) 1995-09-28 1995-09-28 Substituierte Chinolin-2-carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19605170 1996-02-13
DE19605170.3 1996-02-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN00118801A Division CN1282737A (zh) 1995-09-28 2000-06-14 用于制备取代的喹啉－2－甲酰胺的中间体

Publications (2)

Publication Number Publication Date
CN1154365A CN1154365A (zh) 1997-07-16
CN1120157C true CN1120157C (zh) 2003-09-03

Family

ID=26019051

Family Applications (2)

Application Number Title Priority Date Filing Date
CN96122806A Expired - Lifetime CN1120157C (zh) 1995-09-28 1996-09-26 取代的喹啉－2－甲酰胺、其制备方法和其作为药物的应用以及其中间体
CN00118801A Pending CN1282737A (zh) 1995-09-28 2000-06-14 用于制备取代的喹啉－2－甲酰胺的中间体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN00118801A Pending CN1282737A (zh) 1995-09-28 2000-06-14 用于制备取代的喹啉－2－甲酰胺的中间体

Country Status (20)

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US (2) US5726305A (enExample)
EP (1) EP0765871B1 (enExample)
JP (1) JPH09124606A (enExample)
KR (1) KR970061869A (enExample)
CN (2) CN1120157C (enExample)
AT (1) ATE263155T1 (enExample)
AU (1) AU728208B2 (enExample)
CA (1) CA2186717A1 (enExample)
CZ (1) CZ283396A3 (enExample)
DE (1) DE59610950D1 (enExample)
ES (1) ES2215184T3 (enExample)
HU (1) HUP9602685A3 (enExample)
IL (2) IL135495A (enExample)
MX (1) MX9604378A (enExample)
MY (1) MY133647A (enExample)
NO (1) NO308600B1 (enExample)
NZ (1) NZ299455A (enExample)
PL (1) PL316321A1 (enExample)
SG (1) SG45503A1 (enExample)
SI (1) SI9600287A (enExample)

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DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US20020198145A1 (en) * 1999-06-10 2002-12-26 Cognetix, Inc. MuO-conopeptides and their use as local anesthetics
CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP4590157B2 (ja) * 2001-03-21 2010-12-01 アイシス イノヴェイション リミテッド アッセイ、方法および手段
ES2686625T3 (es) * 2001-12-06 2018-10-18 Fibrogen, Inc. Métodos para el tratamiento o prevención de la anemia
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
KR100932169B1 (ko) 2003-06-06 2009-12-16 피브로겐, 인크. 질소-함유 헤테로아릴 화합물 및 내인성 적혈구생성소의증가에서의 그들의 사용
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
WO2005034929A2 (en) * 2003-10-10 2005-04-21 Fibrogen, Inc. Tissue remodeling and vascularization
CN101849943A (zh) * 2005-06-06 2010-10-06 菲布罗根公司 使用HIFα稳定剂的改进的贫血治疗
EP1919463B9 (en) 2005-06-15 2011-02-02 Fibrogen, Inc. Use of hif 1alfa modulators for treatment of cancer
AU2006286654A1 (en) 2005-07-27 2007-03-08 F. Hoffmann-La Roche Ag 4-aryloxy quinoline derivatives as 5-HT6 modulators
US7728130B2 (en) 2005-12-09 2010-06-01 Amgen Inc. Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity
MX2008009581A (es) 2006-01-27 2009-01-07 Fibrogen Inc Compuestos de cianoisoquinolina que estabilizan el factor inducible hipoxia (fih).
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
US7625927B2 (en) * 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
JP5247677B2 (ja) * 2006-03-30 2013-07-24 エルジー エレクトロニクス インコーポレイティド ビデオ信号のデコーディング／エンコーディング方法及び装置
AU2007234408B2 (en) * 2006-04-04 2011-05-19 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as HIF modulators
MX2009000286A (es) 2006-06-26 2009-03-20 Procter & Gamble Inhibidores de prolil hidroxilasa y metodos de uso.
AU2007334323B2 (en) * 2006-12-18 2011-03-10 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
AU2007334321B2 (en) * 2006-12-18 2012-03-08 Amgen Inc. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
JP2010524942A (ja) * 2007-04-18 2010-07-22 アムジエン・インコーポレーテツド プロリルヒドロキシラーゼを阻害するキノロン及びアザキノロン
ES2446418T3 (es) * 2007-04-18 2014-03-07 Amgen, Inc Derivados de indanona que inhiben la prolil hidroxilasa
ES2389063T3 (es) * 2007-05-04 2012-10-22 Amgen, Inc Derivados de tienopiridina y tiazolopiridina que inhiben la actividad prolil hidroxilasa
CA2685219C (en) * 2007-05-04 2012-06-19 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
US8962530B2 (en) * 2007-06-27 2015-02-24 Regents Of The University Of Colorado Inflammatory bowel disease therapies
AU2009314155B2 (en) 2008-11-14 2015-10-08 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
UA107360C2 (en) * 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
NZ600674A (en) * 2009-12-17 2013-05-31 Merck Sharp & Dohme Quinoline amide m1 receptor positive allosteric modulators
JP6002155B2 (ja) 2011-02-07 2016-10-05 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． Ｓ１ｐ調節薬
NO2686520T3 (enExample) 2011-06-06 2018-03-17
SG11201405574UA (en) 2012-03-09 2014-10-30 Fibrogen Inc 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors
BR112015001106B1 (pt) 2012-07-16 2021-11-09 Fibrogen, Inc Métodos para a produção de compostos de isoquinolina
SMT201800565T1 (it) 2012-07-16 2018-11-09 Fibrogen Inc Forme cristalline di un inibitore di prolil idrossilasi
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
MX363388B (es) * 2012-07-27 2019-03-20 Biogen Ma Inc Agentes moduladores de autotaxina.
TWI685487B (zh) 2013-01-24 2020-02-21 美商費比羅根公司 ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形
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CN107427503A (zh) 2015-01-23 2017-12-01 阿克比治疗有限公司 2‑(5‑(3‑氟苯基)‑3‑羟基吡啶甲酰胺)乙酸的固体形式、其组合物及用途
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EP0661269A1 (de) * 1993-12-30 1995-07-05 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
CN1107145A (zh) * 1993-11-02 1995-08-23 赫彻斯特股份公司 取代的杂环羧酰胺、它们的制备及作为药物的应用

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TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
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CN1107145A (zh) * 1993-11-02 1995-08-23 赫彻斯特股份公司 取代的杂环羧酰胺、它们的制备及作为药物的应用
EP0661269A1 (de) * 1993-12-30 1995-07-05 Hoechst Aktiengesellschaft Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
ES2215184T3 (es) 2004-10-01
MY133647A (en) 2007-11-30
US5719164A (en) 1998-02-17
DE59610950D1 (de) 2004-05-06
NZ299455A (en) 1997-06-24
NO964093L (no) 1997-04-01
CN1154365A (zh) 1997-07-16
MX9604378A (es) 1997-03-29
IL135495A (en) 2002-12-01
EP0765871B1 (de) 2004-03-31
IL119302A0 (en) 1996-12-05
SI9600287A (en) 1997-04-30
PL316321A1 (en) 1997-04-01
SG45503A1 (en) 1998-01-16
US5726305A (en) 1998-03-10
CZ283396A3 (en) 1997-04-16
CA2186717A1 (en) 1997-03-29
CN1282737A (zh) 2001-02-07
ATE263155T1 (de) 2004-04-15
NO964093D0 (no) 1996-09-27
HUP9602685A2 (hu) 1998-09-28
AU728208B2 (en) 2001-01-04
EP0765871A1 (de) 1997-04-02
AU6583896A (en) 1997-04-10
HUP9602685A3 (en) 2001-04-28
NO308600B1 (no) 2000-10-02
KR970061869A (ko) 1997-09-12
HU9602685D0 (en) 1996-11-28
JPH09124606A (ja) 1997-05-13

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